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The map label for this gene is upp [H]

Identifier: 118579384

GI number: 118579384

Start: 993449

End: 994075

Strand: Reverse

Name: upp [H]

Synonym: Ppro_0947

Alternate gene names: 118579384

Gene position: 994075-993449 (Counterclockwise)

Preceding gene: 118579390

Following gene: 118579375

Centisome position: 24.8

GC content: 61.72

Gene sequence:

>627_bases
GTGGCGATCTTCGAAGTCAAGCACCCCCTGATCCAGCACAAACTCGGCCTGATGCGCAAGGCGGACCAGAGCACGAAACA
GTTTCGGGAACTGGCGTCCGAAGTCGCCCGCCTTTTGACCTATGAGGCGACAAAAGACCTGGAAACCGAGAGCATCACCA
TCACCGGCTGGGCCGGACCGGTCACCGTCCAGCAGATCAAGGGAAAAAAGATCACGGTGGTGCCGATCCTGCGGGCCGGC
CTGGGGATGATGAACGGCGTCCTGGACATGATCCCCAGCGCCAAGGTCAGCGTGGTCGGCCTCTACCGTAACGAGGAGAC
GCTGGAACCGGTGGCCTACTACGAGAAATTCGCCAGCGGCATGGAGGAGCGCATCGCCCTGATCATCGATCCCATGCTGG
CCACCGGCGGCTCGCTGCTGACAACCATCGAGATGCTGAAAAAGACCGGCTGCAGGCGCATCAAGGGGCTCTTTCTGGTG
GCCGTTCCCGAGGGCCTGGAGCGCATCGGCCGCGCCCATCCCGATGTGGAGATCTACGTTGCCTCCATCGACGAGCGCCT
GAACGAACAGGGCTACATCCTTCCCGGCCTGGGCGATGCCGGGGACAAGATATTCGGCACGAAATAG

Upstream 100 bases:

>100_bases
TGCTGATCCTGGAACCAACGTTACGGGACCTTGACCGGCACGAAGTTGGCCTGTATCCTCCCTGTTCAGCAGACACTTCA
CCCAGAACAGGAGTCACCAC

Downstream 100 bases:

>100_bases
GATTCCTGCGCCAGCCTCGCGGCAGGGTGCAGGTCAATCCTGCTCCCCTCCCCCGAACAGACGAGCAAGGGCCGGACGTT
TCGAGTGAAACGGGCCGGCC

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MAIFEVKHPLIQHKLGLMRKADQSTKQFRELASEVARLLTYEATKDLETESITITGWAGPVTVQQIKGKKITVVPILRAG
LGMMNGVLDMIPSAKVSVVGLYRNEETLEPVAYYEKFASGMEERIALIIDPMLATGGSLLTTIEMLKKTGCRRIKGLFLV
AVPEGLERIGRAHPDVEIYVASIDERLNEQGYILPGLGDAGDKIFGTK

Sequences:

>Translated_208_residues
MAIFEVKHPLIQHKLGLMRKADQSTKQFRELASEVARLLTYEATKDLETESITITGWAGPVTVQQIKGKKITVVPILRAG
LGMMNGVLDMIPSAKVSVVGLYRNEETLEPVAYYEKFASGMEERIALIIDPMLATGGSLLTTIEMLKKTGCRRIKGLFLV
AVPEGLERIGRAHPDVEIYVASIDERLNEQGYILPGLGDAGDKIFGTK
>Mature_207_residues
AIFEVKHPLIQHKLGLMRKADQSTKQFRELASEVARLLTYEATKDLETESITITGWAGPVTVQQIKGKKITVVPILRAGL
GMMNGVLDMIPSAKVSVVGLYRNEETLEPVAYYEKFASGMEERIALIIDPMLATGGSLLTTIEMLKKTGCRRIKGLFLVA
VPEGLERIGRAHPDVEIYVASIDERLNEQGYILPGLGDAGDKIFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=24.7524752475248, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=24.7524752475248, Blast_Score=68, Evalue=5e-12,
Organism=Escherichia coli, GI87082118, Length=208, Percent_Identity=72.1153846153846, Blast_Score=319, Evalue=9e-89,
Organism=Caenorhabditis elegans, GI17539892, Length=202, Percent_Identity=21.2871287128713, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17539894, Length=202, Percent_Identity=21.2871287128713, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6321920, Length=207, Percent_Identity=33.8164251207729, Blast_Score=105, Evalue=7e-24,
Organism=Drosophila melanogaster, GI45550449, Length=149, Percent_Identity=27.5167785234899, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28573516, Length=149, Percent_Identity=27.5167785234899, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28573514, Length=149, Percent_Identity=27.5167785234899, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28573512, Length=149, Percent_Identity=27.5167785234899, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 22871; Mature: 22740

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIFEVKHPLIQHKLGLMRKADQSTKQFRELASEVARLLTYEATKDLETESITITGWAGP
CCEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCC
VTVQQIKGKKITVVPILRAGLGMMNGVLDMIPSAKVSVVGLYRNEETLEPVAYYEKFASG
EEHHHHCCCEEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHC
MEERIALIIDPMLATGGSLLTTIEMLKKTGCRRIKGLFLVAVPEGLERIGRAHPDVEIYV
HHHHHHHHCCHHHHCCCHHHHHHHHHHHHCHHHHCCEEEEECCHHHHHHCCCCCCCEEEE
ASIDERLNEQGYILPGLGDAGDKIFGTK
EEHHHHHCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
AIFEVKHPLIQHKLGLMRKADQSTKQFRELASEVARLLTYEATKDLETESITITGWAGP
CEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCC
VTVQQIKGKKITVVPILRAGLGMMNGVLDMIPSAKVSVVGLYRNEETLEPVAYYEKFASG
EEHHHHCCCEEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHC
MEERIALIIDPMLATGGSLLTTIEMLKKTGCRRIKGLFLVAVPEGLERIGRAHPDVEIYV
HHHHHHHHCCHHHHCCCHHHHHHHHHHHHCHHHHCCEEEEECCHHHHHHCCCCCCCEEEE
ASIDERLNEQGYILPGLGDAGDKIFGTK
EEHHHHHCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA