Definition Pelobacter propionicus DSM 2379 chromosome, complete genome.
Accession NC_008609
Length 4,008,000

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The map label for this gene is serS

Identifier: 118579055

GI number: 118579055

Start: 653431

End: 654699

Strand: Direct

Name: serS

Synonym: Ppro_0616

Alternate gene names: 118579055

Gene position: 653431-654699 (Clockwise)

Preceding gene: 118579052

Following gene: 118579056

Centisome position: 16.3

GC content: 62.49

Gene sequence:

>1269_bases
ATGCTCGACATGAAATTCATACGCGAAAATATCGATGAGACCGAGCGCCGCCTGGCCACGCGGGGCGAGTCCTGCACCCT
GGGAGGTTTTCGCGAGCTGGACCAGAAACGCCTGGCCCTGCTCAAGGAGAGCGAGGCGCTCAAGGCGCTGCGCAATTCGG
TTTCCGACGAGATAGCCCGCATCAAGGACAAGAGCCAGGCCCAGGACAAGATCCTGCAGATGCGCGAGGTCTCCCAGAAG
ATCAAGGGAATGGACGATGAGCTGAAGCAGGTGGATGAAGCCTTGCAGGGCATCCTGCTGACTGTTCCAAATCTGCCGGA
CCCTGCCACGCCGGTGGGTAAATCTGAAAACGATAACGTGGAGATAAGGAAATGGGGCACGCCGGGCAGCTACGGTTTTA
CCCCCAAACCGCACTGGGAGATCGGCGAAGAGCTGGGCATCCTGGATTTCGAGTGCGGGGCCAAGCTGACCGGAGCGCGC
TTCACCCTCTCCCGTGGCGCCGGCGCCCGCATGGAGCGGGCCCTGATCAGCTTTATGCTGGACCTGCATACCGCCAGCCA
TGGCTACCTGGAGGTGCTGCCCCCCTTCATGGTTAACCGCGACAGCATGACCGGCACCGGCCAGCTGCCCAAGTTCGAGG
AAGACCTGTTCAAGATGACCGATCCGGAGTACTTCCTGATCCCCACCGCCGAGGTGCCGGTAACCAACATCCACCGTGGC
GAGATCCTGAAGAAGAGCGACCTTCCTATCCGCTATGCCGCCTATACCCCCTGCTTCCGCCGCGAGGCCGGCTCCTACGG
CAAGGATACCCGCGGCCTGATCCGCCAGCACCAGTTCAACAAGGTGGAGCTGGTCAAGTTCTCCCACCCCTCCCAATCGG
CGGAAGAACTGGAGAAGCTGACCGCCGATGCCGAGAAGGTGCTGCAACTGCTGGAGCTTCCCTACCGGGTCATGGCGCTC
TGCAGCGCCGACATCGGCTTCTCCGCCGCCCGGACCTACGACCTGGAGGTCTGGCTGCCGGGGCAGAACTGCTACCGCGA
GATCTCCTCCTGTAGCTGCTTTGGCGATTTCCAGGCCCGCCGCGCAAACATCCGCTTCCGCGAGGAGGAGAAGTCCAAGC
CAGAGTTCGTCCACACCCTGAACGGCTCCGGTCTGGCGGTGGGACGCACCCTGGTGGCCATCCTGGAGAACTATCAGCAG
GAGGACGGCTCGGTGGTCATCCCCCAGGCCTTGCGCCCCTACATGGGTGGCCTGGAGCGGATCCAGTAG

Upstream 100 bases:

>100_bases
AGGATGATCGCTGATTTCATAGGGCTCTTTGGGATTGACGGGAGGCGTGGGCGGTGCTACTACATACACGCTTGACCATA
AAAAATAAAGGTGAATTAAG

Downstream 100 bases:

>100_bases
GTGTGTCTGTTAAGGTTTGAAAAACTGAAAAGGGTATGCTATAAGAACAGTTCCCGTGACACGGAAGGGTGGCCGAGTGG
TTTAAGGCAGCGGTCTTGAA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MLDMKFIRENIDETERRLATRGESCTLGGFRELDQKRLALLKESEALKALRNSVSDEIARIKDKSQAQDKILQMREVSQK
IKGMDDELKQVDEALQGILLTVPNLPDPATPVGKSENDNVEIRKWGTPGSYGFTPKPHWEIGEELGILDFECGAKLTGAR
FTLSRGAGARMERALISFMLDLHTASHGYLEVLPPFMVNRDSMTGTGQLPKFEEDLFKMTDPEYFLIPTAEVPVTNIHRG
EILKKSDLPIRYAAYTPCFRREAGSYGKDTRGLIRQHQFNKVELVKFSHPSQSAEELEKLTADAEKVLQLLELPYRVMAL
CSADIGFSAARTYDLEVWLPGQNCYREISSCSCFGDFQARRANIRFREEEKSKPEFVHTLNGSGLAVGRTLVAILENYQQ
EDGSVVIPQALRPYMGGLERIQ

Sequences:

>Translated_422_residues
MLDMKFIRENIDETERRLATRGESCTLGGFRELDQKRLALLKESEALKALRNSVSDEIARIKDKSQAQDKILQMREVSQK
IKGMDDELKQVDEALQGILLTVPNLPDPATPVGKSENDNVEIRKWGTPGSYGFTPKPHWEIGEELGILDFECGAKLTGAR
FTLSRGAGARMERALISFMLDLHTASHGYLEVLPPFMVNRDSMTGTGQLPKFEEDLFKMTDPEYFLIPTAEVPVTNIHRG
EILKKSDLPIRYAAYTPCFRREAGSYGKDTRGLIRQHQFNKVELVKFSHPSQSAEELEKLTADAEKVLQLLELPYRVMAL
CSADIGFSAARTYDLEVWLPGQNCYREISSCSCFGDFQARRANIRFREEEKSKPEFVHTLNGSGLAVGRTLVAILENYQQ
EDGSVVIPQALRPYMGGLERIQ
>Mature_422_residues
MLDMKFIRENIDETERRLATRGESCTLGGFRELDQKRLALLKESEALKALRNSVSDEIARIKDKSQAQDKILQMREVSQK
IKGMDDELKQVDEALQGILLTVPNLPDPATPVGKSENDNVEIRKWGTPGSYGFTPKPHWEIGEELGILDFECGAKLTGAR
FTLSRGAGARMERALISFMLDLHTASHGYLEVLPPFMVNRDSMTGTGQLPKFEEDLFKMTDPEYFLIPTAEVPVTNIHRG
EILKKSDLPIRYAAYTPCFRREAGSYGKDTRGLIRQHQFNKVELVKFSHPSQSAEELEKLTADAEKVLQLLELPYRVMAL
CSADIGFSAARTYDLEVWLPGQNCYREISSCSCFGDFQARRANIRFREEEKSKPEFVHTLNGSGLAVGRTLVAILENYQQ
EDGSVVIPQALRPYMGGLERIQ

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=333, Percent_Identity=36.9369369369369, Blast_Score=218, Evalue=7e-57,
Organism=Homo sapiens, GI8923421, Length=393, Percent_Identity=30.5343511450382, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI225579074, Length=333, Percent_Identity=33.033033033033, Blast_Score=178, Evalue=7e-45,
Organism=Escherichia coli, GI1787120, Length=429, Percent_Identity=51.5151515151515, Blast_Score=440, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17539260, Length=395, Percent_Identity=32.4050632911392, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17542084, Length=385, Percent_Identity=27.2727272727273, Blast_Score=133, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6320226, Length=374, Percent_Identity=36.096256684492, Blast_Score=235, Evalue=8e-63,
Organism=Saccharomyces cerevisiae, GI6321799, Length=399, Percent_Identity=31.077694235589, Blast_Score=199, Evalue=6e-52,
Organism=Drosophila melanogaster, GI24581334, Length=332, Percent_Identity=35.5421686746988, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI17737985, Length=371, Percent_Identity=29.1105121293801, Blast_Score=139, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_PELPD (A1ALM7)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_900305.1
- ProteinModelPortal:   A1ALM7
- SMR:   A1ALM7
- STRING:   A1ALM7
- GeneID:   4572137
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_0616
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- PhylomeDB:   A1ALM7
- ProtClustDB:   PRK05431
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 47598; Mature: 47598

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 283-283 BINDING 383-383

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MLDMKFIRENIDETERRLATRGESCTLGGFRELDQKRLALLKESEALKALRNSVSDEIAR
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IKDKSQAQDKILQMREVSQKIKGMDDELKQVDEALQGILLTVPNLPDPATPVGKSENDNV
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCE
EIRKWGTPGSYGFTPKPHWEIGEELGILDFECGAKLTGARFTLSRGAGARMERALISFML
EEEECCCCCCCCCCCCCCCCCHHHCCCEEECCCCCCCCCEEEECCCCCHHHHHHHHHHHH
DLHTASHGYLEVLPPFMVNRDSMTGTGQLPKFEEDLFKMTDPEYFLIPTAEVPVTNIHRG
HHHCCCCCHHEECCHHHCCCCCCCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCC
EILKKSDLPIRYAAYTPCFRREAGSYGKDTRGLIRQHQFNKVELVKFSHPSQSAEELEKL
CCEECCCCCEEEECCCCHHHHHCCCCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHH
TADAEKVLQLLELPYRVMALCSADIGFSAARTYDLEVWLPGQNCYREISSCSCFGDFQAR
HHHHHHHHHHHHCHHHHHHHHHCCCCCCCEEEEEEEEEECCHHHHHHHHHCCCCCCHHHH
RANIRFREEEKSKPEFVHTLNGSGLAVGRTLVAILENYQQEDGSVVIPQALRPYMGGLER
HCCCEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHHHH
IQ
CC
>Mature Secondary Structure
MLDMKFIRENIDETERRLATRGESCTLGGFRELDQKRLALLKESEALKALRNSVSDEIAR
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IKDKSQAQDKILQMREVSQKIKGMDDELKQVDEALQGILLTVPNLPDPATPVGKSENDNV
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCE
EIRKWGTPGSYGFTPKPHWEIGEELGILDFECGAKLTGARFTLSRGAGARMERALISFML
EEEECCCCCCCCCCCCCCCCCHHHCCCEEECCCCCCCCCEEEECCCCCHHHHHHHHHHHH
DLHTASHGYLEVLPPFMVNRDSMTGTGQLPKFEEDLFKMTDPEYFLIPTAEVPVTNIHRG
HHHCCCCCHHEECCHHHCCCCCCCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCC
EILKKSDLPIRYAAYTPCFRREAGSYGKDTRGLIRQHQFNKVELVKFSHPSQSAEELEKL
CCEECCCCCEEEECCCCHHHHHCCCCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHH
TADAEKVLQLLELPYRVMALCSADIGFSAARTYDLEVWLPGQNCYREISSCSCFGDFQAR
HHHHHHHHHHHHCHHHHHHHHHCCCCCCCEEEEEEEEEECCHHHHHHHHHCCCCCCHHHH
RANIRFREEEKSKPEFVHTLNGSGLAVGRTLVAILENYQQEDGSVVIPQALRPYMGGLER
HCCCEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHHHH
IQ
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA