Click here to switch to the map view.

The map label for this gene is fcl [H]

Identifier: 118579849

GI number: 118579849

Start: 1522634

End: 1523602

Strand: Reverse

Name: fcl [H]

Synonym: Ppro_1425

Alternate gene names: 118579849

Gene position: 1523602-1522634 (Counterclockwise)

Preceding gene: 118579850

Following gene: 118579848

Centisome position: 38.01

GC content: 63.05

Gene sequence:

>969_bases
GTGAACAGGGATGCGAGAATATATGTGGCAGGCCACCGCGGCATGGTCGGTTCCGCCATCGTCCGCCAGCTGCGGGCCAG
CGGGTATGAGAACCTCATCCTGCGCACCAGCAAGGAACTGGACCTGCGCGACCAGCAGACCACGGCCCGTTTCCTGGCGG
AGGAGCGGCCGGAGTACGTCTTCCTGACAGCCGCCAGGGTAGGCGGCATCGTTGCCAACAGCAGCTATCCGGCGGAGTTC
ATCCACAACAACCTGCTGATCCAGGAGAACATCATCCACAATTCCTGGAAAAACGGCGTAAAACGGCTGCTCTTTTTGGG
CAGCACCTGCATCTACCCCCGACTGGCCCCCCAACCGCTCAAGGAAGAGTACCTGATGAGCGGCCCCCTGGAGCCGACCA
ACGACGCCTATGCGGTGGCCAAGATCGCCGGCATCTACCAGTGCCGCTCCTACAACCGCCAGTACGGCACGAACTACCTG
GCCATCATGCCCAACAACCTCTATGGCCCGGGCGACAACTTCGACCTGGAGACATCCCACGTCCTGCCGGCCCTGATCCG
CAAGTTCCACGAGGCGAAGGAGAGCGAGGCCTCAACCGTGACCGTCTGGGGGAGCGGCTCCCCACTACGCGAATTCCTGC
AGGTGGACGACCTGGCCGAGGCTTGTCTGTTCCTGATGAACCTGGACGACGACCGCTTCGATACGCTGCTGAACGACCCG
GTGGCCCCGGCTCTGATCAACGTCGGCTCGGGGGAGGAACTTTCCATCCGCGACCTGGCGCTGCTGGTGAAGGAGATCAC
CGGTTTTGACGGCGAACTGCTCTTCGACCGGGACAAACCGGACGGAACCCCGCGCAAACTGGCCGACCTCTCCCGCATCC
ACACACTTGGCTGGCGCCACAGGACCGGGCTCAAGGAGGGGATCGCGGCAGCATACCAGTGGTTCCTGGAGAACGGGAGC
GGTCGGTGA

Upstream 100 bases:

>100_bases
CGGATCAGGGCGCCTGCGGGGCGTGGCTGATCGGGGGTCAAGCGCAGATGGCGGACGGCTCCGGTTGCAAAAAACAGCTT
TTCGGCACAGGGAGGTGGCG

Downstream 100 bases:

>100_bases
CGGGGCGCTATGCATAAAACCTGGATGCGATTCCTGCCGTCATTCATCAGCAGACGGCTTGAGAATCGCCATGAACTTCA
GCGCGCCATCGACAACACCG

Product: NAD-dependent epimerase/dehydratase

Products: NA

Alternate protein names: GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase [H]

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MNRDARIYVAGHRGMVGSAIVRQLRASGYENLILRTSKELDLRDQQTTARFLAEERPEYVFLTAARVGGIVANSSYPAEF
IHNNLLIQENIIHNSWKNGVKRLLFLGSTCIYPRLAPQPLKEEYLMSGPLEPTNDAYAVAKIAGIYQCRSYNRQYGTNYL
AIMPNNLYGPGDNFDLETSHVLPALIRKFHEAKESEASTVTVWGSGSPLREFLQVDDLAEACLFLMNLDDDRFDTLLNDP
VAPALINVGSGEELSIRDLALLVKEITGFDGELLFDRDKPDGTPRKLADLSRIHTLGWRHRTGLKEGIAAAYQWFLENGS
GR

Sequences:

>Translated_322_residues
MNRDARIYVAGHRGMVGSAIVRQLRASGYENLILRTSKELDLRDQQTTARFLAEERPEYVFLTAARVGGIVANSSYPAEF
IHNNLLIQENIIHNSWKNGVKRLLFLGSTCIYPRLAPQPLKEEYLMSGPLEPTNDAYAVAKIAGIYQCRSYNRQYGTNYL
AIMPNNLYGPGDNFDLETSHVLPALIRKFHEAKESEASTVTVWGSGSPLREFLQVDDLAEACLFLMNLDDDRFDTLLNDP
VAPALINVGSGEELSIRDLALLVKEITGFDGELLFDRDKPDGTPRKLADLSRIHTLGWRHRTGLKEGIAAAYQWFLENGS
GR
>Mature_322_residues
MNRDARIYVAGHRGMVGSAIVRQLRASGYENLILRTSKELDLRDQQTTARFLAEERPEYVFLTAARVGGIVANSSYPAEF
IHNNLLIQENIIHNSWKNGVKRLLFLGSTCIYPRLAPQPLKEEYLMSGPLEPTNDAYAVAKIAGIYQCRSYNRQYGTNYL
AIMPNNLYGPGDNFDLETSHVLPALIRKFHEAKESEASTVTVWGSGSPLREFLQVDDLAEACLFLMNLDDDRFDTLLNDP
VAPALINVGSGEELSIRDLALLVKEITGFDGELLFDRDKPDGTPRKLADLSRIHTLGWRHRTGLKEGIAAAYQWFLENGS
GR

Specific function: Two step NADP-dependent conversion of GDP-4-dehydro-6- deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fucose synthase family [H]

Homologues:

Organism=Homo sapiens, GI4507709, Length=318, Percent_Identity=35.8490566037736, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI7657641, Length=247, Percent_Identity=25.5060728744939, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI42516563, Length=327, Percent_Identity=23.2415902140673, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1788365, Length=313, Percent_Identity=54.9520766773163, Blast_Score=369, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17554428, Length=316, Percent_Identity=30.379746835443, Blast_Score=157, Evalue=5e-39,
Organism=Drosophila melanogaster, GI19922778, Length=322, Percent_Identity=30.4347826086957, Blast_Score=169, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =1.1.1.271 [H]

Molecular weight: Translated: 36089; Mature: 36089

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRDARIYVAGHRGMVGSAIVRQLRASGYENLILRTSKELDLRDQQTTARFLAEERPEYV
CCCCCEEEEECCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCEE
FLTAARVGGIVANSSYPAEFIHNNLLIQENIIHNSWKNGVKRLLFLGSTCIYPRLAPQPL
EEEEHHHCCEEECCCCCHHHHHCCEEEEHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCH
KEEYLMSGPLEPTNDAYAVAKIAGIYQCRSYNRQYGTNYLAIMPNNLYGPGDNFDLETSH
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHCCCEEEEECCCCCCCCCCCCCCHHH
VLPALIRKFHEAKESEASTVTVWGSGSPLREFLQVDDLAEACLFLMNLDDDRFDTLLNDP
HHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCC
VAPALINVGSGEELSIRDLALLVKEITGFDGELLFDRDKPDGTPRKLADLSRIHTLGWRH
CCHHEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCHH
RTGLKEGIAAAYQWFLENGSGR
HCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNRDARIYVAGHRGMVGSAIVRQLRASGYENLILRTSKELDLRDQQTTARFLAEERPEYV
CCCCCEEEEECCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCEE
FLTAARVGGIVANSSYPAEFIHNNLLIQENIIHNSWKNGVKRLLFLGSTCIYPRLAPQPL
EEEEHHHCCEEECCCCCHHHHHCCEEEEHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCH
KEEYLMSGPLEPTNDAYAVAKIAGIYQCRSYNRQYGTNYLAIMPNNLYGPGDNFDLETSH
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHCCCEEEEECCCCCCCCCCCCCCHHH
VLPALIRKFHEAKESEASTVTVWGSGSPLREFLQVDDLAEACLFLMNLDDDRFDTLLNDP
HHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCC
VAPALINVGSGEELSIRDLALLVKEITGFDGELLFDRDKPDGTPRKLADLSRIHTLGWRH
CCHHEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCHH
RTGLKEGIAAAYQWFLENGSGR
HCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7815923; 8759852; 9097040; 9278503; 9473059; 9862812 [H]