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The map label for this gene is gdhA [H]

Identifier: 118580133

GI number: 118580133

Start: 1837392

End: 1838654

Strand: Reverse

Name: gdhA [H]

Synonym: Ppro_1713

Alternate gene names: 118580133

Gene position: 1838654-1837392 (Counterclockwise)

Preceding gene: 118580134

Following gene: 118580132

Centisome position: 45.87

GC content: 59.54

Gene sequence:

>1263_bases
ATGCATTCCGATGAGGCAACAAGACTCAACCCGCTGGAAATGGTGCACACCCAGTTAGACAAGGCGGCCAGGCACCTGAA
GGCCGACCTGAACCTGGTGGAAAAGCTGAAATACGCCGAGCGCGCGCTGCTGGTTTCGGTGCCGGTGGTCATGGATGACG
GCCAGCTCAAGGTTTTCCGGGGCTTTCGCGTGCAGTACAATACCGTCAGGGGACCGGCCAAGGGTGGCATCCGCTATCAT
CCGAACGTTGGGCTTGACGAAATCACCGCCCTGGCAGCCTGGATGACCTGGAAGTGCGCCGTGATGAACATCCCTTTCGG
CGGCGCAAAGGGGGGGGTCCAATGCAACCCCAAACAGATGAACGCCGGCGAGATCGAGCGCCTCACCCGCAGGTTTACCG
CAGAAATCTTGAGCTTCATCGGCCCGGACAGGGACATACCGGCGCCGGACGTCAACACCAATTCCCAGATAATGGCCTGG
ATGATGGATACCTACTCCATGCAGATGGGGCATTCGGTACCGGGAGTGGTAACCGGAAAGCCGATCGAAATCGGCGGATC
GGAAGGGAGAAGCGAGGCGACCGGACTGGGGGTCGTCTACACCATCTTCGAGGCTGCACGAAAGCTGGGCATGGATCTGG
GCGGAGCGACCGCCGCCATCCAGGGTTTCGGCAATGTGGGAGCATCCGCGGCCAAGCACCTCTGCCGTGCGGGAGTCAAA
ATCACGGCAGTCAGTACCTCCAAGGGGGGAGTCTACTGCGACCGGGGCATCGACATCTCTGCGCTTCAGGATTACTACCG
GGAACATGCCAGCCTGGCGGGATTCCAGGGGCTCGATGTCATAACCAATGAAGAACTGCTTTCCGTGGATTGCGACATCC
TCATCCCCGCGGCCATGGAAAACGCCATCCACAAGGACAATGCCGCCAAGGTCAGGGCCAGAATCCTGGCCGAGGGCGCC
AACGGCCCGGTTTCCCCCGCAGCCGACGAAATCCTCAATGACAGGGGAGTGTTCATCATCCCCGATATTCTGGCCAATGC
CGGAGGGGTAACGGTTTCCTATTTCGAGTGGGTCCAGGACCTGCAGAACTACTTCTGGAACGAGGATGAGATCAACGAAA
AACTGCGTATGCTGATGGTGAGTGCTTTCAACAAAGTCACCGCCATCGCGGAAGATTCCGGCGTCGACAACAGGACAGCG
GCCCAGATGCTGGGCATCGGCCGGGTGATCGAGGCAACCAGGCTGAGGGGGCTGTATCCGTGA

Upstream 100 bases:

>100_bases
TTTTCAACGTAGTTCTGTATGTCCCCGGAACCCCCTCCCGGCACAGCCGGTGGTTTACTGAAAAGAACAAATTGCACTTC
GTTAAACCGAGGAAGAACTG

Downstream 100 bases:

>100_bases
CATCCGCGGTCTGCCGCTCAGGGTCTCCACCCCTATCTGGACACGGTGTACGTTCTCCAGCATGCCTCATCCGGAACCGG
TACACGTCGGTTCTCAGGCC

Product: Glu/Leu/Phe/Val dehydrogenase, C terminal

Products: NA

Alternate protein names: GDH [H]

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MHSDEATRLNPLEMVHTQLDKAARHLKADLNLVEKLKYAERALLVSVPVVMDDGQLKVFRGFRVQYNTVRGPAKGGIRYH
PNVGLDEITALAAWMTWKCAVMNIPFGGAKGGVQCNPKQMNAGEIERLTRRFTAEILSFIGPDRDIPAPDVNTNSQIMAW
MMDTYSMQMGHSVPGVVTGKPIEIGGSEGRSEATGLGVVYTIFEAARKLGMDLGGATAAIQGFGNVGASAAKHLCRAGVK
ITAVSTSKGGVYCDRGIDISALQDYYREHASLAGFQGLDVITNEELLSVDCDILIPAAMENAIHKDNAAKVRARILAEGA
NGPVSPAADEILNDRGVFIIPDILANAGGVTVSYFEWVQDLQNYFWNEDEINEKLRMLMVSAFNKVTAIAEDSGVDNRTA
AQMLGIGRVIEATRLRGLYP

Sequences:

>Translated_420_residues
MHSDEATRLNPLEMVHTQLDKAARHLKADLNLVEKLKYAERALLVSVPVVMDDGQLKVFRGFRVQYNTVRGPAKGGIRYH
PNVGLDEITALAAWMTWKCAVMNIPFGGAKGGVQCNPKQMNAGEIERLTRRFTAEILSFIGPDRDIPAPDVNTNSQIMAW
MMDTYSMQMGHSVPGVVTGKPIEIGGSEGRSEATGLGVVYTIFEAARKLGMDLGGATAAIQGFGNVGASAAKHLCRAGVK
ITAVSTSKGGVYCDRGIDISALQDYYREHASLAGFQGLDVITNEELLSVDCDILIPAAMENAIHKDNAAKVRARILAEGA
NGPVSPAADEILNDRGVFIIPDILANAGGVTVSYFEWVQDLQNYFWNEDEINEKLRMLMVSAFNKVTAIAEDSGVDNRTA
AQMLGIGRVIEATRLRGLYP
>Mature_420_residues
MHSDEATRLNPLEMVHTQLDKAARHLKADLNLVEKLKYAERALLVSVPVVMDDGQLKVFRGFRVQYNTVRGPAKGGIRYH
PNVGLDEITALAAWMTWKCAVMNIPFGGAKGGVQCNPKQMNAGEIERLTRRFTAEILSFIGPDRDIPAPDVNTNSQIMAW
MMDTYSMQMGHSVPGVVTGKPIEIGGSEGRSEATGLGVVYTIFEAARKLGMDLGGATAAIQGFGNVGASAAKHLCRAGVK
ITAVSTSKGGVYCDRGIDISALQDYYREHASLAGFQGLDVITNEELLSVDCDILIPAAMENAIHKDNAAKVRARILAEGA
NGPVSPAADEILNDRGVFIIPDILANAGGVTVSYFEWVQDLQNYFWNEDEINEKLRMLMVSAFNKVTAIAEDSGVDNRTA
AQMLGIGRVIEATRLRGLYP

Specific function: Unknown

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI31377775, Length=341, Percent_Identity=47.2140762463343, Blast_Score=308, Evalue=6e-84,
Organism=Homo sapiens, GI4885281, Length=341, Percent_Identity=46.6275659824047, Blast_Score=304, Evalue=1e-82,
Organism=Escherichia coli, GI1788059, Length=414, Percent_Identity=31.1594202898551, Blast_Score=180, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17544676, Length=385, Percent_Identity=42.3376623376623, Blast_Score=289, Evalue=2e-78,
Organism=Saccharomyces cerevisiae, GI6319256, Length=413, Percent_Identity=29.2978208232446, Blast_Score=150, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6324951, Length=397, Percent_Identity=28.7153652392947, Blast_Score=147, Evalue=3e-36,
Organism=Drosophila melanogaster, GI45549226, Length=413, Percent_Identity=39.9515738498789, Blast_Score=296, Evalue=2e-80,
Organism=Drosophila melanogaster, GI45553475, Length=357, Percent_Identity=42.8571428571429, Blast_Score=296, Evalue=2e-80,
Organism=Drosophila melanogaster, GI24649283, Length=399, Percent_Identity=37.593984962406, Blast_Score=260, Evalue=1e-69,
Organism=Drosophila melanogaster, GI24649460, Length=282, Percent_Identity=46.0992907801418, Blast_Score=254, Evalue=8e-68,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 9362 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR014362
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.3 [H]

Molecular weight: Translated: 45484; Mature: 45484

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00074 GLFV_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSDEATRLNPLEMVHTQLDKAARHLKADLNLVEKLKYAERALLVSVPVVMDDGQLKVFR
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECEEEECCCEEEEE
GFRVQYNTVRGPAKGGIRYHPNVGLDEITALAAWMTWKCAVMNIPFGGAKGGVQCNPKQM
CCEEEEEEECCCCCCCCEECCCCCHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCC
NAGEIERLTRRFTAEILSFIGPDRDIPAPDVNTNSQIMAWMMDTYSMQMGHSVPGVVTGK
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEECCC
PIEIGGSEGRSEATGLGVVYTIFEAARKLGMDLGGATAAIQGFGNVGASAAKHLCRAGVK
EEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHHHHHCCCE
ITAVSTSKGGVYCDRGIDISALQDYYREHASLAGFQGLDVITNEELLSVDCDILIPAAME
EEEEECCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCEECCCCEEEHHHHH
NAIHKDNAAKVRARILAEGANGPVSPAADEILNDRGVFIIPDILANAGGVTVSYFEWVQD
HHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCEEEHHHHCCCCCCCHHHHHHHHH
LQNYFWNEDEINEKLRMLMVSAFNKVTAIAEDSGVDNRTAAQMLGIGRVIEATRLRGLYP
HHHHCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MHSDEATRLNPLEMVHTQLDKAARHLKADLNLVEKLKYAERALLVSVPVVMDDGQLKVFR
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECEEEECCCEEEEE
GFRVQYNTVRGPAKGGIRYHPNVGLDEITALAAWMTWKCAVMNIPFGGAKGGVQCNPKQM
CCEEEEEEECCCCCCCCEECCCCCHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCC
NAGEIERLTRRFTAEILSFIGPDRDIPAPDVNTNSQIMAWMMDTYSMQMGHSVPGVVTGK
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEECCC
PIEIGGSEGRSEATGLGVVYTIFEAARKLGMDLGGATAAIQGFGNVGASAAKHLCRAGVK
EEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHHHHHCCCE
ITAVSTSKGGVYCDRGIDISALQDYYREHASLAGFQGLDVITNEELLSVDCDILIPAAME
EEEEECCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCEECCCCEEEHHHHH
NAIHKDNAAKVRARILAEGANGPVSPAADEILNDRGVFIIPDILANAGGVTVSYFEWVQD
HHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCEEEHHHHCCCCCCCHHHHHHHHH
LQNYFWNEDEINEKLRMLMVSAFNKVTAIAEDSGVDNRTAAQMLGIGRVIEATRLRGLYP
HHHHCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9680336; 10360571; 9135121; 9654452; 10366510 [H]