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The map label for this gene is ribBA [H]

Identifier: 118580074

GI number: 118580074

Start: 1770978

End: 1772183

Strand: Reverse

Name: ribBA [H]

Synonym: Ppro_1652

Alternate gene names: 118580074

Gene position: 1772183-1770978 (Counterclockwise)

Preceding gene: 118580076

Following gene: 118580073

Centisome position: 44.22

GC content: 61.28

Gene sequence:

>1206_bases
ATGTCTGTATCGAGTACCGAAGAAGCAATCGAGGATATCCGTCAGGGAAAGATGGTCATCCTGGTGGATGATGAAGATCG
TGAAAACGAGGGTGACCTTACCCTGGCTGCCGAGGCGGCAACCCCGGAAAACATCAACTTCATGGCAAAATACGGCCGCG
GCCTGATCTGCCTGACACTGACACCGGACAAATGCGACGCGCTCGGCCTGCGTCCCATGGTGCGCGACAATACATCTCCT
TTCGAGACCGCCTTCACCGTTTCCATCGAGGCAAAAAGCGGGGTCACCACCGGCATCTCGGCCGCCGATCGCGCCCACAC
CATCCTCACCGCCGTCGCCGACAATGCAACCCCCAAGGACCTGGTCAGCCCCGGCCATGTCTTTCCGCTGCGGGCTCGCA
AGGGGGGTGTGCTGGTGCGATCAGGACAGACCGAGGGGTCCGTGGACCTGGCCCGTCTGGCCGGCTTGCGCCCCGCCGGT
GTAATCTGCGAGATCATGAACGACGACGGCAGCATGTCCCGCATGCCGGAGCTGAAGAAGTTCGCCAAGCATCACGGCAT
CAAGATCTGCACCGTTGCCGACCTGGTTGCCTACCGGCTCAGGACCGAGCGGCTGGTACGCACGGTGGCCGAAGCCCAGA
TCCCCTCCCGCTTCGGCGGCGACTGGCGCGCCGTTGCCTTCGAAAACGACGTGGACCACCTGGAGCACATCGCCCTGGTA
AAGGGGGAAATCAAAAAGGGAGAGCCGGTGCTGGTGCGGGTGCACTCGGAATGTCTGACCGGGGACGTGCTGGGGAGTCA
GCGCTGCGATTGCGGCGACCAGTTGCACAGCGCCATGCGCAAGATCGCCGAAGAGGGCAAAGGAGTCATCCTCTATATGC
GCCAGGAAGGACGCGGCATCGGCCTGGTGAACAAACTCAAGGCATACGAACTGCAGGACAAGGGGCTGGACACGGTGGAA
GCAAACCTGAAGCTGGGCTTCAAGGCCGACCTGAGGGATTACGGCATCGGCGCCCAGATCCTGCTGGCGCTGGGAATCAC
CAAGATCCGGCTTTTGACCAACAACCCCAAGAAGCTGATCGGCCTGCAGGGATACGGCATCGACATCGTGGACCGGGTCT
CCATCGAGATGGTGGCGACGGAAAACAACATCGACTATCTCACCACCAAGCGCGACAAGCTCGGCCACATGCTGGAGAAC
CTCTAG

Upstream 100 bases:

>100_bases
GGTTTGTCTCAACCATTGGATCGGGAGAAAAAACGACTCTCCCCTCCCCGCTTCCTGCCGAAGAATCAGCTGTCTCTGTA
ATCTGAAAGGAAAAAACACC

Downstream 100 bases:

>100_bases
GCGATGAACGTGCTGCTGCATCTCTGCTGCGGCCCCTGCGCCCTCTATCCGCTGCGGGTCCTGCGCGAAGCCGGTCACCA
GGTGACCGGCTTCTTCTACA

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MSVSSTEEAIEDIRQGKMVILVDDEDRENEGDLTLAAEAATPENINFMAKYGRGLICLTLTPDKCDALGLRPMVRDNTSP
FETAFTVSIEAKSGVTTGISAADRAHTILTAVADNATPKDLVSPGHVFPLRARKGGVLVRSGQTEGSVDLARLAGLRPAG
VICEIMNDDGSMSRMPELKKFAKHHGIKICTVADLVAYRLRTERLVRTVAEAQIPSRFGGDWRAVAFENDVDHLEHIALV
KGEIKKGEPVLVRVHSECLTGDVLGSQRCDCGDQLHSAMRKIAEEGKGVILYMRQEGRGIGLVNKLKAYELQDKGLDTVE
ANLKLGFKADLRDYGIGAQILLALGITKIRLLTNNPKKLIGLQGYGIDIVDRVSIEMVATENNIDYLTTKRDKLGHMLEN
L

Sequences:

>Translated_401_residues
MSVSSTEEAIEDIRQGKMVILVDDEDRENEGDLTLAAEAATPENINFMAKYGRGLICLTLTPDKCDALGLRPMVRDNTSP
FETAFTVSIEAKSGVTTGISAADRAHTILTAVADNATPKDLVSPGHVFPLRARKGGVLVRSGQTEGSVDLARLAGLRPAG
VICEIMNDDGSMSRMPELKKFAKHHGIKICTVADLVAYRLRTERLVRTVAEAQIPSRFGGDWRAVAFENDVDHLEHIALV
KGEIKKGEPVLVRVHSECLTGDVLGSQRCDCGDQLHSAMRKIAEEGKGVILYMRQEGRGIGLVNKLKAYELQDKGLDTVE
ANLKLGFKADLRDYGIGAQILLALGITKIRLLTNNPKKLIGLQGYGIDIVDRVSIEMVATENNIDYLTTKRDKLGHMLEN
L
>Mature_400_residues
SVSSTEEAIEDIRQGKMVILVDDEDRENEGDLTLAAEAATPENINFMAKYGRGLICLTLTPDKCDALGLRPMVRDNTSPF
ETAFTVSIEAKSGVTTGISAADRAHTILTAVADNATPKDLVSPGHVFPLRARKGGVLVRSGQTEGSVDLARLAGLRPAGV
ICEIMNDDGSMSRMPELKKFAKHHGIKICTVADLVAYRLRTERLVRTVAEAQIPSRFGGDWRAVAFENDVDHLEHIALVK
GEIKKGEPVLVRVHSECLTGDVLGSQRCDCGDQLHSAMRKIAEEGKGVILYMRQEGRGIGLVNKLKAYELQDKGLDTVEA
NLKLGFKADLRDYGIGAQILLALGITKIRLLTNNPKKLIGLQGYGIDIVDRVSIEMVATENNIDYLTTKRDKLGHMLENL

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=198, Percent_Identity=53.030303030303, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI1787533, Length=193, Percent_Identity=54.4041450777202, Blast_Score=207, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6320695, Length=202, Percent_Identity=42.0792079207921, Blast_Score=159, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6319438, Length=170, Percent_Identity=47.6470588235294, Blast_Score=137, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 43728; Mature: 43597

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVSSTEEAIEDIRQGKMVILVDDEDRENEGDLTLAAEAATPENINFMAKYGRGLICLTL
CCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCCCCCCHHEECCCCEEEEEE
TPDKCDALGLRPMVRDNTSPFETAFTVSIEAKSGVTTGISAADRAHTILTAVADNATPKD
CCCCCCCCCCCCHHCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHEEEEECCCCCHHH
LVSPGHVFPLRARKGGVLVRSGQTEGSVDLARLAGLRPAGVICEIMNDDGSMSRMPELKK
HCCCCCEEEEEECCCCEEEECCCCCCCCHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHH
FAKHHGIKICTVADLVAYRLRTERLVRTVAEAQIPSRFGGDWRAVAFENDVDHLEHIALV
HHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCEEEEEECCCHHHHHHHHHH
KGEIKKGEPVLVRVHSECLTGDVLGSQRCDCGDQLHSAMRKIAEEGKGVILYMRQEGRGI
HCCCCCCCEEEEEEECHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCC
GLVNKLKAYELQDKGLDTVEANLKLGFKADLRDYGIGAQILLALGITKIRLLTNNPKKLI
CHHHHHHHEEECCCCCCEEEEEEEECEEECHHHCCCHHHHHHHHCCEEEEEEECCCHHEE
GLQGYGIDIVDRVSIEMVATENNIDYLTTKRDKLGHMLENL
EECCCCCCEEEEEEEEEEEECCCCEEEEECHHHHHHHHHCC
>Mature Secondary Structure 
SVSSTEEAIEDIRQGKMVILVDDEDRENEGDLTLAAEAATPENINFMAKYGRGLICLTL
CCCCHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCCCCCCHHEECCCCEEEEEE
TPDKCDALGLRPMVRDNTSPFETAFTVSIEAKSGVTTGISAADRAHTILTAVADNATPKD
CCCCCCCCCCCCHHCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHEEEEECCCCCHHH
LVSPGHVFPLRARKGGVLVRSGQTEGSVDLARLAGLRPAGVICEIMNDDGSMSRMPELKK
HCCCCCEEEEEECCCCEEEECCCCCCCCHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHH
FAKHHGIKICTVADLVAYRLRTERLVRTVAEAQIPSRFGGDWRAVAFENDVDHLEHIALV
HHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCEEEEEECCCHHHHHHHHHH
KGEIKKGEPVLVRVHSECLTGDVLGSQRCDCGDQLHSAMRKIAEEGKGVILYMRQEGRGI
HCCCCCCCEEEEEEECHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCC
GLVNKLKAYELQDKGLDTVEANLKLGFKADLRDYGIGAQILLALGITKIRLLTNNPKKLI
CHHHHHHHEEECCCCCCEEEEEEEECEEECHHHCCCHHHHHHHHCCEEEEEEECCCHHEE
GLQGYGIDIVDRVSIEMVATENNIDYLTTKRDKLGHMLENL
EECCCCCCEEEEEEEEEEEECCCCEEEEECHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA