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The map label for this gene is ffh [H]

Identifier: 118579532

GI number: 118579532

Start: 1145450

End: 1146811

Strand: Reverse

Name: ffh [H]

Synonym: Ppro_1099

Alternate gene names: 118579532

Gene position: 1146811-1145450 (Counterclockwise)

Preceding gene: 118579533

Following gene: 118579531

Centisome position: 28.61

GC content: 60.79

Gene sequence:

>1362_bases
ATGTTCGACAGCCTCTCAGAAAAACTCGAATCGGTATTCAAAAAGCTCCGCGGCCAGGGAGTGATGACCGAGGACAATAT
CAAGGAAGCGCTGCGCGAAGTGCGCTTGGCGCTGCTTGAGGCGGACGTCAACTTCAAGGTCGTCAAGGATTTCGTCGAGA
GCGTCCGCGCCAAGGCCGTCGGCACCGAGGTGCTGCAGAGCCTCTCACCTGGCCAACAGGTGGTCAAGATCGTCAACGAT
GAACTGGTGGCGATCATGGGCGGACACGAGGACAACAGCATCAACCTGGCGGCAAAGCCGCCGGTTTCCCTGATGATGGT
CGGCCTGCAGGGGGCCGGTAAGACCACCACCTGCGGGAAACTTGCCCTGCATCTGCGGGGCAGGAAGCGCAGGCCGTTGC
TGGTTCCGGCCGACGTCTACCGCCCCGCTGCAATTGACCAGCTCAAGATCGTCGGCAAGCAACTGGGGGTCGCGGTATTC
GACTCTTCGGCCGACCAGAAGCCGGTGGACATCTGCAGCGCTGCCATGAAGTTCGCCGAACTGAACGGCTTCGACACCGT
CATCCTGGATACCGCCGGACGCCATCAGATCGACGATTTCCTGATGGGTGAACTGGCGGAGATCAACGAAACCATACGCC
CCGCAGAGATCCTCTTCGTGGCCGACGCCATGACCGGGCAGGAAGCGGTCAATGTGGCTGCCGGCTTCAACGATCGTCTC
GGCATCACCGGCGTCATCCTGACCAAGATGGACGGCGACGCCAAGGGGGGAGCGGCGCTCTCCATCAAGGCGGTTACGGG
AAAACCGGTCAAATTCGTGGGCATGGGCGAGAAGCTGGACGCCCTGGAGGTGTTCCACGCCGACCGCCTCGTGTCGCGCA
TCCTGGGAATGGGCGACGTCCTGACCCTGGTGGAGAAGGCCCAGTCGGTCTTTGACGAGAAGGATGCCGAACGGCTCAAA
CAGAAGCTGAAGAAAAACCAGTTCGACCTGGAGGACTTCCTCGCCCAGCTCCAGCAGATACGCAAGATGGGTTCCCTGGA
GTCTATCATGGGCATGATTCCGGGCATGGGCAAGATGATGAAGCAGATGCAGGGCGCCCAGCCCAGCGACAAAGAGATCA
ACCGCATCGAGGCCATCATTCGCTCCATGACACCGGGTGAGCGGGCAAACCACAGCATAATCAACGGCAGCCGCCGTCTG
CGCATCGCCAAGGGGAGCGGCACCAGCGTCCCGGAGGTCAACCAACTGCTGAAACGGTTCACCGAGGCGCAGAAGGTGGT
CAAGCAGTTGCAGAAGCTCGGTCCCAAGGGGCTCCTCAAGGGGATGGGCGGACTCGGAAAGGGAAGACTTCCCTTTGGCT
AA

Upstream 100 bases:

>100_bases
CAGGAGCGCGGAAACCAATTATTTCTTGACAGTTTCCGGAAACGTACTCTATAGTAAGCCCCTTTATTATCCTTCGTGCA
TCAGGAATCCGACAAACGCC

Downstream 100 bases:

>100_bases
CACAACGGAGCAGACTTTTTAAATAATCGAACAGAGAATCAAATAGGAGGATTCACCATGGCAACAAAGATCAGGCTTGC
ACGCGCAGGCGCAAAGAAGA

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MFDSLSEKLESVFKKLRGQGVMTEDNIKEALREVRLALLEADVNFKVVKDFVESVRAKAVGTEVLQSLSPGQQVVKIVND
ELVAIMGGHEDNSINLAAKPPVSLMMVGLQGAGKTTTCGKLALHLRGRKRRPLLVPADVYRPAAIDQLKIVGKQLGVAVF
DSSADQKPVDICSAAMKFAELNGFDTVILDTAGRHQIDDFLMGELAEINETIRPAEILFVADAMTGQEAVNVAAGFNDRL
GITGVILTKMDGDAKGGAALSIKAVTGKPVKFVGMGEKLDALEVFHADRLVSRILGMGDVLTLVEKAQSVFDEKDAERLK
QKLKKNQFDLEDFLAQLQQIRKMGSLESIMGMIPGMGKMMKQMQGAQPSDKEINRIEAIIRSMTPGERANHSIINGSRRL
RIAKGSGTSVPEVNQLLKRFTEAQKVVKQLQKLGPKGLLKGMGGLGKGRLPFG

Sequences:

>Translated_453_residues
MFDSLSEKLESVFKKLRGQGVMTEDNIKEALREVRLALLEADVNFKVVKDFVESVRAKAVGTEVLQSLSPGQQVVKIVND
ELVAIMGGHEDNSINLAAKPPVSLMMVGLQGAGKTTTCGKLALHLRGRKRRPLLVPADVYRPAAIDQLKIVGKQLGVAVF
DSSADQKPVDICSAAMKFAELNGFDTVILDTAGRHQIDDFLMGELAEINETIRPAEILFVADAMTGQEAVNVAAGFNDRL
GITGVILTKMDGDAKGGAALSIKAVTGKPVKFVGMGEKLDALEVFHADRLVSRILGMGDVLTLVEKAQSVFDEKDAERLK
QKLKKNQFDLEDFLAQLQQIRKMGSLESIMGMIPGMGKMMKQMQGAQPSDKEINRIEAIIRSMTPGERANHSIINGSRRL
RIAKGSGTSVPEVNQLLKRFTEAQKVVKQLQKLGPKGLLKGMGGLGKGRLPFG
>Mature_453_residues
MFDSLSEKLESVFKKLRGQGVMTEDNIKEALREVRLALLEADVNFKVVKDFVESVRAKAVGTEVLQSLSPGQQVVKIVND
ELVAIMGGHEDNSINLAAKPPVSLMMVGLQGAGKTTTCGKLALHLRGRKRRPLLVPADVYRPAAIDQLKIVGKQLGVAVF
DSSADQKPVDICSAAMKFAELNGFDTVILDTAGRHQIDDFLMGELAEINETIRPAEILFVADAMTGQEAVNVAAGFNDRL
GITGVILTKMDGDAKGGAALSIKAVTGKPVKFVGMGEKLDALEVFHADRLVSRILGMGDVLTLVEKAQSVFDEKDAERLK
QKLKKNQFDLEDFLAQLQQIRKMGSLESIMGMIPGMGKMMKQMQGAQPSDKEINRIEAIIRSMTPGERANHSIINGSRRL
RIAKGSGTSVPEVNQLLKRFTEAQKVVKQLQKLGPKGLLKGMGGLGKGRLPFG

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=445, Percent_Identity=35.5056179775281, Blast_Score=253, Evalue=3e-67,
Organism=Homo sapiens, GI226371618, Length=346, Percent_Identity=37.2832369942197, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI89061728, Length=163, Percent_Identity=38.6503067484663, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI23308697, Length=322, Percent_Identity=29.8136645962733, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI295424842, Length=322, Percent_Identity=29.8136645962733, Blast_Score=106, Evalue=5e-23,
Organism=Escherichia coli, GI1788963, Length=427, Percent_Identity=54.5667447306792, Blast_Score=455, Evalue=1e-129,
Organism=Escherichia coli, GI1789874, Length=215, Percent_Identity=34.8837209302326, Blast_Score=141, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI17539958, Length=445, Percent_Identity=33.2584269662921, Blast_Score=235, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI193206261, Length=310, Percent_Identity=29.3548387096774, Blast_Score=110, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6325345, Length=396, Percent_Identity=34.8484848484849, Blast_Score=233, Evalue=6e-62,
Organism=Saccharomyces cerevisiae, GI6320498, Length=224, Percent_Identity=27.2321428571429, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI17647949, Length=448, Percent_Identity=35.0446428571429, Blast_Score=240, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24641198, Length=317, Percent_Identity=28.0757097791798, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49096; Mature: 49096

Theoretical pI: Translated: 10.01; Mature: 10.01

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDSLSEKLESVFKKLRGQGVMTEDNIKEALREVRLALLEADVNFKVVKDFVESVRAKAV
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
GTEVLQSLSPGQQVVKIVNDELVAIMGGHEDNSINLAAKPPVSLMMVGLQGAGKTTTCGK
HHHHHHHCCCHHHHHHHHCCCEEEEECCCCCCCEEEECCCCCEEEEEECCCCCCCCHHHH
LALHLRGRKRRPLLVPADVYRPAAIDQLKIVGKQLGVAVFDSSADQKPVDICSAAMKFAE
HHHHHCCCCCCCEEECHHCCCCCHHHHHHHHHHHHCEEEECCCCCCCHHHHHHHHHHHHH
LNGFDTVILDTAGRHQIDDFLMGELAEINETIRPAEILFVADAMTGQEAVNVAAGFNDRL
CCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHCCCCCCC
GITGVILTKMDGDAKGGAALSIKAVTGKPVKFVGMGEKLDALEVFHADRLVSRILGMGDV
CCEEEEEEECCCCCCCCCEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCHHH
LTLVEKAQSVFDEKDAERLKQKLKKNQFDLEDFLAQLQQIRKMGSLESIMGMIPGMGKMM
HHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHH
KQMQGAQPSDKEINRIEAIIRSMTPGERANHSIINGSRRLRIAKGSGTSVPEVNQLLKRF
HHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHH
TEAQKVVKQLQKLGPKGLLKGMGGLGKGRLPFG
HHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MFDSLSEKLESVFKKLRGQGVMTEDNIKEALREVRLALLEADVNFKVVKDFVESVRAKAV
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
GTEVLQSLSPGQQVVKIVNDELVAIMGGHEDNSINLAAKPPVSLMMVGLQGAGKTTTCGK
HHHHHHHCCCHHHHHHHHCCCEEEEECCCCCCCEEEECCCCCEEEEEECCCCCCCCHHHH
LALHLRGRKRRPLLVPADVYRPAAIDQLKIVGKQLGVAVFDSSADQKPVDICSAAMKFAE
HHHHHCCCCCCCEEECHHCCCCCHHHHHHHHHHHHCEEEECCCCCCCHHHHHHHHHHHHH
LNGFDTVILDTAGRHQIDDFLMGELAEINETIRPAEILFVADAMTGQEAVNVAAGFNDRL
CCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHCCCCCCC
GITGVILTKMDGDAKGGAALSIKAVTGKPVKFVGMGEKLDALEVFHADRLVSRILGMGDV
CCEEEEEEECCCCCCCCCEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCHHH
LTLVEKAQSVFDEKDAERLKQKLKKNQFDLEDFLAQLQQIRKMGSLESIMGMIPGMGKMM
HHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHH
KQMQGAQPSDKEINRIEAIIRSMTPGERANHSIINGSRRLRIAKGSGTSVPEVNQLLKRF
HHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHH
TEAQKVVKQLQKLGPKGLLKGMGGLGKGRLPFG
HHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8335643; 9384377; 7511896 [H]