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The map label for this gene is gcvT [H]

Identifier: 118580010

GI number: 118580010

Start: 1694488

End: 1695579

Strand: Direct

Name: gcvT [H]

Synonym: Ppro_1587

Alternate gene names: 118580010

Gene position: 1694488-1695579 (Clockwise)

Preceding gene: 118580009

Following gene: 118580011

Centisome position: 42.28

GC content: 62.82

Gene sequence:

>1092_bases
ATGGATGAATCGTTGAAACAGACCCCCCTGAATGCCAGACACAAAAGCCTGAATGCCCGCATGGGCCCCTTTGGCGGCTG
GGATATGCCGATCCAGTACGCGGGGATCATCGCCGAGCATGGCTGGTGCCGACAACGGGCGGCGCTGTTCGATATCTGCC
ACATGGGGGAGTTCCTGTTCGAGGGTGATTTAAATGCCCATGGACTGGAAGAGCTGTTCAGCTTCTCCGTGGCAACCATC
CCGCTGGGGCGCTCGCGCTACGGTTTCCTGCTCAACGATCGGGGGGGGATCATCGACGACCTGATCGTCTTCCGCCTGAC
TGAGAGCAGCGCCATGATCGTGGTCAACGCCGCCACCATCGCCTCTGACTTCAGCGTTATCGCCAGCCGCCTGCGGGGAG
GCTCGTTCAGGGACATTACCGATGAGACCGGCAAGCTGGATGTGCAGGGCCCCCTGGCGCGCCAGGTGCTGGTGGATACC
ATCGGAGGGCAGGTGGCGGAACTGGCCTACTTTAGGTCCATCCCCATGGAGATCCTGGGGTGCCAGGCGCTGGTCAGCCG
CACCGGCTATACCGGTGAACTGGGCTTTGAAATTTTCCTCCCCAGCGCCAGGGTCGGTGAACTGTGGGACCTGCTGCTGC
GTGACCAGCGGGTCAGGCCGGCCGGCCTGGGCGCCCGGGACCTGCTGCGTCTGGAGTTGGGCTACTCCCTCTACGGCCAC
GATATCGACGAGAGCATCACCCCCCTGGAGGCCGGTCTGGAGATGTTTGTCAATTTCGACAAGGATTTTGTAGGCAGGGA
TGCGTTATTGGCCCAGAGGGAGCAGGGGCTTTCCCGATGCAAGGTAGCCTTTCGGGTGGAGGGCCGCCGTTCGCCCCGTC
AGCACTACGACATCCACTGTTGCGGTCAGGTTGTGGGGAGCGTGACCAGCGGCGTCTTCTCCCCCATGCTGGGGTGCGGC
ATCGGCCTGGGGCTGGTCAGGCCGGAGGCTGCCGGGATCGGTACCCGTCTGACCATCGGACACGAACGGGTCAGCATGGA
GGCCGTGGTCTGTGAACTCCCTTTCTATGGCAAGGGGTCGCTCAGGGAGTAG

Upstream 100 bases:

>100_bases
GGCAGGTCGGACAATTGCACACGGGAATTCAGGCTGAGCCGGGAAACAATGGCGGGCGCTAACCTGGCCTCTTCCCGGCA
GTTTTAACGGAGTGGTTGAC

Downstream 100 bases:

>100_bases
ATTCTTCTGGAAACGGATTCCGACGTGCCCTGGCAGGGGATGACTCGCAAGCGGGTCCTGTTCCGTGTGACGGTGCACTA
ATAACGAAGGAGGTTTGTCA

Product: glycine cleavage system T protein

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MDESLKQTPLNARHKSLNARMGPFGGWDMPIQYAGIIAEHGWCRQRAALFDICHMGEFLFEGDLNAHGLEELFSFSVATI
PLGRSRYGFLLNDRGGIIDDLIVFRLTESSAMIVVNAATIASDFSVIASRLRGGSFRDITDETGKLDVQGPLARQVLVDT
IGGQVAELAYFRSIPMEILGCQALVSRTGYTGELGFEIFLPSARVGELWDLLLRDQRVRPAGLGARDLLRLELGYSLYGH
DIDESITPLEAGLEMFVNFDKDFVGRDALLAQREQGLSRCKVAFRVEGRRSPRQHYDIHCCGQVVGSVTSGVFSPMLGCG
IGLGLVRPEAAGIGTRLTIGHERVSMEAVVCELPFYGKGSLRE

Sequences:

>Translated_363_residues
MDESLKQTPLNARHKSLNARMGPFGGWDMPIQYAGIIAEHGWCRQRAALFDICHMGEFLFEGDLNAHGLEELFSFSVATI
PLGRSRYGFLLNDRGGIIDDLIVFRLTESSAMIVVNAATIASDFSVIASRLRGGSFRDITDETGKLDVQGPLARQVLVDT
IGGQVAELAYFRSIPMEILGCQALVSRTGYTGELGFEIFLPSARVGELWDLLLRDQRVRPAGLGARDLLRLELGYSLYGH
DIDESITPLEAGLEMFVNFDKDFVGRDALLAQREQGLSRCKVAFRVEGRRSPRQHYDIHCCGQVVGSVTSGVFSPMLGCG
IGLGLVRPEAAGIGTRLTIGHERVSMEAVVCELPFYGKGSLRE
>Mature_363_residues
MDESLKQTPLNARHKSLNARMGPFGGWDMPIQYAGIIAEHGWCRQRAALFDICHMGEFLFEGDLNAHGLEELFSFSVATI
PLGRSRYGFLLNDRGGIIDDLIVFRLTESSAMIVVNAATIASDFSVIASRLRGGSFRDITDETGKLDVQGPLARQVLVDT
IGGQVAELAYFRSIPMEILGCQALVSRTGYTGELGFEIFLPSARVGELWDLLLRDQRVRPAGLGARDLLRLELGYSLYGH
DIDESITPLEAGLEMFVNFDKDFVGRDALLAQREQGLSRCKVAFRVEGRRSPRQHYDIHCCGQVVGSVTSGVFSPMLGCG
IGLGLVRPEAAGIGTRLTIGHERVSMEAVVCELPFYGKGSLRE

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=366, Percent_Identity=34.4262295081967, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI257796258, Length=348, Percent_Identity=33.3333333333333, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI257796256, Length=299, Percent_Identity=34.7826086956522, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI257796254, Length=365, Percent_Identity=30.958904109589, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI24797151, Length=330, Percent_Identity=25.4545454545455, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI197927446, Length=328, Percent_Identity=28.0487804878049, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI21361378, Length=328, Percent_Identity=28.0487804878049, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI194306651, Length=311, Percent_Identity=26.6881028938907, Blast_Score=89, Evalue=6e-18,
Organism=Escherichia coli, GI1789272, Length=367, Percent_Identity=36.5122615803815, Blast_Score=185, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17560118, Length=375, Percent_Identity=31.7333333333333, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI32563613, Length=362, Percent_Identity=25.6906077348066, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71994052, Length=344, Percent_Identity=24.1279069767442, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71994045, Length=344, Percent_Identity=24.1279069767442, Blast_Score=74, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6320222, Length=366, Percent_Identity=31.6939890710383, Blast_Score=157, Evalue=3e-39,
Organism=Drosophila melanogaster, GI20129441, Length=369, Percent_Identity=33.3333333333333, Blast_Score=175, Evalue=3e-44,
Organism=Drosophila melanogaster, GI20130091, Length=317, Percent_Identity=25.8675078864353, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28571104, Length=270, Percent_Identity=27.4074074074074, Blast_Score=85, Evalue=8e-17,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 39817; Mature: 39817

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDESLKQTPLNARHKSLNARMGPFGGWDMPIQYAGIIAEHGWCRQRAALFDICHMGEFLF
CCCCCCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHE
EGDLNAHGLEELFSFSVATIPLGRSRYGFLLNDRGGIIDDLIVFRLTESSAMIVVNAATI
ECCCCCCCHHHHHHHHHEEEECCCCCCCEEECCCCCHHHHEEEEEEECCCEEEEEEHHHH
ASDFSVIASRLRGGSFRDITDETGKLDVQGPLARQVLVDTIGGQVAELAYFRSIPMEILG
HHHHHHHHHHHCCCCCCCCCCCCCEEECCCHHHHHHHHHHHCCHHHHHHHHHHCCHHHHH
CQALVSRTGYTGELGFEIFLPSARVGELWDLLLRDQRVRPAGLGARDLLRLELGYSLYGH
HHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCEEECC
DIDESITPLEAGLEMFVNFDKDFVGRDALLAQREQGLSRCKVAFRVEGRRSPRQHYDIHC
CCCCCCCHHHHHHHHHHCCCHHHCCHHHHHHHHHCCHHHCEEEEEECCCCCCCCCCCHHH
CGQVVGSVTSGVFSPMLGCGIGLGLVRPEAAGIGTRLTIGHERVSMEAVVCELPFYGKGS
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCHHHEEEEEEEECCCCCCCC
LRE
CCC
>Mature Secondary Structure
MDESLKQTPLNARHKSLNARMGPFGGWDMPIQYAGIIAEHGWCRQRAALFDICHMGEFLF
CCCCCCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHE
EGDLNAHGLEELFSFSVATIPLGRSRYGFLLNDRGGIIDDLIVFRLTESSAMIVVNAATI
ECCCCCCCHHHHHHHHHEEEECCCCCCCEEECCCCCHHHHEEEEEEECCCEEEEEEHHHH
ASDFSVIASRLRGGSFRDITDETGKLDVQGPLARQVLVDTIGGQVAELAYFRSIPMEILG
HHHHHHHHHHHCCCCCCCCCCCCCEEECCCHHHHHHHHHHHCCHHHHHHHHHHCCHHHHH
CQALVSRTGYTGELGFEIFLPSARVGELWDLLLRDQRVRPAGLGARDLLRLELGYSLYGH
HHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCEEECC
DIDESITPLEAGLEMFVNFDKDFVGRDALLAQREQGLSRCKVAFRVEGRRSPRQHYDIHC
CCCCCCCHHHHHHHHHHCCCHHHCCHHHHHHHHHCCHHHCEEEEEECCCCCCCCCCCHHH
CGQVVGSVTSGVFSPMLGCGIGLGLVRPEAAGIGTRLTIGHERVSMEAVVCELPFYGKGS
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCHHHEEEEEEEECCCCCCCC
LRE
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]