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The map label for this gene is glcD [H]

Identifier: 118580952

GI number: 118580952

Start: 2752533

End: 2753927

Strand: Direct

Name: glcD [H]

Synonym: Ppro_2540

Alternate gene names: 118580952

Gene position: 2752533-2753927 (Clockwise)

Preceding gene: 118580951

Following gene: 118580953

Centisome position: 68.68

GC content: 62.58

Gene sequence:

>1395_bases
ATGCTTGACAGGTCGATAATCGAGAAACTTGAGGCGCTGGTCGGAAAAGAGAACGTACTGACCAGCAAGATGGATCTGGT
GGCCTACAGCTACGACGCCACGGCGGATGTACCCCGCCAGGCGCCGGACGTGGTGGTTCTTCCCACCACGAGCGAGATGG
TCCAGGAGATCGTCAACCTGGCCCGGGCCAACAAGATCGCCATCTACCCCCGCGGCTCCGGTACCAACCTGAGCGGCGGC
ACCATTCCGCTCAAGAAAGGGATCGTGCTCTCCATGCAGAGGATGAACAAGATCCTGGACGTCGATGCAGCCAACCTGAC
CGCCGTGGTCCAGCCCGGCGTGGTCATCGCCGCCCTGAACTCCGCCGTAGCCCCCTTCGGCCTGATCTACCCGCCTGACC
CGGGCACCGTCACCACCGCATCCATGGGCGGATCCTGCGCCGAGAACTCCGGCGGCCTGCGCGGCCTCAAGTACGGCGTG
ACCAAGAACTATATCATGGGCCTGGAAGTGGTCCTGGCCAACGGTGAAAAAGTCCGCTTCGGCGGCAAGACCGTCAAGAA
CGTCACCGCATACGACTTCTCCAACCTGTTCGTCGGCTCCGAGGGGACCCTGGGCATCATCACCGAGATCACCGCCAAGC
TGATCCCGGCCCCCAAGTACCGCCGCAGCATGATGGGCATCTTCAAGACCCTGCAGGACGCCGGCAACGCAGTGGCCGGC
ATCATCGCCGCCCAGGTCATCCCCGCCACCCTGGAGATCATGGACCAGATGACCATCCGCACCGTCGAGGACTTCGCCAA
CATCGGCCTGCCCACCGATGCCAAGGCGCTGCTCTTGATCGAGGTGGACGGCATGTCCCAGGACGTGGTCACGGCAGAGG
CCGAGGCGGTCATGAACGTGGTCAAGACTAACAACGGCGACCTGCACACCGCCGATACCGACCAGGAGCGCGACCAGCTC
TGGACCGCCCGCCGCAACGCCCTGCCGGCCCTGGCATCCCTGAACAACACCGTTGTCCTGGAGGACGCCACCGTTCCCCG
GAGCCGCATCACCGATATGCTGGTGGCCTGCGAGAACATAGGCAAGAAGTACAACCTGACCTTAGGCACCTTCGGACATG
CCGGCGACGGCAACCTGCACCCCACCATCCTGTGCGACAAGTACAACAAGGAAGAGATCTCGCGGGTTCACAAGGCGGTT
GACGAGATCTTCGAGGCGGCCCTGGGGTTCGGCGGCACCCTCTCCGGCGAACACGGCATCGGCATCGCCAAGATGAAGTA
CCTAGGGAACGAACTGGGCCAGAGCGGCCTGAACCTGATGAGAAGCATGAAGGAAGCCCTTGACCCCGAGTACCTGTTAA
ACCCCGGGAAGATGGTTCCCCTGAAAGAGGTATGA

Upstream 100 bases:

>100_bases
CTAAACCAAATCACCACCACAGATAAAACGATGTGCCGCTACCATGGCAGACGATTCCAAACCTGGCACTACCCACAGAA
CTCAACAGAGGAGGATGCAG

Downstream 100 bases:

>100_bases
CCATGACCGCAGCAGCGAATACGAAAACCACAGCAACCACGACATACCACGACGACCTGGAGATCGTCAGGCAGGAACTG
GACAAGTGCATGAAATGCGG

Product: FAD linked oxidase domain-containing protein

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MLDRSIIEKLEALVGKENVLTSKMDLVAYSYDATADVPRQAPDVVVLPTTSEMVQEIVNLARANKIAIYPRGSGTNLSGG
TIPLKKGIVLSMQRMNKILDVDAANLTAVVQPGVVIAALNSAVAPFGLIYPPDPGTVTTASMGGSCAENSGGLRGLKYGV
TKNYIMGLEVVLANGEKVRFGGKTVKNVTAYDFSNLFVGSEGTLGIITEITAKLIPAPKYRRSMMGIFKTLQDAGNAVAG
IIAAQVIPATLEIMDQMTIRTVEDFANIGLPTDAKALLLIEVDGMSQDVVTAEAEAVMNVVKTNNGDLHTADTDQERDQL
WTARRNALPALASLNNTVVLEDATVPRSRITDMLVACENIGKKYNLTLGTFGHAGDGNLHPTILCDKYNKEEISRVHKAV
DEIFEAALGFGGTLSGEHGIGIAKMKYLGNELGQSGLNLMRSMKEALDPEYLLNPGKMVPLKEV

Sequences:

>Translated_464_residues
MLDRSIIEKLEALVGKENVLTSKMDLVAYSYDATADVPRQAPDVVVLPTTSEMVQEIVNLARANKIAIYPRGSGTNLSGG
TIPLKKGIVLSMQRMNKILDVDAANLTAVVQPGVVIAALNSAVAPFGLIYPPDPGTVTTASMGGSCAENSGGLRGLKYGV
TKNYIMGLEVVLANGEKVRFGGKTVKNVTAYDFSNLFVGSEGTLGIITEITAKLIPAPKYRRSMMGIFKTLQDAGNAVAG
IIAAQVIPATLEIMDQMTIRTVEDFANIGLPTDAKALLLIEVDGMSQDVVTAEAEAVMNVVKTNNGDLHTADTDQERDQL
WTARRNALPALASLNNTVVLEDATVPRSRITDMLVACENIGKKYNLTLGTFGHAGDGNLHPTILCDKYNKEEISRVHKAV
DEIFEAALGFGGTLSGEHGIGIAKMKYLGNELGQSGLNLMRSMKEALDPEYLLNPGKMVPLKEV
>Mature_464_residues
MLDRSIIEKLEALVGKENVLTSKMDLVAYSYDATADVPRQAPDVVVLPTTSEMVQEIVNLARANKIAIYPRGSGTNLSGG
TIPLKKGIVLSMQRMNKILDVDAANLTAVVQPGVVIAALNSAVAPFGLIYPPDPGTVTTASMGGSCAENSGGLRGLKYGV
TKNYIMGLEVVLANGEKVRFGGKTVKNVTAYDFSNLFVGSEGTLGIITEITAKLIPAPKYRRSMMGIFKTLQDAGNAVAG
IIAAQVIPATLEIMDQMTIRTVEDFANIGLPTDAKALLLIEVDGMSQDVVTAEAEAVMNVVKTNNGDLHTADTDQERDQL
WTARRNALPALASLNNTVVLEDATVPRSRITDMLVACENIGKKYNLTLGTFGHAGDGNLHPTILCDKYNKEEISRVHKAV
DEIFEAALGFGGTLSGEHGIGIAKMKYLGNELGQSGLNLMRSMKEALDPEYLLNPGKMVPLKEV

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=468, Percent_Identity=33.5470085470085, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI37595754, Length=492, Percent_Identity=32.520325203252, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI119964728, Length=432, Percent_Identity=30.787037037037, Blast_Score=186, Evalue=5e-47,
Organism=Homo sapiens, GI4501993, Length=455, Percent_Identity=25.0549450549451, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1789351, Length=461, Percent_Identity=37.527114967462, Blast_Score=320, Evalue=1e-88,
Organism=Escherichia coli, GI1787977, Length=532, Percent_Identity=23.1203007518797, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI48994907, Length=493, Percent_Identity=23.9350912778905, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI48994914, Length=190, Percent_Identity=30, Blast_Score=82, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71992373, Length=470, Percent_Identity=32.3404255319149, Blast_Score=241, Evalue=6e-64,
Organism=Caenorhabditis elegans, GI71992381, Length=470, Percent_Identity=31.2765957446809, Blast_Score=224, Evalue=9e-59,
Organism=Caenorhabditis elegans, GI71992392, Length=386, Percent_Identity=33.160621761658, Blast_Score=209, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17534361, Length=478, Percent_Identity=29.0794979079498, Blast_Score=174, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17556096, Length=467, Percent_Identity=22.9122055674518, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320027, Length=473, Percent_Identity=30.0211416490486, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6320023, Length=478, Percent_Identity=29.4979079497908, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6320764, Length=483, Percent_Identity=27.1221532091097, Blast_Score=166, Evalue=7e-42,
Organism=Drosophila melanogaster, GI18921117, Length=466, Percent_Identity=28.9699570815451, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24639277, Length=466, Percent_Identity=28.9699570815451, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24639275, Length=466, Percent_Identity=28.9699570815451, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24653753, Length=258, Percent_Identity=27.5193798449612, Blast_Score=100, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 49535; Mature: 49535

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDRSIIEKLEALVGKENVLTSKMDLVAYSYDATADVPRQAPDVVVLPTTSEMVQEIVNL
CCCHHHHHHHHHHHCCCHHHHHHHHEEEEECCCCCCCCCCCCCEEEECCCHHHHHHHHHH
ARANKIAIYPRGSGTNLSGGTIPLKKGIVLSMQRMNKILDVDAANLTAVVQPGVVIAALN
HCCCEEEEEECCCCCCCCCCCEECCCCHHHHHHHHHHHHCCCCCCEEEEECCCEEEEEHH
SAVAPFGLIYPPDPGTVTTASMGGSCAENSGGLRGLKYGVTKNYIMGLEVVLANGEKVRF
HCCCCCCEEECCCCCCEEEECCCCCCCCCCCCCCEEEECCCHHHHEEEEEEEECCCEEEE
GGKTVKNVTAYDFSNLFVGSEGTLGIITEITAKLIPAPKYRRSMMGIFKTLQDAGNAVAG
CCCCCCCEEEEECCCEEECCCCCEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHH
IIAAQVIPATLEIMDQMTIRTVEDFANIGLPTDAKALLLIEVDGMSQDVVTAEAEAVMNV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHH
VKTNNGDLHTADTDQERDQLWTARRNALPALASLNNTVVLEDATVPRSRITDMLVACENI
HHCCCCCEECCCCCHHHHHHHHHHHHCCHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHC
GKKYNLTLGTFGHAGDGNLHPTILCDKYNKEEISRVHKAVDEIFEAALGFGGTLSGEHGI
CCEEEEEEECCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
GIAKMKYLGNELGQSGLNLMRSMKEALDPEYLLNPGKMVPLKEV
CHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEECCCCCCCCCCCC
>Mature Secondary Structure
MLDRSIIEKLEALVGKENVLTSKMDLVAYSYDATADVPRQAPDVVVLPTTSEMVQEIVNL
CCCHHHHHHHHHHHCCCHHHHHHHHEEEEECCCCCCCCCCCCCEEEECCCHHHHHHHHHH
ARANKIAIYPRGSGTNLSGGTIPLKKGIVLSMQRMNKILDVDAANLTAVVQPGVVIAALN
HCCCEEEEEECCCCCCCCCCCEECCCCHHHHHHHHHHHHCCCCCCEEEEECCCEEEEEHH
SAVAPFGLIYPPDPGTVTTASMGGSCAENSGGLRGLKYGVTKNYIMGLEVVLANGEKVRF
HCCCCCCEEECCCCCCEEEECCCCCCCCCCCCCCEEEECCCHHHHEEEEEEEECCCEEEE
GGKTVKNVTAYDFSNLFVGSEGTLGIITEITAKLIPAPKYRRSMMGIFKTLQDAGNAVAG
CCCCCCCEEEEECCCEEECCCCCEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHH
IIAAQVIPATLEIMDQMTIRTVEDFANIGLPTDAKALLLIEVDGMSQDVVTAEAEAVMNV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHH
VKTNNGDLHTADTDQERDQLWTARRNALPALASLNNTVVLEDATVPRSRITDMLVACENI
HHCCCCCEECCCCCHHHHHHHHHHHHCCHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHC
GKKYNLTLGTFGHAGDGNLHPTILCDKYNKEEISRVHKAVDEIFEAALGFGGTLSGEHGI
CCEEEEEEECCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
GIAKMKYLGNELGQSGLNLMRSMKEALDPEYLLNPGKMVPLKEV
CHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]