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The map label for this gene is nanT [C]

Identifier: 118480472

GI number: 118480472

Start: 5211157

End: 5212458

Strand: Direct

Name: nanT [C]

Synonym: BALH_4950

Alternate gene names: 118480472

Gene position: 5211157-5212458 (Clockwise)

Preceding gene: 118480465

Following gene: 118480475

Centisome position: 99.13

GC content: 37.86

Gene sequence:

>1302_bases
ATGATGAACGTCACTACTGATGTACAATCAACAACAGAGGAGACGAAAGAGAAAAGATATAAAACATTATTTGGTTCTGC
GCTAGGATATGCAGCAGAAGGTTTAGATATGTTGCTCTTATCTTTCGTACTCGTCTACATTTTAAAAGAATTTCACTTAA
GCCCTGTTGAAGGTGGAAACTTAACATTAGCTACTACCATAGGAATGCTGATCGGGTCTTATTTATTTGGATTTATTGCT
GATTTATTTGGGCGTATCCGTACGATGGCCTTTACAATCTTACTATTTTCACTAGCGACAGCACTTATTTATTTCGCAAC
AGATTATTGGCAATTATTAATTCTTCGCTTTTTAGTAGGAATGGGAGTTGGTGGTGAATTCGGAATTGGGATGGCCATCG
TAACTGAAACTTGGTCTAAAGAAATGCGCGCAAAGGCGACATCAGTTGTTGCACTTGGATGGCAATTTGGCGTATTAGTC
GCTTCGCTCCTACCAGCATTTATCGTTCCGCATTTTGGATGGAGAGCTGTGTTCTTATTTGGACTCATTCCCGCTTTACT
AGCTGTCTATGTCCGTAAGAGTTTAAGTGAACCGAAAATATGGGAACAAAAGCAACGATACAAAAAAGAATTGTTACAAA
AAGAATCTGAAGGTAATTTAACAACTACTGAGGCAGAGCAATTAAAGCAAATGAAAAAGTTCCCACTTCGAAAGTTATTT
GGAAATAAAAAAGTAACGATAACAACAATTGGTCTTATTATTATGTCATTCATCCAAAACTTTGGATATTATGGAATTTT
CACATGGATGCCAACCATTTTAGCGAATAAATATAACTATACATTAGCAAAAGCGAGCGGTTGGATGTTCATCTCTACGA
TCGGCATGCTCATTGGAATTGCAACTTTTGGTATTCTAGCTGATAAAATTGGTCGCCGTAAAACTTTTACAATCTATTAT
GTCGGTGGTACTATATACTGTCTCATTTACTTCTTCTTATTCACAGATTCAACATTATTGTTATGGGGAAGTGCATTGCT
TGGATTCTTTGCCAATGGCATGATGGGGGGATTCGGGGCAGTTTTAGCCGAAAACTATCCTGCTGAAGCTCGCTCTACAG
CAGAAAACTTTATTTTCGGTACAGGACGTGGTTTAGCTGGATTTGGGCCTGTTATTATCGGCTTACTTGCTGCAGGCGGT
AATGTAATGGGAGCATTATCTCTCATCTTCATTATCTATCCAATCGGTTTAGTTACGATGTTATTATGTGTTCCAGAGAC
GAAAGATAAAGTATTAGAATAG

Upstream 100 bases:

>100_bases
TTTAGAAATACGTATGCTTTTTTGGCCTTCTCATCATATCAGGTGAGAAGGCCTTTTGTTATTCTTCCATAGCGACTGTA
GAAGGAAATAAGGAGGAATA

Downstream 100 bases:

>100_bases
ATTGAAACTGTATCCTTCAAAAAAATAGTTGGATAAATAGGAAAGAGGAAGTATCTCAAATGAGATGCTTCCTCTTTTTA
TATAAATACAATTATTTACT

Product: major facilitator family transporter

Products: Proton [Cytoplasm]; N-acetylneuraminate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MMNVTTDVQSTTEETKEKRYKTLFGSALGYAAEGLDMLLLSFVLVYILKEFHLSPVEGGNLTLATTIGMLIGSYLFGFIA
DLFGRIRTMAFTILLFSLATALIYFATDYWQLLILRFLVGMGVGGEFGIGMAIVTETWSKEMRAKATSVVALGWQFGVLV
ASLLPAFIVPHFGWRAVFLFGLIPALLAVYVRKSLSEPKIWEQKQRYKKELLQKESEGNLTTTEAEQLKQMKKFPLRKLF
GNKKVTITTIGLIIMSFIQNFGYYGIFTWMPTILANKYNYTLAKASGWMFISTIGMLIGIATFGILADKIGRRKTFTIYY
VGGTIYCLIYFFLFTDSTLLLWGSALLGFFANGMMGGFGAVLAENYPAEARSTAENFIFGTGRGLAGFGPVIIGLLAAGG
NVMGALSLIFIIYPIGLVTMLLCVPETKDKVLE

Sequences:

>Translated_433_residues
MMNVTTDVQSTTEETKEKRYKTLFGSALGYAAEGLDMLLLSFVLVYILKEFHLSPVEGGNLTLATTIGMLIGSYLFGFIA
DLFGRIRTMAFTILLFSLATALIYFATDYWQLLILRFLVGMGVGGEFGIGMAIVTETWSKEMRAKATSVVALGWQFGVLV
ASLLPAFIVPHFGWRAVFLFGLIPALLAVYVRKSLSEPKIWEQKQRYKKELLQKESEGNLTTTEAEQLKQMKKFPLRKLF
GNKKVTITTIGLIIMSFIQNFGYYGIFTWMPTILANKYNYTLAKASGWMFISTIGMLIGIATFGILADKIGRRKTFTIYY
VGGTIYCLIYFFLFTDSTLLLWGSALLGFFANGMMGGFGAVLAENYPAEARSTAENFIFGTGRGLAGFGPVIIGLLAAGG
NVMGALSLIFIIYPIGLVTMLLCVPETKDKVLE
>Mature_433_residues
MMNVTTDVQSTTEETKEKRYKTLFGSALGYAAEGLDMLLLSFVLVYILKEFHLSPVEGGNLTLATTIGMLIGSYLFGFIA
DLFGRIRTMAFTILLFSLATALIYFATDYWQLLILRFLVGMGVGGEFGIGMAIVTETWSKEMRAKATSVVALGWQFGVLV
ASLLPAFIVPHFGWRAVFLFGLIPALLAVYVRKSLSEPKIWEQKQRYKKELLQKESEGNLTTTEAEQLKQMKKFPLRKLF
GNKKVTITTIGLIIMSFIQNFGYYGIFTWMPTILANKYNYTLAKASGWMFISTIGMLIGIATFGILADKIGRRKTFTIYY
VGGTIYCLIYFFLFTDSTLLLWGSALLGFFANGMMGGFGAVLAENYPAEARSTAENFIFGTGRGLAGFGPVIIGLLAAGG
NVMGALSLIFIIYPIGLVTMLLCVPETKDKVLE

Specific function: May Be A Sugar-Cation Symporter Involved In Sialic Acid Transport As It Is Required For Sialic Acid Uptake. [C]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI7662270, Length=320, Percent_Identity=22.5, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI24308167, Length=401, Percent_Identity=24.6882793017456, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI216548223, Length=283, Percent_Identity=21.5547703180212, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI262399383, Length=260, Percent_Identity=21.9230769230769, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI87082231, Length=434, Percent_Identity=25.8064516129032, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI87082404, Length=375, Percent_Identity=26.9333333333333, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1790550, Length=442, Percent_Identity=25.3393665158371, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1788068, Length=345, Percent_Identity=24.9275362318841, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87081723, Length=380, Percent_Identity=25, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1788292, Length=368, Percent_Identity=26.9021739130435, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1786229, Length=255, Percent_Identity=27.0588235294118, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1789152, Length=449, Percent_Identity=23.6080178173719, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87082159, Length=135, Percent_Identity=26.6666666666667, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1788942, Length=343, Percent_Identity=24.7813411078717, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI32564663, Length=445, Percent_Identity=23.5955056179775, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24640198, Length=291, Percent_Identity=26.8041237113402, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24640196, Length=291, Percent_Identity=26.8041237113402, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24640200, Length=291, Percent_Identity=26.8041237113402, Blast_Score=75, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 47854; Mature: 47854

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: PS50850 MFS ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHCCCHHHHCCC
>Mature Secondary Structure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HHHCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; N-acetylneuraminate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + N-acetylneuraminate [Periplasm] = Proton [Cytoplasm] + N-acetylneuraminate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]