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The map label for this gene is cusC [C]

Identifier: 118580633

GI number: 118580633

Start: 2393761

End: 2395059

Strand: Reverse

Name: cusC [C]

Synonym: Ppro_2218

Alternate gene names: 118580633

Gene position: 2395059-2393761 (Counterclockwise)

Preceding gene: 118580634

Following gene: 118580632

Centisome position: 59.76

GC content: 64.82

Gene sequence:

>1299_bases
GTGAACCTGCCGCAAGGCTGGCAGGGGGAGACCACCAGCGGCACGGCGGTGGCCAATGGTGAAAGGTGGTGGCGCGATTT
CAACGATCCGACCCTGAACAGCCTGATCGAGCGGGCCCTCACCACCAACAACGACCTGGCCGCGGCGACCATCAAGGTAC
GCCGTGCCCAGCTCAACTCCCGGCTGACCGATACCAACATAACCCCCACGGTGACTGTCGAGGCCACAAGCAGCGTCAGC
CGCGACCTGAAGCGGCACACCAGCAGCGAATCCAGCGGTGTCACCGGTGCGGTGAGCTACGAGCTGGACCTGTGGGGTAA
GCTGGCCAGCAACCGCGACGCCAGCCGCTGGGAGGCCGAGGCCACCGAATCCGACCGCCAGAGCACGGCCCTGTCTCTGA
TCGCCACGACAGCAAAGGATTACTGGCAGATCGCCTATCTGAACGAGCGCATCGCTACGACCGAAGCCAGCATCGCCTAT
GCCCGGAAGTGCCTGGATCTGGTGGAGGTAAAATACAACGCCGGCGCCGTCTCCTCCCTGGATCTGGTCCAGGCCCGGCA
GACCCTGGCCAGCCAGCGCGCCGGACTGACCGATCTCATCCGGCAGCGCACGGAGGCGCGCAATGCCCTGGCCATACTGT
TCGACCAGGCCCCTCAGAACAGTGTGCCCGAGCGTGAGCGCCTGCCCGCCGGCCCGCTCCCGGCGGTGAGTGCCGATCTC
CCCGCCAGTCTGCTGGGCAGGCGTCCCGACCTGCGGGCGGCGGAGCAGCGGCTCAGGAAATACCTGGCCAACGTTGATTA
CACCCGCGCCAGCTACTATCCAGCCTTCTCCCTCACCGGAACGCTCGGCACGAGCAGCACCAGCCTGCTGAGTTTTCTGC
AGAACCCCTATGCCGCCCTGGGAGCGAGTCTGACTCTGCCGTTCATCCAGTGGAACACCATGAAGCTTGACGTGGCCATC
TCAAAGACGGAATATGAGGAGGCCGTGGTCAACTTCCGTCAGACGCTCTACGCGGCCCTCAGTGACGTGGAGAACGCCCT
GTCCGGCCGCGTCCAGTACGAGGAGGAAAACAGCTGCCTGGAGGAGTCGCTGAGTCTGGCCAGAAAGGCCGAGGAGTTGG
CCGAGGTCCGCTATCGCGCCGGGGCCACGGAGCTGCAACTCTGGCTGGACGGCCAGGAGAGCCGGCGCAGCGCCGAGAAC
TCCCTGGTCGAGAACAGGCTTAACCGGCTCAAGAATCTAATGACCCTCTACCAGGCCCTGGGTGGAGCCATGACGGCGAC
ATCCGGGGATAAAGAGTGA

Upstream 100 bases:

>100_bases
GTGGCGCCGGGGATCGGTGGCCCTCTTCCTCCTGGCGGCAACGCTCCTGCTTGGCGGCTGCGGCGGCCTGCTTCCCCGTA
GCCAGTACAGCAGGACGGAG

Downstream 100 bases:

>100_bases
CCGGCATCTGTGTGGACCTGCCGCGGAAGCGTGTTCCGGCGCTGAGACCGTGGCAAACGAGGAGGAGAAAATGAAGAAGA
GTGCATGCCTTGTGGTAATC

Product: RND efflux system outer membrane lipoprotein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MNLPQGWQGETTSGTAVANGERWWRDFNDPTLNSLIERALTTNNDLAAATIKVRRAQLNSRLTDTNITPTVTVEATSSVS
RDLKRHTSSESSGVTGAVSYELDLWGKLASNRDASRWEAEATESDRQSTALSLIATTAKDYWQIAYLNERIATTEASIAY
ARKCLDLVEVKYNAGAVSSLDLVQARQTLASQRAGLTDLIRQRTEARNALAILFDQAPQNSVPERERLPAGPLPAVSADL
PASLLGRRPDLRAAEQRLRKYLANVDYTRASYYPAFSLTGTLGTSSTSLLSFLQNPYAALGASLTLPFIQWNTMKLDVAI
SKTEYEEAVVNFRQTLYAALSDVENALSGRVQYEEENSCLEESLSLARKAEELAEVRYRAGATELQLWLDGQESRRSAEN
SLVENRLNRLKNLMTLYQALGGAMTATSGDKE

Sequences:

>Translated_432_residues
MNLPQGWQGETTSGTAVANGERWWRDFNDPTLNSLIERALTTNNDLAAATIKVRRAQLNSRLTDTNITPTVTVEATSSVS
RDLKRHTSSESSGVTGAVSYELDLWGKLASNRDASRWEAEATESDRQSTALSLIATTAKDYWQIAYLNERIATTEASIAY
ARKCLDLVEVKYNAGAVSSLDLVQARQTLASQRAGLTDLIRQRTEARNALAILFDQAPQNSVPERERLPAGPLPAVSADL
PASLLGRRPDLRAAEQRLRKYLANVDYTRASYYPAFSLTGTLGTSSTSLLSFLQNPYAALGASLTLPFIQWNTMKLDVAI
SKTEYEEAVVNFRQTLYAALSDVENALSGRVQYEEENSCLEESLSLARKAEELAEVRYRAGATELQLWLDGQESRRSAEN
SLVENRLNRLKNLMTLYQALGGAMTATSGDKE
>Mature_432_residues
MNLPQGWQGETTSGTAVANGERWWRDFNDPTLNSLIERALTTNNDLAAATIKVRRAQLNSRLTDTNITPTVTVEATSSVS
RDLKRHTSSESSGVTGAVSYELDLWGKLASNRDASRWEAEATESDRQSTALSLIATTAKDYWQIAYLNERIATTEASIAY
ARKCLDLVEVKYNAGAVSSLDLVQARQTLASQRAGLTDLIRQRTEARNALAILFDQAPQNSVPERERLPAGPLPAVSADL
PASLLGRRPDLRAAEQRLRKYLANVDYTRASYYPAFSLTGTLGTSSTSLLSFLQNPYAALGASLTLPFIQWNTMKLDVAI
SKTEYEEAVVNFRQTLYAALSDVENALSGRVQYEEENSCLEESLSLARKAEELAEVRYRAGATELQLWLDGQESRRSAEN
SLVENRLNRLKNLMTLYQALGGAMTATSGDKE

Specific function: In Pathogenic Strains It Allows The Bacteria To Invade Brain Microvascular Endothelial Cells (Bmec) Thus Allowing It To Cross The Blood-Brain Barrier And Cause Neonatal Meningitis. [C]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Attached To The Outer Membrane By A Lipid Anchor [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=409, Percent_Identity=28.6063569682152, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI2367348, Length=437, Percent_Identity=25.4004576659039, Blast_Score=79, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 47605; Mature: 47605

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLPQGWQGETTSGTAVANGERWWRDFNDPTLNSLIERALTTNNDLAAATIKVRRAQLNS
CCCCCCCCCCCCCCCEEECCHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
RLTDTNITPTVTVEATSSVSRDLKRHTSSESSGVTGAVSYELDLWGKLASNRDASRWEAE
CCCCCCCCCEEEEECHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHHHHCCCCCCHHHHH
ATESDRQSTALSLIATTAKDYWQIAYLNERIATTEASIAYARKCLDLVEVKYNAGAVSSL
HHHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
DLVQARQTLASQRAGLTDLIRQRTEARNALAILFDQAPQNSVPERERLPAGPLPAVSADL
HHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEEEECCCCCCCCHHHCCCCCCCCCCCCCC
PASLLGRRPDLRAAEQRLRKYLANVDYTRASYYPAFSLTGTLGTSSTSLLSFLQNPYAAL
CHHHHCCCCCHHHHHHHHHHHHHCCCCCHHCCCCCEEEEECCCCCHHHHHHHHHCCHHHH
GASLTLPFIQWNTMKLDVAISKTEYEEAVVNFRQTLYAALSDVENALSGRVQYEEENSCL
CCCEEEEEEEECEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECHHHHHH
EESLSLARKAEELAEVRYRAGATELQLWLDGQESRRSAENSLVENRLNRLKNLMTLYQAL
HHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGAMTATSGDKE
CCCEECCCCCCC
>Mature Secondary Structure
MNLPQGWQGETTSGTAVANGERWWRDFNDPTLNSLIERALTTNNDLAAATIKVRRAQLNS
CCCCCCCCCCCCCCCEEECCHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
RLTDTNITPTVTVEATSSVSRDLKRHTSSESSGVTGAVSYELDLWGKLASNRDASRWEAE
CCCCCCCCCEEEEECHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHHHHCCCCCCHHHHH
ATESDRQSTALSLIATTAKDYWQIAYLNERIATTEASIAYARKCLDLVEVKYNAGAVSSL
HHHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
DLVQARQTLASQRAGLTDLIRQRTEARNALAILFDQAPQNSVPERERLPAGPLPAVSADL
HHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEEEECCCCCCCCHHHCCCCCCCCCCCCCC
PASLLGRRPDLRAAEQRLRKYLANVDYTRASYYPAFSLTGTLGTSSTSLLSFLQNPYAAL
CHHHHCCCCCHHHHHHHHHHHHHCCCCCHHCCCCCEEEEECCCCCHHHHHHHHHCCHHHH
GASLTLPFIQWNTMKLDVAISKTEYEEAVVNFRQTLYAALSDVENALSGRVQYEEENSCL
CCCEEEEEEEECEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECHHHHHH
EESLSLARKAEELAEVRYRAGATELQLWLDGQESRRSAENSLVENRLNRLKNLMTLYQAL
HHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGAMTATSGDKE
CCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]