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The map label for this gene is hemE

Identifier: 118579058

GI number: 118579058

Start: 656108

End: 657130

Strand: Direct

Name: hemE

Synonym: Ppro_0619

Alternate gene names: 118579058

Gene position: 656108-657130 (Clockwise)

Preceding gene: 118579057

Following gene: 118579059

Centisome position: 16.37

GC content: 63.54

Gene sequence:

>1023_bases
ATGAACACACGTTTTCTCGATGCCTGCTGGGGTAAGCCGGTGGACCGGGTGCCGGTCTGGCTGATGCGCCAGGCTGGGCG
TTACCTTCCGGAGTACATGGCCGTGCGCTCCCGCTGCACCTTCCTGGAACTGTGCAAGACCCCAGAACTGGCCGCGCAGG
TCAGCCTCCAGCCGGTGGACATCCTGGGAGTCGATGCCGCCATCCTCTTCTCCGATATCCTGACGCCGGTGGAACCCATG
GGGATGAAACTGGATTTCGTGCCGGGACCGGTCTTCGAGAAACCGGTGCGCTGCATGGCCGACGTTGAGCGGCTGCGCAT
TCCCCGCATGGAAGACGATCTCCCCTTTGTCTTCGACATCATCAGAATCCTGCGTCGGGAACTGGCCGACAGGGTGCCGC
TGATCGGGTTCGGCGGGGCACCCTTCACCCTGGCCTGCTACATGGTGGAGGGGAAGGGCTCCAAGGACTTTGTCCAGATC
AAGCGCATGATGTACTCCGCGCCGGACGTCTACGCGGCGTTGATGGAAAAGATCACCACCATGAGCATGGAATACCTGAA
CGCCCAGATCGCTGCCGGCGCCCAGGCCATCCAGATCTTCGATACCTGGGGCGGCATCCTCTCGCCGTCGGACTACCGCA
CCCATGTGCTGCCCCATACCACCAGGCTGATCAACGGCCTGAACCGCCTCACAACGCCGGTGATTCACTTCGTCAAGGGG
GCCGGAACCATGCTGGAGACGGTCAGGGAGGCGGGGGGAGACGTTATCGGCCTGGACTGGCATGTCGATCTGGCAACGGC
GCGGAACCAGCTCGGCCCCGGCGTGGCGGTGCAGGGCAACCTGGACCCCACGGTGCTCTTCGCCCCCCAGGCGGTCATCG
AACAGCAGGTGCAACGGGTGCTTGATGAAAACAGGGGCCTCCCCGGCTTTATCTTCAACCTGGGGCACGGCATCCTGCCC
ACGGTCCCGGCGGAGAACGCCCGCTTCATGGTCCAGTGCGTGCAACGGCTGTCGCGATCATGA

Upstream 100 bases:

>100_bases
AGCATTGACTTTTGGGGGGGTACGGTTACAATTCCCCCCTTGAAGCGGCCGGCGCCGCGGCATGCCGGCGGGAACGGAAT
CACGAAACAGGGGAGTTGAC

Downstream 100 bases:

>100_bases
AGGTCATCAGCCGGCAACTGCTGGGCCAGGTGACGGAGCAGGCGCGTGCTTCTGCTCGTCTGCGCTTCAACCACAACCTC
CACCCCGCTGACGAATCCCG

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MNTRFLDACWGKPVDRVPVWLMRQAGRYLPEYMAVRSRCTFLELCKTPELAAQVSLQPVDILGVDAAILFSDILTPVEPM
GMKLDFVPGPVFEKPVRCMADVERLRIPRMEDDLPFVFDIIRILRRELADRVPLIGFGGAPFTLACYMVEGKGSKDFVQI
KRMMYSAPDVYAALMEKITTMSMEYLNAQIAAGAQAIQIFDTWGGILSPSDYRTHVLPHTTRLINGLNRLTTPVIHFVKG
AGTMLETVREAGGDVIGLDWHVDLATARNQLGPGVAVQGNLDPTVLFAPQAVIEQQVQRVLDENRGLPGFIFNLGHGILP
TVPAENARFMVQCVQRLSRS

Sequences:

>Translated_340_residues
MNTRFLDACWGKPVDRVPVWLMRQAGRYLPEYMAVRSRCTFLELCKTPELAAQVSLQPVDILGVDAAILFSDILTPVEPM
GMKLDFVPGPVFEKPVRCMADVERLRIPRMEDDLPFVFDIIRILRRELADRVPLIGFGGAPFTLACYMVEGKGSKDFVQI
KRMMYSAPDVYAALMEKITTMSMEYLNAQIAAGAQAIQIFDTWGGILSPSDYRTHVLPHTTRLINGLNRLTTPVIHFVKG
AGTMLETVREAGGDVIGLDWHVDLATARNQLGPGVAVQGNLDPTVLFAPQAVIEQQVQRVLDENRGLPGFIFNLGHGILP
TVPAENARFMVQCVQRLSRS
>Mature_340_residues
MNTRFLDACWGKPVDRVPVWLMRQAGRYLPEYMAVRSRCTFLELCKTPELAAQVSLQPVDILGVDAAILFSDILTPVEPM
GMKLDFVPGPVFEKPVRCMADVERLRIPRMEDDLPFVFDIIRILRRELADRVPLIGFGGAPFTLACYMVEGKGSKDFVQI
KRMMYSAPDVYAALMEKITTMSMEYLNAQIAAGAQAIQIFDTWGGILSPSDYRTHVLPHTTRLINGLNRLTTPVIHFVKG
AGTMLETVREAGGDVIGLDWHVDLATARNQLGPGVAVQGNLDPTVLFAPQAVIEQQVQRVLDENRGLPGFIFNLGHGILP
TVPAENARFMVQCVQRLSRS

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=348, Percent_Identity=41.9540229885057, Blast_Score=258, Evalue=7e-69,
Organism=Escherichia coli, GI2367337, Length=346, Percent_Identity=50.5780346820809, Blast_Score=332, Evalue=2e-92,
Organism=Saccharomyces cerevisiae, GI6320252, Length=351, Percent_Identity=35.8974358974359, Blast_Score=216, Evalue=4e-57,
Organism=Drosophila melanogaster, GI19921920, Length=344, Percent_Identity=38.953488372093, Blast_Score=238, Evalue=4e-63,
Organism=Drosophila melanogaster, GI221330099, Length=344, Percent_Identity=38.953488372093, Blast_Score=238, Evalue=4e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_PELPD (A1ALN0)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_900308.1
- ProteinModelPortal:   A1ALN0
- SMR:   A1ALN0
- STRING:   A1ALN0
- GeneID:   4572141
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_0619
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- PhylomeDB:   A1ALN0
- ProtClustDB:   PRK00115
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 37799; Mature: 37799

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 72-72 BINDING 147-147 BINDING 202-202 BINDING 316-316

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTRFLDACWGKPVDRVPVWLMRQAGRYLPEYMAVRSRCTFLELCKTPELAAQVSLQPVD
CCCCEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCC
ILGVDAAILFSDILTPVEPMGMKLDFVPGPVFEKPVRCMADVERLRIPRMEDDLPFVFDI
EECCHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
IRILRRELADRVPLIGFGGAPFTLACYMVEGKGSKDFVQIKRMMYSAPDVYAALMEKITT
HHHHHHHHHHCCCEEEECCCCEEEEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
MSMEYLNAQIAAGAQAIQIFDTWGGILSPSDYRTHVLPHTTRLINGLNRLTTPVIHFVKG
HHHHHHHHHHHCCCHHEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
AGTMLETVREAGGDVIGLDWHVDLATARNQLGPGVAVQGNLDPTVLFAPQAVIEQQVQRV
CHHHHHHHHHCCCCEEEEEEEEEHHHHHHHCCCCEEEECCCCCEEEECCHHHHHHHHHHH
LDENRGLPGFIFNLGHGILPTVPAENARFMVQCVQRLSRS
HHHCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MNTRFLDACWGKPVDRVPVWLMRQAGRYLPEYMAVRSRCTFLELCKTPELAAQVSLQPVD
CCCCEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCC
ILGVDAAILFSDILTPVEPMGMKLDFVPGPVFEKPVRCMADVERLRIPRMEDDLPFVFDI
EECCHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
IRILRRELADRVPLIGFGGAPFTLACYMVEGKGSKDFVQIKRMMYSAPDVYAALMEKITT
HHHHHHHHHHCCCEEEECCCCEEEEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
MSMEYLNAQIAAGAQAIQIFDTWGGILSPSDYRTHVLPHTTRLINGLNRLTTPVIHFVKG
HHHHHHHHHHHCCCHHEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
AGTMLETVREAGGDVIGLDWHVDLATARNQLGPGVAVQGNLDPTVLFAPQAVIEQQVQRV
CHHHHHHHHHCCCCEEEEEEEEEHHHHHHHCCCCEEEECCCCCEEEECCHHHHHHHHHHH
LDENRGLPGFIFNLGHGILPTVPAENARFMVQCVQRLSRS
HHHCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA