Click here to switch to the map view.

The map label for this gene is ydgK [H]

Identifier: 118579280

GI number: 118579280

Start: 890073

End: 891347

Strand: Direct

Name: ydgK [H]

Synonym: Ppro_0843

Alternate gene names: 118579280

Gene position: 890073-891347 (Clockwise)

Preceding gene: 118579270

Following gene: 118579289

Centisome position: 22.21

GC content: 65.49

Gene sequence:

>1275_bases
GTGAACGGAGGACGTAAAACGTATTCCATGACGTTATCACACACAACACCGGCTGTTCGACCGCCCCCCATGCCCCGCGG
CCAGATGGTGCGCATGGTGCTGATCCTGGGCGTACTGACCGCCTTCGGCCCCATGTCCATCGACATGTATCTCCCCGCCT
TCCCGCAGATCGCCCGGGATCTGGGGGTGCCGCTGGGCACGGTGCAGCTCTCCATTTCCGCCTTCCTGTTCGGCTCGGCG
GCCGGGCAGCTCCTGTACGGGCCGCTGGCCGATCGCTTTGGTCGGCGCAGGCCGCTGCTGTGCGGACTGACGCTGTACAT
CGCCGCAGCGCTGGGATGCGCCTGTGTGCATACGGGAGAGGGGCTTTTGATCTGGCGTCTGGTGATGGCGGTGGGCGGCG
GGGCCGGCATGGTGATCTCCCGCGCCGTTGTGCGCGATCTCTACGATACCGCCGAGGCTGCCCGGATGTTTTCGCTGCTC
ATGCTGGTCATGGGAGCCGCGCCGATCCTGGCCCCCATCGCGGGAGGGCAAATCCTGCTGATCACCGGCTGGCGCGGCAT
CTTTGCCTTTCTGGGGCTCTTCGCCCTGGTCTCCATCGCCGCCGCGGCCCGGTGGCTCCCCGAATCCCTGCCGCCGGAGC
GGCGCATCCGCATCTCCCTGGCTGAGATGGTCGCGGGGTACGGGCAACTTCTGGCTAACCGCGACTACATCCGCTACTCC
ATCGCCCTGGGATGCGTTGCCGGATTCACCTTTGCGTACATTGCAGGGGCGCCATTTTTCTTCATCGAGCTCCATGGGAT
GTCCCCCCAACGGTTCGCCCTGCTGTTTGGTGCCAATGCCGTTGGGTTGATCGGGGCATCGCAACTGAACCGCCGTCTGC
TGCACCGGTTCAGCGCCCAACGGATCATGAAGACATGCTTTGCCCTGAACGCGGCGGCCACCCTTCTGCTGGTGGCCGTG
GTCATGGCCGGAATCGGCGGCTTCCCTGGGCAGGGGCTGCTGATCTTCTTCTGCGTCAGCATGACCGGCTTCCTCTATCC
CAACGTGACCGCCCTTACCCTGGCTCCCTTTGGAAAGGCTGCCGGAAGTGCGTCGGCGCTCCTGGGCACGATCCAGTATT
CCATCGGCGCAAGCGCCGGAGCGCTGGTGGGGGCGCTGCACAACGGCACGGCGCTGCCCATGACCGCCTCCATGGCTCTC
TGCGGGGTGGTGGGTTGGCTCGCCGTGGCGTTGAGCGCCTCGGCGGAAGATCACCCTTTCAACCGCGTTTCCTGA

Upstream 100 bases:

>100_bases
TCTCGTGTAGTATGCTGGGTTCCATGGTCACGCGGAGCGGGATGGGCGGATGTTGTCCTGGCTTTGATACCCATGGGGTT
ACCGTGGGTAACCAGCTGCT

Downstream 100 bases:

>100_bases
ACCACTCCCCCTGTTCCCGTCTCGCCCATCCCCGCCCCGGCCAGGATCGCCTCGATCTCTTCGATGATCTCTTCCTGGCG
GGCCAGGTTCTGTTTCCGCT

Product: Bcr/CflA subfamily drug resistance transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MNGGRKTYSMTLSHTTPAVRPPPMPRGQMVRMVLILGVLTAFGPMSIDMYLPAFPQIARDLGVPLGTVQLSISAFLFGSA
AGQLLYGPLADRFGRRRPLLCGLTLYIAAALGCACVHTGEGLLIWRLVMAVGGGAGMVISRAVVRDLYDTAEAARMFSLL
MLVMGAAPILAPIAGGQILLITGWRGIFAFLGLFALVSIAAAARWLPESLPPERRIRISLAEMVAGYGQLLANRDYIRYS
IALGCVAGFTFAYIAGAPFFFIELHGMSPQRFALLFGANAVGLIGASQLNRRLLHRFSAQRIMKTCFALNAAATLLLVAV
VMAGIGGFPGQGLLIFFCVSMTGFLYPNVTALTLAPFGKAAGSASALLGTIQYSIGASAGALVGALHNGTALPMTASMAL
CGVVGWLAVALSASAEDHPFNRVS

Sequences:

>Translated_424_residues
MNGGRKTYSMTLSHTTPAVRPPPMPRGQMVRMVLILGVLTAFGPMSIDMYLPAFPQIARDLGVPLGTVQLSISAFLFGSA
AGQLLYGPLADRFGRRRPLLCGLTLYIAAALGCACVHTGEGLLIWRLVMAVGGGAGMVISRAVVRDLYDTAEAARMFSLL
MLVMGAAPILAPIAGGQILLITGWRGIFAFLGLFALVSIAAAARWLPESLPPERRIRISLAEMVAGYGQLLANRDYIRYS
IALGCVAGFTFAYIAGAPFFFIELHGMSPQRFALLFGANAVGLIGASQLNRRLLHRFSAQRIMKTCFALNAAATLLLVAV
VMAGIGGFPGQGLLIFFCVSMTGFLYPNVTALTLAPFGKAAGSASALLGTIQYSIGASAGALVGALHNGTALPMTASMAL
CGVVGWLAVALSASAEDHPFNRVS
>Mature_424_residues
MNGGRKTYSMTLSHTTPAVRPPPMPRGQMVRMVLILGVLTAFGPMSIDMYLPAFPQIARDLGVPLGTVQLSISAFLFGSA
AGQLLYGPLADRFGRRRPLLCGLTLYIAAALGCACVHTGEGLLIWRLVMAVGGGAGMVISRAVVRDLYDTAEAARMFSLL
MLVMGAAPILAPIAGGQILLITGWRGIFAFLGLFALVSIAAAARWLPESLPPERRIRISLAEMVAGYGQLLANRDYIRYS
IALGCVAGFTFAYIAGAPFFFIELHGMSPQRFALLFGANAVGLIGASQLNRRLLHRFSAQRIMKTCFALNAAATLLLVAV
VMAGIGGFPGQGLLIFFCVSMTGFLYPNVTALTLAPFGKAAGSASALLGTIQYSIGASAGALVGALHNGTALPMTASMAL
CGVVGWLAVALSASAEDHPFNRVS

Specific function: Involved In Sulfonamide (Sulfathiazole) And Bicyclomycin Resistance. Probable Membrane Translocase. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=379, Percent_Identity=34.8284960422164, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI48994889, Length=383, Percent_Identity=34.4647519582245, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI87082312, Length=397, Percent_Identity=28.9672544080605, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1790146, Length=349, Percent_Identity=26.3610315186246, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1787065, Length=260, Percent_Identity=26.1538461538462, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1790794, Length=247, Percent_Identity=21.8623481781377, Blast_Score=65, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6319657, Length=169, Percent_Identity=27.2189349112426, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44490; Mature: 44490

Theoretical pI: Translated: 10.24; Mature: 10.24

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGGRKTYSMTLSHTTPAVRPPPMPRGQMVRMVLILGVLTAFGPMSIDMYLPAFPQIARD
CCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHH
LGVPLGTVQLSISAFLFGSAAGQLLYGPLADRFGRRRPLLCGLTLYIAAALGCACVHTGE
HCCCCHHHHHHHHHHHHHHHCCHHEECHHHHHCCCCCCHHHHHHHHHHHHHHHHHEECCC
GLLIWRLVMAVGGGAGMVISRAVVRDLYDTAEAARMFSLLMLVMGAAPILAPIAGGQILL
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEE
ITGWRGIFAFLGLFALVSIAAAARWLPESLPPERRIRISLAEMVAGYGQLLANRDYIRYS
EECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHH
IALGCVAGFTFAYIAGAPFFFIELHGMSPQRFALLFGANAVGLIGASQLNRRLLHRFSAQ
HHHHHHHHHHHHHHHCCCEEEEEEECCCCHHEEEEECCCHHHHCCHHHHHHHHHHHHHHH
RIMKTCFALNAAATLLLVAVVMAGIGGFPGQGLLIFFCVSMTGFLYPNVTALTLAPFGKA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCC
AGSASALLGTIQYSIGASAGALVGALHNGTALPMTASMALCGVVGWLAVALSASAEDHPF
CCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
NRVS
CCCC
>Mature Secondary Structure
MNGGRKTYSMTLSHTTPAVRPPPMPRGQMVRMVLILGVLTAFGPMSIDMYLPAFPQIARD
CCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHH
LGVPLGTVQLSISAFLFGSAAGQLLYGPLADRFGRRRPLLCGLTLYIAAALGCACVHTGE
HCCCCHHHHHHHHHHHHHHHCCHHEECHHHHHCCCCCCHHHHHHHHHHHHHHHHHEECCC
GLLIWRLVMAVGGGAGMVISRAVVRDLYDTAEAARMFSLLMLVMGAAPILAPIAGGQILL
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEE
ITGWRGIFAFLGLFALVSIAAAARWLPESLPPERRIRISLAEMVAGYGQLLANRDYIRYS
EECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHH
IALGCVAGFTFAYIAGAPFFFIELHGMSPQRFALLFGANAVGLIGASQLNRRLLHRFSAQ
HHHHHHHHHHHHHHHCCCEEEEEEECCCCHHEEEEECCCHHHHCCHHHHHHHHHHHHHHH
RIMKTCFALNAAATLLLVAVVMAGIGGFPGQGLLIFFCVSMTGFLYPNVTALTLAPFGKA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCC
AGSASALLGTIQYSIGASAGALVGALHNGTALPMTASMALCGVVGWLAVALSASAEDHPF
CCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
NRVS
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9202461 [H]