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The map label for this gene is atoB [H]

Identifier: 118480378

GI number: 118480378

Start: 5100753

End: 5102036

Strand: Reverse

Name: atoB [H]

Synonym: BALH_4843

Alternate gene names: 118480378

Gene position: 5102036-5100753 (Counterclockwise)

Preceding gene: 118480379

Following gene: 118480377

Centisome position: 97.05

GC content: 44.94

Gene sequence:

>1284_bases
ATGAATACAACTTTAGAGAGAGGTGCAATCATTGCACCTCTTCTCAACGTAACAATGCCGAGCGAGCGCTCGGTGCTAAA
AAAAGAAATGGGGGAAAGAAACATGAGTAAAACAGTTATTTTAAGTGCTGCAAGAACACCGGTTGGAAAATTTGGAGGAT
CTTTAAAAGATGTAAAAGCAACAGAACTTGGAGGAATTGCAATTAAAGCGGCGCTTGAAAGAGCGAATGTTTCAGCTAGT
GATGTTGAGGAAGTTATATTCGGAACGGTTATTCAAGGTGGACAGGGACAAATTCCATCACGCCAAGCGGCACGGGCTGC
TGGAATCCCTTGGGAGGTGCAGACGGAAACAGTGAATAAAGTTTGTGCATCGGGGCTTCGTGCAGTTACGTTAGCCGATC
AAATTATTCGTACTGGTGATCAATCATTGATTGTGGCTGGCGGTATGGAATCGATGAGTAACAGTCCTTATATTTTACGA
GGAGCAAGATGGGGATACAGAATGGGTAACAACGAAGTCATTGATTTAAACGTTGCTGACGGTTTAACATGCGCATTTTC
AGGTATACACATGGGTGTTTATGGCGGAGAAGTTGCGAAGGAGGATGGAATTTCTCGCGAAGCGCAAGATGAATGGGCAT
ATCGTAGCCATCAGCGTGCAGTTTCAGCGCATAAAGAAGGACGTTTTGAAGAGGAAATCGTGCCAGTAACGATTCCACAA
AGAAAAGGCGATCCTATTGTCGTTGCAAAGGATGAGGCGCCACGCGCGGATACAACAATTGAAAAACTAGCAAAATTAAA
ACCTGTATTTGATAAGACAGCGACGGTGACAGCTGGTAATGCACCAGGGCTAAACGATGGTGGCGCTGCACTTGTATTAA
TGAGCGAAGACAGAGCGAAGCAAGAAGGAAGAAAGCCGTTAGCGACAATTTTGGCACATACAGCAATTGCAGTGGAGTCT
AAAGATTTCCCGAGAACGCCAGGTTATGCAATTAACGCATTGCTTGAAAAAACAGGCAAGACAATTGAAGACATCGATTT
ATTCGAGATTAACGAAGCATTTGCAGCGGTAGCAATTGCAAGTACAGAAATCGCAGGAATTGACCCAGAAAAATTGAATG
TAAATGGCGGCGCAGTGGCGATGGGACATCCGATTGGAGCAAGCGGAGCGCGCATTATCGTTACACTAATCCATGCACTT
AAGCAACGCGGCGGTGGAATTGGAATTGCTTCGATTTGTAGTGGTGGCGGTCAAGGCGATGCAGTGATGATTGAAGTTCA
CTAA

Upstream 100 bases:

>100_bases
AGCGAAAGAAGTAGAAGAGAAGGTTCAAACGCTTGATGTAACAGAGATTTTAGAACGCTCTGTTATCGGACAGAAGAAAG
AAGCGATGTAATCTGCAAGC

Downstream 100 bases:

>100_bases
TTAAGATTAGAAGGTATATCGTTTATTAAAAATTAAGGGGGAAGAAGAAATGGGTGTACAAAAAATTGTTGTAATTGGTG
CAGGACAAATGGGGTCAGGA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MNTTLERGAIIAPLLNVTMPSERSVLKKEMGERNMSKTVILSAARTPVGKFGGSLKDVKATELGGIAIKAALERANVSAS
DVEEVIFGTVIQGGQGQIPSRQAARAAGIPWEVQTETVNKVCASGLRAVTLADQIIRTGDQSLIVAGGMESMSNSPYILR
GARWGYRMGNNEVIDLNVADGLTCAFSGIHMGVYGGEVAKEDGISREAQDEWAYRSHQRAVSAHKEGRFEEEIVPVTIPQ
RKGDPIVVAKDEAPRADTTIEKLAKLKPVFDKTATVTAGNAPGLNDGGAALVLMSEDRAKQEGRKPLATILAHTAIAVES
KDFPRTPGYAINALLEKTGKTIEDIDLFEINEAFAAVAIASTEIAGIDPEKLNVNGGAVAMGHPIGASGARIIVTLIHAL
KQRGGGIGIASICSGGGQGDAVMIEVH

Sequences:

>Translated_427_residues
MNTTLERGAIIAPLLNVTMPSERSVLKKEMGERNMSKTVILSAARTPVGKFGGSLKDVKATELGGIAIKAALERANVSAS
DVEEVIFGTVIQGGQGQIPSRQAARAAGIPWEVQTETVNKVCASGLRAVTLADQIIRTGDQSLIVAGGMESMSNSPYILR
GARWGYRMGNNEVIDLNVADGLTCAFSGIHMGVYGGEVAKEDGISREAQDEWAYRSHQRAVSAHKEGRFEEEIVPVTIPQ
RKGDPIVVAKDEAPRADTTIEKLAKLKPVFDKTATVTAGNAPGLNDGGAALVLMSEDRAKQEGRKPLATILAHTAIAVES
KDFPRTPGYAINALLEKTGKTIEDIDLFEINEAFAAVAIASTEIAGIDPEKLNVNGGAVAMGHPIGASGARIIVTLIHAL
KQRGGGIGIASICSGGGQGDAVMIEVH
>Mature_427_residues
MNTTLERGAIIAPLLNVTMPSERSVLKKEMGERNMSKTVILSAARTPVGKFGGSLKDVKATELGGIAIKAALERANVSAS
DVEEVIFGTVIQGGQGQIPSRQAARAAGIPWEVQTETVNKVCASGLRAVTLADQIIRTGDQSLIVAGGMESMSNSPYILR
GARWGYRMGNNEVIDLNVADGLTCAFSGIHMGVYGGEVAKEDGISREAQDEWAYRSHQRAVSAHKEGRFEEEIVPVTIPQ
RKGDPIVVAKDEAPRADTTIEKLAKLKPVFDKTATVTAGNAPGLNDGGAALVLMSEDRAKQEGRKPLATILAHTAIAVES
KDFPRTPGYAINALLEKTGKTIEDIDLFEINEAFAAVAIASTEIAGIDPEKLNVNGGAVAMGHPIGASGARIIVTLIHAL
KQRGGGIGIASICSGGGQGDAVMIEVH

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4557237, Length=415, Percent_Identity=46.2650602409639, Blast_Score=351, Evalue=8e-97,
Organism=Homo sapiens, GI148539872, Length=389, Percent_Identity=48.0719794344473, Blast_Score=339, Evalue=3e-93,
Organism=Homo sapiens, GI167614485, Length=391, Percent_Identity=39.386189258312, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI4501853, Length=393, Percent_Identity=38.1679389312977, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI4504327, Length=449, Percent_Identity=32.5167037861915, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI194353979, Length=391, Percent_Identity=31.2020460358056, Blast_Score=137, Evalue=2e-32,
Organism=Escherichia coli, GI1788554, Length=392, Percent_Identity=50.5102040816327, Blast_Score=352, Evalue=2e-98,
Organism=Escherichia coli, GI87082165, Length=391, Percent_Identity=45.5242966751918, Blast_Score=338, Evalue=6e-94,
Organism=Escherichia coli, GI1787663, Length=400, Percent_Identity=37.75, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI48994986, Length=399, Percent_Identity=35.8395989974937, Blast_Score=215, Evalue=3e-57,
Organism=Escherichia coli, GI1788683, Length=414, Percent_Identity=31.1594202898551, Blast_Score=196, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI25147385, Length=386, Percent_Identity=44.300518134715, Blast_Score=313, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI133906874, Length=389, Percent_Identity=43.4447300771208, Blast_Score=293, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI17535921, Length=393, Percent_Identity=40.4580152671756, Blast_Score=254, Evalue=6e-68,
Organism=Caenorhabditis elegans, GI17551802, Length=434, Percent_Identity=34.331797235023, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17535917, Length=396, Percent_Identity=35.3535353535354, Blast_Score=205, Evalue=4e-53,
Organism=Saccharomyces cerevisiae, GI6325229, Length=397, Percent_Identity=45.8438287153652, Blast_Score=328, Evalue=7e-91,
Organism=Saccharomyces cerevisiae, GI6322031, Length=423, Percent_Identity=34.9881796690307, Blast_Score=209, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24655093, Length=391, Percent_Identity=47.3145780051151, Blast_Score=354, Evalue=8e-98,
Organism=Drosophila melanogaster, GI24640423, Length=404, Percent_Identity=44.5544554455446, Blast_Score=324, Evalue=7e-89,
Organism=Drosophila melanogaster, GI17648125, Length=388, Percent_Identity=39.6907216494845, Blast_Score=253, Evalue=1e-67,
Organism=Drosophila melanogaster, GI17137578, Length=433, Percent_Identity=30.9468822170901, Blast_Score=178, Evalue=8e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 44862; Mature: 44862

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTTLERGAIIAPLLNVTMPSERSVLKKEMGERNMSKTVILSAARTPVGKFGGSLKDVKA
CCCCCCCCEEEEHHHHCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCHHHHCCCCCCCCH
TELGGIAIKAALERANVSASDVEEVIFGTVIQGGQGQIPSRQAARAAGIPWEVQTETVNK
HHCCCCHHEEHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCEEEHHHHHH
VCASGLRAVTLADQIIRTGDQSLIVAGGMESMSNSPYILRGARWGYRMGNNEVIDLNVAD
HHHCCCHHHHHHHHHHHCCCCEEEEECCHHHCCCCCEEEEECCCCEECCCCCEEEEECCC
GLTCAFSGIHMGVYGGEVAKEDGISREAQDEWAYRSHQRAVSAHKEGRFEEEIVPVTIPQ
CCEEEECCEEEEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECC
RKGDPIVVAKDEAPRADTTIEKLAKLKPVFDKTATVTAGNAPGLNDGGAALVLMSEDRAK
CCCCEEEEECCCCCCCHHHHHHHHHHCHHHCCCEEEECCCCCCCCCCCEEEEEECCCHHH
QEGRKPLATILAHTAIAVESKDFPRTPGYAINALLEKTGKTIEDIDLFEINEAFAAVAIA
HHCCCHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHCCCCCCCCEEEHHHHHHEEEEE
STEIAGIDPEKLNVNGGAVAMGHPIGASGARIIVTLIHALKQRGGGIGIASICSGGGQGD
CCEECCCCCCEEECCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEHHHHCCCCCCC
AVMIEVH
EEEEEEC
>Mature Secondary Structure
MNTTLERGAIIAPLLNVTMPSERSVLKKEMGERNMSKTVILSAARTPVGKFGGSLKDVKA
CCCCCCCCEEEEHHHHCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCHHHHCCCCCCCCH
TELGGIAIKAALERANVSASDVEEVIFGTVIQGGQGQIPSRQAARAAGIPWEVQTETVNK
HHCCCCHHEEHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCEEEHHHHHH
VCASGLRAVTLADQIIRTGDQSLIVAGGMESMSNSPYILRGARWGYRMGNNEVIDLNVAD
HHHCCCHHHHHHHHHHHCCCCEEEEECCHHHCCCCCEEEEECCCCEECCCCCEEEEECCC
GLTCAFSGIHMGVYGGEVAKEDGISREAQDEWAYRSHQRAVSAHKEGRFEEEIVPVTIPQ
CCEEEECCEEEEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECC
RKGDPIVVAKDEAPRADTTIEKLAKLKPVFDKTATVTAGNAPGLNDGGAALVLMSEDRAK
CCCCEEEEECCCCCCCHHHHHHHHHHCHHHCCCEEEECCCCCCCCCCCEEEEEECCCHHH
QEGRKPLATILAHTAIAVESKDFPRTPGYAINALLEKTGKTIEDIDLFEINEAFAAVAIA
HHCCCHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHCCCCCCCCEEEHHHHHHEEEEE
STEIAGIDPEKLNVNGGAVAMGHPIGASGARIIVTLIHALKQRGGGIGIASICSGGGQGD
CCEECCCCCCEEECCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEHHHHCCCCCCC
AVMIEVH
EEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]