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The map label for this gene is sppA [C]

Identifier: 118580963

GI number: 118580963

Start: 2764534

End: 2765421

Strand: Reverse

Name: sppA [C]

Synonym: Ppro_2551

Alternate gene names: 118580963

Gene position: 2765421-2764534 (Counterclockwise)

Preceding gene: 118580965

Following gene: 118580961

Centisome position: 69.0

GC content: 62.16

Gene sequence:

>888_bases
ATGTCAAAAAAAATGCTGATGATCATCTCCGCGGTTGTCATCGTCCTGGGGGGGCTCTTCGTTGTTTCGATGCTGATCGC
CAGGGTTCTCTTGGGTGATGCCGATGTGAAGATCGCCGGGAACCGGGGGGTAGGGCTGGTGGAAGTCAGAGGGATGATTC
TCGACTCCCGGGAAACCGTCAGGCAGTTGCGCTATTTCCTCAAGCAGGACGAGATCAGGGCGGTGGTGCTGCGGGTTGAC
TCGCCTGGCGGCGTGGTGGCCCCCTCCCAGGAGATATGTGAAGAAGTCAGGAAGTTCGCGGCCCGGAAGAAGATTATCGT
TTCCATGGGGAGCCTGGCCGCCTCGGGCGGCTACTACGTCTCTGCCCCGGCCACGCTGATCTATGCCAACCCCGGCACCC
TCACGGCCAGTATCGGGGTGATCCTGAAACTCTCCAACATCGAGACGCTGATGGACAGGATCGGCATCAAGTCCCACACC
CTGAAGACCGGCAAGTACAAGGACTCCGGTTCTCCGCTGCGCAAGCTGTCTGAAGATGACCGGGCCATGCTGCAGTCCGT
GATCGACAGCACGCATGAACAGTTTGTCCGGGCGGTGGCCAGCGGCCGCAAGCTGCCTGTCCAGCAGGTGCGCAGGATCG
CCGACGGCCGCATCCTCTCCGGCGAACAGGCTCTGGCCCTGAAACTGGTGGACCGCCTGGGAACGTTGCAGGATGCCATC
GAGGAGGCAGGGAGGCTGTCCGGCATTGAGGGTGAGCCGGAGGTGGTGCTTCCCCCCCGGAAGAAGGTGAACTACTGGGA
TCTGCTGGCCGATGGGACCGAAGGGGCGCTGGAGAAGGCCCTGGGAAGGGCCAGCGGGGGCATGCTGCTGATGTACGGGA
GGGAGTGA

Upstream 100 bases:

>100_bases
GGAGCGGGTAGTTACCGTGGCTATCGGATGTCACCAAGATCTTCATGGCGCCAGTGTAGCAAATCGCATCTTTTAATGAA
AATAAAAAGCGGGTCGTGAC

Downstream 100 bases:

>100_bases
GGAAGTGAGGGAGGCCTGCTCCTTACCCCTTACCTCTGACGCCTAACCCTTTGTCCCTCACCGTCTCTCTTTCAGTTTGG
CATGGGCGTCCAAGAGGATG

Product: signal peptide peptidase SppA, 36K type

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MSKKMLMIISAVVIVLGGLFVVSMLIARVLLGDADVKIAGNRGVGLVEVRGMILDSRETVRQLRYFLKQDEIRAVVLRVD
SPGGVVAPSQEICEEVRKFAARKKIIVSMGSLAASGGYYVSAPATLIYANPGTLTASIGVILKLSNIETLMDRIGIKSHT
LKTGKYKDSGSPLRKLSEDDRAMLQSVIDSTHEQFVRAVASGRKLPVQQVRRIADGRILSGEQALALKLVDRLGTLQDAI
EEAGRLSGIEGEPEVVLPPRKKVNYWDLLADGTEGALEKALGRASGGMLLMYGRE

Sequences:

>Translated_295_residues
MSKKMLMIISAVVIVLGGLFVVSMLIARVLLGDADVKIAGNRGVGLVEVRGMILDSRETVRQLRYFLKQDEIRAVVLRVD
SPGGVVAPSQEICEEVRKFAARKKIIVSMGSLAASGGYYVSAPATLIYANPGTLTASIGVILKLSNIETLMDRIGIKSHT
LKTGKYKDSGSPLRKLSEDDRAMLQSVIDSTHEQFVRAVASGRKLPVQQVRRIADGRILSGEQALALKLVDRLGTLQDAI
EEAGRLSGIEGEPEVVLPPRKKVNYWDLLADGTEGALEKALGRASGGMLLMYGRE
>Mature_294_residues
SKKMLMIISAVVIVLGGLFVVSMLIARVLLGDADVKIAGNRGVGLVEVRGMILDSRETVRQLRYFLKQDEIRAVVLRVDS
PGGVVAPSQEICEEVRKFAARKKIIVSMGSLAASGGYYVSAPATLIYANPGTLTASIGVILKLSNIETLMDRIGIKSHTL
KTGKYKDSGSPLRKLSEDDRAMLQSVIDSTHEQFVRAVASGRKLPVQQVRRIADGRILSGEQALALKLVDRLGTLQDAIE
EAGRLSGIEGEPEVVLPPRKKVNYWDLLADGTEGALEKALGRASGGMLLMYGRE

Specific function: Digestion Of The Cleaved Signal Peptides. This Activity Is Necessary To Maintain Proper Secretion Of Mature Proteins Across The Membrane. [C]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=259, Percent_Identity=34.3629343629344, Blast_Score=130, Evalue=8e-32,
Organism=Escherichia coli, GI1787527, Length=189, Percent_Identity=30.1587301587302, Blast_Score=72, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004635
- InterPro:   IPR002142 [H]

Pfam domain/function: PF01343 Peptidase_S49 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 31870; Mature: 31739

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKMLMIISAVVIVLGGLFVVSMLIARVLLGDADVKIAGNRGVGLVEVRGMILDSRETV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEHHHHCCCHHHH
RQLRYFLKQDEIRAVVLRVDSPGGVVAPSQEICEEVRKFAARKKIIVSMGSLAASGGYYV
HHHHHHHHHCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
SAPATLIYANPGTLTASIGVILKLSNIETLMDRIGIKSHTLKTGKYKDSGSPLRKLSEDD
ECCEEEEEECCCCEEEEHEEEEEEHHHHHHHHHCCCCHHEEECCCCCCCCCHHHHCCHHH
RAMLQSVIDSTHEQFVRAVASGRKLPVQQVRRIADGRILSGEQALALKLVDRLGTLQDAI
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHH
EEAGRLSGIEGEPEVVLPPRKKVNYWDLLADGTEGALEKALGRASGGMLLMYGRE
HHHHHCCCCCCCCCEEECCCCCCCHHHEECCCCHHHHHHHHHCCCCCEEEEECCC
>Mature Secondary Structure 
SKKMLMIISAVVIVLGGLFVVSMLIARVLLGDADVKIAGNRGVGLVEVRGMILDSRETV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEHHHHCCCHHHH
RQLRYFLKQDEIRAVVLRVDSPGGVVAPSQEICEEVRKFAARKKIIVSMGSLAASGGYYV
HHHHHHHHHCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
SAPATLIYANPGTLTASIGVILKLSNIETLMDRIGIKSHTLKTGKYKDSGSPLRKLSEDD
ECCEEEEEECCCCEEEEHEEEEEEHHHHHHHHHCCCCHHEEECCCCCCCCCHHHHCCHHH
RAMLQSVIDSTHEQFVRAVASGRKLPVQQVRRIADGRILSGEQALALKLVDRLGTLQDAI
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHH
EEAGRLSGIEGEPEVVLPPRKKVNYWDLLADGTEGALEKALGRASGGMLLMYGRE
HHHHHCCCCCCCCCEEECCCCCCCHHHEECCCCHHHHHHHHHCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]