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The map label for this gene is lexA1 [H]

Identifier: 118578636

GI number: 118578636

Start: 193122

End: 193724

Strand: Reverse

Name: lexA1 [H]

Synonym: Ppro_0192

Alternate gene names: 118578636

Gene position: 193724-193122 (Counterclockwise)

Preceding gene: 118578672

Following gene: 118578635

Centisome position: 4.83

GC content: 54.56

Gene sequence:

>603_bases
GTGATCCCCCTTACTGACCGACAGCAAAAGGTTCTGGATTTCATCACCAGCTTTATTAAAACCAATAGTTTCCCACCCAC
TTGGCGGGACATTGCGGCGCATCTGGGGATTACCAGCACCTTCGGAGTGAATCGGCATCTTGATGCCCTGGAGAAGAAGG
GGTGGATAAAGCGAGCGGGTACTTCACGGAGGATTGTATTGACCTCACAGGAGGTGCGGTCGATATCGCTGCCGATTGTC
GGAACGGTACGGGCCGGGCACCTTCAACCTGCTGTCGAGGACATCCAAGGGTTCTTTGCCGTGGATCAGGAACAGGTGAA
GGGGGATGGCTGCTTTCTATTGCGGGTCAAGGGTGACTCGATGATCGGCGCCGGGATCTTTGATGGGGACCTGGCTTTGG
TACGCCCCCAGCCAGTGGCTGATAATCGTGATACTGTGGTCGTCATGGTGGATGGCGAGGCGACCCTGAAATGGTTCCAT
CGCGAGCAGAATCGTATCCGCCTGCAACCGGCCAACCCAAATATGGCTCCGATATTTGTTGGTCCGGATAAAGACGTGTC
GATCGTCGGCAAGGTAATTGGCATCTATCGACAGTTGGAGTAA

Upstream 100 bases:

>100_bases
CTGACTGATAATCTTGCAGGGGGGAAGGTGCAGCGTCTTGACAAGAAGGTGTGGGCAAGGGTATATAGTGTTCATATGGA
CACTATGTGGAGGCGCAACT

Downstream 100 bases:

>100_bases
GACGTGGAGCGGATCAAGGAACAGATACGGATCGCCACGATCTTTACCCCAGGCCGACAGATCAGGCCGGTCTGGTTCGA
CTGGCACAACCGGAAGCACA

Product: SOS-response transcriptional repressor LexA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 200; Mature: 200

Protein sequence:

>200_residues
MIPLTDRQQKVLDFITSFIKTNSFPPTWRDIAAHLGITSTFGVNRHLDALEKKGWIKRAGTSRRIVLTSQEVRSISLPIV
GTVRAGHLQPAVEDIQGFFAVDQEQVKGDGCFLLRVKGDSMIGAGIFDGDLALVRPQPVADNRDTVVVMVDGEATLKWFH
REQNRIRLQPANPNMAPIFVGPDKDVSIVGKVIGIYRQLE

Sequences:

>Translated_200_residues
MIPLTDRQQKVLDFITSFIKTNSFPPTWRDIAAHLGITSTFGVNRHLDALEKKGWIKRAGTSRRIVLTSQEVRSISLPIV
GTVRAGHLQPAVEDIQGFFAVDQEQVKGDGCFLLRVKGDSMIGAGIFDGDLALVRPQPVADNRDTVVVMVDGEATLKWFH
REQNRIRLQPANPNMAPIFVGPDKDVSIVGKVIGIYRQLE
>Mature_200_residues
MIPLTDRQQKVLDFITSFIKTNSFPPTWRDIAAHLGITSTFGVNRHLDALEKKGWIKRAGTSRRIVLTSQEVRSISLPIV
GTVRAGHLQPAVEDIQGFFAVDQEQVKGDGCFLLRVKGDSMIGAGIFDGDLALVRPQPVADNRDTVVVMVDGEATLKWFH
REQNRIRLQPANPNMAPIFVGPDKDVSIVGKVIGIYRQLE

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1790476, Length=199, Percent_Identity=38.6934673366834, Blast_Score=114, Evalue=6e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24 [H]

EC number: =3.4.21.88 [H]

Molecular weight: Translated: 22199; Mature: 22199

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPLTDRQQKVLDFITSFIKTNSFPPTWRDIAAHLGITSTFGVNRHLDALEKKGWIKRAG
CCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHCCCEECCC
TSRRIVLTSQEVRSISLPIVGTVRAGHLQPAVEDIQGFFAVDQEQVKGDGCFLLRVKGDS
CCCEEEEECCCCEEEECCEEEEEECCCCCHHHHHHHHHEEECHHHHCCCCEEEEEECCCC
MIGAGIFDGDLALVRPQPVADNRDTVVVMVDGEATLKWFHREQNRIRLQPANPNMAPIFV
EEECEEECCCEEEECCCCCCCCCCEEEEEECCCHHHHHEECCCCEEEEEECCCCEEEEEE
GPDKDVSIVGKVIGIYRQLE
CCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIPLTDRQQKVLDFITSFIKTNSFPPTWRDIAAHLGITSTFGVNRHLDALEKKGWIKRAG
CCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHCCCEECCC
TSRRIVLTSQEVRSISLPIVGTVRAGHLQPAVEDIQGFFAVDQEQVKGDGCFLLRVKGDS
CCCEEEEECCCCEEEECCEEEEEECCCCCHHHHHHHHHEEECHHHHCCCCEEEEEECCCC
MIGAGIFDGDLALVRPQPVADNRDTVVVMVDGEATLKWFHREQNRIRLQPANPNMAPIFV
EEECEEECCCEEEECCCCCCCCCCEEEEEECCCHHHHHEECCCCEEEEEECCCCEEEEEE
GPDKDVSIVGKVIGIYRQLE
CCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA