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The map label for this gene is macA [H]

Identifier: 118580635

GI number: 118580635

Start: 2397288

End: 2398487

Strand: Reverse

Name: macA [H]

Synonym: Ppro_2220

Alternate gene names: 118580635

Gene position: 2398487-2397288 (Counterclockwise)

Preceding gene: 118580636

Following gene: 118580634

Centisome position: 59.84

GC content: 59.92

Gene sequence:

>1200_bases
ATGAATATGTCGCGAAAACAGATCATTATCGGAACCGTTGTGCTCCTGGTCCTGCTGGGAACCGGCCTGGCTGTCAAGAA
GCTGTTCTTCGGCAAACCAAAGGCAACCTTTGTTACCGCCGATGCCGTCAGGATGGACCTGGAAGAGAGCGTCCTTGCCA
CCGGCATCGTCAAGGCGTTCAAGACCGTCGAGGTGGGGTCGCAGGTGACCGGCCAGTTGCAGACCCTGCACGTCGAACTT
GGCGACCGGGTGAAAAAGGGACAGCTTTTGGCCGAGATCGATCCGGTGCTTCAGAAAAACACCCTCATGGATGCCGAGGC
GGAGGTGGTGAACCTGGCCGCCCAGAAACGCTCCAAGCAGGCGTTGCTGAAACAGTACGAGCTGGCCTTCAAGCGCCAAA
GCCGGATGAATGCACAGGATGCTTCCTCCAGGTCGGACCTGGAGAGCGCCCAGGCCCAGCTGGAGAGCACAGGCTGTGAC
ATCTCCGCCCTGGATGCCCAGATCAGGAAGGCAAGAATCGCCGTGGATAACGCAAAAGCCAACCTGGGCTACCACCACAT
CAGCGCTCCCATCGATGGGATTGTCATCTCCATTGATACCGAGGAGGGGCAGACGGTGGTTTCCACACAGTCTTCCACCA
CCATCATAACCCTGGCCACCCTTGATACCATGACCGTCAAGGCCAAGATCTCCGAGGCGGATGTCAACCGGGTCAGGCCC
GGCCTGACGACCTACTTCACCCTGCTGGGCGATAGCGACACGCGCTACTACGGCAAGCTGCGGGCCATCGAACCGGGGCC
GGTTTCCAGCAGTACCAGCAGTTCTAGTTCCAGCAGCAGCTCCAGCTCCAGTTCGGCAATCTATTACTATGGCCTGTTCG
AGGTGCCCAATCCCGCCGGGAGGCTTAAGGTCTCCATGACCGCCCAGGTTTCCATTCTCCTCAATCAAGTCCGACAGGCG
CTCTGCATCCCGGTTTCGGCCCTGGGAGAGAAGCTTAAGGATAACCGCTACCGGGTCAGGGTGTTGAAAGATGGAGAAGC
TCTGGAGCGAACCATCCGCACCGGCATCTCCAACAACGTCCAGGTGCAGGTGCTGGAGGGGTTGCGCGAAGGGGAGAAGG
TGGTGGTGGGTGACAGCACGACGCTTCCGGCAACGGAAGCATCCGGCGCCATGGGCGCTCCCCCGGGCGGGAGGCGCTGA

Upstream 100 bases:

>100_bases
CGTGACGATTCCCTACGTTGAAGAGTACTGGCCTGCCTGAGAATTCCTGGCGCCATTGACTATTCGCGGGCGACTGTAGA
AACAAAACGGAAATGACACC

Downstream 100 bases:

>100_bases
GCATGGAACGGCCATTACTAGAACTCCAGGGGGTGGGGCGGCGCTTTGTCACCGGAGGAGAGGAGATCCCGGTGCTGAAG
GGGATCGACCTGAGCATCCG

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MNMSRKQIIIGTVVLLVLLGTGLAVKKLFFGKPKATFVTADAVRMDLEESVLATGIVKAFKTVEVGSQVTGQLQTLHVEL
GDRVKKGQLLAEIDPVLQKNTLMDAEAEVVNLAAQKRSKQALLKQYELAFKRQSRMNAQDASSRSDLESAQAQLESTGCD
ISALDAQIRKARIAVDNAKANLGYHHISAPIDGIVISIDTEEGQTVVSTQSSTTIITLATLDTMTVKAKISEADVNRVRP
GLTTYFTLLGDSDTRYYGKLRAIEPGPVSSSTSSSSSSSSSSSSSAIYYYGLFEVPNPAGRLKVSMTAQVSILLNQVRQA
LCIPVSALGEKLKDNRYRVRVLKDGEALERTIRTGISNNVQVQVLEGLREGEKVVVGDSTTLPATEASGAMGAPPGGRR

Sequences:

>Translated_399_residues
MNMSRKQIIIGTVVLLVLLGTGLAVKKLFFGKPKATFVTADAVRMDLEESVLATGIVKAFKTVEVGSQVTGQLQTLHVEL
GDRVKKGQLLAEIDPVLQKNTLMDAEAEVVNLAAQKRSKQALLKQYELAFKRQSRMNAQDASSRSDLESAQAQLESTGCD
ISALDAQIRKARIAVDNAKANLGYHHISAPIDGIVISIDTEEGQTVVSTQSSTTIITLATLDTMTVKAKISEADVNRVRP
GLTTYFTLLGDSDTRYYGKLRAIEPGPVSSSTSSSSSSSSSSSSSAIYYYGLFEVPNPAGRLKVSMTAQVSILLNQVRQA
LCIPVSALGEKLKDNRYRVRVLKDGEALERTIRTGISNNVQVQVLEGLREGEKVVVGDSTTLPATEASGAMGAPPGGRR
>Mature_399_residues
MNMSRKQIIIGTVVLLVLLGTGLAVKKLFFGKPKATFVTADAVRMDLEESVLATGIVKAFKTVEVGSQVTGQLQTLHVEL
GDRVKKGQLLAEIDPVLQKNTLMDAEAEVVNLAAQKRSKQALLKQYELAFKRQSRMNAQDASSRSDLESAQAQLESTGCD
ISALDAQIRKARIAVDNAKANLGYHHISAPIDGIVISIDTEEGQTVVSTQSSTTIITLATLDTMTVKAKISEADVNRVRP
GLTTYFTLLGDSDTRYYGKLRAIEPGPVSSSTSSSSSSSSSSSSSAIYYYGLFEVPNPAGRLKVSMTAQVSILLNQVRQA
LCIPVSALGEKLKDNRYRVRVLKDGEALERTIRTGISNNVQVQVLEGLREGEKVVVGDSTTLPATEASGAMGAPPGGRR

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=375, Percent_Identity=40.8, Blast_Score=286, Evalue=2e-78,
Organism=Escherichia coli, GI87082036, Length=344, Percent_Identity=25.5813953488372, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42774; Mature: 42774

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMSRKQIIIGTVVLLVLLGTGLAVKKLFFGKPKATFVTADAVRMDLEESVLATGIVKAF
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHH
KTVEVGSQVTGQLQTLHVELGDRVKKGQLLAEIDPVLQKNTLMDAEAEVVNLAAQKRSKQ
HHHHCCCHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
ALLKQYELAFKRQSRMNAQDASSRSDLESAQAQLESTGCDISALDAQIRKARIAVDNAKA
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHEEEEECCCC
NLGYHHISAPIDGIVISIDTEEGQTVVSTQSSTTIITLATLDTMTVKAKISEADVNRVRP
CCCEEEECCCCCEEEEEEECCCCCEEEEECCCCEEEEEEEECEEEEEEEECHHHHHHCCC
GLTTYFTLLGDSDTRYYGKLRAIEPGPVSSSTSSSSSSSSSSSSSAIYYYGLFEVPNPAG
CCEEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCC
RLKVSMTAQVSILLNQVRQALCIPVSALGEKLKDNRYRVRVLKDGEALERTIRTGISNNV
CEEEEEHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEEEECCHHHHHHHHHCCCCCE
QVQVLEGLREGEKVVVGDSTTLPATEASGAMGAPPGGRR
EEEEEHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNMSRKQIIIGTVVLLVLLGTGLAVKKLFFGKPKATFVTADAVRMDLEESVLATGIVKAF
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHH
KTVEVGSQVTGQLQTLHVELGDRVKKGQLLAEIDPVLQKNTLMDAEAEVVNLAAQKRSKQ
HHHHCCCHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
ALLKQYELAFKRQSRMNAQDASSRSDLESAQAQLESTGCDISALDAQIRKARIAVDNAKA
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHEEEEECCCC
NLGYHHISAPIDGIVISIDTEEGQTVVSTQSSTTIITLATLDTMTVKAKISEADVNRVRP
CCCEEEECCCCCEEEEEEECCCCCEEEEECCCCEEEEEEEECEEEEEEEECHHHHHHCCC
GLTTYFTLLGDSDTRYYGKLRAIEPGPVSSSTSSSSSSSSSSSSSAIYYYGLFEVPNPAG
CCEEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCC
RLKVSMTAQVSILLNQVRQALCIPVSALGEKLKDNRYRVRVLKDGEALERTIRTGISNNV
CEEEEEHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEEEECCHHHHHHHHHCCCCCE
QVQVLEGLREGEKVVVGDSTTLPATEASGAMGAPPGGRR
EEEEEHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]