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The map label for this gene is cobB [H]

Identifier: 118579393

GI number: 118579393

Start: 1000309

End: 1001070

Strand: Direct

Name: cobB [H]

Synonym: Ppro_0957

Alternate gene names: 118579393

Gene position: 1000309-1001070 (Clockwise)

Preceding gene: 118579392

Following gene: 118579394

Centisome position: 24.96

GC content: 61.55

Gene sequence:

>762_bases
ATGCATCCATTGGAGCCGGTAGCCTGCGCCGAGCTGATCAGAAACTCGAAATCAATGGTCGCGCTGACCGGGGCGGGCAT
ATCCACCGCGGCCGGCATCCCCGACTTCAGGGGGCCCAAGGGGCTGTACGTCACCCGGCGCTACGACCCCGAACTGGTTT
TCGAGATTGACAACTTTCAGCGCGCACCGCAGTATTTCTACGAGTTTACCAGCGATTTTGCCACTGCGGTGAGGGATGTT
GCTCCCACCTTTACCCATCGTTTCCTCGCCCAGCAGGAGCAGGCGGGACAGCTGGAGGGGGTCATCACCCAGAACATCGA
TATCCTGCACCAGATGGCGGGGAGCAGGAACGTCCTGGAACTGCACGGTTCCTACCGTTCGGCCACCTGCCAGTCCTGCC
GCACGCGGTTGCACGAGCTGGATTACCCTTGGTGGATCGATGCCATGGCCGGCAGCAGCCACCCACCGGTGGTACATTGC
CCATCCTGTGACGGGCTCCTGAAGCCGGACATCGTATTTTTCGGCGAAGCGGTCAACGGCTTTGGTCGGGCCGAAGCCAT
GGTCGCAGCCTGCGACCTCTTGCTGGTGCTGGGGTCGTCCCTGAACGTCACCCCGGCATCGCTGCTTCCCTACAGCACAT
CTGCCCCGACGGTTATCGTCAATCGGGGCAGCGTCATGTTGCCGCCAGCTCCCAACCGCTACTTCGTGGACGAGGATCTG
GACGACTATTTCACGAAGGTTGCGGACCATGTGCGGCGCTGA

Upstream 100 bases:

>100_bases
TTTGCCGCTCTCGGCGTTACCGGTGGCTGCTCCAGGGGAATGAACCGGGAAACGCGACACCCCTCAGTTGCCGTGTTTTG
AATGAAAGAGGAGGCGTTTG

Downstream 100 bases:

>100_bases
ACAGGGGGAGCGTCGAGGTACGATGAACCTGAATTCTTCAGTTGGGAGCAGTCTCCTTTCGCGCGGACGAAAGATTCCTG
GTGCGCTCTCTCCGACAGCC

Product: silent information regulator protein Sir2

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MHPLEPVACAELIRNSKSMVALTGAGISTAAGIPDFRGPKGLYVTRRYDPELVFEIDNFQRAPQYFYEFTSDFATAVRDV
APTFTHRFLAQQEQAGQLEGVITQNIDILHQMAGSRNVLELHGSYRSATCQSCRTRLHELDYPWWIDAMAGSSHPPVVHC
PSCDGLLKPDIVFFGEAVNGFGRAEAMVAACDLLLVLGSSLNVTPASLLPYSTSAPTVIVNRGSVMLPPAPNRYFVDEDL
DDYFTKVADHVRR

Sequences:

>Translated_253_residues
MHPLEPVACAELIRNSKSMVALTGAGISTAAGIPDFRGPKGLYVTRRYDPELVFEIDNFQRAPQYFYEFTSDFATAVRDV
APTFTHRFLAQQEQAGQLEGVITQNIDILHQMAGSRNVLELHGSYRSATCQSCRTRLHELDYPWWIDAMAGSSHPPVVHC
PSCDGLLKPDIVFFGEAVNGFGRAEAMVAACDLLLVLGSSLNVTPASLLPYSTSAPTVIVNRGSVMLPPAPNRYFVDEDL
DDYFTKVADHVRR
>Mature_253_residues
MHPLEPVACAELIRNSKSMVALTGAGISTAAGIPDFRGPKGLYVTRRYDPELVFEIDNFQRAPQYFYEFTSDFATAVRDV
APTFTHRFLAQQEQAGQLEGVITQNIDILHQMAGSRNVLELHGSYRSATCQSCRTRLHELDYPWWIDAMAGSSHPPVVHC
PSCDGLLKPDIVFFGEAVNGFGRAEAMVAACDLLLVLGSSLNVTPASLLPYSTSAPTVIVNRGSVMLPPAPNRYFVDEDL
DDYFTKVADHVRR

Specific function: Modulates the activity of chromatin proteins, thereby having an effect on transcription per subunit [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7657575, Length=248, Percent_Identity=34.2741935483871, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI13775602, Length=230, Percent_Identity=36.5217391304348, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI13775600, Length=230, Percent_Identity=36.5217391304348, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI6912660, Length=225, Percent_Identity=38.6666666666667, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI63054862, Length=214, Percent_Identity=38.3177570093458, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI300797705, Length=208, Percent_Identity=36.5384615384615, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI13787215, Length=240, Percent_Identity=32.0833333333333, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI6912664, Length=240, Percent_Identity=32.0833333333333, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI300795542, Length=226, Percent_Identity=32.3008849557522, Blast_Score=107, Evalue=7e-24,
Organism=Homo sapiens, GI6912662, Length=253, Percent_Identity=33.596837944664, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI215982798, Length=200, Percent_Identity=34, Blast_Score=101, Evalue=7e-22,
Organism=Homo sapiens, GI300797577, Length=255, Percent_Identity=30.1960784313725, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI7706712, Length=205, Percent_Identity=31.7073170731707, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI300797597, Length=256, Percent_Identity=29.6875, Blast_Score=79, Evalue=5e-15,
Organism=Escherichia coli, GI308199517, Length=192, Percent_Identity=30.2083333333333, Blast_Score=78, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17541892, Length=228, Percent_Identity=35.5263157894737, Blast_Score=140, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI71990482, Length=244, Percent_Identity=31.9672131147541, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17567771, Length=252, Percent_Identity=28.968253968254, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71990487, Length=246, Percent_Identity=31.7073170731707, Blast_Score=94, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6320163, Length=256, Percent_Identity=30.859375, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324504, Length=252, Percent_Identity=30.5555555555556, Blast_Score=105, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6325242, Length=217, Percent_Identity=33.1797235023041, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324599, Length=271, Percent_Identity=26.1992619926199, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17137536, Length=248, Percent_Identity=34.2741935483871, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24648389, Length=220, Percent_Identity=34.0909090909091, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI28571445, Length=183, Percent_Identity=33.879781420765, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24645650, Length=212, Percent_Identity=30.188679245283, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24650933, Length=206, Percent_Identity=31.5533980582524, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI28571443, Length=118, Percent_Identity=37.2881355932203, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28571441, Length=118, Percent_Identity=37.2881355932203, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 27894; Mature: 27894

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPLEPVACAELIRNSKSMVALTGAGISTAAGIPDFRGPKGLYVTRRYDPELVFEIDNFQ
CCCCCHHHHHHHHHCCCCEEEEECCCCHHHCCCCCCCCCCCEEEEEECCCEEEEEECCHH
RAPQYFYEFTSDFATAVRDVAPTFTHRFLAQQEQAGQLEGVITQNIDILHQMAGSRNVLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEE
LHGSYRSATCQSCRTRLHELDYPWWIDAMAGSSHPPVVHCPSCDGLLKPDIVFFGEAVNG
ECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEECCCCCCCCCCCEEEEECHHCC
FGRAEAMVAACDLLLVLGSSLNVTPASLLPYSTSAPTVIVNRGSVMLPPAPNRYFVDEDL
CCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCEEEEECCCEEECCCCCCEECCCCH
DDYFTKVADHVRR
HHHHHHHHHHHCC
>Mature Secondary Structure
MHPLEPVACAELIRNSKSMVALTGAGISTAAGIPDFRGPKGLYVTRRYDPELVFEIDNFQ
CCCCCHHHHHHHHHCCCCEEEEECCCCHHHCCCCCCCCCCCEEEEEECCCEEEEEECCHH
RAPQYFYEFTSDFATAVRDVAPTFTHRFLAQQEQAGQLEGVITQNIDILHQMAGSRNVLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEE
LHGSYRSATCQSCRTRLHELDYPWWIDAMAGSSHPPVVHCPSCDGLLKPDIVFFGEAVNG
ECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEECCCCCCCCCCCEEEEECHHCC
FGRAEAMVAACDLLLVLGSSLNVTPASLLPYSTSAPTVIVNRGSVMLPPAPNRYFVDEDL
CCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCEEEEECCCEEECCCCCCEECCCCH
DDYFTKVADHVRR
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA