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The map label for this gene is thrC [H]

Identifier: 118580809

GI number: 118580809

Start: 2593450

End: 2594835

Strand: Reverse

Name: thrC [H]

Synonym: Ppro_2395

Alternate gene names: 118580809

Gene position: 2594835-2593450 (Counterclockwise)

Preceding gene: 118580810

Following gene: 118580793

Centisome position: 64.74

GC content: 59.88

Gene sequence:

>1386_bases
ATGCGTTATATAAGCACCCGCGGCGGTATTCAGCCGATCAACTTCAAGGACGCCGTCATGATGGGATTGGCAACCGACGG
CGGCCTGCTCCTACCTGAATCATACCCCCAGATCAGCCGTCAGGAGCTGGATCAGTGGCGTTCCCTTTCTTATCCTGACT
TGGCCTTGCGGATCATCTCCCCCTTCGTGGACGACATACCGGTCGACGACCTTAAGGGGTTGATCCAGCGCTCCTACGCT
ACCTTCAACCATCCCCAGGTGACGCCGGTTGTACACAGGGATGGCGTCCATATCCTGGAGCTGTTCCACGGCGTGACCCT
GGCTTTCAAGGATGTGGCCCTGCAACTTTTGGGTAATCTGTTCGAGTATATCCTGGCGGAGCGGGGAGAACGGCTCAACA
TCCTGGGCGCCACCTCGGGTGACACAGGGAGCGCCGCTATCCATGGGGTGCGCGGCAAGAAGGGGATAACCATCTTCATC
CTGCACCCCCACGGCAAGACCTCACCAGTGCAGGCGCTGCAGATGATCACTGTCGGTGACGCAAACGTGCACAATATTGC
CATCCGCGGCACCTTCGACGACTGCCAGAACATGGTAAAGGCTCTGTTCAACGACCTCCAGTTCAAGGAGAAGTACTCCC
TGGGCGCGGTCAACTCCATCAACTGGGCCCGCGTCCTGGCCCAGGTGGTGTACTACTTCTATGCCTGGCTACGGGTGACC
GACGAGGGTGACCGGCCGGTCTGCTTCTCTGTTCCCACCGGTAACTTCGGTGACATCTTTGCCGGCTACGTGGCCAAGCG
CATGGGGCTCCCCATGGGACGTCTGCTTTTGGCGACCAACGAGAACAACATCCTGACCCGTTTCGTCAGGGATGGCGACT
ACTCCCTGGCCAACGTTGTCGCCACCGTCTCCCCCTCAATGGACATCCAGTTGGCTTCCAACTTTGAACGTTACCTGTTT
CATCTGTATGACCAGGATCCGGGCCGAGTGCGGGCTGCCTTTGCCGAGTTGAGGGAGTGTGGGCGCATCAGTTTTACCCC
GGCCGAGATGGAGCAGGTTCGGGCGGATTTTTGTTCCGCCACGGTGGACCAGGCCGCTACCTTGGAGACCATCGGCAGCT
TCAACCGGGAAACCGGCTATCTGTTGGACCCGCACACCGCCGTGGGGGTGCGGGCTGCTCTGGACCTGCTCCCCTCTGAT
GCGGCCCGCGTCTGTCTGGCAACTGCCCATCCGGCCAAGTTTGGAGAAGCCGTGGAAAAGGCGGTGGGGACGCCCGCTCC
GGTTCCTGGTTCCATTGCGGCCCTGGCCGGCATGGAGACACGCTGTACCGTAATGGATGCCGATCTGGAGAAAGTGCGCC
AGTTCGTTGTTGAGCATGTGGCGTAA

Upstream 100 bases:

>100_bases
CGCCGGGCGAGCTGCGCCGTGACCTGGGTTGAGGTGCTTTCATATTTTTCCAAACCGTGCTAAACTGCCGCTTCTTAATC
TATCCTGAAAGGAATACGTG

Downstream 100 bases:

>100_bases
ACGGGTATAAGGGTGGTGTCAGTTGTGCGGTAGTCGCAGTCGTATGCATCGGTACTGTAAATTACTGTTGACAAAAGCAC
GATCTCTTGGCATGTATACA

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MRYISTRGGIQPINFKDAVMMGLATDGGLLLPESYPQISRQELDQWRSLSYPDLALRIISPFVDDIPVDDLKGLIQRSYA
TFNHPQVTPVVHRDGVHILELFHGVTLAFKDVALQLLGNLFEYILAERGERLNILGATSGDTGSAAIHGVRGKKGITIFI
LHPHGKTSPVQALQMITVGDANVHNIAIRGTFDDCQNMVKALFNDLQFKEKYSLGAVNSINWARVLAQVVYYFYAWLRVT
DEGDRPVCFSVPTGNFGDIFAGYVAKRMGLPMGRLLLATNENNILTRFVRDGDYSLANVVATVSPSMDIQLASNFERYLF
HLYDQDPGRVRAAFAELRECGRISFTPAEMEQVRADFCSATVDQAATLETIGSFNRETGYLLDPHTAVGVRAALDLLPSD
AARVCLATAHPAKFGEAVEKAVGTPAPVPGSIAALAGMETRCTVMDADLEKVRQFVVEHVA

Sequences:

>Translated_461_residues
MRYISTRGGIQPINFKDAVMMGLATDGGLLLPESYPQISRQELDQWRSLSYPDLALRIISPFVDDIPVDDLKGLIQRSYA
TFNHPQVTPVVHRDGVHILELFHGVTLAFKDVALQLLGNLFEYILAERGERLNILGATSGDTGSAAIHGVRGKKGITIFI
LHPHGKTSPVQALQMITVGDANVHNIAIRGTFDDCQNMVKALFNDLQFKEKYSLGAVNSINWARVLAQVVYYFYAWLRVT
DEGDRPVCFSVPTGNFGDIFAGYVAKRMGLPMGRLLLATNENNILTRFVRDGDYSLANVVATVSPSMDIQLASNFERYLF
HLYDQDPGRVRAAFAELRECGRISFTPAEMEQVRADFCSATVDQAATLETIGSFNRETGYLLDPHTAVGVRAALDLLPSD
AARVCLATAHPAKFGEAVEKAVGTPAPVPGSIAALAGMETRCTVMDADLEKVRQFVVEHVA
>Mature_461_residues
MRYISTRGGIQPINFKDAVMMGLATDGGLLLPESYPQISRQELDQWRSLSYPDLALRIISPFVDDIPVDDLKGLIQRSYA
TFNHPQVTPVVHRDGVHILELFHGVTLAFKDVALQLLGNLFEYILAERGERLNILGATSGDTGSAAIHGVRGKKGITIFI
LHPHGKTSPVQALQMITVGDANVHNIAIRGTFDDCQNMVKALFNDLQFKEKYSLGAVNSINWARVLAQVVYYFYAWLRVT
DEGDRPVCFSVPTGNFGDIFAGYVAKRMGLPMGRLLLATNENNILTRFVRDGDYSLANVVATVSPSMDIQLASNFERYLF
HLYDQDPGRVRAAFAELRECGRISFTPAEMEQVRADFCSATVDQAATLETIGSFNRETGYLLDPHTAVGVRAALDLLPSD
AARVCLATAHPAKFGEAVEKAVGTPAPVPGSIAALAGMETRCTVMDADLEKVRQFVVEHVA

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI149193323, Length=456, Percent_Identity=39.2543859649123, Blast_Score=317, Evalue=1e-86,
Organism=Homo sapiens, GI153792148, Length=435, Percent_Identity=35.4022988505747, Blast_Score=233, Evalue=2e-61,
Organism=Escherichia coli, GI1786185, Length=462, Percent_Identity=35.2813852813853, Blast_Score=249, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6319901, Length=457, Percent_Identity=47.7024070021882, Blast_Score=406, Evalue=1e-114,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 50578; Mature: 50578

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYISTRGGIQPINFKDAVMMGLATDGGLLLPESYPQISRQELDQWRSLSYPDLALRIIS
CCEECCCCCCCCCCCHHHEEEEEECCCCEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHH
PFVDDIPVDDLKGLIQRSYATFNHPQVTPVVHRDGVHILELFHGVTLAFKDVALQLLGNL
HHHHCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
FEYILAERGERLNILGATSGDTGSAAIHGVRGKKGITIFILHPHGKTSPVQALQMITVGD
HHHHHHCCCCEEEEEEECCCCCCCCEEEECCCCCCEEEEEECCCCCCCHHHHEEEEEECC
ANVHNIAIRGTFDDCQNMVKALFNDLQFKEKYSLGAVNSINWARVLAQVVYYFYAWLRVT
CCEEEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHEEE
DEGDRPVCFSVPTGNFGDIFAGYVAKRMGLPMGRLLLATNENNILTRFVRDGDYSLANVV
CCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECCCCCHHHHHH
ATVSPSMDIQLASNFERYLFHLYDQDPGRVRAAFAELRECGRISFTPAEMEQVRADFCSA
EECCCCCCEEEHHCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
TVDQAATLETIGSFNRETGYLLDPHTAVGVRAALDLLPSDAARVCLATAHPAKFGEAVEK
HHHHHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHHCCCCHHHEEEEECCCHHHHHHHHH
AVGTPAPVPGSIAALAGMETRCTVMDADLEKVRQFVVEHVA
HCCCCCCCCCCHHHHCCCCCEEEEECCCHHHHHHHHHHHCC
>Mature Secondary Structure
MRYISTRGGIQPINFKDAVMMGLATDGGLLLPESYPQISRQELDQWRSLSYPDLALRIIS
CCEECCCCCCCCCCCHHHEEEEEECCCCEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHH
PFVDDIPVDDLKGLIQRSYATFNHPQVTPVVHRDGVHILELFHGVTLAFKDVALQLLGNL
HHHHCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
FEYILAERGERLNILGATSGDTGSAAIHGVRGKKGITIFILHPHGKTSPVQALQMITVGD
HHHHHHCCCCEEEEEEECCCCCCCCEEEECCCCCCEEEEEECCCCCCCHHHHEEEEEECC
ANVHNIAIRGTFDDCQNMVKALFNDLQFKEKYSLGAVNSINWARVLAQVVYYFYAWLRVT
CCEEEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHEEE
DEGDRPVCFSVPTGNFGDIFAGYVAKRMGLPMGRLLLATNENNILTRFVRDGDYSLANVV
CCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECCCCCHHHHHH
ATVSPSMDIQLASNFERYLFHLYDQDPGRVRAAFAELRECGRISFTPAEMEQVRADFCSA
EECCCCCCEEEHHCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
TVDQAATLETIGSFNRETGYLLDPHTAVGVRAALDLLPSDAARVCLATAHPAKFGEAVEK
HHHHHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHHCCCCHHHEEEEECCCHHHHHHHHH
AVGTPAPVPGSIAALAGMETRCTVMDADLEKVRQFVVEHVA
HCCCCCCCCCCHHHHCCCCCEEEEECCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]