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The map label for this gene is nuoM [H]

Identifier: 118580058

GI number: 118580058

Start: 1750400

End: 1752004

Strand: Direct

Name: nuoM [H]

Synonym: Ppro_1635

Alternate gene names: 118580058

Gene position: 1750400-1752004 (Clockwise)

Preceding gene: 118580057

Following gene: 118580059

Centisome position: 43.67

GC content: 62.24

Gene sequence:

>1605_bases
ATGCCTAGCAACGGTCTTCTAATCCTCGCCCTGTTCTGCCTGCCGCTGGTGGGCGCCCTGGCCGTACCGTTTCTGCCCGC
AAGCGAAAACGGTAAAATCGCCCGCATGTGGGGCATGCTCTGCATGCTGGCTGTGCTGGTCATGGCAGGCGGCATCTTCG
CCGGCTTCGGCACCCCCTGCCTGCCCGCCTCCCTGCTTGACCTGAACATCCCCTGGGTGGGGAGCCTTGGCATCAACTTC
CACCTGGCCGTGGATGGCCTGAACATCTACCTGCTGCTTCTCACCGGACTGCTCTTCCCGGTGGTGCTGGGCTGCTGCTG
GAAACGGCCGGAGACCCAGAACAACCTGTTTGTCGCCATGGCGCTCTTCCTGGAGGCGACCCTTCTCGGCACCTTCCTGG
CCCAGAACCTGATGCTCTTCTTCGTCTTCTGGGAAGTGGTCCTGATCCCCATGTTCATCATCGTCCTTGCCTTTGGCGGT
GAGAACAAGCGCTCCGCCGCCTTCACCTTCTTCATGTACACCATGGCAGGCAGTATCCTCTTTCTGGCCGCCGTCATCAT
GATGGGCATGGAGAGCCTGAACCAGACAGGTGCCTGGAACTTCGAATTCGCACATCTCATGGCCCTGAAACTTGACTGGA
ACACGCAGCTGTTCGTCTTCATCGCCGTCATGCTGGCCTGCGCCATCAAGTGCCCGCTGTTCCCGTTCCACTCCTGGCTG
CCCTTGGCCTATTACGAAGCTCCTCCGGCAGGCACCGCCCTCATGGCCGGCGCCCTGTCCAAGATGGGCGCCTTCGGCAT
CATCAAACTGGCCTTACCCTTGTGCCCCGACGTTGCCCGGGCCTTCGGACCCACGGTCATGCTCTTTGCCGTGATCAGCA
TCCTCTACGGCGCCATCATCGCCCTGAAACAGACCGACTTCAAGAAGCTGGTCGCCTTCTCGTCCCTGTCCCACATGGGC
TACATCGTCCTGGGCATCTTCAGCTTCCACCAGGCCGCCATCCACGGTGCCCTGTTCCAGATCTTGAGCCACGGCGTCGC
CGTTGCCGGCCTGTTCCTGCTCCTGGGACTTCTGGAACTGCGCCTGGGCAGGGAGTACCTGAACCTGACCGCCCTTTCCA
CCCATGCGCCAAGGCTTGCGGTCATGCTCATGCTCTTCATCCTGGCCTCCGTCGCGCTGCCCTTGACCAGCGGCTTCACC
TCCGAATTCCTGATCCTGTTCGGCGCCTTCCAGCAGGGCATCGCCGCCCTGCAGGCCAACCAGGGAGCCACCATGCTCAC
CAGCGTGCTTCTGGCCTCCACCGGCATGGTGCTTGGCGCAACCTACATGCTGCGCTTCGGCCGGGCCATCCTCTACGGCC
AGACCAAAGAGGGGGTAGGGGTCAAGGACATGAGCCTCATGGAAGGGATCGGCTTCATCCCGCTGCTTGTCATGATCATC
TGGATCGGCGTCAACCCCATGCCGATCATGAACAAGGTAACCACCGCGGTAAGCGCGCTTGGCACCCAGCCGGCAAACGC
CCAGATCCAACCGGCGGCGGCACAACCGGCGGCGTCACCCGCGGCGCCCACACCATCTGTCAAGGGAGGCGCCAATGGCC
ACTGA

Upstream 100 bases:

>100_bases
AGCGCCAACCTCCTCTCCCGCATGCAGAGCGGCAACGTCCAGGCCTATGTGCTCTACGCCCTGGCCGGGCTGGCCCTGAT
CATCTGGTGGGGGGTGGCCA

Downstream 100 bases:

>100_bases
TCTTCTGTACGGCCTTCTGCCGGAACACATCCTCTTGGGCCTGATCCTGGTCCTCATGCTGCTGGAGATACTCAGCGTTG
ACAAGCGTGCCGGCAGCGCC

Product: proton-translocating NADH-quinone oxidoreductase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 534; Mature: 533

Protein sequence:

>534_residues
MPSNGLLILALFCLPLVGALAVPFLPASENGKIARMWGMLCMLAVLVMAGGIFAGFGTPCLPASLLDLNIPWVGSLGINF
HLAVDGLNIYLLLLTGLLFPVVLGCCWKRPETQNNLFVAMALFLEATLLGTFLAQNLMLFFVFWEVVLIPMFIIVLAFGG
ENKRSAAFTFFMYTMAGSILFLAAVIMMGMESLNQTGAWNFEFAHLMALKLDWNTQLFVFIAVMLACAIKCPLFPFHSWL
PLAYYEAPPAGTALMAGALSKMGAFGIIKLALPLCPDVARAFGPTVMLFAVISILYGAIIALKQTDFKKLVAFSSLSHMG
YIVLGIFSFHQAAIHGALFQILSHGVAVAGLFLLLGLLELRLGREYLNLTALSTHAPRLAVMLMLFILASVALPLTSGFT
SEFLILFGAFQQGIAALQANQGATMLTSVLLASTGMVLGATYMLRFGRAILYGQTKEGVGVKDMSLMEGIGFIPLLVMII
WIGVNPMPIMNKVTTAVSALGTQPANAQIQPAAAQPAASPAAPTPSVKGGANGH

Sequences:

>Translated_534_residues
MPSNGLLILALFCLPLVGALAVPFLPASENGKIARMWGMLCMLAVLVMAGGIFAGFGTPCLPASLLDLNIPWVGSLGINF
HLAVDGLNIYLLLLTGLLFPVVLGCCWKRPETQNNLFVAMALFLEATLLGTFLAQNLMLFFVFWEVVLIPMFIIVLAFGG
ENKRSAAFTFFMYTMAGSILFLAAVIMMGMESLNQTGAWNFEFAHLMALKLDWNTQLFVFIAVMLACAIKCPLFPFHSWL
PLAYYEAPPAGTALMAGALSKMGAFGIIKLALPLCPDVARAFGPTVMLFAVISILYGAIIALKQTDFKKLVAFSSLSHMG
YIVLGIFSFHQAAIHGALFQILSHGVAVAGLFLLLGLLELRLGREYLNLTALSTHAPRLAVMLMLFILASVALPLTSGFT
SEFLILFGAFQQGIAALQANQGATMLTSVLLASTGMVLGATYMLRFGRAILYGQTKEGVGVKDMSLMEGIGFIPLLVMII
WIGVNPMPIMNKVTTAVSALGTQPANAQIQPAAAQPAASPAAPTPSVKGGANGH
>Mature_533_residues
PSNGLLILALFCLPLVGALAVPFLPASENGKIARMWGMLCMLAVLVMAGGIFAGFGTPCLPASLLDLNIPWVGSLGINFH
LAVDGLNIYLLLLTGLLFPVVLGCCWKRPETQNNLFVAMALFLEATLLGTFLAQNLMLFFVFWEVVLIPMFIIVLAFGGE
NKRSAAFTFFMYTMAGSILFLAAVIMMGMESLNQTGAWNFEFAHLMALKLDWNTQLFVFIAVMLACAIKCPLFPFHSWLP
LAYYEAPPAGTALMAGALSKMGAFGIIKLALPLCPDVARAFGPTVMLFAVISILYGAIIALKQTDFKKLVAFSSLSHMGY
IVLGIFSFHQAAIHGALFQILSHGVAVAGLFLLLGLLELRLGREYLNLTALSTHAPRLAVMLMLFILASVALPLTSGFTS
EFLILFGAFQQGIAALQANQGATMLTSVLLASTGMVLGATYMLRFGRAILYGQTKEGVGVKDMSLMEGIGFIPLLVMIIW
IGVNPMPIMNKVTTAVSALGTQPANAQIQPAAAQPAASPAAPTPSVKGGANGH

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=254, Percent_Identity=35.0393700787402, Blast_Score=130, Evalue=3e-30,
Organism=Escherichia coli, GI1788613, Length=456, Percent_Identity=32.0175438596491, Blast_Score=258, Evalue=9e-70,
Organism=Escherichia coli, GI1788827, Length=342, Percent_Identity=29.8245614035088, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1788829, Length=486, Percent_Identity=24.8971193415638, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1788614, Length=352, Percent_Identity=27.2727272727273, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1788831, Length=406, Percent_Identity=25.8620689655172, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI145693160, Length=450, Percent_Identity=26.4444444444444, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 56982; Mature: 56851

Theoretical pI: Translated: 8.39; Mature: 8.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSNGLLILALFCLPLVGALAVPFLPASENGKIARMWGMLCMLAVLVMAGGIFAGFGTPC
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCC
LPASLLDLNIPWVGSLGINFHLAVDGLNIYLLLLTGLLFPVVLGCCWKRPETQNNLFVAM
CCHHHHCCCCCCEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
ALFLEATLLGTFLAQNLMLFFVFWEVVLIPMFIIVLAFGGENKRSAAFTFFMYTMAGSIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
FLAAVIMMGMESLNQTGAWNFEFAHLMALKLDWNTQLFVFIAVMLACAIKCPLFPFHSWL
HHHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCC
PLAYYEAPPAGTALMAGALSKMGAFGIIKLALPLCPDVARAFGPTVMLFAVISILYGAII
CEEEECCCCCCHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHCHHHHHHHHHHHHHHHHH
ALKQTDFKKLVAFSSLSHMGYIVLGIFSFHQAAIHGALFQILSHGVAVAGLFLLLGLLEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLGREYLNLTALSTHAPRLAVMLMLFILASVALPLTSGFTSEFLILFGAFQQGIAALQAN
HHCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCC
QGATMLTSVLLASTGMVLGATYMLRFGRAILYGQTKEGVGVKDMSLMEGIGFIPLLVMII
CCHHHHHHHHHHHCCHHHHHHHHHHHCCHHEECCCCCCCCCCHHHHHHCCCHHHHHHHHH
WIGVNPMPIMNKVTTAVSALGTQPANAQIQPAAAQPAASPAAPTPSVKGGANGH
HHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PSNGLLILALFCLPLVGALAVPFLPASENGKIARMWGMLCMLAVLVMAGGIFAGFGTPC
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCC
LPASLLDLNIPWVGSLGINFHLAVDGLNIYLLLLTGLLFPVVLGCCWKRPETQNNLFVAM
CCHHHHCCCCCCEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
ALFLEATLLGTFLAQNLMLFFVFWEVVLIPMFIIVLAFGGENKRSAAFTFFMYTMAGSIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
FLAAVIMMGMESLNQTGAWNFEFAHLMALKLDWNTQLFVFIAVMLACAIKCPLFPFHSWL
HHHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCC
PLAYYEAPPAGTALMAGALSKMGAFGIIKLALPLCPDVARAFGPTVMLFAVISILYGAII
CEEEECCCCCCHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHCHHHHHHHHHHHHHHHHH
ALKQTDFKKLVAFSSLSHMGYIVLGIFSFHQAAIHGALFQILSHGVAVAGLFLLLGLLEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLGREYLNLTALSTHAPRLAVMLMLFILASVALPLTSGFTSEFLILFGAFQQGIAALQAN
HHCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCC
QGATMLTSVLLASTGMVLGATYMLRFGRAILYGQTKEGVGVKDMSLMEGIGFIPLLVMII
CCHHHHHHHHHHHCCHHHHHHHHHHHCCHHEECCCCCCCCCCHHHHHHCCCHHHHHHHHH
WIGVNPMPIMNKVTTAVSALGTQPANAQIQPAAAQPAASPAAPTPSVKGGANGH
HHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA