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The map label for this gene is serA [H]

Identifier: 118580120

GI number: 118580120

Start: 1825152

End: 1826771

Strand: Reverse

Name: serA [H]

Synonym: Ppro_1699

Alternate gene names: 118580120

Gene position: 1826771-1825152 (Counterclockwise)

Preceding gene: 118580124

Following gene: 118580119

Centisome position: 45.58

GC content: 61.98

Gene sequence:

>1620_bases
ATGAGGATTATCGTAACGGATGAAGTTTCCGCCGAAGGCCTGGCCCTGTTGACCCAGGAGCCGCGCATTCAGCTTGACGT
CAAACTGGGGCTGAGCAAGGAACAGCTGCTGGAGATTCTGGGCGAGTACGACGTAATCATCACCCGCAGCGGCACGTCCG
TTGACCGGGATGTGCTGGATGCGGGAAAGCGGCTGAAGATCGTCGCCCGCGCCGGGGTCGGTATCGACAATGTTGACGTG
GACTACGCCAGCTCCAAGGGGGTCATCGTCATCAATGCCCCCTTCGGCAACACCAACAGCGCGGCCGAGCACGCCCTGGC
CCTACTGATGACCTTCTGCCGCAAGATCACCATCGCCAATGCCAGCCTGAAGTCGGGCGAGTGGAAGCGGGCACCCTTCA
CCGGCTACGAACTCAGGGGCAAGGTTGCCGGCGTCATCGGCCTGGGCAAGGTCGGCGGCCGGGTGGCCACGCGTCTGAAG
GCATTCGAGTGCGAGGTGCTGGCCTGCGACCCCTACGTGTCGGTGAAACGCGCCCACGACCTGGGGGTCAAGCTGGTCTC
CCACGACGAGATCTACAAGAACTGCGACATCATCACCCTGCATATCCCGCTTAACGACGAGACCCGCGACATGATCTCCG
CCCGGGAATTCGGCCTGATGAAGAGCGGCGTAATCGTCATCAACGCGGCCCGCGGCGGCATCATCAACGAGCAGGCCCTG
CTGGACAACCTCAACTCCGGCAAGGTGCTGGGCGGCGGCGTTGACGTGTGGAGCGAGGAGCCGCCCAAGTCGGATCTGCT
CAGGCAGCTGATCGGTCACGAACGGCTGGTGGTCACCCCGCACCTGGGGGCCAATACCCACGAGGCGCAGATCAACGTGG
CGGTGGACGTTTCCCGGGAGATCGTCAACTATCTGGACGACCAGCCCATGGAGAGCGCCGTCAACATCCCCCGCTTCGAC
ATGGCCCTGATGGACCAGATGCGGCCGTTCCTCAACCTGATGAACGTCATCTGCGAGATCGGCGTGCAGCTCTTGGACAA
CAACGTGGACAAGGTCAGCTTCGGCTATAGCGGCAGCATCGCCCACTACGACTGCACCCCCCTGACGGTCACCGGCCTCT
CCTCCCTGCTGAACCGGGTGGTGGACCAGGATGTGAACATGGTCAATGCCACGCTGATCGCCGACCAGATGGGGATCGTG
GTGGAGGAGAACAAGTCCACCAGCTGCGACGCCTTCTCCAATGTGATCACCCTGATCATCGAAGGGGGCGGCAAGAAGCG
CACCGTCTCCGGAACACTCTTCGAGGGAGCGCCCCGCATCGTTCGCCTGCGCGACTTCTCCATCGATTTCTCGCCGGAAG
AGCACATGCTGCTCTTGCACTACATCGACCTCCCCGGCATGATCGGCAGGATCGGCACCATCATGGGCACGCACGACATC
AACATCGCCTCCATGAACCTGGGGCGCCGCGAGAAGAAGGGCGAGGCCATGGTCATCCTCTCCCTGGATTCGGCGGTGCC
ATTGCAGGTTGTTGAAGAGATCAGGACAGCTACGGACGCATCGTTCATCAAACCGCTTCACCTGAAAAGCGTTTCCTGTT
CCCGCGGCCGCGGTCTCTAG

Upstream 100 bases:

>100_bases
TGCGTTTTTTGGTTGTCGGTACTATTATGCCCCTTTACATAAGTCTGGATTCGCGACATACCAGGCACGGATCCGGGCCA
TATCAAAAGCGAGGCTTGTA

Downstream 100 bases:

>100_bases
CGGCCGGAATCACGCCATGACATTCCCCTCCATCGACCCGGTCTTTCTCAGCATCGGCCCGCTCCACTTCCGCTGGTACG
GGCTGATGTACGTGCTGAGC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 539; Mature: 539

Protein sequence:

>539_residues
MRIIVTDEVSAEGLALLTQEPRIQLDVKLGLSKEQLLEILGEYDVIITRSGTSVDRDVLDAGKRLKIVARAGVGIDNVDV
DYASSKGVIVINAPFGNTNSAAEHALALLMTFCRKITIANASLKSGEWKRAPFTGYELRGKVAGVIGLGKVGGRVATRLK
AFECEVLACDPYVSVKRAHDLGVKLVSHDEIYKNCDIITLHIPLNDETRDMISAREFGLMKSGVIVINAARGGIINEQAL
LDNLNSGKVLGGGVDVWSEEPPKSDLLRQLIGHERLVVTPHLGANTHEAQINVAVDVSREIVNYLDDQPMESAVNIPRFD
MALMDQMRPFLNLMNVICEIGVQLLDNNVDKVSFGYSGSIAHYDCTPLTVTGLSSLLNRVVDQDVNMVNATLIADQMGIV
VEENKSTSCDAFSNVITLIIEGGGKKRTVSGTLFEGAPRIVRLRDFSIDFSPEEHMLLLHYIDLPGMIGRIGTIMGTHDI
NIASMNLGRREKKGEAMVILSLDSAVPLQVVEEIRTATDASFIKPLHLKSVSCSRGRGL

Sequences:

>Translated_539_residues
MRIIVTDEVSAEGLALLTQEPRIQLDVKLGLSKEQLLEILGEYDVIITRSGTSVDRDVLDAGKRLKIVARAGVGIDNVDV
DYASSKGVIVINAPFGNTNSAAEHALALLMTFCRKITIANASLKSGEWKRAPFTGYELRGKVAGVIGLGKVGGRVATRLK
AFECEVLACDPYVSVKRAHDLGVKLVSHDEIYKNCDIITLHIPLNDETRDMISAREFGLMKSGVIVINAARGGIINEQAL
LDNLNSGKVLGGGVDVWSEEPPKSDLLRQLIGHERLVVTPHLGANTHEAQINVAVDVSREIVNYLDDQPMESAVNIPRFD
MALMDQMRPFLNLMNVICEIGVQLLDNNVDKVSFGYSGSIAHYDCTPLTVTGLSSLLNRVVDQDVNMVNATLIADQMGIV
VEENKSTSCDAFSNVITLIIEGGGKKRTVSGTLFEGAPRIVRLRDFSIDFSPEEHMLLLHYIDLPGMIGRIGTIMGTHDI
NIASMNLGRREKKGEAMVILSLDSAVPLQVVEEIRTATDASFIKPLHLKSVSCSRGRGL
>Mature_539_residues
MRIIVTDEVSAEGLALLTQEPRIQLDVKLGLSKEQLLEILGEYDVIITRSGTSVDRDVLDAGKRLKIVARAGVGIDNVDV
DYASSKGVIVINAPFGNTNSAAEHALALLMTFCRKITIANASLKSGEWKRAPFTGYELRGKVAGVIGLGKVGGRVATRLK
AFECEVLACDPYVSVKRAHDLGVKLVSHDEIYKNCDIITLHIPLNDETRDMISAREFGLMKSGVIVINAARGGIINEQAL
LDNLNSGKVLGGGVDVWSEEPPKSDLLRQLIGHERLVVTPHLGANTHEAQINVAVDVSREIVNYLDDQPMESAVNIPRFD
MALMDQMRPFLNLMNVICEIGVQLLDNNVDKVSFGYSGSIAHYDCTPLTVTGLSSLLNRVVDQDVNMVNATLIADQMGIV
VEENKSTSCDAFSNVITLIIEGGGKKRTVSGTLFEGAPRIVRLRDFSIDFSPEEHMLLLHYIDLPGMIGRIGTIMGTHDI
NIASMNLGRREKKGEAMVILSLDSAVPLQVVEEIRTATDASFIKPLHLKSVSCSRGRGL

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=441, Percent_Identity=33.7868480725624, Blast_Score=257, Evalue=2e-68,
Organism=Homo sapiens, GI61743967, Length=259, Percent_Identity=33.976833976834, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI4557497, Length=259, Percent_Identity=33.976833976834, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI6912396, Length=324, Percent_Identity=28.7037037037037, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI145580578, Length=299, Percent_Identity=29.7658862876254, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI4557499, Length=299, Percent_Identity=29.7658862876254, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI145580575, Length=258, Percent_Identity=31.0077519379845, Blast_Score=116, Evalue=5e-26,
Organism=Escherichia coli, GI1789279, Length=298, Percent_Identity=32.5503355704698, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1787645, Length=261, Percent_Identity=31.8007662835249, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI87082289, Length=291, Percent_Identity=27.1477663230241, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1788660, Length=228, Percent_Identity=31.5789473684211, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI87081824, Length=242, Percent_Identity=26.8595041322314, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=304, Percent_Identity=39.1447368421053, Blast_Score=237, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI25147481, Length=274, Percent_Identity=29.9270072992701, Blast_Score=122, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6320925, Length=330, Percent_Identity=29.0909090909091, Blast_Score=176, Evalue=8e-45,
Organism=Saccharomyces cerevisiae, GI6322116, Length=381, Percent_Identity=27.0341207349081, Blast_Score=170, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6324055, Length=229, Percent_Identity=33.1877729257642, Blast_Score=133, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6324964, Length=272, Percent_Identity=26.4705882352941, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6324980, Length=188, Percent_Identity=26.063829787234, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19921140, Length=302, Percent_Identity=42.7152317880795, Blast_Score=245, Evalue=7e-65,
Organism=Drosophila melanogaster, GI28571528, Length=292, Percent_Identity=31.1643835616438, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24585516, Length=283, Percent_Identity=25.7950530035336, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI28574284, Length=324, Percent_Identity=25.6172839506173, Blast_Score=115, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24585514, Length=324, Percent_Identity=25.6172839506173, Blast_Score=115, Evalue=1e-25,
Organism=Drosophila melanogaster, GI28574282, Length=324, Percent_Identity=25.6172839506173, Blast_Score=115, Evalue=1e-25,
Organism=Drosophila melanogaster, GI45551003, Length=324, Percent_Identity=25.6172839506173, Blast_Score=115, Evalue=1e-25,
Organism=Drosophila melanogaster, GI28574286, Length=318, Percent_Identity=27.0440251572327, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI45552429, Length=324, Percent_Identity=25.6172839506173, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24646446, Length=268, Percent_Identity=27.9850746268657, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24646448, Length=268, Percent_Identity=27.9850746268657, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24646452, Length=268, Percent_Identity=27.9850746268657, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24646450, Length=268, Percent_Identity=27.9850746268657, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI62472511, Length=268, Percent_Identity=27.9850746268657, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 58618; Mature: 58618

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIIVTDEVSAEGLALLTQEPRIQLDVKLGLSKEQLLEILGEYDVIITRSGTSVDRDVLD
CEEEEECCCCCCCEEEEECCCCEEEEEEECCCHHHHHHHHCCCCEEEEECCCCCCHHHHC
AGKRLKIVARAGVGIDNVDVDYASSKGVIVINAPFGNTNSAAEHALALLMTFCRKITIAN
CCCEEEEEEECCCCCCCCCCEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHEEEEC
ASLKSGEWKRAPFTGYELRGKVAGVIGLGKVGGRVATRLKAFECEVLACDPYVSVKRAHD
CCCCCCCCCCCCCCCEEECCEEEEEEEECCCCHHHHHHHEEEEEEEEEECCCHHHHHHHC
LGVKLVSHDEIYKNCDIITLHIPLNDETRDMISAREFGLMKSGVIVINAARGGIINEQAL
CCEEEEECCHHHCCCCEEEEEEECCCCHHHHHHHHHHCCEECCEEEEECCCCCCCCCHHH
LDNLNSGKVLGGGVDVWSEEPPKSDLLRQLIGHERLVVTPHLGANTHEAQINVAVDVSRE
HCCCCCCCEEECCEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEEEECHHH
IVNYLDDQPMESAVNIPRFDMALMDQMRPFLNLMNVICEIGVQLLDNNVDKVSFGYSGSI
HHHHHCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCE
AHYDCTPLTVTGLSSLLNRVVDQDVNMVNATLIADQMGIVVEENKSTSCDAFSNVITLII
EEECCCCEEHHHHHHHHHHHHHCCCCHHEEEEEECCCCEEEECCCCCCHHHHHCEEEEEE
EGGGKKRTVSGTLFEGAPRIVRLRDFSIDFSPEEHMLLLHYIDLPGMIGRIGTIMGTHDI
ECCCCEEEEEEEEECCCCCEEEEEEEEECCCCCCCEEEEEEECCCHHHHHHHHHEECCCC
NIASMNLGRREKKGEAMVILSLDSAVPLQVVEEIRTATDASFIKPLHLKSVSCSRGRGL
EEEEECCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCHHHCCCEEECCCCCCCCCCC
>Mature Secondary Structure
MRIIVTDEVSAEGLALLTQEPRIQLDVKLGLSKEQLLEILGEYDVIITRSGTSVDRDVLD
CEEEEECCCCCCCEEEEECCCCEEEEEEECCCHHHHHHHHCCCCEEEEECCCCCCHHHHC
AGKRLKIVARAGVGIDNVDVDYASSKGVIVINAPFGNTNSAAEHALALLMTFCRKITIAN
CCCEEEEEEECCCCCCCCCCEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHEEEEC
ASLKSGEWKRAPFTGYELRGKVAGVIGLGKVGGRVATRLKAFECEVLACDPYVSVKRAHD
CCCCCCCCCCCCCCCEEECCEEEEEEEECCCCHHHHHHHEEEEEEEEEECCCHHHHHHHC
LGVKLVSHDEIYKNCDIITLHIPLNDETRDMISAREFGLMKSGVIVINAARGGIINEQAL
CCEEEEECCHHHCCCCEEEEEEECCCCHHHHHHHHHHCCEECCEEEEECCCCCCCCCHHH
LDNLNSGKVLGGGVDVWSEEPPKSDLLRQLIGHERLVVTPHLGANTHEAQINVAVDVSRE
HCCCCCCCEEECCEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEEEECHHH
IVNYLDDQPMESAVNIPRFDMALMDQMRPFLNLMNVICEIGVQLLDNNVDKVSFGYSGSI
HHHHHCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCE
AHYDCTPLTVTGLSSLLNRVVDQDVNMVNATLIADQMGIVVEENKSTSCDAFSNVITLII
EEECCCCEEHHHHHHHHHHHHHCCCCHHEEEEEECCCCEEEECCCCCCHHHHHCEEEEEE
EGGGKKRTVSGTLFEGAPRIVRLRDFSIDFSPEEHMLLLHYIDLPGMIGRIGTIMGTHDI
ECCCCEEEEEEEEECCCCCEEEEEEEEECCCCCCCEEEEEEECCCHHHHHHHHHEECCCC
NIASMNLGRREKKGEAMVILSLDSAVPLQVVEEIRTATDASFIKPLHLKSVSCSRGRGL
EEEEECCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCHHHCCCEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]