Click here to switch to the map view.

The map label for this gene is gmk [H]

Identifier: 118580815

GI number: 118580815

Start: 2598772

End: 2599380

Strand: Reverse

Name: gmk [H]

Synonym: Ppro_2401

Alternate gene names: 118580815

Gene position: 2599380-2598772 (Counterclockwise)

Preceding gene: 118580816

Following gene: 118580814

Centisome position: 64.85

GC content: 63.55

Gene sequence:

>609_bases
ATGAACCGCGAAGGTCTGATCATGATCATCTCCGCCCCCTCCGGGGCGGGCAAGACAACCCTCTGCCGCCGGCTGCGCCA
GCGTTTCCCCGCCATGCGCGAGTCCATCAGCTTTTCCACCCGCCAACCGCGGCCGGGGGAGAAGGACGGAGAGGATTATT
GCTTCGTCTCCCGGGACGAGTTCCAGGCCATGGTGACGCAGGGAGCCTTCGCCGAATGGGCCGAGGTGCATGGCAACCTG
TACGGCACGGCGCTCAGGACTCTGGAGGAGGCGCGCGAAACGGGGACCGATCTGCTGCTGGATATCGATTGTCAGGGAGC
CCTGTCCCTGAAGAAAAATTTCCCCGGCGGGGTGTACGTCTTTATCATCCCCCCCAGCATGGATGAACTGCGCCGCCGCC
TTGAGGGGCGCTCGTCCGATGTGCCGGAGGTTATCGAGCGCCGCATCAGGCGCGCTTCCGACGAGATCAGGGAGGCGCGC
TGGTATGACTACATCATCATCAACGACCGCATCGAGGAGGCCTTCGAGGAACTGTCGGCGGTGGTGCTGGCCCAGAGCCG
GACGACCCCGCGCATGCTGGGGCGGGTGGCGAAATTGTTTGATATTTGA

Upstream 100 bases:

>100_bases
AATGTGGAGTAGATGCAGGGATCGGGAGTGAGTGAGGAGTGAGGAACGGTGTCCTCGTCCCCAGTTACCAGTTGTTGGCC
CCATAACAGGAAGGCATTCC

Downstream 100 bases:

>100_bases
CGGCGAATGGGGTAACAATGCTGTTCCAATCAACACGCAGCAGGAAGGAGTAATCGTATGGCACGGGTAACAGTTGAAGA
CTGCCTTGATAAAGTTGAGA

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MNREGLIMIISAPSGAGKTTLCRRLRQRFPAMRESISFSTRQPRPGEKDGEDYCFVSRDEFQAMVTQGAFAEWAEVHGNL
YGTALRTLEEARETGTDLLLDIDCQGALSLKKNFPGGVYVFIIPPSMDELRRRLEGRSSDVPEVIERRIRRASDEIREAR
WYDYIIINDRIEEAFEELSAVVLAQSRTTPRMLGRVAKLFDI

Sequences:

>Translated_202_residues
MNREGLIMIISAPSGAGKTTLCRRLRQRFPAMRESISFSTRQPRPGEKDGEDYCFVSRDEFQAMVTQGAFAEWAEVHGNL
YGTALRTLEEARETGTDLLLDIDCQGALSLKKNFPGGVYVFIIPPSMDELRRRLEGRSSDVPEVIERRIRRASDEIREAR
WYDYIIINDRIEEAFEELSAVVLAQSRTTPRMLGRVAKLFDI
>Mature_202_residues
MNREGLIMIISAPSGAGKTTLCRRLRQRFPAMRESISFSTRQPRPGEKDGEDYCFVSRDEFQAMVTQGAFAEWAEVHGNL
YGTALRTLEEARETGTDLLLDIDCQGALSLKKNFPGGVYVFIIPPSMDELRRRLEGRSSDVPEVIERRIRRASDEIREAR
WYDYIIINDRIEEAFEELSAVVLAQSRTTPRMLGRVAKLFDI

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=175, Percent_Identity=37.1428571428571, Blast_Score=126, Evalue=1e-29,
Organism=Homo sapiens, GI4504221, Length=175, Percent_Identity=37.1428571428571, Blast_Score=126, Evalue=1e-29,
Organism=Homo sapiens, GI226874831, Length=175, Percent_Identity=37.1428571428571, Blast_Score=126, Evalue=1e-29,
Organism=Homo sapiens, GI21361598, Length=198, Percent_Identity=31.3131313131313, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI38570142, Length=184, Percent_Identity=31.5217391304348, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI52630447, Length=198, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI186972120, Length=185, Percent_Identity=26.4864864864865, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI186700629, Length=185, Percent_Identity=26.4864864864865, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI186700627, Length=185, Percent_Identity=26.4864864864865, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI4505237, Length=179, Percent_Identity=24.0223463687151, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI262118255, Length=179, Percent_Identity=24.0223463687151, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI262118259, Length=179, Percent_Identity=24.0223463687151, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI262118263, Length=179, Percent_Identity=24.0223463687151, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1790080, Length=203, Percent_Identity=43.3497536945813, Blast_Score=169, Evalue=9e-44,
Organism=Caenorhabditis elegans, GI193203132, Length=176, Percent_Identity=34.6590909090909, Blast_Score=123, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17508835, Length=176, Percent_Identity=34.6590909090909, Blast_Score=122, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71988041, Length=181, Percent_Identity=25.9668508287293, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71988048, Length=167, Percent_Identity=26.9461077844311, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17556244, Length=128, Percent_Identity=30.46875, Blast_Score=63, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=39.344262295082, Blast_Score=148, Evalue=6e-37,
Organism=Drosophila melanogaster, GI21356141, Length=182, Percent_Identity=36.8131868131868, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI161077626, Length=184, Percent_Identity=28.804347826087, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24640542, Length=184, Percent_Identity=28.804347826087, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45554489, Length=184, Percent_Identity=28.804347826087, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221330162, Length=187, Percent_Identity=29.9465240641711, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221330164, Length=187, Percent_Identity=29.9465240641711, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221330166, Length=187, Percent_Identity=29.9465240641711, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45554481, Length=180, Percent_Identity=30.5555555555556, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI85724806, Length=182, Percent_Identity=30.2197802197802, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI116007136, Length=182, Percent_Identity=30.2197802197802, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI161077752, Length=160, Percent_Identity=29.375, Blast_Score=64, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 23065; Mature: 23065

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNREGLIMIISAPSGAGKTTLCRRLRQRFPAMRESISFSTRQPRPGEKDGEDYCFVSRDE
CCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEHHH
FQAMVTQGAFAEWAEVHGNLYGTALRTLEEARETGTDLLLDIDCQGALSLKKNFPGGVYV
HHHHHHHCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHCCCCCCEEE
FIIPPSMDELRRRLEGRSSDVPEVIERRIRRASDEIREARWYDYIIINDRIEEAFEELSA
EEECCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHH
VVLAQSRTTPRMLGRVAKLFDI
HHHHCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MNREGLIMIISAPSGAGKTTLCRRLRQRFPAMRESISFSTRQPRPGEKDGEDYCFVSRDE
CCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEHHH
FQAMVTQGAFAEWAEVHGNLYGTALRTLEEARETGTDLLLDIDCQGALSLKKNFPGGVYV
HHHHHHHCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHCCCCCCEEE
FIIPPSMDELRRRLEGRSSDVPEVIERRIRRASDEIREARWYDYIIINDRIEEAFEELSA
EEECCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHH
VVLAQSRTTPRMLGRVAKLFDI
HHHHCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA