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The map label for this gene is hmuU [H]

Identifier: 118579686

GI number: 118579686

Start: 1316202

End: 1317248

Strand: Direct

Name: hmuU [H]

Synonym: Ppro_1257

Alternate gene names: 118579686

Gene position: 1316202-1317248 (Clockwise)

Preceding gene: 118579685

Following gene: 118579687

Centisome position: 32.84

GC content: 63.61

Gene sequence:

>1047_bases
ATGACCGAAGCAACCATGGATATGAACGAACGCCACTGCCTGTACCCGTCCCGCGTCCTGCTGGTCTTTTCCGGCCTGGG
GCTGTTCGCCCTGCTTATGCTGCTGCTTAATATCGGCATCGGCTCCGTATCGTTTTCGCCGGCCAGGATCATCGACATCG
TGCTCCATCCGGACAGCGGCACCGCCAGCGCCATCATCTGGGACATCCGCATCCCGCGGGCCCTGGGCGCCGTCATGGGG
GGGGCGTTCCTGGCGATTTCCGGTCTGCTGCTCCAGGTCTATTTCCGCAACCCCATCGTCGGCCCCTATATCCTGGGGAT
CTCCTCGGGAGCGACGGTCATGGTCTCCCTGGTCATGCTGACCACCCTGACCGTGGGGTTTACGGTGCTGAACCCCTACA
TGTGTACCCTGGCATCCATTCTCGGCGCCTACGCGGTCATGTCCCTGATCCTGGTGATCGCCTCGCGGGTAAAAAGCGGC
ATCACCCTGCTGATCGTCGGCCTCATGATGGGGTATCTGTGCGGCGCCGTTACCGCCGTGCTCACCGCCCTGGCAGAGAA
GGAGAAGATCAAGGGATTCATCCTCTGGGAACTGGGGAGCTTCTCCGGCTTCAAATGGAGCGAAATCTCCATGCTGGCGC
TCATGGGCGGGGCTCTGCTGGTCCTCGTGTTCGCGCTCAGCAAGCCTCTCAACGCCTTTCTCCTGGGAGAGGAGTATGCC
GCCTCCATGGGGGTCAACATCCGCCGCTTCCGCGTGCTGATCCTGATGAGCGCCTGCGCCCTGGCCGGCATGGTCACCGC
CCTGGCCGGCCCCATCGCCTTCGTGGGGATGGCGGTGCCGCACATGGCCCGGCTGTTCTTCGGCACCTCGGACAACCGGA
TCCTGATCCCCGGCGCCAGCCTGGTCGGCGCAGCCGTCGCCAGCCTGTGCGACCTGATCGCCCGCATGGTCATGTCCCCG
GTGGAGCTGCCGCTGTCGTCCATTACCGCCTTTTTCGGGGCGCCCATCGTCCTGACCCTGCTGATCAGAAGGAAGGTGGA
GTTATGA

Upstream 100 bases:

>100_bases
AACTCGCCGCCATCGTCCATCCCGATGTCTATCCCGGCTACAGGCTGAAGTTCTTCGAGGAACTCCCCGCTACTGAGCCT
GCCGATAAAGGAAAACCGCT

Downstream 100 bases:

>100_bases
GCGGAAGCGACGGAAGATTCGTGATCGAATGCCGGGAACTGTCGGTCGGCTACAAACGGAAGGCCGTGCTCTCACAGATC
ACCATGGGGTTCGAGGAGGG

Product: transport system permease

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MTEATMDMNERHCLYPSRVLLVFSGLGLFALLMLLLNIGIGSVSFSPARIIDIVLHPDSGTASAIIWDIRIPRALGAVMG
GAFLAISGLLLQVYFRNPIVGPYILGISSGATVMVSLVMLTTLTVGFTVLNPYMCTLASILGAYAVMSLILVIASRVKSG
ITLLIVGLMMGYLCGAVTAVLTALAEKEKIKGFILWELGSFSGFKWSEISMLALMGGALLVLVFALSKPLNAFLLGEEYA
ASMGVNIRRFRVLILMSACALAGMVTALAGPIAFVGMAVPHMARLFFGTSDNRILIPGASLVGAAVASLCDLIARMVMSP
VELPLSSITAFFGAPIVLTLLIRRKVEL

Sequences:

>Translated_348_residues
MTEATMDMNERHCLYPSRVLLVFSGLGLFALLMLLLNIGIGSVSFSPARIIDIVLHPDSGTASAIIWDIRIPRALGAVMG
GAFLAISGLLLQVYFRNPIVGPYILGISSGATVMVSLVMLTTLTVGFTVLNPYMCTLASILGAYAVMSLILVIASRVKSG
ITLLIVGLMMGYLCGAVTAVLTALAEKEKIKGFILWELGSFSGFKWSEISMLALMGGALLVLVFALSKPLNAFLLGEEYA
ASMGVNIRRFRVLILMSACALAGMVTALAGPIAFVGMAVPHMARLFFGTSDNRILIPGASLVGAAVASLCDLIARMVMSP
VELPLSSITAFFGAPIVLTLLIRRKVEL
>Mature_347_residues
TEATMDMNERHCLYPSRVLLVFSGLGLFALLMLLLNIGIGSVSFSPARIIDIVLHPDSGTASAIIWDIRIPRALGAVMGG
AFLAISGLLLQVYFRNPIVGPYILGISSGATVMVSLVMLTTLTVGFTVLNPYMCTLASILGAYAVMSLILVIASRVKSGI
TLLIVGLMMGYLCGAVTAVLTALAEKEKIKGFILWELGSFSGFKWSEISMLALMGGALLVLVFALSKPLNAFLLGEEYAA
SMGVNIRRFRVLILMSACALAGMVTALAGPIAFVGMAVPHMARLFFGTSDNRILIPGASLVGAAVASLCDLIARMVMSPV
ELPLSSITAFFGAPIVLTLLIRRKVEL

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=280, Percent_Identity=34.2857142857143, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1790741, Length=287, Percent_Identity=32.404181184669, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1790740, Length=281, Percent_Identity=31.3167259786477, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1786805, Length=307, Percent_Identity=30.6188925081433, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1786804, Length=316, Percent_Identity=28.1645569620253, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1786347, Length=284, Percent_Identity=28.8732394366197, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 36852; Mature: 36721

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEATMDMNERHCLYPSRVLLVFSGLGLFALLMLLLNIGIGSVSFSPARIIDIVLHPDSG
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCC
TASAIIWDIRIPRALGAVMGGAFLAISGLLLQVYFRNPIVGPYILGISSGATVMVSLVML
CCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHH
TTLTVGFTVLNPYMCTLASILGAYAVMSLILVIASRVKSGITLLIVGLMMGYLCGAVTAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LTALAEKEKIKGFILWELGSFSGFKWSEISMLALMGGALLVLVFALSKPLNAFLLGEEYA
HHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHEEECHHHH
ASMGVNIRRFRVLILMSACALAGMVTALAGPIAFVGMAVPHMARLFFGTSDNRILIPGAS
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHH
LVGAAVASLCDLIARMVMSPVELPLSSITAFFGAPIVLTLLIRRKVEL
HHHHHHHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TEATMDMNERHCLYPSRVLLVFSGLGLFALLMLLLNIGIGSVSFSPARIIDIVLHPDSG
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCC
TASAIIWDIRIPRALGAVMGGAFLAISGLLLQVYFRNPIVGPYILGISSGATVMVSLVML
CCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHH
TTLTVGFTVLNPYMCTLASILGAYAVMSLILVIASRVKSGITLLIVGLMMGYLCGAVTAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LTALAEKEKIKGFILWELGSFSGFKWSEISMLALMGGALLVLVFALSKPLNAFLLGEEYA
HHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHEEECHHHH
ASMGVNIRRFRVLILMSACALAGMVTALAGPIAFVGMAVPHMARLFFGTSDNRILIPGAS
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHH
LVGAAVASLCDLIARMVMSPVELPLSSITAFFGAPIVLTLLIRRKVEL
HHHHHHHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]