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The map label for this gene is prs [H]

Identifier: 118579181

GI number: 118579181

Start: 783995

End: 784939

Strand: Direct

Name: prs [H]

Synonym: Ppro_0743

Alternate gene names: 118579181

Gene position: 783995-784939 (Clockwise)

Preceding gene: 118579180

Following gene: 118579182

Centisome position: 19.56

GC content: 60.0

Gene sequence:

>945_bases
ATGCAGGATAAGATCAGGGTTTTCAGCGGTAACTCAAATCAGAAACTGGCAATCAGCATCTGCGCAAGCCTCGGCGTCAA
ACTTGGCGCAGCACGGGTGCGCAACTTCTCCGACGGCGAGATCATGGTCGAAATTGGAGAAAATGTTCGCGGCCGCGATG
TTTACATCATCCAGTCCACTTGCGCGCCAACCAACAGCAATCTGATGGAGTTGCTGATCATGGCCGATGCCCTCAAGCGG
GCTTCGGCTGCCACCATCACCGCGGTGATCCCCTATTACGGCTATGCCCGCCAGGATCGCAAGGCCGCGCCGCGCACCCC
CATTACCGCCAAGCTGGTGGCTGACCTGATCACCACATCCGGTGTCGACCGGGTCGTGACCATCGACCTGCATGCCGGCC
AGATCCAGGGTTTCTTCAATATTCCGGTGGACAACCTCTACGCCGCCCCGGTCATACTCAGCTACCTGAAGAGCCGCTTC
GAGGGGCAGCCGGTTGTCATGGTCTCGCCCGATGCCGGCGGCACCGAGCGCGCCCGGGCATTCGCCAAGCGTCTGGGATG
TACCCTGGCGGTCATCGACAAGCGCCGCACCGGACCCAACGTGGCCGAGATCATGCACCTGATCGGCGATGTGCGCGACA
AGGTCGCCATCATCCTGGATGACATGGTTGACACTGCCGGCACCCTGACCCAGGGCGCCAAAGCGCTCAAGGAGAACGGC
GCCAAGGCCATCTATGCCTGCGCGACCCACGGGGTGCTCTCCGGCCCCGCCATCGAGCGGATAAATAATTCGGATATCGA
GGAAATTGTTCTTACCGACACCATTCCGCTGGGCGAAAGGCAGGAGCAGACCGACAAGGTCAAGATTCTCTCCGTGGCCG
ATCTGCTGGCTGAGGCCATCAAGCGCATTCACCAGGATGAATCGGTCAGTTCGCTCTTCGTATAA

Upstream 100 bases:

>100_bases
CTGTGAAAGATGTTGCTTTTTTTTGCCTGTTTTAGTATAGCTCTCATTTGCTTTTTTATGATTTATCAGATTATTAGCCG
GGTGAAAGGTAGGCAGAATC

Downstream 100 bases:

>100_bases
CCCCCCAGTCCGCACCGGGCGGATTGGCTTGCCACGATTTGACGGAGTTGACAATACAACGAGTAGGTGGGGATGCCCAC
CACTAACAGTGGAGGAAGGT

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MQDKIRVFSGNSNQKLAISICASLGVKLGAARVRNFSDGEIMVEIGENVRGRDVYIIQSTCAPTNSNLMELLIMADALKR
ASAATITAVIPYYGYARQDRKAAPRTPITAKLVADLITTSGVDRVVTIDLHAGQIQGFFNIPVDNLYAAPVILSYLKSRF
EGQPVVMVSPDAGGTERARAFAKRLGCTLAVIDKRRTGPNVAEIMHLIGDVRDKVAIILDDMVDTAGTLTQGAKALKENG
AKAIYACATHGVLSGPAIERINNSDIEEIVLTDTIPLGERQEQTDKVKILSVADLLAEAIKRIHQDESVSSLFV

Sequences:

>Translated_314_residues
MQDKIRVFSGNSNQKLAISICASLGVKLGAARVRNFSDGEIMVEIGENVRGRDVYIIQSTCAPTNSNLMELLIMADALKR
ASAATITAVIPYYGYARQDRKAAPRTPITAKLVADLITTSGVDRVVTIDLHAGQIQGFFNIPVDNLYAAPVILSYLKSRF
EGQPVVMVSPDAGGTERARAFAKRLGCTLAVIDKRRTGPNVAEIMHLIGDVRDKVAIILDDMVDTAGTLTQGAKALKENG
AKAIYACATHGVLSGPAIERINNSDIEEIVLTDTIPLGERQEQTDKVKILSVADLLAEAIKRIHQDESVSSLFV
>Mature_314_residues
MQDKIRVFSGNSNQKLAISICASLGVKLGAARVRNFSDGEIMVEIGENVRGRDVYIIQSTCAPTNSNLMELLIMADALKR
ASAATITAVIPYYGYARQDRKAAPRTPITAKLVADLITTSGVDRVVTIDLHAGQIQGFFNIPVDNLYAAPVILSYLKSRF
EGQPVVMVSPDAGGTERARAFAKRLGCTLAVIDKRRTGPNVAEIMHLIGDVRDKVAIILDDMVDTAGTLTQGAKALKENG
AKAIYACATHGVLSGPAIERINNSDIEEIVLTDTIPLGERQEQTDKVKILSVADLLAEAIKRIHQDESVSSLFV

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=310, Percent_Identity=50.6451612903226, Blast_Score=326, Evalue=2e-89,
Organism=Homo sapiens, GI4506129, Length=310, Percent_Identity=50.3225806451613, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI84875539, Length=313, Percent_Identity=49.8402555910543, Blast_Score=318, Evalue=5e-87,
Organism=Homo sapiens, GI28557709, Length=310, Percent_Identity=49.0322580645161, Blast_Score=313, Evalue=1e-85,
Organism=Homo sapiens, GI194018537, Length=344, Percent_Identity=39.5348837209302, Blast_Score=212, Evalue=3e-55,
Organism=Homo sapiens, GI4506133, Length=342, Percent_Identity=38.5964912280702, Blast_Score=207, Evalue=8e-54,
Organism=Homo sapiens, GI310128524, Length=147, Percent_Identity=33.3333333333333, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI310115209, Length=147, Percent_Identity=33.3333333333333, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI310118259, Length=147, Percent_Identity=33.3333333333333, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI310119946, Length=147, Percent_Identity=33.3333333333333, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1787458, Length=311, Percent_Identity=54.0192926045016, Blast_Score=338, Evalue=4e-94,
Organism=Caenorhabditis elegans, GI25149168, Length=310, Percent_Identity=50.3225806451613, Blast_Score=312, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI17554702, Length=310, Percent_Identity=50.3225806451613, Blast_Score=312, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI71989924, Length=310, Percent_Identity=50.3225806451613, Blast_Score=311, Evalue=3e-85,
Organism=Caenorhabditis elegans, GI17554704, Length=308, Percent_Identity=50.3246753246753, Blast_Score=310, Evalue=6e-85,
Organism=Caenorhabditis elegans, GI17570245, Length=335, Percent_Identity=35.2238805970149, Blast_Score=203, Evalue=9e-53,
Organism=Saccharomyces cerevisiae, GI6321776, Length=312, Percent_Identity=46.7948717948718, Blast_Score=292, Evalue=5e-80,
Organism=Saccharomyces cerevisiae, GI6319403, Length=316, Percent_Identity=46.8354430379747, Blast_Score=273, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6320946, Length=313, Percent_Identity=46.3258785942492, Blast_Score=272, Evalue=5e-74,
Organism=Saccharomyces cerevisiae, GI6322667, Length=197, Percent_Identity=41.6243654822335, Blast_Score=163, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6324511, Length=113, Percent_Identity=46.9026548672566, Blast_Score=107, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21355239, Length=310, Percent_Identity=50.9677419354839, Blast_Score=315, Evalue=2e-86,
Organism=Drosophila melanogaster, GI45551540, Length=333, Percent_Identity=47.4474474474475, Blast_Score=302, Evalue=2e-82,
Organism=Drosophila melanogaster, GI24651458, Length=353, Percent_Identity=38.2436260623229, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24651456, Length=353, Percent_Identity=38.2436260623229, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI281362873, Length=353, Percent_Identity=38.2436260623229, Blast_Score=228, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24651454, Length=353, Percent_Identity=38.2436260623229, Blast_Score=228, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24651462, Length=372, Percent_Identity=36.2903225806452, Blast_Score=220, Evalue=8e-58,
Organism=Drosophila melanogaster, GI24651464, Length=372, Percent_Identity=36.2903225806452, Blast_Score=220, Evalue=8e-58,
Organism=Drosophila melanogaster, GI45552010, Length=372, Percent_Identity=36.2903225806452, Blast_Score=220, Evalue=8e-58,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 33832; Mature: 33832

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDKIRVFSGNSNQKLAISICASLGVKLGAARVRNFSDGEIMVEIGENVRGRDVYIIQST
CCCCEEEEECCCCCEEEEEEHHHHCHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEECC
CAPTNSNLMELLIMADALKRASAATITAVIPYYGYARQDRKAAPRTPITAKLVADLITTS
CCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
GVDRVVTIDLHAGQIQGFFNIPVDNLYAAPVILSYLKSRFEGQPVVMVSPDAGGTERARA
CCCEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHH
FAKRLGCTLAVIDKRRTGPNVAEIMHLIGDVRDKVAIILDDMVDTAGTLTQGAKALKENG
HHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AKAIYACATHGVLSGPAIERINNSDIEEIVLTDTIPLGERQEQTDKVKILSVADLLAEAI
CCEEEEEECCCCCCCHHHHHCCCCCHHHEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHH
KRIHQDESVSSLFV
HHHHCCCCHHHHCC
>Mature Secondary Structure
MQDKIRVFSGNSNQKLAISICASLGVKLGAARVRNFSDGEIMVEIGENVRGRDVYIIQST
CCCCEEEEECCCCCEEEEEEHHHHCHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEECC
CAPTNSNLMELLIMADALKRASAATITAVIPYYGYARQDRKAAPRTPITAKLVADLITTS
CCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
GVDRVVTIDLHAGQIQGFFNIPVDNLYAAPVILSYLKSRFEGQPVVMVSPDAGGTERARA
CCCEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHH
FAKRLGCTLAVIDKRRTGPNVAEIMHLIGDVRDKVAIILDDMVDTAGTLTQGAKALKENG
HHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AKAIYACATHGVLSGPAIERINNSDIEEIVLTDTIPLGERQEQTDKVKILSVADLLAEAI
CCEEEEEECCCCCCCHHHHHCCCCCHHHEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHH
KRIHQDESVSSLFV
HHHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA