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The map label for this gene is nat [H]

Identifier: 118580327

GI number: 118580327

Start: 2055693

End: 2056499

Strand: Direct

Name: nat [H]

Synonym: Ppro_1909

Alternate gene names: 118580327

Gene position: 2055693-2056499 (Clockwise)

Preceding gene: 118580326

Following gene: 118580328

Centisome position: 51.29

GC content: 48.57

Gene sequence:

>807_bases
ATGAATATTGAGTCATTCCTCATACGCATCGGCGTTCAATCACTTCCGGAGTCTCCACTGAACCGCCTTCAGGCACTTCA
CAGGGCTATGACCCAAACCGTGCCCTTTGAAAACCTTGCGGTTCTTGAGGGGCAAAAAATCAGCCTGGACCCAGAAACCT
TATTTACAAAAATAGTTGAACGAGGCCGGGGTGGATACTGTTTTGAGTTGAATACCATGCTGGCTGAAGTTCTTGATTTT
ATGGGCTACAAGGTGGAGCGTCTTTTAGGAAGAGTCTGGGCGAACGGTGCAGCGTCACCCCCACTTACCCATATGACATT
AAAGGTGACGGTGGAAAATCAATCTTACCTTTGCGATGTTGGATTCGGTGGTGGCACACTTAGAGAGCCATTGCCTTGGA
ATACCGGAGCAATAGTGAATCAGTCGTCAGACAGTTTCCGCCTTGATAAGACTGATAACGCAGAAACCATGCTTTCGCGT
CTGACAGGCGATTCATGGAAGAACCTATACAGTCTTCTCCCATGTGTGGTTCGCGTCCAGGATTATATTCCTGCCAATCA
TTACACCTCCACTCATCCCGATTCGTATTTTACCCAGGGACCTGTTGCCGCCCTGACAACCGAAGACGGACGTATTACGC
TCCGTGGCCGCATTTTTCGAAGTGTAGGAGCAAATCGAGAGGAGGAACGGGAATTGGCGACCTTCGATGAACTTATTCAG
GTATTATCCCGAGATTTTGGTTTGGACAATCTGGATGTTAAGAACCTGAAGAGTCGCCTTTCAGGGCTCTTCCTCCAAGC
AGGGTAG

Upstream 100 bases:

>100_bases
AACGCTGTCCTCGCAGGAATTGTTCTGGTGAGCGGCTACCCCCGCCCGTCAGGTCAAGTGCGAAACCGTTGGTGAAGAAC
TATAATTAGAAGGATCCACC

Downstream 100 bases:

>100_bases
TGCTTACCTATGAAAACGAAGATTCAACATGCGAATAGACTGTTTCGCTACGCTCTCAGGTCAACCGCAAAGCCGTTAGC
GAGATAACTGAAATGGAAAA

Product: N-acetyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MNIESFLIRIGVQSLPESPLNRLQALHRAMTQTVPFENLAVLEGQKISLDPETLFTKIVERGRGGYCFELNTMLAEVLDF
MGYKVERLLGRVWANGAASPPLTHMTLKVTVENQSYLCDVGFGGGTLREPLPWNTGAIVNQSSDSFRLDKTDNAETMLSR
LTGDSWKNLYSLLPCVVRVQDYIPANHYTSTHPDSYFTQGPVAALTTEDGRITLRGRIFRSVGANREEERELATFDELIQ
VLSRDFGLDNLDVKNLKSRLSGLFLQAG

Sequences:

>Translated_268_residues
MNIESFLIRIGVQSLPESPLNRLQALHRAMTQTVPFENLAVLEGQKISLDPETLFTKIVERGRGGYCFELNTMLAEVLDF
MGYKVERLLGRVWANGAASPPLTHMTLKVTVENQSYLCDVGFGGGTLREPLPWNTGAIVNQSSDSFRLDKTDNAETMLSR
LTGDSWKNLYSLLPCVVRVQDYIPANHYTSTHPDSYFTQGPVAALTTEDGRITLRGRIFRSVGANREEERELATFDELIQ
VLSRDFGLDNLDVKNLKSRLSGLFLQAG
>Mature_268_residues
MNIESFLIRIGVQSLPESPLNRLQALHRAMTQTVPFENLAVLEGQKISLDPETLFTKIVERGRGGYCFELNTMLAEVLDF
MGYKVERLLGRVWANGAASPPLTHMTLKVTVENQSYLCDVGFGGGTLREPLPWNTGAIVNQSSDSFRLDKTDNAETMLSR
LTGDSWKNLYSLLPCVVRVQDYIPANHYTSTHPDSYFTQGPVAALTTEDGRITLRGRIFRSVGANREEERELATFDELIQ
VLSRDFGLDNLDVKNLKSRLSGLFLQAG

Specific function: Could have a role in acetylating, and hence inactivating, the antitubercular drug isoniazid [H]

COG id: COG2162

COG function: function code Q; Arylamine N-acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the arylamine N-acetyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI237649132, Length=273, Percent_Identity=29.3040293040293, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI237649130, Length=273, Percent_Identity=29.3040293040293, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI237649128, Length=273, Percent_Identity=29.3040293040293, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI237649126, Length=273, Percent_Identity=29.3040293040293, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI237649124, Length=273, Percent_Identity=29.3040293040293, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI237649122, Length=273, Percent_Identity=29.3040293040293, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI237649119, Length=273, Percent_Identity=29.3040293040293, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI42741671, Length=273, Percent_Identity=29.3040293040293, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI237649009, Length=273, Percent_Identity=29.3040293040293, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI116295260, Length=257, Percent_Identity=27.6264591439689, Blast_Score=82, Evalue=7e-16,
Organism=Escherichia coli, GI1787736, Length=256, Percent_Identity=31.640625, Blast_Score=113, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001447 [H]

Pfam domain/function: PF00797 Acetyltransf_2 [H]

EC number: =2.3.1.5 [H]

Molecular weight: Translated: 29946; Mature: 29946

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIESFLIRIGVQSLPESPLNRLQALHRAMTQTVPFENLAVLEGQKISLDPETLFTKIVE
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCEECCCHHHHHHHHHH
RGRGGYCFELNTMLAEVLDFMGYKVERLLGRVWANGAASPPLTHMTLKVTVENQSYLCDV
CCCCCEEEEHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCEEEEE
GFGGGTLREPLPWNTGAIVNQSSDSFRLDKTDNAETMLSRLTGDSWKNLYSLLPCVVRVQ
CCCCCCCCCCCCCCCCCEEECCCCCEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHH
DYIPANHYTSTHPDSYFTQGPVAALTTEDGRITLRGRIFRSVGANREEERELATFDELIQ
HHCCCCCCCCCCCCCCCCCCCEEEEEECCCEEEEHHHHHHHHCCCCHHHHHHHHHHHHHH
VLSRDFGLDNLDVKNLKSRLSGLFLQAG
HHHHHCCCCCCCHHHHHHHHHHHEECCC
>Mature Secondary Structure
MNIESFLIRIGVQSLPESPLNRLQALHRAMTQTVPFENLAVLEGQKISLDPETLFTKIVE
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCEECCCHHHHHHHHHH
RGRGGYCFELNTMLAEVLDFMGYKVERLLGRVWANGAASPPLTHMTLKVTVENQSYLCDV
CCCCCEEEEHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCEEEEE
GFGGGTLREPLPWNTGAIVNQSSDSFRLDKTDNAETMLSRLTGDSWKNLYSLLPCVVRVQ
CCCCCCCCCCCCCCCCCEEECCCCCEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHH
DYIPANHYTSTHPDSYFTQGPVAALTTEDGRITLRGRIFRSVGANREEERELATFDELIQ
HHCCCCCCCCCCCCCCCCCCCEEEEEECCCEEEEHHHHHHHHCCCCHHHHHHHHHHHHHH
VLSRDFGLDNLDVKNLKSRLSGLFLQAG
HHHHHCCCCCCCHHHHHHHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9973365; 12054803 [H]