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The map label for this gene is serA [H]

Identifier: 118580582

GI number: 118580582

Start: 2336028

End: 2337101

Strand: Direct

Name: serA [H]

Synonym: Ppro_2166

Alternate gene names: 118580582

Gene position: 2336028-2337101 (Clockwise)

Preceding gene: 118580579

Following gene: 118580583

Centisome position: 58.28

GC content: 62.57

Gene sequence:

>1074_bases
ATGCTACGTACACCAGTAACAAGCCGTCAGCAACTCGACGCCAGCCATACAGGGAGGGTGCATACCATGAACGTCCTGAT
TGCAAGTTCAATTGACGGAGAGGCGATCGAAAGGCTTGAGCAGGAGCACCAGGTCATCCGCGCTTTCCCGAACAGTAGCG
AGGAGAGCCTGCACGCGCTGATTCGCGACTGCGAAGCCCTGGTGTTCCGCAGCGGCATACGGGTAAGCGCCGACCTGATG
GGGTGCGCGCCCAGGCTGAAGCTGCTGGTGCGCGCCGGTTCGGGGATGGACAACCTTGACGTGGAATACGCCCGAAAGCG
GGGGGTACAACTGGTGCGCATACCGCAACCATCGGCCAGGGCCGTGGCGGAAATGGCCTTCGCCTTCATGCTGGCACTCA
GCCGCCGCCTGCTTGAGGCCGACCGCTCCATGCGCAACGGGCGCTGGGAAAAGCACGAATTTTCCGGATACCTCCTGCGG
GACAAGACGCTGGGTGTCGTGGGCATCGGCAACACCGGCAGCTGCGTTGCCCAGATGGGGGTTGCCTGGGGCATGCGGGT
TATCGGCTGCGTCCAGCACCCTTCCCGGGAGCGGGAGGAAGGCTTCTGCGAAAAGGGGATTCAGATGCTGGAGTTCGACC
AGGTCATAGCCAATGCCGATTATCTGAGCATCCACGTCCCGCTCAAGGATAACACGCGCAGGCTCCTGGACGCCGATGCG
CTGAGTCGCATGAAACCGGGCGCATACCTGATCAACCTGGCACGGGGGGGCATTGTCGACGAGCAGGCTTTGTATGAATC
GCTGACACACAACGGCGGACTGAGGGGGGCGGCGCTGGACGTCCACGAGCATGAGGGTCAGGGCTGCATGTCGCCCTTGG
CAATGCTGAACAACGTCATCCTCACGCCGCACATCGGCGCCATGGCCATCGATGCCCAGCGGGAGATCGGCCAGAAGGTG
GTCGAAATCATCGACGCCTTCGCGAACGCACACGGCAGCGACGCATGGCAGGGAAAGGTGGCCGAAGTGGCCCAGGGCTA
TACCCGCATCCAGGGGGAGGTGAACCGTGGCTAG

Upstream 100 bases:

>100_bases
TGCGCTATAATCCTACACAAGAATCGGCTGCTGCACAGCCCCACCCACTCAGGAAGGCGATTTCCGGAATTGAAGCAACG
CCACACGCCGGAGAACGCCC

Downstream 100 bases:

>100_bases
GAAGACGACCCAGTTCAGGCAGCTGCTGAACTCCGGCGGGATAGAGTTTCTGCTGGAGGCGCACGACGGCATGAGTGCCA
GAATCGTTGAGGAGGCCGGG

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MLRTPVTSRQQLDASHTGRVHTMNVLIASSIDGEAIERLEQEHQVIRAFPNSSEESLHALIRDCEALVFRSGIRVSADLM
GCAPRLKLLVRAGSGMDNLDVEYARKRGVQLVRIPQPSARAVAEMAFAFMLALSRRLLEADRSMRNGRWEKHEFSGYLLR
DKTLGVVGIGNTGSCVAQMGVAWGMRVIGCVQHPSREREEGFCEKGIQMLEFDQVIANADYLSIHVPLKDNTRRLLDADA
LSRMKPGAYLINLARGGIVDEQALYESLTHNGGLRGAALDVHEHEGQGCMSPLAMLNNVILTPHIGAMAIDAQREIGQKV
VEIIDAFANAHGSDAWQGKVAEVAQGYTRIQGEVNRG

Sequences:

>Translated_357_residues
MLRTPVTSRQQLDASHTGRVHTMNVLIASSIDGEAIERLEQEHQVIRAFPNSSEESLHALIRDCEALVFRSGIRVSADLM
GCAPRLKLLVRAGSGMDNLDVEYARKRGVQLVRIPQPSARAVAEMAFAFMLALSRRLLEADRSMRNGRWEKHEFSGYLLR
DKTLGVVGIGNTGSCVAQMGVAWGMRVIGCVQHPSREREEGFCEKGIQMLEFDQVIANADYLSIHVPLKDNTRRLLDADA
LSRMKPGAYLINLARGGIVDEQALYESLTHNGGLRGAALDVHEHEGQGCMSPLAMLNNVILTPHIGAMAIDAQREIGQKV
VEIIDAFANAHGSDAWQGKVAEVAQGYTRIQGEVNRG
>Mature_357_residues
MLRTPVTSRQQLDASHTGRVHTMNVLIASSIDGEAIERLEQEHQVIRAFPNSSEESLHALIRDCEALVFRSGIRVSADLM
GCAPRLKLLVRAGSGMDNLDVEYARKRGVQLVRIPQPSARAVAEMAFAFMLALSRRLLEADRSMRNGRWEKHEFSGYLLR
DKTLGVVGIGNTGSCVAQMGVAWGMRVIGCVQHPSREREEGFCEKGIQMLEFDQVIANADYLSIHVPLKDNTRRLLDADA
LSRMKPGAYLINLARGGIVDEQALYESLTHNGGLRGAALDVHEHEGQGCMSPLAMLNNVILTPHIGAMAIDAQREIGQKV
VEIIDAFANAHGSDAWQGKVAEVAQGYTRIQGEVNRG

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=307, Percent_Identity=35.1791530944625, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI61743967, Length=269, Percent_Identity=32.3420074349442, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI4557497, Length=269, Percent_Identity=32.3420074349442, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI145580578, Length=240, Percent_Identity=33.75, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI4557499, Length=240, Percent_Identity=33.75, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI145580575, Length=246, Percent_Identity=32.520325203252, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI6912396, Length=226, Percent_Identity=29.646017699115, Blast_Score=108, Evalue=7e-24,
Organism=Escherichia coli, GI87082289, Length=324, Percent_Identity=29.0123456790123, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1789279, Length=271, Percent_Identity=31.3653136531365, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1787645, Length=280, Percent_Identity=27.5, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1788660, Length=273, Percent_Identity=28.9377289377289, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87081824, Length=194, Percent_Identity=29.8969072164948, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=305, Percent_Identity=36.3934426229508, Blast_Score=187, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI25147481, Length=254, Percent_Identity=29.5275590551181, Blast_Score=106, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320925, Length=339, Percent_Identity=30.0884955752212, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6322116, Length=326, Percent_Identity=30.6748466257669, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6324055, Length=241, Percent_Identity=29.8755186721992, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6324964, Length=275, Percent_Identity=28.7272727272727, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6324980, Length=196, Percent_Identity=27.5510204081633, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19921140, Length=336, Percent_Identity=30.952380952381, Blast_Score=167, Evalue=8e-42,
Organism=Drosophila melanogaster, GI28574286, Length=294, Percent_Identity=32.6530612244898, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24585514, Length=285, Percent_Identity=30.5263157894737, Blast_Score=128, Evalue=6e-30,
Organism=Drosophila melanogaster, GI28574282, Length=285, Percent_Identity=30.5263157894737, Blast_Score=128, Evalue=6e-30,
Organism=Drosophila melanogaster, GI28574284, Length=285, Percent_Identity=30.5263157894737, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI45551003, Length=285, Percent_Identity=30.5263157894737, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI45552429, Length=285, Percent_Identity=30.5263157894737, Blast_Score=128, Evalue=8e-30,
Organism=Drosophila melanogaster, GI28571528, Length=315, Percent_Identity=30.4761904761905, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24585516, Length=303, Percent_Identity=26.7326732673267, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24646446, Length=231, Percent_Identity=32.034632034632, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24646448, Length=231, Percent_Identity=32.034632034632, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24646452, Length=231, Percent_Identity=32.034632034632, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24646450, Length=231, Percent_Identity=32.034632034632, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI62472511, Length=231, Percent_Identity=32.034632034632, Blast_Score=108, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 39200; Mature: 39200

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRTPVTSRQQLDASHTGRVHTMNVLIASSIDGEAIERLEQEHQVIRAFPNSSEESLHAL
CCCCCCCCHHHCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHH
IRDCEALVFRSGIRVSADLMGCAPRLKLLVRAGSGMDNLDVEYARKRGVQLVRIPQPSAR
HHHHHHHHHHCCCEEEHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHCCCEEEECCCCHHH
AVAEMAFAFMLALSRRLLEADRSMRNGRWEKHEFSGYLLRDKTLGVVGIGNTGSCVAQMG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCEEEECCCEEEEEECCCCHHHHHHH
VAWGMRVIGCVQHPSREREEGFCEKGIQMLEFDQVIANADYLSIHVPLKDNTRRLLDADA
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHH
LSRMKPGAYLINLARGGIVDEQALYESLTHNGGLRGAALDVHEHEGQGCMSPLAMLNNVI
HHHCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHCCEE
LTPHIGAMAIDAQREIGQKVVEIIDAFANAHGSDAWQGKVAEVAQGYTRIQGEVNRG
ECCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLRTPVTSRQQLDASHTGRVHTMNVLIASSIDGEAIERLEQEHQVIRAFPNSSEESLHAL
CCCCCCCCHHHCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHH
IRDCEALVFRSGIRVSADLMGCAPRLKLLVRAGSGMDNLDVEYARKRGVQLVRIPQPSAR
HHHHHHHHHHCCCEEEHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHCCCEEEECCCCHHH
AVAEMAFAFMLALSRRLLEADRSMRNGRWEKHEFSGYLLRDKTLGVVGIGNTGSCVAQMG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCEEEECCCEEEEEECCCCHHHHHHH
VAWGMRVIGCVQHPSREREEGFCEKGIQMLEFDQVIANADYLSIHVPLKDNTRRLLDADA
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHH
LSRMKPGAYLINLARGGIVDEQALYESLTHNGGLRGAALDVHEHEGQGCMSPLAMLNNVI
HHHCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHCCEE
LTPHIGAMAIDAQREIGQKVVEIIDAFANAHGSDAWQGKVAEVAQGYTRIQGEVNRG
ECCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]