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The map label for this gene is guaC

Identifier: 118480484

GI number: 118480484

Start: 5224593

End: 5225579

Strand: Direct

Name: guaC

Synonym: BALH_4963

Alternate gene names: 118480484

Gene position: 5224593-5225579 (Clockwise)

Preceding gene: 118480481

Following gene: 118480485

Centisome position: 99.38

GC content: 36.68

Gene sequence:

>987_bases
ATGATGGAAAACGTATTCGACTATGAAGATATTCAATTAATTCCTGCAAAATGTATTGTAAATAGCCGCTCTGAATGTGA
TACAACTGTCACTTTAGGAAAACATAAATTTAAATTACCTGTCGTACCTGCAAATATGCAAACGATTATTGATGAAAGAA
TTGCAACTTATTTAGCTGAAAATAATTACTTCTATATCATGCATCGTTTCCAACCAGAGAAACGAATCTCATTCATTAGA
GATATGCAATCACGTGGATTAATTGCTTCTATTAGCGTTGGTGTAAAAGAAGACGAGTATGAATTCGTGCAACAATTAGC
TGCTGAGCATCTTACGCCTGAATACATCACAATTGATATCGCGCATGGACATTCTAATGCTGTAATCAACATGATTCAAC
ATATTAAAAAGCATTTACCAGAAAGCTTCGTTATCGCTGGAAACGTTGGAACTCCAGAAGCGGTAAGAGAATTAGAAAAC
GCTGGTGCTGATGCAACAAAAGTTGGTATTGGACCTGGTAAAGTTTGTATTACTAAAATTAAAACAGGATTTGGAACTGG
CGGTTGGCAACTAGCTGCACTTCGCTGGTGTGCAAAAGCTGCAAGTAAACCCATTATCGCTGACGGTGGTATTCGTACAC
ATGGCGACGTAGCTAAATCTATTCGATTTGGGGCGACTATGGTTATGATCGGTTCTCTATTTGCTGGTCATGAAGAGTCT
CCAGGGGAAACAATCGAAAAAGATGGTAAACTTTATAAAGAGTACTTCGGTTCAGCTTCTGAATTCCAAAAAGGTGAGAA
GAAAAACGTTGAAGGTAAAAAAATGTTCGTTGAGCATAAAGGTTCTTTAGAAGACACTTTAATCGAAATGGAACAAGATC
TTCAATCTTCTATCTCTTACGCTGGTGGAACAAAATTAGACTCAATTCGTACTGTAGATTATGTAGTCGTAAAAAACTCT
ATTTTCAACGGTGATAAAGTATATTAA

Upstream 100 bases:

>100_bases
CATGAAAACCTTTGACTTATGAGTGAAAATAATGTAAATTATCCTTTGGACGAACATTTTTAAACAAACTTAATAAAATA
TTCGTATTTTAGGGGTGTAA

Downstream 100 bases:

>100_bases
TTTTTAAACTTAACTCGAAGGACAAGTATTTTTATGCTTGTCCTTTTTCATATATAGAAATGTAAAATATTTTCATTTTA
CTGAATTTTCTAGTATCATG

Product: guanosine 5'-monophosphate oxidoreductase

Products: NA

Alternate protein names: Guanosine 5'-monophosphate oxidoreductase; Guanosine monophosphate reductase

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MMENVFDYEDIQLIPAKCIVNSRSECDTTVTLGKHKFKLPVVPANMQTIIDERIATYLAENNYFYIMHRFQPEKRISFIR
DMQSRGLIASISVGVKEDEYEFVQQLAAEHLTPEYITIDIAHGHSNAVINMIQHIKKHLPESFVIAGNVGTPEAVRELEN
AGADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAASKPIIADGGIRTHGDVAKSIRFGATMVMIGSLFAGHEES
PGETIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMFVEHKGSLEDTLIEMEQDLQSSISYAGGTKLDSIRTVDYVVVKNS
IFNGDKVY

Sequences:

>Translated_328_residues
MMENVFDYEDIQLIPAKCIVNSRSECDTTVTLGKHKFKLPVVPANMQTIIDERIATYLAENNYFYIMHRFQPEKRISFIR
DMQSRGLIASISVGVKEDEYEFVQQLAAEHLTPEYITIDIAHGHSNAVINMIQHIKKHLPESFVIAGNVGTPEAVRELEN
AGADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAASKPIIADGGIRTHGDVAKSIRFGATMVMIGSLFAGHEES
PGETIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMFVEHKGSLEDTLIEMEQDLQSSISYAGGTKLDSIRTVDYVVVKNS
IFNGDKVY
>Mature_328_residues
MMENVFDYEDIQLIPAKCIVNSRSECDTTVTLGKHKFKLPVVPANMQTIIDERIATYLAENNYFYIMHRFQPEKRISFIR
DMQSRGLIASISVGVKEDEYEFVQQLAAEHLTPEYITIDIAHGHSNAVINMIQHIKKHLPESFVIAGNVGTPEAVRELEN
AGADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAASKPIIADGGIRTHGDVAKSIRFGATMVMIGSLFAGHEES
PGETIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMFVEHKGSLEDTLIEMEQDLQSSISYAGGTKLDSIRTVDYVVVKNS
IFNGDKVY

Specific function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily

Homologues:

Organism=Homo sapiens, GI50541956, Length=343, Percent_Identity=34.6938775510204, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI50541954, Length=343, Percent_Identity=34.6938775510204, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI50541952, Length=343, Percent_Identity=34.6938775510204, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI50541948, Length=343, Percent_Identity=34.6938775510204, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI156104880, Length=338, Percent_Identity=31.0650887573964, Blast_Score=164, Evalue=8e-41,
Organism=Homo sapiens, GI66933016, Length=245, Percent_Identity=32.6530612244898, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI217035148, Length=252, Percent_Identity=32.5396825396825, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI217035146, Length=252, Percent_Identity=32.5396825396825, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI217035150, Length=252, Percent_Identity=32.9365079365079, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI217035152, Length=252, Percent_Identity=32.9365079365079, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI156616279, Length=252, Percent_Identity=32.9365079365079, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI34328928, Length=252, Percent_Identity=32.5396825396825, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI34328930, Length=252, Percent_Identity=32.9365079365079, Blast_Score=107, Evalue=1e-23,
Organism=Escherichia coli, GI1786293, Length=337, Percent_Identity=31.4540059347181, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1788855, Length=294, Percent_Identity=34.3537414965986, Blast_Score=112, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17560440, Length=324, Percent_Identity=31.7901234567901, Blast_Score=157, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI71994385, Length=151, Percent_Identity=38.4105960264901, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71994389, Length=151, Percent_Identity=38.4105960264901, Blast_Score=91, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6323585, Length=252, Percent_Identity=31.3492063492063, Blast_Score=109, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6323464, Length=206, Percent_Identity=33.495145631068, Blast_Score=105, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6322012, Length=210, Percent_Identity=32.8571428571429, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6319352, Length=138, Percent_Identity=31.1594202898551, Blast_Score=66, Evalue=7e-12,
Organism=Drosophila melanogaster, GI28571163, Length=250, Percent_Identity=32.4, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24641071, Length=253, Percent_Identity=32.0158102766798, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24641073, Length=253, Percent_Identity=32.0158102766798, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): GUAC_BACAH (A0RLN5)

Other databases:

- EMBL:   CP000485
- RefSeq:   YP_897635.1
- ProteinModelPortal:   A0RLN5
- SMR:   A0RLN5
- STRING:   A0RLN5
- EnsemblBacteria:   EBBACT00000068004
- GeneID:   4543702
- GenomeReviews:   CP000485_GR
- KEGG:   btl:BALH_4963
- eggNOG:   COG0516
- GeneTree:   EBGT00050000000995
- HOGENOM:   HBG298985
- OMA:   PDYITID
- ProtClustDB:   PRK05458
- BioCyc:   BTHU412694:BALH_4963-MONOMER
- HAMAP:   MF_01511
- InterPro:   IPR013785
- InterPro:   IPR001295
- InterPro:   IPR005994
- InterPro:   IPR015875
- InterPro:   IPR001093
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF036500
- TIGRFAMs:   TIGR01306

Pfam domain/function: PF00478 IMPDH

EC number: =1.7.1.7

Molecular weight: Translated: 36303; Mature: 36303

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00487 IMP_DH_GMP_RED; PS00912 DHODEHASE_2

Important sites: ACT_SITE 176-176

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMENVFDYEDIQLIPAKCIVNSRSECDTTVTLGKHKFKLPVVPANMQTIIDERIATYLAE
CCCCCCCCCCCEEECHHHHCCCCCCCCCEEEECCEEEEEEEECCHHHHHHHHHHHHHHHC
NNYFYIMHRFQPEKRISFIRDMQSRGLIASISVGVKEDEYEFVQQLAAEHLTPEYITIDI
CCEEEEEEECCCHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEE
AHGHSNAVINMIQHIKKHLPESFVIAGNVGTPEAVRELENAGADATKVGIGPGKVCITKI
ECCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCCEEECCCCCCEEEEEE
KTGFGTGGWQLAALRWCAKAASKPIIADGGIRTHGDVAKSIRFGATMVMIGSLFAGHEES
CCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
PGETIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMFVEHKGSLEDTLIEMEQDLQSSISY
CCCHHHHHHHHHHHHCCCHHHHHCCCCCCCCHHEEEEECCCCHHHHHHHHHHHHHHHHHH
AGGTKLDSIRTVDYVVVKNSIFNGDKVY
CCCCCCCCEEEEEEEEEECCCCCCCCCC
>Mature Secondary Structure
MMENVFDYEDIQLIPAKCIVNSRSECDTTVTLGKHKFKLPVVPANMQTIIDERIATYLAE
CCCCCCCCCCCEEECHHHHCCCCCCCCCEEEECCEEEEEEEECCHHHHHHHHHHHHHHHC
NNYFYIMHRFQPEKRISFIRDMQSRGLIASISVGVKEDEYEFVQQLAAEHLTPEYITIDI
CCEEEEEEECCCHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEE
AHGHSNAVINMIQHIKKHLPESFVIAGNVGTPEAVRELENAGADATKVGIGPGKVCITKI
ECCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCCEEECCCCCCEEEEEE
KTGFGTGGWQLAALRWCAKAASKPIIADGGIRTHGDVAKSIRFGATMVMIGSLFAGHEES
CCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
PGETIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMFVEHKGSLEDTLIEMEQDLQSSISY
CCCHHHHHHHHHHHHCCCHHHHHCCCCCCCCHHEEEEECCCCHHHHHHHHHHHHHHHHHH
AGGTKLDSIRTVDYVVVKNSIFNGDKVY
CCCCCCCCEEEEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA