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The map label for this gene is manP [H]

Identifier: 118480303

GI number: 118480303

Start: 5017535

End: 5019502

Strand: Reverse

Name: manP [H]

Synonym: BALH_4764

Alternate gene names: 118480303

Gene position: 5019502-5017535 (Counterclockwise)

Preceding gene: 118480304

Following gene: 118480302

Centisome position: 95.48

GC content: 37.25

Gene sequence:

>1968_bases
GTGAGGAGGATTAAAATGAAAGTACTAGCGATTACATCGTGTCCGAATGGGATTGCCCATACGTATATGGCTGCAGAAAA
CTTGCAAAAAGCAGCAGATAAATTAGGAATTCAAATGAAAGTTGAAACACAAGGTGGTATAGGTGTTGAAAATGAACTTA
CTGAGCAAGAGATTCATGAAGCGGATGGCATCATTATAGCTGCAGATCGTGCTGTAAATAAAGATAGATTCATAGGTAAA
AAGTTATTAGTCGTAGGAGTTAAAGATGGTATACGTAAACCAGAGGAACTGATTCAAAAAGTAGTAGATGGTAATGTTCC
TGTTTATCATTCAGATGTGAAAGAGGCAGGAGATGACTCAAAAGGGAAAAAGCAAAATCCTATATACCGTCATTTAATGA
ATGGTGTATCATTCATGGTTCCTTTCATTGTTGTAGGAGGATTATTAATTGCAATCGCATTGACACTTGGCGGCGAAAAA
ACTCCTGGTGGTTTAGTGATACCAGAAGGTTCTTTTTGGAAAACAATTGAGCAGATAGGTGGAGCTTCATTTGCATTTAT
GGTTCCAATTTTAGCTGGCTATATTGCGTACAGTATAGCTGATAAACCTGGACTTGTTCCTGGTATGATTGGCGGATATA
TTGCAGCAACGGGAAGTTTTTATGGTAGTGAGAGTGGAGCTGGTTTCCTAGGTGGCATTATCGCAGGTTTCTTAGCTGGT
TATGTTGCTTTAGGAATTAAAAAATTAAAGGTACCAAAAGCGATTCAACCAATTATGCCGATTATTATTATTCCGGTATT
TACATCACTTATTGTTGGTTTAGCATTTGTATTTATTATCGGTGCTCCTGTAGCACAAGTATTTGAATCATTAACAGCTT
GGTTAGCTGGTATGCAAGGTTCAAGTTCAATTCTTTTAGCATTAATCTTAGGTGCAATGATTTCATTTGATATGGGTGGT
CCAGTAAATAAAGTGGCATTCTTATTTGGTTCCGCAATGATTGGAGAAGGAAATTATGAAATTATGGGACCGATTGCAGC
AGCGATTTGTATTCCACCAATCGGGATGGGACTTGCTACGTTTATAGGAAAGAGAAAGTTCCAAGAAGCTGAAAAGGAAA
TGGGGAAAGCCTCATTTACGATGGGCTTATTCGGTATTACAGAAGGAGCTATTCCTTTTGCGGCACAGGATCCATTACGT
GTTATTCCAAGTATTATGGCGGGTTCTATGACAGGTGCAGTTATTGCAATGATTGGTAACGTAGGAGATAGAGTAGCACA
TGGTGGACCGATCGTTGCGGTACTAGGAGCGGTAGATAACGTATTTATGTTCTTTGTTGCTATTATTGCAGGTTCTATTG
TTACAGCGGTTATTGTGAATGTATTAAAGAAAGATATTTTAAAACCTGAAGAAACACAGGAATTAAAAGAAATGAAAGAA
GTTTCAGCAACTAAGGAAGTAACGGAAGTTCAAGAACAAGAAATAGAACAGAAAGCTGAAAAGGTTGAAATTCAGAAGTT
AACAGATATAACGAGTTTGGAGCTAATTGATGTTAATTTAGCAGGAGAGACACGTGACGATATTATTGATGAAATGATTG
GGAAATTAAATGCCGTAGGTGCTTTACATTCTGATTCTGAGTTTAAGCAAGCAATTATGAGCCGCGAAGCAGAGAGTAGT
ACAGGCATTGGAATGAATATTGCGATTCCTCATGGGAAGTCGAATGCAGTAAAAAAACCAAGTGTTGTATTTGGAATTAA
ACAATCAGGGGTAGATTGGAAGAGTTTAGATGGAACGGATGCAAAATTAATATTTATGATTGCAGTTCCGAAAGAGAGTG
AAGGAAATGAGCACTTAAAGATTCTTCAAATGCTTTCAAGAAAACTTATGGATGATAGTTATAGAGAGAGATTAATATCT
GTCCAAACGAAAGAAGAAGCACATAAGTTATTAGATGACATCGTATAA

Upstream 100 bases:

>100_bases
TGCTCCGGTAAAATAATGTTTTTTCCGGAGGTTACGGTAAAAAAGAAAACTTTTATGAATCGAATATTGATATATATTAT
TTGTAGGCGCTTACATAAGG

Downstream 100 bases:

>100_bases
AATGGAGGATTTTAATCATGACAGAACCGTTATTTTTTGCACCCATTTTTAAAGAAAGAATTTGGGGTGGTACGAAATTA
ACTTCTTTCGGATATGAAAT

Product: phosphotransferase system (PTS) mannose-specific enzyme IIBCA

Products: NA

Alternate protein names: EIIBCA-Man; EII-Man; Mannose-specific phosphotransferase enzyme IIB component; PTS system mannose-specific EIIB component; Mannose permease IIC component; PTS system mannose-specific EIIC component; Mannose-specific phosphotransferase enzyme IIA component; PTS system mannose-specific EIIA component [H]

Number of amino acids: Translated: 655; Mature: 655

Protein sequence:

>655_residues
MRRIKMKVLAITSCPNGIAHTYMAAENLQKAADKLGIQMKVETQGGIGVENELTEQEIHEADGIIIAADRAVNKDRFIGK
KLLVVGVKDGIRKPEELIQKVVDGNVPVYHSDVKEAGDDSKGKKQNPIYRHLMNGVSFMVPFIVVGGLLIAIALTLGGEK
TPGGLVIPEGSFWKTIEQIGGASFAFMVPILAGYIAYSIADKPGLVPGMIGGYIAATGSFYGSESGAGFLGGIIAGFLAG
YVALGIKKLKVPKAIQPIMPIIIIPVFTSLIVGLAFVFIIGAPVAQVFESLTAWLAGMQGSSSILLALILGAMISFDMGG
PVNKVAFLFGSAMIGEGNYEIMGPIAAAICIPPIGMGLATFIGKRKFQEAEKEMGKASFTMGLFGITEGAIPFAAQDPLR
VIPSIMAGSMTGAVIAMIGNVGDRVAHGGPIVAVLGAVDNVFMFFVAIIAGSIVTAVIVNVLKKDILKPEETQELKEMKE
VSATKEVTEVQEQEIEQKAEKVEIQKLTDITSLELIDVNLAGETRDDIIDEMIGKLNAVGALHSDSEFKQAIMSREAESS
TGIGMNIAIPHGKSNAVKKPSVVFGIKQSGVDWKSLDGTDAKLIFMIAVPKESEGNEHLKILQMLSRKLMDDSYRERLIS
VQTKEEAHKLLDDIV

Sequences:

>Translated_655_residues
MRRIKMKVLAITSCPNGIAHTYMAAENLQKAADKLGIQMKVETQGGIGVENELTEQEIHEADGIIIAADRAVNKDRFIGK
KLLVVGVKDGIRKPEELIQKVVDGNVPVYHSDVKEAGDDSKGKKQNPIYRHLMNGVSFMVPFIVVGGLLIAIALTLGGEK
TPGGLVIPEGSFWKTIEQIGGASFAFMVPILAGYIAYSIADKPGLVPGMIGGYIAATGSFYGSESGAGFLGGIIAGFLAG
YVALGIKKLKVPKAIQPIMPIIIIPVFTSLIVGLAFVFIIGAPVAQVFESLTAWLAGMQGSSSILLALILGAMISFDMGG
PVNKVAFLFGSAMIGEGNYEIMGPIAAAICIPPIGMGLATFIGKRKFQEAEKEMGKASFTMGLFGITEGAIPFAAQDPLR
VIPSIMAGSMTGAVIAMIGNVGDRVAHGGPIVAVLGAVDNVFMFFVAIIAGSIVTAVIVNVLKKDILKPEETQELKEMKE
VSATKEVTEVQEQEIEQKAEKVEIQKLTDITSLELIDVNLAGETRDDIIDEMIGKLNAVGALHSDSEFKQAIMSREAESS
TGIGMNIAIPHGKSNAVKKPSVVFGIKQSGVDWKSLDGTDAKLIFMIAVPKESEGNEHLKILQMLSRKLMDDSYRERLIS
VQTKEEAHKLLDDIV
>Mature_655_residues
MRRIKMKVLAITSCPNGIAHTYMAAENLQKAADKLGIQMKVETQGGIGVENELTEQEIHEADGIIIAADRAVNKDRFIGK
KLLVVGVKDGIRKPEELIQKVVDGNVPVYHSDVKEAGDDSKGKKQNPIYRHLMNGVSFMVPFIVVGGLLIAIALTLGGEK
TPGGLVIPEGSFWKTIEQIGGASFAFMVPILAGYIAYSIADKPGLVPGMIGGYIAATGSFYGSESGAGFLGGIIAGFLAG
YVALGIKKLKVPKAIQPIMPIIIIPVFTSLIVGLAFVFIIGAPVAQVFESLTAWLAGMQGSSSILLALILGAMISFDMGG
PVNKVAFLFGSAMIGEGNYEIMGPIAAAICIPPIGMGLATFIGKRKFQEAEKEMGKASFTMGLFGITEGAIPFAAQDPLR
VIPSIMAGSMTGAVIAMIGNVGDRVAHGGPIVAVLGAVDNVFMFFVAIIAGSIVTAVIVNVLKKDILKPEETQELKEMKE
VSATKEVTEVQEQEIEQKAEKVEIQKLTDITSLELIDVNLAGETRDDIIDEMIGKLNAVGALHSDSEFKQAIMSREAESS
TGIGMNIAIPHGKSNAVKKPSVVFGIKQSGVDWKSLDGTDAKLIFMIAVPKESEGNEHLKILQMLSRKLMDDSYRERLIS
VQTKEEAHKLLDDIV

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1299

COG function: function code G; Phosphotransferase system, fructose-specific IIC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1788492, Length=464, Percent_Identity=44.6120689655172, Blast_Score=372, Evalue=1e-104,
Organism=Escherichia coli, GI1786951, Length=474, Percent_Identity=37.3417721518987, Blast_Score=271, Evalue=7e-74,
Organism=Escherichia coli, GI87082348, Length=486, Percent_Identity=34.156378600823, Blast_Score=261, Evalue=1e-70,
Organism=Escherichia coli, GI1790386, Length=304, Percent_Identity=47.0394736842105, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI1788729, Length=399, Percent_Identity=28.3208020050125, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1790387, Length=96, Percent_Identity=43.75, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI2367327, Length=123, Percent_Identity=32.520325203252, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1788730, Length=96, Percent_Identity=37.5, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI48994992, Length=148, Percent_Identity=25.6756756756757, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1788726, Length=143, Percent_Identity=27.2727272727273, Blast_Score=63, Evalue=6e-11,
Organism=Escherichia coli, GI1790390, Length=97, Percent_Identity=34.020618556701, Blast_Score=63, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR004715
- InterPro:   IPR003353
- InterPro:   IPR006327 [H]

Pfam domain/function: PF00359 PTS_EIIA_2; PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 69766; Mature: 69766

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00372 PTS_EIIA_TYPE_2_HIS ; PS51094 PTS_EIIA_TYPE_2 ; PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRIKMKVLAITSCPNGIAHTYMAAENLQKAADKLGIQMKVETQGGIGVENELTEQEIHE
CCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHH
ADGIIIAADRAVNKDRFIGKKLLVVGVKDGIRKPEELIQKVVDGNVPVYHSDVKEAGDDS
HCCEEEEECCCCCCHHHCCCEEEEEECHHHCCCHHHHHHHHHCCCCCEEECHHHHCCCCC
KGKKQNPIYRHLMNGVSFMVPFIVVGGLLIAIALTLGGEKTPGGLVIPEGSFWKTIEQIG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHC
GASFAFMVPILAGYIAYSIADKPGLVPGMIGGYIAATGSFYGSESGAGFLGGIIAGFLAG
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
YVALGIKKLKVPKAIQPIMPIIIIPVFTSLIVGLAFVFIIGAPVAQVFESLTAWLAGMQG
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
SSSILLALILGAMISFDMGGPVNKVAFLFGSAMIGEGNYEIMGPIAAAICIPPIGMGLAT
CHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHCCCHHHHHH
FIGKRKFQEAEKEMGKASFTMGLFGITEGAIPFAAQDPLRVIPSIMAGSMTGAVIAMIGN
HHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHC
VGDRVAHGGPIVAVLGAVDNVFMFFVAIIAGSIVTAVIVNVLKKDILKPEETQELKEMKE
CHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
VSATKEVTEVQEQEIEQKAEKVEIQKLTDITSLELIDVNLAGETRDDIIDEMIGKLNAVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHC
ALHSDSEFKQAIMSREAESSTGIGMNIAIPHGKSNAVKKPSVVFGIKQSGVDWKSLDGTD
CCCCCHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCC
AKLIFMIAVPKESEGNEHLKILQMLSRKLMDDSYRERLISVQTKEEAHKLLDDIV
CEEEEEEEECCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRRIKMKVLAITSCPNGIAHTYMAAENLQKAADKLGIQMKVETQGGIGVENELTEQEIHE
CCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHH
ADGIIIAADRAVNKDRFIGKKLLVVGVKDGIRKPEELIQKVVDGNVPVYHSDVKEAGDDS
HCCEEEEECCCCCCHHHCCCEEEEEECHHHCCCHHHHHHHHHCCCCCEEECHHHHCCCCC
KGKKQNPIYRHLMNGVSFMVPFIVVGGLLIAIALTLGGEKTPGGLVIPEGSFWKTIEQIG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHC
GASFAFMVPILAGYIAYSIADKPGLVPGMIGGYIAATGSFYGSESGAGFLGGIIAGFLAG
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
YVALGIKKLKVPKAIQPIMPIIIIPVFTSLIVGLAFVFIIGAPVAQVFESLTAWLAGMQG
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
SSSILLALILGAMISFDMGGPVNKVAFLFGSAMIGEGNYEIMGPIAAAICIPPIGMGLAT
CHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHCCCHHHHHH
FIGKRKFQEAEKEMGKASFTMGLFGITEGAIPFAAQDPLRVIPSIMAGSMTGAVIAMIGN
HHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHC
VGDRVAHGGPIVAVLGAVDNVFMFFVAIIAGSIVTAVIVNVLKKDILKPEETQELKEMKE
CHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
VSATKEVTEVQEQEIEQKAEKVEIQKLTDITSLELIDVNLAGETRDDIIDEMIGKLNAVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHC
ALHSDSEFKQAIMSREAESSTGIGMNIAIPHGKSNAVKKPSVVFGIKQSGVDWKSLDGTD
CCCCCHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCC
AKLIFMIAVPKESEGNEHLKILQMLSRKLMDDSYRERLISVQTKEEAHKLLDDIV
CEEEEEEEECCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]