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The map label for this gene is ymxG [H]

Identifier: 118580533

GI number: 118580533

Start: 2276361

End: 2277650

Strand: Reverse

Name: ymxG [H]

Synonym: Ppro_2117

Alternate gene names: 118580533

Gene position: 2277650-2276361 (Counterclockwise)

Preceding gene: 118580536

Following gene: 118580531

Centisome position: 56.83

GC content: 59.46

Gene sequence:

>1290_bases
ATGGGTAAAAAGCAGGGTATAGTGAAATCCATGATCTGCTCAACCACCCTCGACAACGGCATCCGGGTTGTCACCCAGCG
CGTGAAGTACATGCACACCGTATCCATGGGCATCTGGGTGGCCAACGGAACACGGCATGAGGCTCCGCACCTTAACGGCA
TCGCCCACTTTATCGAGCATCTGCTCTTCAAGGGGACCGCCCGGCGCTCGGCCCGCCAGATAGCCATGGAGATCGACTCC
ATGGGAGGGATTCTCAACGCCTTCACCAGCCACGAGTACGTCTGCTACTACGCCAAGGTTCTGGCGAAGTTCCTGCCGCG
CATAACCGACCTGCTGTGTGACATCTTTCTCTGTTCTTCCTTCCCCAGTGAAGAGATCGAGCGCGAACGCAGGGTCATCC
TGCAGGAAATCAAGATGCGCGACGATACGCCGGACGTGTTCATCCACGATCAGTTTCACCAGAACTTCTGGCAGGGGGAC
TCCCTGGGGTTGACCATCCCCGGCTCCCACGAGACGGTGAGCTCCCTTTCCCGTGAACAGATCATCGACTACAAGCAGAG
TCGTTACCGACCGCGGGACATCGTCATCTCCGCCGCCGGAAATGTCAGGCATGAAGAGCTGCTCTCATTGATGGAAGGCG
CCTTTTCCGGCATGACCTCTGATCAGCGCTCCCGGACGGAAGCGCCGGTTGCACACGTCGGACCGCGGATAAACCAGTGC
GAGCGCGACCTGGAGCAGACCCTGCTCTGCATGGGGACCAACGGGCTCTCCCAGGACCATCCCGACCGCTTTGCCCTGCA
TCTGCTGAACACGGTCCTGGGGGGAGGCATGAGTTCGCGCCTGTTCCAGGAGGTGCGTGAAAATCGGGGGCTGGCCTATT
CGATCTATTCCTATGTCATCTCCCATGCCGATTGCGGTGCCCTGGTGATCCATGCCGGTACGGAGCAGGAGCAGTGCCGG
GAGGTGATTGAGATCGCGCTGCGGCAGATGGGGCAACTCAAGCGGGAAATGGTCCCCCAGGATGAGCTCGATTCAGCCCG
GGAGCAGCTCAAGGGCAACCTGCTGATGTCTCTGGAGAGCAGCGACAACCTGATGACCCGGCTGGCCAAGAACGATATTT
ATCTGCATCGCAACCAGACCGTTGAGGAGGTGCTGGCCGCCTTTGATGCCGTGACCGGAGAAGATATCCTGCGGTTGGGC
AACCAGCTCTTCGACGGAAGCCGCATCCACCTGGAAGTGATGGGGAAAACGTGGCATACCGGGCTGACGGAGGATCTGCT
GCGGCTCTGA

Upstream 100 bases:

>100_bases
CCTGCTGTTTTTATTCGGAGATGCTTGCATGTAAGTAGCAAAATATCGGCGCTTCCTGCAAGCGTTTGTTTAAAACCAAA
TAATATTCAGTGGGTTGGAC

Downstream 100 bases:

>100_bases
TCCCGGCGCCTGGCGCACCTTTCACGACAGCATCCCCCTGTGGCTATCCCCTCAGATTTTTCCCGTATGGCCGAATCCCC
CTGCTCCCCGTTCACTCTCC

Product: processing peptidase

Products: NA

Alternate protein names: ORFP [H]

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MGKKQGIVKSMICSTTLDNGIRVVTQRVKYMHTVSMGIWVANGTRHEAPHLNGIAHFIEHLLFKGTARRSARQIAMEIDS
MGGILNAFTSHEYVCYYAKVLAKFLPRITDLLCDIFLCSSFPSEEIERERRVILQEIKMRDDTPDVFIHDQFHQNFWQGD
SLGLTIPGSHETVSSLSREQIIDYKQSRYRPRDIVISAAGNVRHEELLSLMEGAFSGMTSDQRSRTEAPVAHVGPRINQC
ERDLEQTLLCMGTNGLSQDHPDRFALHLLNTVLGGGMSSRLFQEVRENRGLAYSIYSYVISHADCGALVIHAGTEQEQCR
EVIEIALRQMGQLKREMVPQDELDSAREQLKGNLLMSLESSDNLMTRLAKNDIYLHRNQTVEEVLAAFDAVTGEDILRLG
NQLFDGSRIHLEVMGKTWHTGLTEDLLRL

Sequences:

>Translated_429_residues
MGKKQGIVKSMICSTTLDNGIRVVTQRVKYMHTVSMGIWVANGTRHEAPHLNGIAHFIEHLLFKGTARRSARQIAMEIDS
MGGILNAFTSHEYVCYYAKVLAKFLPRITDLLCDIFLCSSFPSEEIERERRVILQEIKMRDDTPDVFIHDQFHQNFWQGD
SLGLTIPGSHETVSSLSREQIIDYKQSRYRPRDIVISAAGNVRHEELLSLMEGAFSGMTSDQRSRTEAPVAHVGPRINQC
ERDLEQTLLCMGTNGLSQDHPDRFALHLLNTVLGGGMSSRLFQEVRENRGLAYSIYSYVISHADCGALVIHAGTEQEQCR
EVIEIALRQMGQLKREMVPQDELDSAREQLKGNLLMSLESSDNLMTRLAKNDIYLHRNQTVEEVLAAFDAVTGEDILRLG
NQLFDGSRIHLEVMGKTWHTGLTEDLLRL
>Mature_428_residues
GKKQGIVKSMICSTTLDNGIRVVTQRVKYMHTVSMGIWVANGTRHEAPHLNGIAHFIEHLLFKGTARRSARQIAMEIDSM
GGILNAFTSHEYVCYYAKVLAKFLPRITDLLCDIFLCSSFPSEEIERERRVILQEIKMRDDTPDVFIHDQFHQNFWQGDS
LGLTIPGSHETVSSLSREQIIDYKQSRYRPRDIVISAAGNVRHEELLSLMEGAFSGMTSDQRSRTEAPVAHVGPRINQCE
RDLEQTLLCMGTNGLSQDHPDRFALHLLNTVLGGGMSSRLFQEVRENRGLAYSIYSYVISHADCGALVIHAGTEQEQCRE
VIEIALRQMGQLKREMVPQDELDSAREQLKGNLLMSLESSDNLMTRLAKNDIYLHRNQTVEEVLAAFDAVTGEDILRLGN
QLFDGSRIHLEVMGKTWHTGLTEDLLRL

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=393, Percent_Identity=32.5699745547074, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI46593007, Length=307, Percent_Identity=32.2475570032573, Blast_Score=161, Evalue=9e-40,
Organism=Homo sapiens, GI24308013, Length=422, Percent_Identity=28.436018957346, Blast_Score=147, Evalue=1e-35,
Organism=Escherichia coli, GI1787770, Length=220, Percent_Identity=23.1818181818182, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71999683, Length=421, Percent_Identity=27.0783847980998, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17553678, Length=389, Percent_Identity=25.706940874036, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17510601, Length=426, Percent_Identity=20.8920187793427, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323192, Length=425, Percent_Identity=29.1764705882353, Blast_Score=193, Evalue=5e-50,
Organism=Saccharomyces cerevisiae, GI6321813, Length=412, Percent_Identity=24.7572815533981, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6319426, Length=414, Percent_Identity=21.0144927536232, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357875, Length=387, Percent_Identity=29.7157622739018, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24646943, Length=387, Percent_Identity=29.7157622739018, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI19921772, Length=426, Percent_Identity=24.1784037558685, Blast_Score=128, Evalue=7e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 48527; Mature: 48396

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKKQGIVKSMICSTTLDNGIRVVTQRVKYMHTVSMGIWVANGTRHEAPHLNGIAHFIEH
CCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHH
LLFKGTARRSARQIAMEIDSMGGILNAFTSHEYVCYYAKVLAKFLPRITDLLCDIFLCSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FPSEEIERERRVILQEIKMRDDTPDVFIHDQFHQNFWQGDSLGLTIPGSHETVSSLSREQ
CCHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHCCCCCCEEECCCCHHHHHHHHHHH
IIDYKQSRYRPRDIVISAAGNVRHEELLSLMEGAFSGMTSDQRSRTEAPVAHVGPRINQC
HHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHCCCCHHHHCCCHHHH
ERDLEQTLLCMGTNGLSQDHPDRFALHLLNTVLGGGMSSRLFQEVRENRGLAYSIYSYVI
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHH
SHADCGALVIHAGTEQEQCREVIEIALRQMGQLKREMVPQDELDSAREQLKGNLLMSLES
HCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEECC
SDNLMTRLAKNDIYLHRNQTVEEVLAAFDAVTGEDILRLGNQLFDGSRIHLEVMGKTWHT
CHHHHHHHHHCCEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEECCHHCC
GLTEDLLRL
CHHHHHHCC
>Mature Secondary Structure 
GKKQGIVKSMICSTTLDNGIRVVTQRVKYMHTVSMGIWVANGTRHEAPHLNGIAHFIEH
CCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHH
LLFKGTARRSARQIAMEIDSMGGILNAFTSHEYVCYYAKVLAKFLPRITDLLCDIFLCSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FPSEEIERERRVILQEIKMRDDTPDVFIHDQFHQNFWQGDSLGLTIPGSHETVSSLSREQ
CCHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHCCCCCCEEECCCCHHHHHHHHHHH
IIDYKQSRYRPRDIVISAAGNVRHEELLSLMEGAFSGMTSDQRSRTEAPVAHVGPRINQC
HHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHCCCCHHHHCCCHHHH
ERDLEQTLLCMGTNGLSQDHPDRFALHLLNTVLGGGMSSRLFQEVRENRGLAYSIYSYVI
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHH
SHADCGALVIHAGTEQEQCREVIEIALRQMGQLKREMVPQDELDSAREQLKGNLLMSLES
HCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEECC
SDNLMTRLAKNDIYLHRNQTVEEVLAAFDAVTGEDILRLGNQLFDGSRIHLEVMGKTWHT
CHHHHHHHHHCCEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEECCHHCC
GLTEDLLRL
CHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 8098035 [H]