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The map label for this gene is groEL

Identifier: 118581209

GI number: 118581209

Start: 3067552

End: 3069216

Strand: Reverse

Name: groEL

Synonym: Ppro_2802

Alternate gene names: 118581209

Gene position: 3069216-3067552 (Counterclockwise)

Preceding gene: 118581210

Following gene: 118581208

Centisome position: 76.58

GC content: 59.1

Gene sequence:

>1665_bases
ATGGCAGCAAAAATCATCAAGTTTGACCAGGAAGGGCGTAACGCCATCCTGAAGGGCGTCAACATCCTCGCCGATACCGT
AAAAGTTACCCTCGGCCCCAAGGGTCGTAATGTCGTTATCGACAAATCCTTCGGCGCACCGCTGATCACCAAGGACGGCG
TGACCGTTGCTAAGGAAATCGAACTGGAAGACAAGTTCGAAAACATGGGCGCCCAGCTGGTCAAGGAAGTCGCCTCCAAG
ACTTCCGACGTTGCCGGTGACGGCACCACCACCGCAACGGTTCTGGCCCAGGCCATCTACCGCCAGGGCTCCAAGCTGGT
GGCAGCCGGTCACAACCCCATGGAAATCAAGCGCGGCATCGATAAGGCTGTTGAAACCATCGTCGCCGAACTGCAGAAGA
TCTCCAAGCCGATCGTCGACCACAAGGAAATCGCCCAGGTCGGCACCATTTCCGCCAACAACGACAAGACCATCGGTGAC
ATCATCGCCGAGGCCATGGAGAAGGTCGGCAAGGAAGGGGTTATCACCGTCGAGGAAGCCAAGTCCATGGATACCACCCT
GGAAACCGTGGAAGGCATGCAGTTCGACCGTGGCTATCTCTCCCCCTACTTCGTCACCGATCCGGAGCGTATGGAAGCTG
CCCTGGAGAACGCCCTGATCCTGATCCACGACAAGAAGATCTCCAACATGAAGGACCTGCTCCCGATTCTGGAGCAGACC
GCCAAGTCCGGTCGTCCGCTGCTGATCATCGCCGAGGACATTGAAGGCGAAGCCCTGGCAACTCTGGTTGTCAACAAGCT
GCGTGGCGTGCTGAACGTGGCTGCCGTCAAGGCACCCGGCTTCGGTGACCGTCGCAAGGCAATGCTGGAAGACATCGCCA
CCCTGACCGGCGGCCTGGTGATCTCCGAAGAAGTCGGCCACAAGCTTGAGCAGGCCACCATGGACATGCTCGGCCGCGCC
AAGCGCATCACCATTGACAAGGACAACACCACCATCATCGATGGTGAAGGCAAGGAAGCCGACATCCAGGGTCGCGTCAA
GCAGATCCGCGCCCAGATCGAAGAAACCACCAGCGACTACGACAAGGAAAAGCTGCAGGAGCGCCTTGCCAAACTGGTGG
GCGGCGTGGCCGTCATCAAGGTCGGCGCGGCAACCGAAGTCGAGATGAAAGAAAAGAAGGCCCGCGTCGAGGATGCGCTG
CACGCTACCCGTGCCGCTGTTGATGAAGGCGTGGTCCCTGGTGGTGGCGTTGCCTATATCCGTACACTGAGCGCACTGGA
TAACCTGAATCTGGAAAACGAGCAGCAGTTCGGCGTAACCGTGGTCAAGTTGGCACTTGAAGCGCCGATCCGCCAGATCG
CTGACAATGCCGGTATCGATGCCTCCATCGTTGTCGACAAGGTCAGGAACGGCAAGGATGCCTTCGGTTACGACGCAGCC
TCCGATGAGTATGTGGACATGCTCAAGGCCGGCATCATCGACCCGACCAAGGTTTCCCGCTCCGCTCTGCAGAACGCTTC
CTCCATCGCCGGTCTGATGCTGACCACCGAAGCGCTGATCGCCGAGAAGCCGCGTGAAGAAGGTGCCATGGGTGGCGGTA
TGCCTGGTGGCATGGGCGGCATGGGTGGCATGGGTGGCATGGGTGGCATGGGCGGCATGATGTAA

Upstream 100 bases:

>100_bases
GGGCGCGTGACATGCTCCGAGCAAATGCGGCATAGTGAGGGCGAATCGTTATCGCCTCTCCCCCAACAGGCACTTTATTC
TTTAATGGAGGAATTCATCA

Downstream 100 bases:

>100_bases
TATCGCCGCTGCACCATTGTATGCTGAATGTGCGGTAATCGACATGGCCGGGGGCGTCTGCTCCCGGCCATGTGTCGTTT
TGAAAAACATTACCAGGCGA

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60

Number of amino acids: Translated: 554; Mature: 553

Protein sequence:

>554_residues
MAAKIIKFDQEGRNAILKGVNILADTVKVTLGPKGRNVVIDKSFGAPLITKDGVTVAKEIELEDKFENMGAQLVKEVASK
TSDVAGDGTTTATVLAQAIYRQGSKLVAAGHNPMEIKRGIDKAVETIVAELQKISKPIVDHKEIAQVGTISANNDKTIGD
IIAEAMEKVGKEGVITVEEAKSMDTTLETVEGMQFDRGYLSPYFVTDPERMEAALENALILIHDKKISNMKDLLPILEQT
AKSGRPLLIIAEDIEGEALATLVVNKLRGVLNVAAVKAPGFGDRRKAMLEDIATLTGGLVISEEVGHKLEQATMDMLGRA
KRITIDKDNTTIIDGEGKEADIQGRVKQIRAQIEETTSDYDKEKLQERLAKLVGGVAVIKVGAATEVEMKEKKARVEDAL
HATRAAVDEGVVPGGGVAYIRTLSALDNLNLENEQQFGVTVVKLALEAPIRQIADNAGIDASIVVDKVRNGKDAFGYDAA
SDEYVDMLKAGIIDPTKVSRSALQNASSIAGLMLTTEALIAEKPREEGAMGGGMPGGMGGMGGMGGMGGMGGMM

Sequences:

>Translated_554_residues
MAAKIIKFDQEGRNAILKGVNILADTVKVTLGPKGRNVVIDKSFGAPLITKDGVTVAKEIELEDKFENMGAQLVKEVASK
TSDVAGDGTTTATVLAQAIYRQGSKLVAAGHNPMEIKRGIDKAVETIVAELQKISKPIVDHKEIAQVGTISANNDKTIGD
IIAEAMEKVGKEGVITVEEAKSMDTTLETVEGMQFDRGYLSPYFVTDPERMEAALENALILIHDKKISNMKDLLPILEQT
AKSGRPLLIIAEDIEGEALATLVVNKLRGVLNVAAVKAPGFGDRRKAMLEDIATLTGGLVISEEVGHKLEQATMDMLGRA
KRITIDKDNTTIIDGEGKEADIQGRVKQIRAQIEETTSDYDKEKLQERLAKLVGGVAVIKVGAATEVEMKEKKARVEDAL
HATRAAVDEGVVPGGGVAYIRTLSALDNLNLENEQQFGVTVVKLALEAPIRQIADNAGIDASIVVDKVRNGKDAFGYDAA
SDEYVDMLKAGIIDPTKVSRSALQNASSIAGLMLTTEALIAEKPREEGAMGGGMPGGMGGMGGMGGMGGMGGMM
>Mature_553_residues
AAKIIKFDQEGRNAILKGVNILADTVKVTLGPKGRNVVIDKSFGAPLITKDGVTVAKEIELEDKFENMGAQLVKEVASKT
SDVAGDGTTTATVLAQAIYRQGSKLVAAGHNPMEIKRGIDKAVETIVAELQKISKPIVDHKEIAQVGTISANNDKTIGDI
IAEAMEKVGKEGVITVEEAKSMDTTLETVEGMQFDRGYLSPYFVTDPERMEAALENALILIHDKKISNMKDLLPILEQTA
KSGRPLLIIAEDIEGEALATLVVNKLRGVLNVAAVKAPGFGDRRKAMLEDIATLTGGLVISEEVGHKLEQATMDMLGRAK
RITIDKDNTTIIDGEGKEADIQGRVKQIRAQIEETTSDYDKEKLQERLAKLVGGVAVIKVGAATEVEMKEKKARVEDALH
ATRAAVDEGVVPGGGVAYIRTLSALDNLNLENEQQFGVTVVKLALEAPIRQIADNAGIDASIVVDKVRNGKDAFGYDAAS
DEYVDMLKAGIIDPTKVSRSALQNASSIAGLMLTTEALIAEKPREEGAMGGGMPGGMGGMGGMGGMGGMGGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=527, Percent_Identity=50.4743833017078, Blast_Score=527, Evalue=1e-149,
Organism=Homo sapiens, GI31542947, Length=527, Percent_Identity=50.4743833017078, Blast_Score=527, Evalue=1e-149,
Organism=Homo sapiens, GI38455427, Length=537, Percent_Identity=22.5325884543762, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI63162572, Length=545, Percent_Identity=20.3669724770642, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1790586, Length=530, Percent_Identity=68.3018867924528, Blast_Score=715, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=528, Percent_Identity=53.9772727272727, Blast_Score=559, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI193210679, Length=210, Percent_Identity=54.7619047619048, Blast_Score=227, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17564182, Length=551, Percent_Identity=24.6823956442831, Blast_Score=81, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=54.7709923664122, Blast_Score=551, Evalue=1e-158,
Organism=Saccharomyces cerevisiae, GI6322524, Length=545, Percent_Identity=22.0183486238532, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=52.561669829222, Blast_Score=547, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=52.561669829222, Blast_Score=547, Evalue=1e-156,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=50.0948766603416, Blast_Score=525, Evalue=1e-149,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=50.0948766603416, Blast_Score=525, Evalue=1e-149,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=50.0948766603416, Blast_Score=525, Evalue=1e-149,
Organism=Drosophila melanogaster, GI17864606, Length=553, Percent_Identity=43.9421338155515, Blast_Score=458, Evalue=1e-129,
Organism=Drosophila melanogaster, GI24584129, Length=523, Percent_Identity=38.4321223709369, Blast_Score=335, Evalue=5e-92,
Organism=Drosophila melanogaster, GI19921262, Length=523, Percent_Identity=38.4321223709369, Blast_Score=335, Evalue=5e-92,
Organism=Drosophila melanogaster, GI24645179, Length=512, Percent_Identity=22.265625, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH60_PELPD (A1AST1)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_902459.1
- ProteinModelPortal:   A1AST1
- SMR:   A1AST1
- STRING:   A1AST1
- GeneID:   4573669
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_2802
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- OMA:   NSDTSIG
- PhylomeDB:   A1AST1
- ProtClustDB:   PRK00013
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 58846; Mature: 58714

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKIIKFDQEGRNAILKGVNILADTVKVTLGPKGRNVVIDKSFGAPLITKDGVTVAKEI
CCCCEEEECCCCHHHHHHHHHHHHHHEEEEECCCCCEEEEECCCCCCEEECCCCEEEHHC
ELEDKFENMGAQLVKEVASKTSDVAGDGTTTATVLAQAIYRQGSKLVAAGHNPMEIKRGI
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCHHHHHHHH
DKAVETIVAELQKISKPIVDHKEIAQVGTISANNDKTIGDIIAEAMEKVGKEGVITVEEA
HHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEHHHH
KSMDTTLETVEGMQFDRGYLSPYFVTDPERMEAALENALILIHDKKISNMKDLLPILEQT
HHHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHCCEEEEECCHHCCHHHHHHHHHHH
AKSGRPLLIIAEDIEGEALATLVVNKLRGVLNVAAVKAPGFGDRRKAMLEDIATLTGGLV
HHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCEE
ISEEVGHKLEQATMDMLGRAKRITIDKDNTTIIDGEGKEADIQGRVKQIRAQIEETTSDY
EEHHHHHHHHHHHHHHHCCCEEEEEECCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
DKEKLQERLAKLVGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVDEGVVPGGGVAYI
HHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
RTLSALDNLNLENEQQFGVTVVKLALEAPIRQIADNAGIDASIVVDKVRNGKDAFGYDAA
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCC
SDEYVDMLKAGIIDPTKVSRSALQNASSIAGLMLTTEALIAEKPREEGAMGGGMPGGMGG
CHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCC
MGGMGGMGGMGGMM
CCCCCCCCCCCCCC
>Mature Secondary Structure 
AAKIIKFDQEGRNAILKGVNILADTVKVTLGPKGRNVVIDKSFGAPLITKDGVTVAKEI
CCCEEEECCCCHHHHHHHHHHHHHHEEEEECCCCCEEEEECCCCCCEEECCCCEEEHHC
ELEDKFENMGAQLVKEVASKTSDVAGDGTTTATVLAQAIYRQGSKLVAAGHNPMEIKRGI
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCHHHHHHHH
DKAVETIVAELQKISKPIVDHKEIAQVGTISANNDKTIGDIIAEAMEKVGKEGVITVEEA
HHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEHHHH
KSMDTTLETVEGMQFDRGYLSPYFVTDPERMEAALENALILIHDKKISNMKDLLPILEQT
HHHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHCCEEEEECCHHCCHHHHHHHHHHH
AKSGRPLLIIAEDIEGEALATLVVNKLRGVLNVAAVKAPGFGDRRKAMLEDIATLTGGLV
HHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCEE
ISEEVGHKLEQATMDMLGRAKRITIDKDNTTIIDGEGKEADIQGRVKQIRAQIEETTSDY
EEHHHHHHHHHHHHHHHCCCEEEEEECCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
DKEKLQERLAKLVGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVDEGVVPGGGVAYI
HHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
RTLSALDNLNLENEQQFGVTVVKLALEAPIRQIADNAGIDASIVVDKVRNGKDAFGYDAA
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCC
SDEYVDMLKAGIIDPTKVSRSALQNASSIAGLMLTTEALIAEKPREEGAMGGGMPGGMGG
CHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCC
MGGMGGMGGMGGMM
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA