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The map label for this gene is nuoL [H]

Identifier: 118579078

GI number: 118579078

Start: 674011

End: 675930

Strand: Direct

Name: nuoL [H]

Synonym: Ppro_0639

Alternate gene names: 118579078

Gene position: 674011-675930 (Clockwise)

Preceding gene: 118579077

Following gene: 118579079

Centisome position: 16.82

GC content: 61.98

Gene sequence:

>1920_bases
ATGATCAAACTGACGCTCATACCGCTCCTGCCGTTGTTGGGCTTTTTGTTCAACGGCCTCTTCGGCAACCGTCTTCCCCG
CTGGGTGGTCTCCACCATCGCCTGCGGGCTGCCTGCGCTCTCCTTCCTGGTCACGCTGGTCCTGTACAGTAGCCTCGTCG
CCACGGGCCAGCCCATAGCCGAGACCCTCTACACCTGGGTGGCCCTGGATCCGCTCAACGTGGACGTGGCCTTCTACCTG
GACCAGGCCTCCGCCGTCATGTGCCTGGTGGTCACCGGGGTCGGTACCCTGATCCACCTGTACTCCGTGGGCTACATGTC
CCATGACGAAGACCAGCCGCGCTACTTCGCGTACCTGAACCTGTTTTTGTTCTTCATGCTCATGCTGGTCCTGGGCAAGA
ACATGATCATGCTCTTCGCCGGCTGGGAAGGGGTGGGTCTGGCCTCCTACCTGCTCATCGGCTTCTGGTACCAGGACGAC
GAGAAATCCGCCGCCGGCATGAAAGCCTTCATCGTCAACCGCGTAGGCGACACCGGCTTTGTCCTGGCCGCGCTTCTGAT
CTTCTCCTACTCCCACACCCTTGACTTCCAGGGGATAAACGCCTACTTCGGTACGGCCGGGCTTCCGGTCTCCACCATGA
ACCTGATCGGGATCCTGCTCTTGATCGGCGCCTGCGGCAAATCGGCCCAGATTCCGCTCCATGTCTGGCTGCCCGACGCC
ATGGCCGGCCCCACCCCGGTCTCGGCCCTGATCCACGCCGCCACCATGGTCACCGCCGGCGTGTATCTCCTCTCCCGCAT
GAACGGTGTCCTCTTGCAGGCCCCCGGCGCCATGCAGGTCGTCATGTGGGGCGGGGCACTCACCGCCTTTGTGGGCGCCA
CCATGGGTCTCACCCAGTACAACCTGAAGAAAGTGCTGGCCTACTCCACCATGAGCCAGATCGGCTACATGTTCATGGCC
TGCGGCCTGGGCTCCTTCTCCGCCGCCATGTTCCACCTGTACAGCCATGCCTTCTTCAAAGCCTGCCTGTTCCTCGGCGC
CGGCGCCGTCCTGCACGCCCTGCACGGCGAAGAAGACATGAGGAAAATGGGCGGCCTGGCCAAGAAGATGCCCCTCACCT
TTGTCACCTTCCTGGCGGGCAGCCTGGCCCTGTGCGGCGTGCCCCCCTTTGCCGGCTTCTTCTCCAAGGACGAGATCCTC
TGGAGCGCCTTTGCCTCGGCCCACGGCGGCTCCACCGCCCTGTGGCTGGTGGGCGCAGTCGCCGCCGGCATGACCTCCTT
CTACATGTTCCGGGCCATCATCATGACCTTCTTTGGTCAAGACAACGTGCCCGCGAAACTGAAACACGGCATCCACGAGC
CCCCCTTCAGCATGGCCATCGTCCTGATCATCTTAGGCGTAAGCTCCGTCGCTGCCGGCTTCATCGGCCTGCCCCAGGTA
CTGGCCGACAAGTTTGGCTTCGGCTCCCCCTTCTTCAGCTTCCTTGAACCGGTCTTCGGTCACCACGCCCTGAAAGCGGG
CGTCACCCACCAGACCGAACTCATGTTCATGGGTATCTCCATCGCCATCGCCCTGGGCGGCATCTTCCTGGCATGGGTCT
TCTACGGCCTGAACCCGGCCCTGCCCGAAGCCATCAAGAAGAAAGCCGGCTGCATCTACACTACCATCAGCCAGGGATAC
TACTTCGACGCCATCTACGAGAAAGTCATCGTCAAATCCCTGGACACGCTATCGGACTCAGTACTCTACAACATAGCGGA
GAAACTCTTGAACTACGTCACCATCGTCAAAGCAGGAGCCACAGCGCGCTACAGCGCCAACCTCCTCTCCCGCATGCAGA
GCGGCAACGTCCAGGCCTATGTGCTCTACGCCCTGGCCGGGCTGGCCCTGATCATCTGGTGGGGGGTGGCCAATGCCTAG

Upstream 100 bases:

>100_bases
ATCCTGCGAAATCGCCCTGGCCATGGCCATCGTCGTACTGCTTGTCAAACGCCGCGGTTCACTGGATCTGGGCGCACACC
AGGAACTGAAAGGGTAGGCA

Downstream 100 bases:

>100_bases
CAACGGTCTTCTAATCCTCGCCCTGTTCTGCCTGCCGCTGGTGGGCGCCCTGGCCGTACCGTTTCTGCCCGCAAGCGAAA
ACGGTAAAATCGCCCGCATG

Product: proton-translocating NADH-quinone oxidoreductase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 639; Mature: 639

Protein sequence:

>639_residues
MIKLTLIPLLPLLGFLFNGLFGNRLPRWVVSTIACGLPALSFLVTLVLYSSLVATGQPIAETLYTWVALDPLNVDVAFYL
DQASAVMCLVVTGVGTLIHLYSVGYMSHDEDQPRYFAYLNLFLFFMLMLVLGKNMIMLFAGWEGVGLASYLLIGFWYQDD
EKSAAGMKAFIVNRVGDTGFVLAALLIFSYSHTLDFQGINAYFGTAGLPVSTMNLIGILLLIGACGKSAQIPLHVWLPDA
MAGPTPVSALIHAATMVTAGVYLLSRMNGVLLQAPGAMQVVMWGGALTAFVGATMGLTQYNLKKVLAYSTMSQIGYMFMA
CGLGSFSAAMFHLYSHAFFKACLFLGAGAVLHALHGEEDMRKMGGLAKKMPLTFVTFLAGSLALCGVPPFAGFFSKDEIL
WSAFASAHGGSTALWLVGAVAAGMTSFYMFRAIIMTFFGQDNVPAKLKHGIHEPPFSMAIVLIILGVSSVAAGFIGLPQV
LADKFGFGSPFFSFLEPVFGHHALKAGVTHQTELMFMGISIAIALGGIFLAWVFYGLNPALPEAIKKKAGCIYTTISQGY
YFDAIYEKVIVKSLDTLSDSVLYNIAEKLLNYVTIVKAGATARYSANLLSRMQSGNVQAYVLYALAGLALIIWWGVANA

Sequences:

>Translated_639_residues
MIKLTLIPLLPLLGFLFNGLFGNRLPRWVVSTIACGLPALSFLVTLVLYSSLVATGQPIAETLYTWVALDPLNVDVAFYL
DQASAVMCLVVTGVGTLIHLYSVGYMSHDEDQPRYFAYLNLFLFFMLMLVLGKNMIMLFAGWEGVGLASYLLIGFWYQDD
EKSAAGMKAFIVNRVGDTGFVLAALLIFSYSHTLDFQGINAYFGTAGLPVSTMNLIGILLLIGACGKSAQIPLHVWLPDA
MAGPTPVSALIHAATMVTAGVYLLSRMNGVLLQAPGAMQVVMWGGALTAFVGATMGLTQYNLKKVLAYSTMSQIGYMFMA
CGLGSFSAAMFHLYSHAFFKACLFLGAGAVLHALHGEEDMRKMGGLAKKMPLTFVTFLAGSLALCGVPPFAGFFSKDEIL
WSAFASAHGGSTALWLVGAVAAGMTSFYMFRAIIMTFFGQDNVPAKLKHGIHEPPFSMAIVLIILGVSSVAAGFIGLPQV
LADKFGFGSPFFSFLEPVFGHHALKAGVTHQTELMFMGISIAIALGGIFLAWVFYGLNPALPEAIKKKAGCIYTTISQGY
YFDAIYEKVIVKSLDTLSDSVLYNIAEKLLNYVTIVKAGATARYSANLLSRMQSGNVQAYVLYALAGLALIIWWGVANA
>Mature_639_residues
MIKLTLIPLLPLLGFLFNGLFGNRLPRWVVSTIACGLPALSFLVTLVLYSSLVATGQPIAETLYTWVALDPLNVDVAFYL
DQASAVMCLVVTGVGTLIHLYSVGYMSHDEDQPRYFAYLNLFLFFMLMLVLGKNMIMLFAGWEGVGLASYLLIGFWYQDD
EKSAAGMKAFIVNRVGDTGFVLAALLIFSYSHTLDFQGINAYFGTAGLPVSTMNLIGILLLIGACGKSAQIPLHVWLPDA
MAGPTPVSALIHAATMVTAGVYLLSRMNGVLLQAPGAMQVVMWGGALTAFVGATMGLTQYNLKKVLAYSTMSQIGYMFMA
CGLGSFSAAMFHLYSHAFFKACLFLGAGAVLHALHGEEDMRKMGGLAKKMPLTFVTFLAGSLALCGVPPFAGFFSKDEIL
WSAFASAHGGSTALWLVGAVAAGMTSFYMFRAIIMTFFGQDNVPAKLKHGIHEPPFSMAIVLIILGVSSVAAGFIGLPQV
LADKFGFGSPFFSFLEPVFGHHALKAGVTHQTELMFMGISIAIALGGIFLAWVFYGLNPALPEAIKKKAGCIYTTISQGY
YFDAIYEKVIVKSLDTLSDSVLYNIAEKLLNYVTIVKAGATARYSANLLSRMQSGNVQAYVLYALAGLALIIWWGVANA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=483, Percent_Identity=36.0248447204969, Blast_Score=277, Evalue=2e-74,
Organism=Escherichia coli, GI1788614, Length=583, Percent_Identity=42.0240137221269, Blast_Score=369, Evalue=1e-103,
Organism=Escherichia coli, GI1788829, Length=432, Percent_Identity=34.0277777777778, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI1788831, Length=336, Percent_Identity=33.0357142857143, Blast_Score=145, Evalue=1e-35,
Organism=Escherichia coli, GI1788827, Length=373, Percent_Identity=32.4396782841823, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI2367154, Length=410, Percent_Identity=25.3658536585366, Blast_Score=102, Evalue=1e-22,
Organism=Escherichia coli, GI1788613, Length=403, Percent_Identity=26.5508684863524, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI145693160, Length=340, Percent_Identity=25.2941176470588, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 68759; Mature: 68759

Theoretical pI: Translated: 8.06; Mature: 8.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKLTLIPLLPLLGFLFNGLFGNRLPRWVVSTIACGLPALSFLVTLVLYSSLVATGQPIA
CEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
ETLYTWVALDPLNVDVAFYLDQASAVMCLVVTGVGTLIHLYSVGYMSHDEDQPRYFAYLN
HHHHHHHEECCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
LFLFFMLMLVLGKNMIMLFAGWEGVGLASYLLIGFWYQDDEKSAAGMKAFIVNRVGDTGF
HHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHEEECCCCCCCCHHHHHHHHCCCHHH
VLAALLIFSYSHTLDFQGINAYFGTAGLPVSTMNLIGILLLIGACGKSAQIPLHVWLPDA
HHHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCC
MAGPTPVSALIHAATMVTAGVYLLSRMNGVLLQAPGAMQVVMWGGALTAFVGATMGLTQY
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEECHHHHHHHHHHHCHHHH
NLKKVLAYSTMSQIGYMFMACGLGSFSAAMFHLYSHAFFKACLFLGAGAVLHALHGEEDM
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
RKMGGLAKKMPLTFVTFLAGSLALCGVPPFAGFFSKDEILWSAFASAHGGSTALWLVGAV
HHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHH
AAGMTSFYMFRAIIMTFFGQDNVPAKLKHGIHEPPFSMAIVLIILGVSSVAAGFIGLPQV
HHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHH
LADKFGFGSPFFSFLEPVFGHHALKAGVTHQTELMFMGISIAIALGGIFLAWVFYGLNPA
HHHHCCCCCHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LPEAIKKKAGCIYTTISQGYYFDAIYEKVIVKSLDTLSDSVLYNIAEKLLNYVTIVKAGA
HHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TARYSANLLSRMQSGNVQAYVLYALAGLALIIWWGVANA
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIKLTLIPLLPLLGFLFNGLFGNRLPRWVVSTIACGLPALSFLVTLVLYSSLVATGQPIA
CEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
ETLYTWVALDPLNVDVAFYLDQASAVMCLVVTGVGTLIHLYSVGYMSHDEDQPRYFAYLN
HHHHHHHEECCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
LFLFFMLMLVLGKNMIMLFAGWEGVGLASYLLIGFWYQDDEKSAAGMKAFIVNRVGDTGF
HHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHEEECCCCCCCCHHHHHHHHCCCHHH
VLAALLIFSYSHTLDFQGINAYFGTAGLPVSTMNLIGILLLIGACGKSAQIPLHVWLPDA
HHHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCC
MAGPTPVSALIHAATMVTAGVYLLSRMNGVLLQAPGAMQVVMWGGALTAFVGATMGLTQY
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEECHHHHHHHHHHHCHHHH
NLKKVLAYSTMSQIGYMFMACGLGSFSAAMFHLYSHAFFKACLFLGAGAVLHALHGEEDM
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
RKMGGLAKKMPLTFVTFLAGSLALCGVPPFAGFFSKDEILWSAFASAHGGSTALWLVGAV
HHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHH
AAGMTSFYMFRAIIMTFFGQDNVPAKLKHGIHEPPFSMAIVLIILGVSSVAAGFIGLPQV
HHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHH
LADKFGFGSPFFSFLEPVFGHHALKAGVTHQTELMFMGISIAIALGGIFLAWVFYGLNPA
HHHHCCCCCHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LPEAIKKKAGCIYTTISQGYYFDAIYEKVIVKSLDTLSDSVLYNIAEKLLNYVTIVKAGA
HHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TARYSANLLSRMQSGNVQAYVLYALAGLALIIWWGVANA
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]