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The map label for this gene is glyA

Identifier: 118580168

GI number: 118580168

Start: 1879566

End: 1880807

Strand: Direct

Name: glyA

Synonym: Ppro_1748

Alternate gene names: 118580168

Gene position: 1879566-1880807 (Clockwise)

Preceding gene: 118580167

Following gene: 118580171

Centisome position: 46.9

GC content: 60.71

Gene sequence:

>1242_bases
ATGTCCATCCTTTCCACACTAGACCCTGAAGTTGCCGACGCCATCAGGCTGGAAGCCGACCGCCAGGAGTACAACCTGGA
GCTGATCGCCTCGGAGAACTTTGTGTCGACGGCGGTCCTGGAAGCCCAGGGTTCGGTGCTGACCAACAAGTACGCCGAGG
GGTATCCCGGCAAACGCTACTACGGCGGATGCCACAACGTCGATATTGTAGAGGCGCTTGCTATTGAACGCGCCAAACAG
CTCTTCGACGCCGAGCATGCCAACGTGCAGCCGCATTCCGGCTCCCAGGCAAACATGGCAGTTTACTTTTCCGCCCTCAA
GCCGGGTGACACCATCCTGGGGATGAATCTCTCCCATGGAGGTCACCTGACCCACGGCAGCCCGGTGAATTTCTCCGGTC
GTTTCTTCAACGTCGTGCCCTATGGCGTCTCTCCGGAAACCCAGACCATCGATTACGCCGAGGTGGAGCGCCTGGCCCTG
GAGCATAAGCCAAAAATGATCGTGGTCGGTGCCAGCGCCTACCCGCGCACCATCGACTTCGCCGCCTTCCGTGCCATTGC
CGACAAGGTGGGCGCCCTGGTCATGGTCGACATGGCCCATATTGCCGGACTGGTGGCAGCCGGCCTGCACCCCAGCCCGA
TTCCCCACGCAGAATTCGTAACCACCACCACCCACAAGACCTTGCGCGGTCCGCGGGGCGGCATGATCCTCTGTCAGGAG
CGCTTCGCCAAGAGCATCAACTCCCAGATCTTCCCCGGTATCCAGGGTGGGCCGCTGATGCACGTCATTGCCGCCAAGGC
GGTTGCCTTCAAGGAAGCCCTGCAGCCGGAATTCAAGCAGTACCAGCAGCAGGTGGTGAACAACGCCAGGACCCTGGCCG
AGGAACTGGTGAAGCGCGGCTTCAAGCTGACCAGCGGCGGAACCGACAATCACCTGATGCTGCTGGACTTCTCCGGTACG
GAGATCACCGGCAAGGCCGCCGAGGAGGCGCTTGACAAGGCGGGCATTACGGCAAACAAGAATACGGTTCCCTTCGAGAC
CCGTTCACCCTTTGTTACCTCCGGCATCCGCATCGGCACGCCGGCGGCCACAACCCATGGCCTGAAAGAGGCCGAGATGG
TGCTGGTGGCCGGTTTCATCGCCGACGCCGTTGCCAACATCGGCAGCGATGAAACGCTTGCAGCCATCAAGCTGCAGGTC
AACCAGTTGATGAAAAAATTTCCCCTCTACGCCAAAGGGTAG

Upstream 100 bases:

>100_bases
TAAGGTTGTTATCATAGATTGTATCGAGCGGGACTTTAATAGAGTCCCGCTTCGTGTTTCCGGAAAAAACTGCGGAGAAT
CACATTTACAAGGAGATACC

Downstream 100 bases:

>100_bases
GGCGGGTGCTTGGCCTGCGGCCGATACGCTTGCCGACCGTCGGATAGAGACCCATGTTTCACATAGAAAGAGCCCTGGGC
TTAAGGCCTCAGGGCTCTTT

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MSILSTLDPEVADAIRLEADRQEYNLELIASENFVSTAVLEAQGSVLTNKYAEGYPGKRYYGGCHNVDIVEALAIERAKQ
LFDAEHANVQPHSGSQANMAVYFSALKPGDTILGMNLSHGGHLTHGSPVNFSGRFFNVVPYGVSPETQTIDYAEVERLAL
EHKPKMIVVGASAYPRTIDFAAFRAIADKVGALVMVDMAHIAGLVAAGLHPSPIPHAEFVTTTTHKTLRGPRGGMILCQE
RFAKSINSQIFPGIQGGPLMHVIAAKAVAFKEALQPEFKQYQQQVVNNARTLAEELVKRGFKLTSGGTDNHLMLLDFSGT
EITGKAAEEALDKAGITANKNTVPFETRSPFVTSGIRIGTPAATTHGLKEAEMVLVAGFIADAVANIGSDETLAAIKLQV
NQLMKKFPLYAKG

Sequences:

>Translated_413_residues
MSILSTLDPEVADAIRLEADRQEYNLELIASENFVSTAVLEAQGSVLTNKYAEGYPGKRYYGGCHNVDIVEALAIERAKQ
LFDAEHANVQPHSGSQANMAVYFSALKPGDTILGMNLSHGGHLTHGSPVNFSGRFFNVVPYGVSPETQTIDYAEVERLAL
EHKPKMIVVGASAYPRTIDFAAFRAIADKVGALVMVDMAHIAGLVAAGLHPSPIPHAEFVTTTTHKTLRGPRGGMILCQE
RFAKSINSQIFPGIQGGPLMHVIAAKAVAFKEALQPEFKQYQQQVVNNARTLAEELVKRGFKLTSGGTDNHLMLLDFSGT
EITGKAAEEALDKAGITANKNTVPFETRSPFVTSGIRIGTPAATTHGLKEAEMVLVAGFIADAVANIGSDETLAAIKLQV
NQLMKKFPLYAKG
>Mature_412_residues
SILSTLDPEVADAIRLEADRQEYNLELIASENFVSTAVLEAQGSVLTNKYAEGYPGKRYYGGCHNVDIVEALAIERAKQL
FDAEHANVQPHSGSQANMAVYFSALKPGDTILGMNLSHGGHLTHGSPVNFSGRFFNVVPYGVSPETQTIDYAEVERLALE
HKPKMIVVGASAYPRTIDFAAFRAIADKVGALVMVDMAHIAGLVAAGLHPSPIPHAEFVTTTTHKTLRGPRGGMILCQER
FAKSINSQIFPGIQGGPLMHVIAAKAVAFKEALQPEFKQYQQQVVNNARTLAEELVKRGFKLTSGGTDNHLMLLDFSGTE
ITGKAAEEALDKAGITANKNTVPFETRSPFVTSGIRIGTPAATTHGLKEAEMVLVAGFIADAVANIGSDETLAAIKLQVN
QLMKKFPLYAKG

Specific function: Interconversion of serine and glycine

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family

Homologues:

Organism=Homo sapiens, GI19923315, Length=452, Percent_Identity=44.6902654867257, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI261862352, Length=452, Percent_Identity=44.6902654867257, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI261862350, Length=452, Percent_Identity=44.6902654867257, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI261862348, Length=452, Percent_Identity=44.6902654867257, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI261862346, Length=452, Percent_Identity=44.0265486725664, Blast_Score=353, Evalue=1e-97,
Organism=Homo sapiens, GI22547186, Length=401, Percent_Identity=47.8802992518703, Blast_Score=338, Evalue=5e-93,
Organism=Homo sapiens, GI22547189, Length=386, Percent_Identity=46.6321243523316, Blast_Score=309, Evalue=2e-84,
Organism=Escherichia coli, GI1788902, Length=411, Percent_Identity=60.3406326034063, Blast_Score=501, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI25144732, Length=404, Percent_Identity=47.029702970297, Blast_Score=356, Evalue=1e-98,
Organism=Caenorhabditis elegans, GI25144729, Length=404, Percent_Identity=47.029702970297, Blast_Score=356, Evalue=2e-98,
Organism=Saccharomyces cerevisiae, GI6319739, Length=401, Percent_Identity=47.3815461346633, Blast_Score=370, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6323087, Length=408, Percent_Identity=45.343137254902, Blast_Score=346, Evalue=3e-96,
Organism=Drosophila melanogaster, GI24640005, Length=453, Percent_Identity=45.6953642384106, Blast_Score=381, Evalue=1e-106,
Organism=Drosophila melanogaster, GI221329721, Length=453, Percent_Identity=45.6953642384106, Blast_Score=380, Evalue=1e-106,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): GLYA_PELPD (A1APU0)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_901418.1
- ProteinModelPortal:   A1APU0
- SMR:   A1APU0
- STRING:   A1APU0
- GeneID:   4572574
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_1748
- eggNOG:   COG0112
- HOGENOM:   HBG301263
- OMA:   GRAYVTC
- PhylomeDB:   A1APU0
- ProtClustDB:   PRK00011
- GO:   GO:0005737
- HAMAP:   MF_00051_B
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11680
- PIRSF:   PIRSF000412

Pfam domain/function: PF00464 SHMT; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.1.2.1

Molecular weight: Translated: 44386; Mature: 44255

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSILSTLDPEVADAIRLEADRQEYNLELIASENFVSTAVLEAQGSVLTNKYAEGYPGKRY
CCCHHHCCHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHCCCCHHHHHHHCCCCCCCC
YGGCHNVDIVEALAIERAKQLFDAEHANVQPHSGSQANMAVYFSALKPGDTILGMNLSHG
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEECCC
GHLTHGSPVNFSGRFFNVVPYGVSPETQTIDYAEVERLALEHKPKMIVVGASAYPRTIDF
CCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHH
AAFRAIADKVGALVMVDMAHIAGLVAAGLHPSPIPHAEFVTTTTHKTLRGPRGGMILCQE
HHHHHHHHHHHHEEEHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHCCCCCCEEEEHH
RFAKSINSQIFPGIQGGPLMHVIAAKAVAFKEALQPEFKQYQQQVVNNARTLAEELVKRG
HHHHHHCHHCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCC
FKLTSGGTDNHLMLLDFSGTEITGKAAEEALDKAGITANKNTVPFETRSPFVTSGIRIGT
CEEECCCCCCEEEEEECCCCEECCHHHHHHHHHCCCCCCCCCCCCCCCCCCEECCEEECC
PAATTHGLKEAEMVLVAGFIADAVANIGSDETLAAIKLQVNQLMKKFPLYAKG
CCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SILSTLDPEVADAIRLEADRQEYNLELIASENFVSTAVLEAQGSVLTNKYAEGYPGKRY
CCHHHCCHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHCCCCHHHHHHHCCCCCCCC
YGGCHNVDIVEALAIERAKQLFDAEHANVQPHSGSQANMAVYFSALKPGDTILGMNLSHG
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEECCC
GHLTHGSPVNFSGRFFNVVPYGVSPETQTIDYAEVERLALEHKPKMIVVGASAYPRTIDF
CCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHH
AAFRAIADKVGALVMVDMAHIAGLVAAGLHPSPIPHAEFVTTTTHKTLRGPRGGMILCQE
HHHHHHHHHHHHEEEHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHCCCCCCEEEEHH
RFAKSINSQIFPGIQGGPLMHVIAAKAVAFKEALQPEFKQYQQQVVNNARTLAEELVKRG
HHHHHHCHHCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCC
FKLTSGGTDNHLMLLDFSGTEITGKAAEEALDKAGITANKNTVPFETRSPFVTSGIRIGT
CEEECCCCCCEEEEEECCCCEECCHHHHHHHHHCCCCCCCCCCCCCCCCCCEECCEEECC
PAATTHGLKEAEMVLVAGFIADAVANIGSDETLAAIKLQVNQLMKKFPLYAKG
CCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA