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The map label for this gene is gabT [C]

Identifier: 118579005

GI number: 118579005

Start: 601550

End: 602836

Strand: Direct

Name: gabT [C]

Synonym: Ppro_0566

Alternate gene names: 118579005

Gene position: 601550-602836 (Clockwise)

Preceding gene: 118579004

Following gene: 118579006

Centisome position: 15.01

GC content: 69.08

Gene sequence:

>1287_bases
ATGACCACAAATGCCGAGATCGTCGCCCGCCAGGAGCGGGTCTTCACCCCTGCCCTGCACATTTACCACCCCGTTGCCAT
CGAAAACGGGGAGGGGAGCTGGGTTACCGACCGGGAGGGGAAGCGCTATCTGGACCTGGCCACCGGCATCGCCGTCCTGA
ACATCGGCCACAACCATCCCCGGGTGCGGCAGCGGGTTGCCCACCAGCTGGAGCGGTTCGTCCACACCGGCGGGATCTAC
TACAACGACACCAGCGTTGAAGCGGCGGAACTCCTCGCCTCGGTCACGCCGCCCGGTCTGGACATGGTCTTCTTCAGCAA
CGCCGGCGCCGAGGCGGTGGAGGGCGCCCTCAAGCTGGCCCGCTTCGTTACCGGCCGCCAGGGGATCATCGCCTTCAGCG
GCGCCTTCCACGGCCGTACCCTGGGGGCGGTGTCGGTCACCACCAGTTCGGCCCGCTACCGCTCCCGCTACCAGCCGCTC
CTGCCGTCGGTCTACCACGCCCCCTACCCGTACTGCTACCGCTGCCCCCTGGGGCGCCGCCCGGAGAGCTGTTCGCTGGA
CTGCTTCCGCGCCCTGGAGGAGATGCTGGAGCGGCTGATCACCCCGGCCGAGGTGGCTGCCATTCTGATCGAACCGGTCC
TGGGCGAGGGGGGCTATGCCCCGGCGCCGCCCGAGTTTCTGAGGCGGCTTCGTCGGCTCTGCGACGAACATGGTATCCTG
CTGATTTTCGACGAGGTCCAGTCGGGCATGGGTCGCACCGGCGACTGGTTCGCGGCCCAGCGCTACGACGTGACCCCGGA
TGTCATGACCGTTGCCAAGGGGATCGCCTCCGGGTTTCCCCTCTCGGCGGTGGTGGCGAAGCGACGCATCATGGAGCAGT
GGCCCTGCGGCGCCCATGGCACCACCTTCGGCGGCAACCCGGTCGCCTGCGCGGCGGCCATCGCCACCATGGAGACCATC
CGCGACGAGGGTCTCCTTCCCCGCTGCCGCGAGCTGGGGGAGCGGGCCATGGTGCGCCTGCGGGGGATGGGGGAGCGGCA
CCCGCTGATCGGCGATGTCCGGGGGATGGGGCTGATGATCGGCGTCGAACTTTTGGAGCCGGACGCCAGACCGGCGGGTG
ACGCCTGCGAGCGGCTGATGGCCTGGTGCCGCGAACGGGGGCTGCTGATCATCAACTGTGGCCCGGACCGGAACGTGCTC
CGCCTGGTGCCGCCGCTCACCATCGGTGACGACGAGCTGGAGCAGGCGCTCTCCATCATCGATGAGGGGCTGGGTGCGGT
GGCATGA

Upstream 100 bases:

>100_bases
TCCCCGGGGGGGTGCGTATGGTTTTTGATAGGAACGGCGCACGCCGGAAAGGAGGCGGCGGTCGTGACGCAGGTACCCCC
ATGCAGAAAGGAGCGACCCC

Downstream 100 bases:

>100_bases
GGCCGGTGCGGGTGATCATCATGGGGGCAGCGGGCAGGGACTTCCACAACTTTGCCTGCTGTTTCCGCGACAACCCCGCC
TACCGGGTCGTCGCCTTCAC

Product: 4-aminobutyrate aminotransferase

Products: succinate semialdehyde; L-glutamate

Alternate protein names: ORF B [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MTTNAEIVARQERVFTPALHIYHPVAIENGEGSWVTDREGKRYLDLATGIAVLNIGHNHPRVRQRVAHQLERFVHTGGIY
YNDTSVEAAELLASVTPPGLDMVFFSNAGAEAVEGALKLARFVTGRQGIIAFSGAFHGRTLGAVSVTTSSARYRSRYQPL
LPSVYHAPYPYCYRCPLGRRPESCSLDCFRALEEMLERLITPAEVAAILIEPVLGEGGYAPAPPEFLRRLRRLCDEHGIL
LIFDEVQSGMGRTGDWFAAQRYDVTPDVMTVAKGIASGFPLSAVVAKRRIMEQWPCGAHGTTFGGNPVACAAAIATMETI
RDEGLLPRCRELGERAMVRLRGMGERHPLIGDVRGMGLMIGVELLEPDARPAGDACERLMAWCRERGLLIINCGPDRNVL
RLVPPLTIGDDELEQALSIIDEGLGAVA

Sequences:

>Translated_428_residues
MTTNAEIVARQERVFTPALHIYHPVAIENGEGSWVTDREGKRYLDLATGIAVLNIGHNHPRVRQRVAHQLERFVHTGGIY
YNDTSVEAAELLASVTPPGLDMVFFSNAGAEAVEGALKLARFVTGRQGIIAFSGAFHGRTLGAVSVTTSSARYRSRYQPL
LPSVYHAPYPYCYRCPLGRRPESCSLDCFRALEEMLERLITPAEVAAILIEPVLGEGGYAPAPPEFLRRLRRLCDEHGIL
LIFDEVQSGMGRTGDWFAAQRYDVTPDVMTVAKGIASGFPLSAVVAKRRIMEQWPCGAHGTTFGGNPVACAAAIATMETI
RDEGLLPRCRELGERAMVRLRGMGERHPLIGDVRGMGLMIGVELLEPDARPAGDACERLMAWCRERGLLIINCGPDRNVL
RLVPPLTIGDDELEQALSIIDEGLGAVA
>Mature_427_residues
TTNAEIVARQERVFTPALHIYHPVAIENGEGSWVTDREGKRYLDLATGIAVLNIGHNHPRVRQRVAHQLERFVHTGGIYY
NDTSVEAAELLASVTPPGLDMVFFSNAGAEAVEGALKLARFVTGRQGIIAFSGAFHGRTLGAVSVTTSSARYRSRYQPLL
PSVYHAPYPYCYRCPLGRRPESCSLDCFRALEEMLERLITPAEVAAILIEPVLGEGGYAPAPPEFLRRLRRLCDEHGILL
IFDEVQSGMGRTGDWFAAQRYDVTPDVMTVAKGIASGFPLSAVVAKRRIMEQWPCGAHGTTFGGNPVACAAAIATMETIR
DEGLLPRCRELGERAMVRLRGMGERHPLIGDVRGMGLMIGVELLEPDARPAGDACERLMAWCRERGLLIINCGPDRNVLR
LVPPLTIGDDELEQALSIIDEGLGAVA

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=425, Percent_Identity=33.1764705882353, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI4557809, Length=424, Percent_Identity=33.0188679245283, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI37574042, Length=422, Percent_Identity=29.6208530805687, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI24119277, Length=433, Percent_Identity=28.8683602771363, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI226442705, Length=422, Percent_Identity=28.9099526066351, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI226442709, Length=391, Percent_Identity=29.923273657289, Blast_Score=185, Evalue=7e-47,
Organism=Homo sapiens, GI284507298, Length=327, Percent_Identity=33.9449541284404, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI188536080, Length=461, Percent_Identity=25.8134490238612, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI38679950, Length=461, Percent_Identity=25.8134490238612, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI38679946, Length=461, Percent_Identity=25.8134490238612, Blast_Score=119, Evalue=4e-27,
Organism=Escherichia coli, GI1789016, Length=426, Percent_Identity=40.3755868544601, Blast_Score=313, Evalue=1e-86,
Organism=Escherichia coli, GI1787560, Length=400, Percent_Identity=42, Blast_Score=288, Evalue=4e-79,
Organism=Escherichia coli, GI1788044, Length=410, Percent_Identity=37.8048780487805, Blast_Score=245, Evalue=3e-66,
Organism=Escherichia coli, GI1789759, Length=411, Percent_Identity=36.2530413625304, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI145693181, Length=414, Percent_Identity=33.0917874396135, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1786349, Length=349, Percent_Identity=31.8051575931232, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1786991, Length=445, Percent_Identity=28.314606741573, Blast_Score=143, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI32564660, Length=425, Percent_Identity=33.1764705882353, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI25144271, Length=429, Percent_Identity=31.7016317016317, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI71992977, Length=452, Percent_Identity=29.8672566371681, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI25144274, Length=302, Percent_Identity=30.794701986755, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17541228, Length=448, Percent_Identity=27.4553571428571, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71981843, Length=177, Percent_Identity=31.0734463276836, Blast_Score=85, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6324432, Length=404, Percent_Identity=33.1683168316832, Blast_Score=234, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6323470, Length=418, Percent_Identity=32.2966507177034, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6324386, Length=302, Percent_Identity=28.1456953642384, Blast_Score=122, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6321456, Length=378, Percent_Identity=26.1904761904762, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI161085790, Length=446, Percent_Identity=34.304932735426, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI28574759, Length=442, Percent_Identity=34.1628959276018, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI21357415, Length=429, Percent_Identity=31.002331002331, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI21356575, Length=418, Percent_Identity=31.8181818181818, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI281366494, Length=387, Percent_Identity=25.8397932816537, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24667139, Length=387, Percent_Identity=25.8397932816537, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24667143, Length=387, Percent_Identity=25.8397932816537, Blast_Score=114, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.19

Molecular weight: Translated: 46797; Mature: 46666

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTNAEIVARQERVFTPALHIYHPVAIENGEGSWVTDREGKRYLDLATGIAVLNIGHNHP
CCCCHHHHHHHHHHCCCHHHHEEEEEEECCCCCEEECCCCCEEHHHHHCEEEEECCCCCH
RVRQRVAHQLERFVHTGGIYYNDTSVEAAELLASVTPPGLDMVFFSNAGAEAVEGALKLA
HHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHH
RFVTGRQGIIAFSGAFHGRTLGAVSVTTSSARYRSRYQPLLPSVYHAPYPYCYRCPLGRR
HHHCCCCCEEEEECCCCCCEEEEEEEECCHHHHHHHCCCCCCHHHCCCCCCEEECCCCCC
PESCSLDCFRALEEMLERLITPAEVAAILIEPVLGEGGYAPAPPEFLRRLRRLCDEHGIL
CCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCEE
LIFDEVQSGMGRTGDWFAAQRYDVTPDVMTVAKGIASGFPLSAVVAKRRIMEQWPCGAHG
EEEHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCC
TTFGGNPVACAAAIATMETIRDEGLLPRCRELGERAMVRLRGMGERHPLIGDVRGMGLMI
CCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCEEEE
GVELLEPDARPAGDACERLMAWCRERGLLIINCGPDRNVLRLVPPLTIGDDELEQALSII
EHEEECCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCEEEECCCCCCCHHHHHHHHHHH
DEGLGAVA
HHHHCCCC
>Mature Secondary Structure 
TTNAEIVARQERVFTPALHIYHPVAIENGEGSWVTDREGKRYLDLATGIAVLNIGHNHP
CCCHHHHHHHHHHCCCHHHHEEEEEEECCCCCEEECCCCCEEHHHHHCEEEEECCCCCH
RVRQRVAHQLERFVHTGGIYYNDTSVEAAELLASVTPPGLDMVFFSNAGAEAVEGALKLA
HHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHH
RFVTGRQGIIAFSGAFHGRTLGAVSVTTSSARYRSRYQPLLPSVYHAPYPYCYRCPLGRR
HHHCCCCCEEEEECCCCCCEEEEEEEECCHHHHHHHCCCCCCHHHCCCCCCEEECCCCCC
PESCSLDCFRALEEMLERLITPAEVAAILIEPVLGEGGYAPAPPEFLRRLRRLCDEHGIL
CCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCEE
LIFDEVQSGMGRTGDWFAAQRYDVTPDVMTVAKGIASGFPLSAVVAKRRIMEQWPCGAHG
EEEHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCC
TTFGGNPVACAAAIATMETIRDEGLLPRCRELGERAMVRLRGMGERHPLIGDVRGMGLMI
CCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCEEEE
GVELLEPDARPAGDACERLMAWCRERGLLIINCGPDRNVLRLVPPLTIGDDELEQALSII
EHEEECCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCEEEECCCCCCCHHHHHHHHHHH
DEGLGAVA
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Pyridoxal 5'-phosphate lysine-residue [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 3.3 {4-aminobutanoate}} 1.1 {4-aminobutanoate}} 1.3 {2-oxoglutarate}} 0.7 {2-oxoglutarate}} [C]

Substrates: 4-aminobutanoate; 2-oxoglutarate

Specific reaction: 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate

General reaction: Amino group transfer [C]

Inhibitor: 2-Oxoglutarate; Lysyl reagents; SH-group reagents [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA