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The map label for this gene is fadH [C]

Identifier: 118579216

GI number: 118579216

Start: 826465

End: 827625

Strand: Direct

Name: fadH [C]

Synonym: Ppro_0778

Alternate gene names: 118579216

Gene position: 826465-827625 (Clockwise)

Preceding gene: 118579215

Following gene: 118579218

Centisome position: 20.62

GC content: 63.39

Gene sequence:

>1161_bases
ATGATGGGCCAGGTGGAGGAAACCAGTCACACAATCCGAATGGAGGATTCAGGCATGGCGAAACTTTTTGAAAAGAGCGT
TATCAAATCCATGGAGCTTGACAACCGCTTCGTCCGTTCCGCAACCTGGGAAGGAATGGCGGGAACGGATGGCTCCTGTA
CCCAGCCGCTGATCGACCAGACAGCCGCTCTTGCCGAAGGAGGGGTGGGGCTGATCATCACCGGTCACGCCTTTGTCAGC
CCGGAGGGGCAGGCCGGGCCGTGGCAGATCGGGGTGCACCGTGATGATCTGCTGCCAGGCCTGACCTGCATGGCCGATGC
CGTGCACCGGGCAGGCGGGAAAATCGCCCTGCAGATCGCCCATGCAGGATGCTACGGCTTTGCCTCCGGAACCGGCATTG
AGGCGGTCGGCCCCTCGTGCGGCATTCCGGACAAGACCCCCCCTTGTCGGGAACTCACTCGGGAAGAGATCGGCGTTATC
CGGGCCGCCTTCGGCAGGGCAGCCGGCCGGGCCAAGTCGGCCGGTTTCGACGCAGTCCAGATCCATGCCGCTCACGGCTA
TCTGCTGAGTGAATTCCTCTCCCCCTTCTTTAACCGGCGCAACGACGAGTACGGAGGCCCGGTGGAGAACCGGGCTCGCA
TCGTTCTGGAGGTCCTGGAGAGCGTCAGGCAGGAGGTGGGTGACGACTATCCGGTGCTGATCAAGCTCAATTCCCAGGAC
TTCATCGACGGCGGTCTCTCGGTGGATGACATGCTTGTCGTTGCCGTCCTTCTGGAGAAGGGGGGAGTGGATGCCATCGA
GATGAGCGGTGGCACCATCTACGCCTCGGGCGAGCTCTCGGCCATCCGCACCGGCGTGCTGGCCACACCCGAAGAGGAGG
TCTACTACCGGGATGCGGCGTTGCGTTTTAAACAAGAGATTGCTGTCCCGCTGATGCTGGTGGGAGGGGTCCGCTCCCTG
GAGGTTGCCGAGGCCCTGGTGGAGGACGGCGTCACTGACTACGTATCCCTCTGCCGCCCCCTGATCCGGGAACCGGGGCT
GGTCAATCGCTGGCGCTCCGGTGACCGGCGCAAGGCGGGCTGCCTTTCGGAAAACGCCTGCTTCGGGCCGCTGATGAAGG
GAGAGGGGCTGGTCTGCCCGCTGAAAAGGGGGGAGTCGTAG

Upstream 100 bases:

>100_bases
TCCCGGCCGGTCACAGCGTCCAGGGGGCGCTCATGTACGGCTTTCCCCTGTACCGCTACCAGCGTATTCCGTCGCGCCAG
GCAGCCAGGGTGGTGTGGAG

Downstream 100 bases:

>100_bases
GAGAGTCTGACCTCGAATAAAAAGAACCTTGCCCGTTCGGGCGAAAGCTGGCCGGTTTCTCCGCGAAACCGGCCAGTTCC
GTTCCTGGGTCAGGGGATTG

Product: NADH:flavin oxidoreductase/NADH oxidase

Products: trans-transtetradehydroacyl-CoA; NADPH [C]

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MMGQVEETSHTIRMEDSGMAKLFEKSVIKSMELDNRFVRSATWEGMAGTDGSCTQPLIDQTAALAEGGVGLIITGHAFVS
PEGQAGPWQIGVHRDDLLPGLTCMADAVHRAGGKIALQIAHAGCYGFASGTGIEAVGPSCGIPDKTPPCRELTREEIGVI
RAAFGRAAGRAKSAGFDAVQIHAAHGYLLSEFLSPFFNRRNDEYGGPVENRARIVLEVLESVRQEVGDDYPVLIKLNSQD
FIDGGLSVDDMLVVAVLLEKGGVDAIEMSGGTIYASGELSAIRTGVLATPEEEVYYRDAALRFKQEIAVPLMLVGGVRSL
EVAEALVEDGVTDYVSLCRPLIREPGLVNRWRSGDRRKAGCLSENACFGPLMKGEGLVCPLKRGES

Sequences:

>Translated_386_residues
MMGQVEETSHTIRMEDSGMAKLFEKSVIKSMELDNRFVRSATWEGMAGTDGSCTQPLIDQTAALAEGGVGLIITGHAFVS
PEGQAGPWQIGVHRDDLLPGLTCMADAVHRAGGKIALQIAHAGCYGFASGTGIEAVGPSCGIPDKTPPCRELTREEIGVI
RAAFGRAAGRAKSAGFDAVQIHAAHGYLLSEFLSPFFNRRNDEYGGPVENRARIVLEVLESVRQEVGDDYPVLIKLNSQD
FIDGGLSVDDMLVVAVLLEKGGVDAIEMSGGTIYASGELSAIRTGVLATPEEEVYYRDAALRFKQEIAVPLMLVGGVRSL
EVAEALVEDGVTDYVSLCRPLIREPGLVNRWRSGDRRKAGCLSENACFGPLMKGEGLVCPLKRGES
>Mature_386_residues
MMGQVEETSHTIRMEDSGMAKLFEKSVIKSMELDNRFVRSATWEGMAGTDGSCTQPLIDQTAALAEGGVGLIITGHAFVS
PEGQAGPWQIGVHRDDLLPGLTCMADAVHRAGGKIALQIAHAGCYGFASGTGIEAVGPSCGIPDKTPPCRELTREEIGVI
RAAFGRAAGRAKSAGFDAVQIHAAHGYLLSEFLSPFFNRRNDEYGGPVENRARIVLEVLESVRQEVGDDYPVLIKLNSQD
FIDGGLSVDDMLVVAVLLEKGGVDAIEMSGGTIYASGELSAIRTGVLATPEEEVYYRDAALRFKQEIAVPLMLVGGVRSL
EVAEALVEDGVTDYVSLCRPLIREPGLVNRWRSGDRRKAGCLSENACFGPLMKGEGLVCPLKRGES

Specific function: Reduces a range of alternative electron acceptors [H]

COG id: COG1902

COG function: function code C; NADH:flavin oxidoreductases, Old Yellow Enzyme family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1789463, Length=324, Percent_Identity=30.2469135802469, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1787939, Length=302, Percent_Identity=32.1192052980132, Blast_Score=112, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17565138, Length=340, Percent_Identity=30.8823529411765, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17559802, Length=342, Percent_Identity=30.7017543859649, Blast_Score=128, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17540738, Length=355, Percent_Identity=30.4225352112676, Blast_Score=127, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI72001454, Length=349, Percent_Identity=29.7994269340974, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17559804, Length=340, Percent_Identity=29.4117647058824, Blast_Score=118, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17564188, Length=340, Percent_Identity=29.1176470588235, Blast_Score=117, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI17566914, Length=254, Percent_Identity=31.496062992126, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17566916, Length=302, Percent_Identity=25.4966887417219, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321973, Length=170, Percent_Identity=31.1764705882353, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6325086, Length=170, Percent_Identity=29.4117647058824, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013027
- InterPro:   IPR016040
- InterPro:   IPR001155
- InterPro:   IPR001327
- InterPro:   IPR000103 [H]

Pfam domain/function: PF00724 Oxidored_FMN; PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: 1.3.1.34 [C]

Molecular weight: Translated: 41270; Mature: 41270

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMGQVEETSHTIRMEDSGMAKLFEKSVIKSMELDNRFVRSATWEGMAGTDGSCTQPLIDQ
CCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
TAALAEGGVGLIITGHAFVSPEGQAGPWQIGVHRDDLLPGLTCMADAVHRAGGKIALQIA
HHHHHCCCEEEEEECCEEECCCCCCCCEEECCCHHHHCCHHHHHHHHHHHCCCEEEEEEE
HAGCYGFASGTGIEAVGPSCGIPDKTPPCRELTREEIGVIRAAFGRAAGRAKSAGFDAVQ
ECCCEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
IHAAHGYLLSEFLSPFFNRRNDEYGGPVENRARIVLEVLESVRQEVGDDYPVLIKLNSQD
EEEHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCC
FIDGGLSVDDMLVVAVLLEKGGVDAIEMSGGTIYASGELSAIRTGVLATPEEEVYYRDAA
CCCCCCCHHHHHHHHHHHHCCCCCEEEECCCEEEECCCHHHHHHCCCCCCHHHHHHHHHH
LRFKQEIAVPLMLVGGVRSLEVAEALVEDGVTDYVSLCRPLIREPGLVNRWRSGDRRKAG
HHHHHHHCCHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHCCCCCCCCC
CLSENACFGPLMKGEGLVCPLKRGES
CCCCCCCCCCCCCCCCCEECCCCCCC
>Mature Secondary Structure
MMGQVEETSHTIRMEDSGMAKLFEKSVIKSMELDNRFVRSATWEGMAGTDGSCTQPLIDQ
CCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
TAALAEGGVGLIITGHAFVSPEGQAGPWQIGVHRDDLLPGLTCMADAVHRAGGKIALQIA
HHHHHCCCEEEEEECCEEECCCCCCCCEEECCCHHHHCCHHHHHHHHHHHCCCEEEEEEE
HAGCYGFASGTGIEAVGPSCGIPDKTPPCRELTREEIGVIRAAFGRAAGRAKSAGFDAVQ
ECCCEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
IHAAHGYLLSEFLSPFFNRRNDEYGGPVENRARIVLEVLESVRQEVGDDYPVLIKLNSQD
EEEHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCC
FIDGGLSVDDMLVVAVLLEKGGVDAIEMSGGTIYASGELSAIRTGVLATPEEEVYYRDAA
CCCCCCCHHHHHHHHHHHHCCCCCEEEECCCEEEECCCHHHHHHCCCCCCHHHHHHHHHH
LRFKQEIAVPLMLVGGVRSLEVAEALVEDGVTDYVSLCRPLIREPGLVNRWRSGDRRKAG
HHHHHHHCCHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHCCCCCCCCC
CLSENACFGPLMKGEGLVCPLKRGES
CCCCCCCCCCCCCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: FAD. [C]

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: transDidehydroacyl-CoA; NADP+ [C]

Specific reaction: transDidehydroacyl-CoA + NADP+ =trans-transtetradehydroacyl-CoA + NADPH [C]

General reaction: Redox reaction [C]

Inhibitor: Iodoacetic acid; N-Ethyl maleimide [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8357835 [H]