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The map label for this gene is pheS

Identifier: 118580719

GI number: 118580719

Start: 2487017

End: 2488033

Strand: Reverse

Name: pheS

Synonym: Ppro_2304

Alternate gene names: 118580719

Gene position: 2488033-2487017 (Counterclockwise)

Preceding gene: 118580720

Following gene: 118580718

Centisome position: 62.08

GC content: 61.95

Gene sequence:

>1017_bases
ATGCGGGAACAGCTTGAACAATTGAGATGCGAAGCGTTTCAGGCCATCGCCGATGCTTCCACCGGAGAAGCGCTTCAGAA
CATCAGGATAAAGTACCTGGGGCGCAAGGGCGCCATGACCGCCCTCATGAAGGGCCTGGGCGCCCTGTCGGCCGAGGAAC
GTCCGGTTGTGGGCCAGATGGTCAACAGCATCAGGGACGAGATCGAATCCGGTATCGAGGCCGGCCTGTTCGCGGCGCGC
GAACGCGCCCGGGACGAGAAGCTGCGCTCGGAACGCATCGACGTCACCCTTCCGGGACGTCGCCCGGGGTGCGGCAGCAA
ACACCCCATCACCCTGGTGATCGAGGAGGTCTGCGACATCTTCGCCGGCCTGGGTTTCTCCGTCGCCGAGGGGCCGGAGA
TCGAACACGACTGGTATAATTTCGAGGCGCTTAACTTTCCGCCCGAACACCCGGCCAGGGACATGCAGGATACCTTCTTC
GTGGACAACAACCTGCTGTTGCGCACCCACACCTCTCCGGTGCAGATCCGTACCATGCTGAAACGCAAGCCGCCTCTGCG
CATTATCGCGCCCGGAACGGTGTACCGCTGCGACTCCGACGCCACCCATTCGCCCATGTTTCACCAGATCGAGGGGCTGA
TGGTGGATCAGGGGGTCAGTTTTGGTGACCTGAAGGGTATCCTGACCATCTTTACCAACCAGCTCTTCGGCCAGAAGACC
GGCGTGCGGCTGCGACCCAGCTTCTTTCCCTTTACCGAGCCGTCGGCCGAGGTGGACATCGCCTGCGTCATCTGTGGCGG
CAAGGGATGTCGGGTCTGCAAGAACAGCGGCTGGCTGGAGATCCTTGGCGCCGGCATGGTCGACCCCGAGGTCTACCGCC
ACGTGGGCTACGATGCCGAGGCTGTGTCCGGTTTTGCCTTTGGCATGGGCATCGAGCGCATCGCCATGCTGAAATACGGA
ATCAGCGACATGCGCCTGCTCTTCGAGAACGACGTGCGGTTCCTGCGCCAGTTCTAA

Upstream 100 bases:

>100_bases
TTGCCAGAGCCAGCATCTAGTTTGTGGTAGTGCTGTGCAGATCAATTCATTGGGGAATGGGACGAAATACTCCCATTCCC
TTTTTTTAAGGGTAAACACC

Downstream 100 bases:

>100_bases
AGCCTCGTCAACCCCGCGCGTGATCCGTCATGTGCGAATATAAACAACTACTTCTCGGTGCTACTCATATGAATGTTACC
TATAACTGGCTCAAGGAATT

Product: phenylalanyl-tRNA synthetase subunit alpha

Products: NA

Alternate protein names: Phenylalanine--tRNA ligase alpha chain; PheRS

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MREQLEQLRCEAFQAIADASTGEALQNIRIKYLGRKGAMTALMKGLGALSAEERPVVGQMVNSIRDEIESGIEAGLFAAR
ERARDEKLRSERIDVTLPGRRPGCGSKHPITLVIEEVCDIFAGLGFSVAEGPEIEHDWYNFEALNFPPEHPARDMQDTFF
VDNNLLLRTHTSPVQIRTMLKRKPPLRIIAPGTVYRCDSDATHSPMFHQIEGLMVDQGVSFGDLKGILTIFTNQLFGQKT
GVRLRPSFFPFTEPSAEVDIACVICGGKGCRVCKNSGWLEILGAGMVDPEVYRHVGYDAEAVSGFAFGMGIERIAMLKYG
ISDMRLLFENDVRFLRQF

Sequences:

>Translated_338_residues
MREQLEQLRCEAFQAIADASTGEALQNIRIKYLGRKGAMTALMKGLGALSAEERPVVGQMVNSIRDEIESGIEAGLFAAR
ERARDEKLRSERIDVTLPGRRPGCGSKHPITLVIEEVCDIFAGLGFSVAEGPEIEHDWYNFEALNFPPEHPARDMQDTFF
VDNNLLLRTHTSPVQIRTMLKRKPPLRIIAPGTVYRCDSDATHSPMFHQIEGLMVDQGVSFGDLKGILTIFTNQLFGQKT
GVRLRPSFFPFTEPSAEVDIACVICGGKGCRVCKNSGWLEILGAGMVDPEVYRHVGYDAEAVSGFAFGMGIERIAMLKYG
ISDMRLLFENDVRFLRQF
>Mature_338_residues
MREQLEQLRCEAFQAIADASTGEALQNIRIKYLGRKGAMTALMKGLGALSAEERPVVGQMVNSIRDEIESGIEAGLFAAR
ERARDEKLRSERIDVTLPGRRPGCGSKHPITLVIEEVCDIFAGLGFSVAEGPEIEHDWYNFEALNFPPEHPARDMQDTFF
VDNNLLLRTHTSPVQIRTMLKRKPPLRIIAPGTVYRCDSDATHSPMFHQIEGLMVDQGVSFGDLKGILTIFTNQLFGQKT
GVRLRPSFFPFTEPSAEVDIACVICGGKGCRVCKNSGWLEILGAGMVDPEVYRHVGYDAEAVSGFAFGMGIERIAMLKYG
ISDMRLLFENDVRFLRQF

Specific function: Unknown

COG id: COG0016

COG function: function code J; Phenylalanyl-tRNA synthetase alpha subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha chain type 1 subfamily

Homologues:

Organism=Homo sapiens, GI4758340, Length=281, Percent_Identity=31.6725978647687, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI5729820, Length=300, Percent_Identity=29.3333333333333, Blast_Score=118, Evalue=6e-27,
Organism=Escherichia coli, GI1788007, Length=335, Percent_Identity=51.044776119403, Blast_Score=349, Evalue=2e-97,
Organism=Caenorhabditis elegans, GI32563657, Length=275, Percent_Identity=31.2727272727273, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17508957, Length=275, Percent_Identity=31.2727272727273, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI32566635, Length=256, Percent_Identity=31.25, Blast_Score=111, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6321087, Length=279, Percent_Identity=29.3906810035842, Blast_Score=123, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6325304, Length=279, Percent_Identity=26.8817204301075, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI18858079, Length=276, Percent_Identity=31.1594202898551, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI17137424, Length=299, Percent_Identity=26.7558528428094, Blast_Score=102, Evalue=5e-22,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYFA_PELPD (A1ARE1)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_901969.1
- ProteinModelPortal:   A1ARE1
- SMR:   A1ARE1
- STRING:   A1ARE1
- GeneID:   4574910
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_2304
- eggNOG:   COG0016
- HOGENOM:   HBG284353
- OMA:   FRASYFP
- PhylomeDB:   A1ARE1
- ProtClustDB:   PRK00488
- GO:   GO:0005737
- HAMAP:   MF_00281
- InterPro:   IPR006195
- InterPro:   IPR004529
- InterPro:   IPR004188
- InterPro:   IPR022911
- InterPro:   IPR002319
- InterPro:   IPR010978
- PANTHER:   PTHR11538
- TIGRFAMs:   TIGR00468

Pfam domain/function: PF02912 Phe_tRNA-synt_N; PF01409 tRNA-synt_2d; SSF46589 tRNA_binding_arm

EC number: =6.1.1.20

Molecular weight: Translated: 37650; Mature: 37650

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREQLEQLRCEAFQAIADASTGEALQNIRIKYLGRKGAMTALMKGLGALSAEERPVVGQM
CHHHHHHHHHHHHHHHHCCCHHHHHHHCHHEEECCCHHHHHHHHHHHCCCCCCCCHHHHH
VNSIRDEIESGIEAGLFAARERARDEKLRSERIDVTLPGRRPGCGSKHPITLVIEEVCDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCHHHHHHHHHHH
FAGLGFSVAEGPEIEHDWYNFEALNFPPEHPARDMQDTFFVDNNLLLRTHTSPVQIRTML
HHCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCEEEECCCEEEEECCCHHHHHHHH
KRKPPLRIIAPGTVYRCDSDATHSPMFHQIEGLMVDQGVSFGDLKGILTIFTNQLFGQKT
HCCCCEEEECCCEEEECCCCCCCCCHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHCCCC
GVRLRPSFFPFTEPSAEVDIACVICGGKGCRVCKNSGWLEILGAGMVDPEVYRHVGYDAE
CCEECCCCCCCCCCCCCEEEEEEEECCCCCCEECCCCCEEEECCCCCCHHHHHHCCCCHH
AVSGFAFGMGIERIAMLKYGISDMRLLFENDVRFLRQF
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MREQLEQLRCEAFQAIADASTGEALQNIRIKYLGRKGAMTALMKGLGALSAEERPVVGQM
CHHHHHHHHHHHHHHHHCCCHHHHHHHCHHEEECCCHHHHHHHHHHHCCCCCCCCHHHHH
VNSIRDEIESGIEAGLFAARERARDEKLRSERIDVTLPGRRPGCGSKHPITLVIEEVCDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCHHHHHHHHHHH
FAGLGFSVAEGPEIEHDWYNFEALNFPPEHPARDMQDTFFVDNNLLLRTHTSPVQIRTML
HHCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCEEEECCCEEEEECCCHHHHHHHH
KRKPPLRIIAPGTVYRCDSDATHSPMFHQIEGLMVDQGVSFGDLKGILTIFTNQLFGQKT
HCCCCEEEECCCEEEECCCCCCCCCHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHCCCC
GVRLRPSFFPFTEPSAEVDIACVICGGKGCRVCKNSGWLEILGAGMVDPEVYRHVGYDAE
CCEECCCCCCCCCCCCCEEEEEEEECCCCCCEECCCCCEEEECCCCCCHHHHHHCCCCHH
AVSGFAFGMGIERIAMLKYGISDMRLLFENDVRFLRQF
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA