Click here to switch to the map view.

The map label for this gene is bioF [H]

Identifier: 118581174

GI number: 118581174

Start: 3028347

End: 3029546

Strand: Reverse

Name: bioF [H]

Synonym: Ppro_2767

Alternate gene names: 118581174

Gene position: 3029546-3028347 (Counterclockwise)

Preceding gene: 118581175

Following gene: 118581173

Centisome position: 75.59

GC content: 64.08

Gene sequence:

>1200_bases
ATGGGACTCTTTGACAAACTGGCTACCATCGCCCAGGGCCGGGCGGCGCTGGAAGAGTTGGGCATCGACCCCTTCAACGT
GGAGATCGAGGAAATCCTGTCGCCCACCGAGGCGCGCATCAATGGCCGCGAAACACTGCTGGCGGGAACTAACAACTACC
TGGGCCTGACCTTCGATCCCCGCTGTATCGAGGCTGCCTGCACGGCAACCCATGCCGAGGGGACCGGAACCACCGGTTCG
CGCATGGCCAACGGCACCTTTTCCGGCCATCGCGCCCTGGAGCGGGAGCTGGCCGCTTTCTACGGCTATGCCTCGGCCAT
CGTCTTCTCCACCGGATTCGTGGCCAATCTGGGAGCCATCTCCACCCTGACCGGTCCGGGGGACCTGATCCTGCTGGATG
CCGACAGTCATGCCAGCATCTACGACGGCTGCCGCATGAGCGGCGCCGACATCATCCGCTTCCGCCACAACAACGCGGCC
GATCTGGAGAAGCGGCTCCGCCGCCTGGGGGAGCGGACGAAGGATGCCCTGGTGATCATCGAGGGGATCTACAGCATGCT
GGGCGACCGGGCGCCCCTGGCGGAAATCGTCGCCCTGAAGAAACAGTACGGCTTCTGGCTGATGGTCGATGAGGCCCATT
CCCTGGGTGTGCTGGGAAAGAAGGGGAGGGGGCTGGTGGAGGAGGCCGGCTGCCTGGATCAGGTGGATTTCATCGTCGGT
ACCTTCAGCAAGAGCCTGGGGACCATCGGCGGCTTCTGCGTCAGCAATCACCCCGAACTGGACCTGGTGCGCTATGCCAG
CCGCTCCTACGTCTTTACCGCCTCACCGTCTCCCGCCACCATCGCCTCGGTGCGCCAGGCGCTCAGGCTGCTGGAAGCGG
GCACCGACCTGCGCGACCGTCTCTGGGCCAACGCCCGCCAGCTCTATGAAGGGCTGGGCAAGCTGGGCTTCAGGCTCGGT
CCCGAACCGACACCGGTGGTGGCTGTCTACATGGGATCAAAAGAGGAAACCCTGCTGGCCTGGAAGTGGATGCTCGACCA
GGGAGTCTACGTCAATCTGGTGCTTCCGCCGGCGGCGCCCGACGGCACCAGTCTTTTGCGCTGCAGCGTCGGCGCGGCCC
ATACGCCGGAGCAGATCGATGTTATCATAGAAGCCTTCGCAACCCTGAAAACCGTTGGGACTCTTCCCAGGGCTGTGTAA

Upstream 100 bases:

>100_bases
AGGATAGCTTCGATTTTTCCTTTCCCTTGAACGAACTCTCCGGTATCAGGACGGTGAAGGATTTCGTGCTGCGCATTCAA
CAGGAAATCGCGGGGTAGGT

Downstream 100 bases:

>100_bases
CGGGGGGCTCCTGATGAGGTTTTTCTCAGCCTTTCTACGCGCACTGGGAGATAACATTCCTCGGATAAGGGGTGTGCCAA
GGCTGGAAACGATCGATTTT

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MGLFDKLATIAQGRAALEELGIDPFNVEIEEILSPTEARINGRETLLAGTNNYLGLTFDPRCIEAACTATHAEGTGTTGS
RMANGTFSGHRALERELAAFYGYASAIVFSTGFVANLGAISTLTGPGDLILLDADSHASIYDGCRMSGADIIRFRHNNAA
DLEKRLRRLGERTKDALVIIEGIYSMLGDRAPLAEIVALKKQYGFWLMVDEAHSLGVLGKKGRGLVEEAGCLDQVDFIVG
TFSKSLGTIGGFCVSNHPELDLVRYASRSYVFTASPSPATIASVRQALRLLEAGTDLRDRLWANARQLYEGLGKLGFRLG
PEPTPVVAVYMGSKEETLLAWKWMLDQGVYVNLVLPPAAPDGTSLLRCSVGAAHTPEQIDVIIEAFATLKTVGTLPRAV

Sequences:

>Translated_399_residues
MGLFDKLATIAQGRAALEELGIDPFNVEIEEILSPTEARINGRETLLAGTNNYLGLTFDPRCIEAACTATHAEGTGTTGS
RMANGTFSGHRALERELAAFYGYASAIVFSTGFVANLGAISTLTGPGDLILLDADSHASIYDGCRMSGADIIRFRHNNAA
DLEKRLRRLGERTKDALVIIEGIYSMLGDRAPLAEIVALKKQYGFWLMVDEAHSLGVLGKKGRGLVEEAGCLDQVDFIVG
TFSKSLGTIGGFCVSNHPELDLVRYASRSYVFTASPSPATIASVRQALRLLEAGTDLRDRLWANARQLYEGLGKLGFRLG
PEPTPVVAVYMGSKEETLLAWKWMLDQGVYVNLVLPPAAPDGTSLLRCSVGAAHTPEQIDVIIEAFATLKTVGTLPRAV
>Mature_398_residues
GLFDKLATIAQGRAALEELGIDPFNVEIEEILSPTEARINGRETLLAGTNNYLGLTFDPRCIEAACTATHAEGTGTTGSR
MANGTFSGHRALERELAAFYGYASAIVFSTGFVANLGAISTLTGPGDLILLDADSHASIYDGCRMSGADIIRFRHNNAAD
LEKRLRRLGERTKDALVIIEGIYSMLGDRAPLAEIVALKKQYGFWLMVDEAHSLGVLGKKGRGLVEEAGCLDQVDFIVGT
FSKSLGTIGGFCVSNHPELDLVRYASRSYVFTASPSPATIASVRQALRLLEAGTDLRDRLWANARQLYEGLGKLGFRLGP
EPTPVVAVYMGSKEETLLAWKWMLDQGVYVNLVLPPAAPDGTSLLRCSVGAAHTPEQIDVIIEAFATLKTVGTLPRAV

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI284448556, Length=348, Percent_Identity=34.7701149425287, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI7657118, Length=348, Percent_Identity=34.7701149425287, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI83977442, Length=366, Percent_Identity=31.6939890710383, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI83977440, Length=366, Percent_Identity=31.6939890710383, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI83977444, Length=366, Percent_Identity=31.6939890710383, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI119220554, Length=370, Percent_Identity=35.1351351351351, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI4758668, Length=365, Percent_Identity=35.8904109589041, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI4502025, Length=364, Percent_Identity=30.4945054945055, Blast_Score=164, Evalue=9e-41,
Organism=Homo sapiens, GI40316939, Length=364, Percent_Identity=30.4945054945055, Blast_Score=164, Evalue=9e-41,
Organism=Homo sapiens, GI5454084, Length=374, Percent_Identity=30.7486631016043, Blast_Score=157, Evalue=2e-38,
Organism=Escherichia coli, GI1790046, Length=373, Percent_Identity=36.9973190348526, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI1786993, Length=350, Percent_Identity=32.2857142857143, Blast_Score=169, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71994529, Length=369, Percent_Identity=34.6883468834688, Blast_Score=211, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI32566772, Length=359, Percent_Identity=35.3760445682451, Blast_Score=197, Evalue=9e-51,
Organism=Caenorhabditis elegans, GI17560912, Length=367, Percent_Identity=32.1525885558583, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17560914, Length=367, Percent_Identity=32.1525885558583, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI71982617, Length=315, Percent_Identity=26.984126984127, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI71982625, Length=312, Percent_Identity=27.2435897435897, Blast_Score=128, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6320267, Length=349, Percent_Identity=30.945558739255, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6320438, Length=373, Percent_Identity=27.3458445040214, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6323954, Length=276, Percent_Identity=30.0724637681159, Blast_Score=132, Evalue=9e-32,
Organism=Drosophila melanogaster, GI24662918, Length=337, Percent_Identity=33.5311572700297, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI17136286, Length=369, Percent_Identity=33.0623306233062, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI24653280, Length=313, Percent_Identity=33.2268370607029, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24653276, Length=313, Percent_Identity=33.2268370607029, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24653278, Length=313, Percent_Identity=33.2268370607029, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI17137420, Length=339, Percent_Identity=29.7935103244838, Blast_Score=160, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 42895; Mature: 42763

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLFDKLATIAQGRAALEELGIDPFNVEIEEILSPTEARINGRETLLAGTNNYLGLTFDP
CCHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHCCCHHHCCCCCEEEEECCCCEEEEEECC
RCIEAACTATHAEGTGTTGSRMANGTFSGHRALERELAAFYGYASAIVFSTGFVANLGAI
HHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCC
STLTGPGDLILLDADSHASIYDGCRMSGADIIRFRHNNAADLEKRLRRLGERTKDALVII
EEECCCCCEEEEECCCCCCHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCHHHEEHH
EGIYSMLGDRAPLAEIVALKKQYGFWLMVDEAHSLGVLGKKGRGLVEEAGCLDQVDFIVG
HHHHHHHCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHCCCHHHHHHHHH
TFSKSLGTIGGFCVSNHPELDLVRYASRSYVFTASPSPATIASVRQALRLLEAGTDLRDR
HHHHHHHCCCCEEECCCCCHHHEEECCCCEEEECCCCCHHHHHHHHHHHHHHCCCCHHHH
LWANARQLYEGLGKLGFRLGPEPTPVVAVYMGSKEETLLAWKWMLDQGVYVNLVLPPAAP
HHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCEEEEEEEHHCCCCEEEEEECCCCC
DGTSLLRCSVGAAHTPEQIDVIIEAFATLKTVGTLPRAV
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
GLFDKLATIAQGRAALEELGIDPFNVEIEEILSPTEARINGRETLLAGTNNYLGLTFDP
CHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHCCCHHHCCCCCEEEEECCCCEEEEEECC
RCIEAACTATHAEGTGTTGSRMANGTFSGHRALERELAAFYGYASAIVFSTGFVANLGAI
HHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCC
STLTGPGDLILLDADSHASIYDGCRMSGADIIRFRHNNAADLEKRLRRLGERTKDALVII
EEECCCCCEEEEECCCCCCHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCHHHEEHH
EGIYSMLGDRAPLAEIVALKKQYGFWLMVDEAHSLGVLGKKGRGLVEEAGCLDQVDFIVG
HHHHHHHCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHCCCHHHHHHHHH
TFSKSLGTIGGFCVSNHPELDLVRYASRSYVFTASPSPATIASVRQALRLLEAGTDLRDR
HHHHHHHCCCCEEECCCCCHHHEEECCCCEEEECCCCCHHHHHHHHHHHHHHCCCCHHHH
LWANARQLYEGLGKLGFRLGPEPTPVVAVYMGSKEETLLAWKWMLDQGVYVNLVLPPAAP
HHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCEEEEEEEHHCCCCEEEEEECCCCC
DGTSLLRCSVGAAHTPEQIDVIIEAFATLKTVGTLPRAV
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]