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The map label for this gene is ygcA [C]

Identifier: 118580203

GI number: 118580203

Start: 1910804

End: 1912144

Strand: Reverse

Name: ygcA [C]

Synonym: Ppro_1783

Alternate gene names: 118580203

Gene position: 1912144-1910804 (Counterclockwise)

Preceding gene: 118580204

Following gene: 118580202

Centisome position: 47.71

GC content: 62.94

Gene sequence:

>1341_bases
ATGAATCATGATCCCGCCGAGCAGCTGATCAGCATCGACAGGCTGGCCTTCGGCGGCAGCGGTGTGGGACGTATCGACGG
CAAGGTCTGCTTCGTCCCCTTCGCCTGCCCGGGTGACGAGCTTCTCGTCCGCATCACCGCCGAGAAGCGCTCCTACCTGA
CCGCCCGGATCATCTCCATCGTTACCCCCGGACAGGACAGGATCACTCCTCCCTGTCCCCTGTTCGGTTCCTGCGGCGGC
TGCAGCTGGCAGCACATAGCCTATCACCGGCAGCTGGAGGAAAAGCGGCGGATCTTTGCCGACGCACTCTGGCGCGGGGC
TCGCGCACCCGGAGAGCTGGTGGCGGATGTGGTCGCCTCACCCCTGACCTATGGCTACCGCAGCCGGGTACAGTTCAAGC
TCCATGGCGCAGGCCCCAACCTGCGCATCGGCTTCTATCGCCAGGGAACCCATTTCGTGGAGGATGCCGGGCAGGGATGC
CCCATTGCGCTGCCGGTCATCAACCGGATTCTGGGCAGTTTGCGGGAGATGCTCCCGGCATTCCCCGATCCGACCAAGAT
TCCCCAGATCAATCTGGAGTGCGCCGAGAAGGGCGCGGTGGTGATCGTCAACTACATTGGGGATGATCACCAGGGCGCCA
AAGCCTTCTTCCGGGAGCGGGCCGCGCAGCTGGAACAGGCGACCGCCCTCTATCTGCAGACCGGCAGAAAATCCACGCTC
CAGAAGGTATTCGGAGACGACCTGCTGCAGTACTCACAGGAGGGAGAGTCGTCAACAGCCCCCGCCTGTTCCCTGACCTA
CCGGCCAGGTGGGTTCGCTCAAGTCAACGCGGCCCAGAACAGCGCCCTTCTCCGGCTGGTGAGGGAGTTTGCCGACTGCC
GACGAGACGATCAGATACTGGACCTGTACTGCGGCAATGGGAATTTTTCGCTTCCCCTGGCCCGGGGGGTGGCTGCCGTC
ACCGGCATCGAGGAATACGGCGATTCCATCGCGGCTGCCCGACATAACGCCCGCCTGAACGGCATAACAAATGTCGAGTT
CATCTGCGCCGATGCCGCCGCAGGGGCAGGAAAACTCATGGGCGACGGACGGAGATTCCCTACCATCATCCTGGATCCCC
CCCGCAGTGGCGCAGCTGATCTGCTGGAGCACATCCCTCGCTTGGGGGCGGACAAGATCATCTACATTTCCTGCGACCCC
AGTACCCTTGCCCGGGACTGCGGCGTGCTCTTCGGCAAGGGGTACACTGTCGTTTCCAGCGTACCGGTGGACATGTTCCC
CCAGACCTTTCATCTGGAGAGCGTCACCCTGCTACGTCGCAGAAACGGAGCCGTGCCATGA

Upstream 100 bases:

>100_bases
GGAGACCCGGCCAAGGCAACGGCAGAAAAGGGTGCCCGGCTGGAGGAGCTGGTGGTGAAGAAGCTGGTGGAACTGATACA
GACAGTGGAAACCTGCCGTA

Downstream 100 bases:

>100_bases
GCATTTTTTCCCGCCTGTTTTCCAAGAGCAGCGATGACCTGCTCACATGGGGTGACACCTTCTTTGCCGCTCGGGTATAA
GGGAGACAATGAAGACATCT

Product: RNA methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MNHDPAEQLISIDRLAFGGSGVGRIDGKVCFVPFACPGDELLVRITAEKRSYLTARIISIVTPGQDRITPPCPLFGSCGG
CSWQHIAYHRQLEEKRRIFADALWRGARAPGELVADVVASPLTYGYRSRVQFKLHGAGPNLRIGFYRQGTHFVEDAGQGC
PIALPVINRILGSLREMLPAFPDPTKIPQINLECAEKGAVVIVNYIGDDHQGAKAFFRERAAQLEQATALYLQTGRKSTL
QKVFGDDLLQYSQEGESSTAPACSLTYRPGGFAQVNAAQNSALLRLVREFADCRRDDQILDLYCGNGNFSLPLARGVAAV
TGIEEYGDSIAAARHNARLNGITNVEFICADAAAGAGKLMGDGRRFPTIILDPPRSGAADLLEHIPRLGADKIIYISCDP
STLARDCGVLFGKGYTVVSSVPVDMFPQTFHLESVTLLRRRNGAVP

Sequences:

>Translated_446_residues
MNHDPAEQLISIDRLAFGGSGVGRIDGKVCFVPFACPGDELLVRITAEKRSYLTARIISIVTPGQDRITPPCPLFGSCGG
CSWQHIAYHRQLEEKRRIFADALWRGARAPGELVADVVASPLTYGYRSRVQFKLHGAGPNLRIGFYRQGTHFVEDAGQGC
PIALPVINRILGSLREMLPAFPDPTKIPQINLECAEKGAVVIVNYIGDDHQGAKAFFRERAAQLEQATALYLQTGRKSTL
QKVFGDDLLQYSQEGESSTAPACSLTYRPGGFAQVNAAQNSALLRLVREFADCRRDDQILDLYCGNGNFSLPLARGVAAV
TGIEEYGDSIAAARHNARLNGITNVEFICADAAAGAGKLMGDGRRFPTIILDPPRSGAADLLEHIPRLGADKIIYISCDP
STLARDCGVLFGKGYTVVSSVPVDMFPQTFHLESVTLLRRRNGAVP
>Mature_446_residues
MNHDPAEQLISIDRLAFGGSGVGRIDGKVCFVPFACPGDELLVRITAEKRSYLTARIISIVTPGQDRITPPCPLFGSCGG
CSWQHIAYHRQLEEKRRIFADALWRGARAPGELVADVVASPLTYGYRSRVQFKLHGAGPNLRIGFYRQGTHFVEDAGQGC
PIALPVINRILGSLREMLPAFPDPTKIPQINLECAEKGAVVIVNYIGDDHQGAKAFFRERAAQLEQATALYLQTGRKSTL
QKVFGDDLLQYSQEGESSTAPACSLTYRPGGFAQVNAAQNSALLRLVREFADCRRDDQILDLYCGNGNFSLPLARGVAAV
TGIEEYGDSIAAARHNARLNGITNVEFICADAAAGAGKLMGDGRRFPTIILDPPRSGAADLLEHIPRLGADKIIYISCDP
STLARDCGVLFGKGYTVVSSVPVDMFPQTFHLESVTLLRRRNGAVP

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain [H]

Homologues:

Organism=Homo sapiens, GI34222389, Length=378, Percent_Identity=24.8677248677249, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI51173878, Length=378, Percent_Identity=24.8677248677249, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI269784680, Length=191, Percent_Identity=31.413612565445, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI269784676, Length=191, Percent_Identity=31.413612565445, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI20149688, Length=191, Percent_Identity=31.413612565445, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI269784678, Length=239, Percent_Identity=28.4518828451883, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1789148, Length=431, Percent_Identity=31.7865429234339, Blast_Score=228, Evalue=5e-61,
Organism=Escherichia coli, GI1790403, Length=351, Percent_Identity=29.9145299145299, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787083, Length=178, Percent_Identity=32.0224719101124, Blast_Score=83, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6322909, Length=421, Percent_Identity=23.7529691211401, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24666579, Length=425, Percent_Identity=24.4705882352941, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016027
- InterPro:   IPR001566
- InterPro:   IPR002792
- InterPro:   IPR010280 [H]

Pfam domain/function: PF01938 TRAM; PF05958 tRNA_U5-meth_tr [H]

EC number: NA

Molecular weight: Translated: 48388; Mature: 48388

Theoretical pI: Translated: 7.81; Mature: 7.81

Prosite motif: PS50926 TRAM ; PS01231 TRMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHDPAEQLISIDRLAFGGSGVGRIDGKVCFVPFACPGDELLVRITAEKRSYLTARIISI
CCCCHHHHHHHHHHHEECCCCCCCCCCEEEEEEECCCCCEEEEEEECCHHHHHHEEEHEE
VTPGQDRITPPCPLFGSCGGCSWQHIAYHRQLEEKRRIFADALWRGARAPGELVADVVAS
ECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
PLTYGYRSRVQFKLHGAGPNLRIGFYRQGTHFVEDAGQGCPIALPVINRILGSLREMLPA
HHHCCCCCEEEEEEECCCCCEEEEEEECCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHCC
FPDPTKIPQINLECAEKGAVVIVNYIGDDHQGAKAFFRERAAQLEQATALYLQTGRKSTL
CCCCCCCCEEEHEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
QKVFGDDLLQYSQEGESSTAPACSLTYRPGGFAQVNAAQNSALLRLVREFADCRRDDQIL
HHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEECHHHHHHHHHHHHHHHCCCCCCEE
DLYCGNGNFSLPLARGVAAVTGIEEYGDSIAAARHNARLNGITNVEFICADAAAGAGKLM
EEEECCCCCCCHHHHHHHHHHCHHHHCCHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCC
GDGRRFPTIILDPPRSGAADLLEHIPRLGADKIIYISCDPSTLARDCGVLFGKGYTVVSS
CCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCEEEEEECCHHHHHHCCCEECCCEEEEEC
VPVDMFPQTFHLESVTLLRRRNGAVP
CCHHHCCCEEEHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNHDPAEQLISIDRLAFGGSGVGRIDGKVCFVPFACPGDELLVRITAEKRSYLTARIISI
CCCCHHHHHHHHHHHEECCCCCCCCCCEEEEEEECCCCCEEEEEEECCHHHHHHEEEHEE
VTPGQDRITPPCPLFGSCGGCSWQHIAYHRQLEEKRRIFADALWRGARAPGELVADVVAS
ECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
PLTYGYRSRVQFKLHGAGPNLRIGFYRQGTHFVEDAGQGCPIALPVINRILGSLREMLPA
HHHCCCCCEEEEEEECCCCCEEEEEEECCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHCC
FPDPTKIPQINLECAEKGAVVIVNYIGDDHQGAKAFFRERAAQLEQATALYLQTGRKSTL
CCCCCCCCEEEHEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
QKVFGDDLLQYSQEGESSTAPACSLTYRPGGFAQVNAAQNSALLRLVREFADCRRDDQIL
HHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEECHHHHHHHHHHHHHHHCCCCCCEE
DLYCGNGNFSLPLARGVAAVTGIEEYGDSIAAARHNARLNGITNVEFICADAAAGAGKLM
EEEECCCCCCCHHHHHHHHHHCHHHHCCHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCC
GDGRRFPTIILDPPRSGAADLLEHIPRLGADKIIYISCDPSTLARDCGVLFGKGYTVVSS
CCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCEEEEEECCHHHHHHCCCEECCCEEEEEC
VPVDMFPQTFHLESVTLLRRRNGAVP
CCHHHCCCEEEHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA