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The map label for this gene is zraR [H]

Identifier: 118579310

GI number: 118579310

Start: 917445

End: 918155

Strand: Reverse

Name: zraR [H]

Synonym: Ppro_0873

Alternate gene names: 118579310

Gene position: 918155-917445 (Counterclockwise)

Preceding gene: 118579312

Following gene: 118579309

Centisome position: 22.91

GC content: 55.98

Gene sequence:

>711_bases
ATGACGGCTGAATGCGTTAAGCCCGACAGACTCCTGGACGAGATCGGTGACATGAAGGCTGCCCTCCAGGTCAAGTTGCT
ACGGGTGCTGCAGGCCAGGGAGTTCGAACCGGTCGGATCGGCCAAATGCCAGAAAGTAGATGTGCGCATTGTCGCCGCAA
CCAACAGGAACCTTGAAGAGCTGGTGGAAAACGGGAATTTCCGGGAAGACCTCTATTACCGCCTGTCGGTCATACCGGTC
ACCATACCGCCGCTGCGGGAGCGCAGAGAGGACATCCCACTCCTGATTCACAACTTTCTGACCATCTTCAACGACAACAG
CAGGTATTCGGTAAAAGGGTTCTCCCGTGAAGCGCTGGAAATACTGTGCAATTACAGCTGGCCGGGCAATGTCAGGGAAC
TTGAGAACCTGGTGGAGCGCCTGGTGATCATCAAGAACAGCGGCGTCATCACCCCCAACGATCTGCCCGAAAAATACCTC
TCCAGCAACCGGGTCAGGCTCCAGGCGCCAGCGATTCAGGAGGAGAGCACACTCCCGGCGCAAGGCATCTGCCTCAACAC
AGTGGTGGAGCAGTTTGAAAACAACCTGATCCTCCAGGCCCTGGCCCGCACCGGGGGCAACAAAAAAGAGGCCGCCGAAC
TGCTCAACCTGAAAAGGACCACCTTGATCGAGAAACTGAAGAAGAAGAATCTGGTCTTCGTCGAGGAATAG

Upstream 100 bases:

>100_bases
TTACCGGACAAATATACGGGATACACCAAGAAAACGCAAGCTAAAGCTGACGACTTATTCAATAAATACAGCAGGTTAAC
CAATTGAAAACGCCCTGGAG

Downstream 100 bases:

>100_bases
GAACCGCCATGCCCATCAGCATCAGCGAAAAGCCATCGCTGCTCTCGGCCCTTCTTGCACAGGCGCCCCAGGAGCGGTCC
AGCGTCGAGACAGACACCGC

Product: sigma-54 dependent trancsriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MTAECVKPDRLLDEIGDMKAALQVKLLRVLQAREFEPVGSAKCQKVDVRIVAATNRNLEELVENGNFREDLYYRLSVIPV
TIPPLRERREDIPLLIHNFLTIFNDNSRYSVKGFSREALEILCNYSWPGNVRELENLVERLVIIKNSGVITPNDLPEKYL
SSNRVRLQAPAIQEESTLPAQGICLNTVVEQFENNLILQALARTGGNKKEAAELLNLKRTTLIEKLKKKNLVFVEE

Sequences:

>Translated_236_residues
MTAECVKPDRLLDEIGDMKAALQVKLLRVLQAREFEPVGSAKCQKVDVRIVAATNRNLEELVENGNFREDLYYRLSVIPV
TIPPLRERREDIPLLIHNFLTIFNDNSRYSVKGFSREALEILCNYSWPGNVRELENLVERLVIIKNSGVITPNDLPEKYL
SSNRVRLQAPAIQEESTLPAQGICLNTVVEQFENNLILQALARTGGNKKEAAELLNLKRTTLIEKLKKKNLVFVEE
>Mature_235_residues
TAECVKPDRLLDEIGDMKAALQVKLLRVLQAREFEPVGSAKCQKVDVRIVAATNRNLEELVENGNFREDLYYRLSVIPVT
IPPLRERREDIPLLIHNFLTIFNDNSRYSVKGFSREALEILCNYSWPGNVRELENLVERLVIIKNSGVITPNDLPEKYLS
SNRVRLQAPAIQEESTLPAQGICLNTVVEQFENNLILQALARTGGNKKEAAELLNLKRTTLIEKLKKKNLVFVEE

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=218, Percent_Identity=44.954128440367, Blast_Score=186, Evalue=1e-48,
Organism=Escherichia coli, GI1788550, Length=221, Percent_Identity=41.1764705882353, Blast_Score=175, Evalue=2e-45,
Organism=Escherichia coli, GI1789233, Length=222, Percent_Identity=41.8918918918919, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1789087, Length=225, Percent_Identity=43.1111111111111, Blast_Score=157, Evalue=7e-40,
Organism=Escherichia coli, GI1790299, Length=233, Percent_Identity=41.6309012875536, Blast_Score=153, Evalue=9e-39,
Organism=Escherichia coli, GI87082117, Length=225, Percent_Identity=40, Blast_Score=151, Evalue=3e-38,
Organism=Escherichia coli, GI1788905, Length=224, Percent_Identity=41.9642857142857, Blast_Score=150, Evalue=5e-38,
Organism=Escherichia coli, GI87082152, Length=224, Percent_Identity=38.8392857142857, Blast_Score=134, Evalue=7e-33,
Organism=Escherichia coli, GI1786524, Length=223, Percent_Identity=37.219730941704, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI1787583, Length=221, Percent_Identity=33.9366515837104, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI87081872, Length=225, Percent_Identity=37.3333333333333, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI87081858, Length=222, Percent_Identity=31.0810810810811, Blast_Score=103, Evalue=9e-24,
Organism=Escherichia coli, GI1789828, Length=148, Percent_Identity=36.4864864864865, Blast_Score=93, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 26882; Mature: 26751

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAECVKPDRLLDEIGDMKAALQVKLLRVLQAREFEPVGSAKCQKVDVRIVAATNRNLEE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEEECCCCHHH
LVENGNFREDLYYRLSVIPVTIPPLRERREDIPLLIHNFLTIFNDNSRYSVKGFSREALE
HHHCCCCCHHHEEEEEEEEEECCCHHHHHCCCHHHHHHHHHHHCCCCEEEECCCCHHHHH
ILCNYSWPGNVRELENLVERLVIIKNSGVITPNDLPEKYLSSNRVRLQAPAIQEESTLPA
HHHCCCCCCCHHHHHHHHHHHEEECCCCEECCCCCCHHHHCCCCEEEECCCCCCCCCCCC
QGICLNTVVEQFENNLILQALARTGGNKKEAAELLNLKRTTLIEKLKKKNLVFVEE
CCHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEC
>Mature Secondary Structure 
TAECVKPDRLLDEIGDMKAALQVKLLRVLQAREFEPVGSAKCQKVDVRIVAATNRNLEE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEEECCCCHHH
LVENGNFREDLYYRLSVIPVTIPPLRERREDIPLLIHNFLTIFNDNSRYSVKGFSREALE
HHHCCCCCHHHEEEEEEEEEECCCHHHHHCCCHHHHHHHHHHHCCCCEEEECCCCHHHHH
ILCNYSWPGNVRELENLVERLVIIKNSGVITPNDLPEKYLSSNRVRLQAPAIQEESTLPA
HHHCCCCCCCHHHHHHHHHHHEEECCCCEECCCCCCHHHHCCCCEEEECCCCCCCCCCCC
QGICLNTVVEQFENNLILQALARTGGNKKEAAELLNLKRTTLIEKLKKKNLVFVEE
CCHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]