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The map label for this gene is acdA [H]

Identifier: 118480096

GI number: 118480096

Start: 4777216

End: 4779042

Strand: Reverse

Name: acdA [H]

Synonym: BALH_4545

Alternate gene names: 118480096

Gene position: 4779042-4777216 (Counterclockwise)

Preceding gene: 118480097

Following gene: 118480095

Centisome position: 90.91

GC content: 37.93

Gene sequence:

>1827_bases
ATGAGAGAAGCGGCTTATGAAAATATGAAGGAGGAAATTTTCATGGAAAAAACAGTAGGAAATGCGGTTAAAGGCGGTAG
CTTTTTAGTAGATGAGATTACGATTGATCAAGTGTTTACGCCAGAAGATTTTTCATCTGAGCATAAAATGATTGCAAAAA
CGACAGAGGACTTTATCGTAAATGAAGTTCTTCCAGAGCTTGAATATTTAGAGCAACATGAGTTTGATCGTTCTGTTCGT
CTTTTAAAAGAAGCTGGTGAACTTGGTTTATTAGGCGCTGACGTACCAGAAGAGTACGGTGGAATTGGTCTTGATAAAGT
AAGTTCAGCGTTAATCGCAGAGAAATTCTCTCGCGCTGGTGGCTTTGCAATTACTCACGGTGCTCACGTAGGTATCGGAT
CTTTACCAATCGTATTATTCGGTAACGAAGAGCAAAAGAAAAAGTATTTACCATTACTTGCAACTGGTGAAAAATTAGCT
GCATACGCATTAACAGAGCCAGGTTCAGGATCTGACGCATTAGGTGCAAAAACAACTGCACGTTTAAATGCAGAAGGTAC
ACATTACGTATTAAACGGTGAAAAACAGTGGATTACAAACTCTGCATTCGCTGACGTATTTATTGTATATGCAAAAATCG
ATGGAGAGCACTTCTCAGCATTTATCGTAGAGAAAGACTACGCTGGCGTATCTACAAGTCCAGAAGAAAAGAAAATGGGT
ATTAAATGTTCTTCAACTCGTACGTTAATTTTAGAAGATGCGTTAGTACCGAAAGAAAACTTACTTGGTGAAATCGGTAA
AGGTCATATTATCGCATTCAACATTTTAAATATCGGTCGTTATAAATTAGGTGTTGGTACGGTTGGATCTGCGAAACGTG
CAGTAGAAATTTCAGCACAATATGCAAACCAACGTCAACAGTTCAAACAACCAATTGCTCGCTTCCCATTAATTCAAGAG
AAACTTGCGAATATGGCAGCGAAAACATATGCAGCTGAAAGCTCTGTATATCGTACAGTAGGTTTATTCGAAAGTCGTAT
GAGCACATTATCTGAAGAAGAAGTAAAAGACGGTAAAGCAGTAGCAGCTTCTATCGCTGAATATGCAATCGAGTGCTCTT
TAAACAAAGTATTCGGTTCTGAAGTGTTAGACTATACAGTAGATGAAGGTGTTCAAATTCACGGTGGTTACGGATTTATG
GCAGAGTACGAGATTGAAAGAATGTATCGTGATTCTCGTATTAACCGTATTTTTGAAGGGACGAACGAAATTAACCGCCT
AATCGTACCAGGTACGTTCTTACGTAAAGCAATGAAAGGTGAATTACCACTTCTTCAAAAAGCACAAAAATTACAAGAAG
AGTTAATGATGATGATGCCAGAAGAAGTAGGCGATGAGCCATTAGCACTTCAAAAGTATTTAGTAACTAATGCGAAGAAA
ATTGGCTTAATGGTAGCTGGATTAGCTGCTCAAAAATACGGTAAAGCATTAGATAAAGAGCAAGAAATTCTTGTGAATAT
CGCTGACATCGTAAGCAATCTATACGCAATGGAGTCAGCTGTTCTTCGTACAGAAAAAGCCATTAAAACAACTGGTCTTG
AAAAGAATAAACAAAAAGTGTTATACACTGAAGTATTCTGCCAAGAAGCATTTAACGAAATCGAAGCACATGCAAAAGAA
ACACTTATCGCAGTTGAAAACGGCGACATGTTACGCATGATGTTATCATCATTACGTAAATTAACTCGCCACACACCACT
TAACGTAATTCCGAAGAAACGTGAAATTGCTGCGAAAATTTTAGAAGATGAGCGTTACACAGTTTAA

Upstream 100 bases:

>100_bases
AGCGGCTCGCTTAGAATGTGAGAACGAGACGCCGACAATGCAAAGAATGGAAGCAACAAAGGTTTATAAAAAATAAACGG
GAGAGCCAGCTTCTTTCGAA

Downstream 100 bases:

>100_bases
TTATAAACTAAAACCAGTAGTCACAATTTTGTGCAGCTACTGGTTTTTTTATGAATAAATGTTGAAATAATTAGATGCTA
CTAATTATTCAGTGGTGAAA

Product: acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 608; Mature: 608

Protein sequence:

>608_residues
MREAAYENMKEEIFMEKTVGNAVKGGSFLVDEITIDQVFTPEDFSSEHKMIAKTTEDFIVNEVLPELEYLEQHEFDRSVR
LLKEAGELGLLGADVPEEYGGIGLDKVSSALIAEKFSRAGGFAITHGAHVGIGSLPIVLFGNEEQKKKYLPLLATGEKLA
AYALTEPGSGSDALGAKTTARLNAEGTHYVLNGEKQWITNSAFADVFIVYAKIDGEHFSAFIVEKDYAGVSTSPEEKKMG
IKCSSTRTLILEDALVPKENLLGEIGKGHIIAFNILNIGRYKLGVGTVGSAKRAVEISAQYANQRQQFKQPIARFPLIQE
KLANMAAKTYAAESSVYRTVGLFESRMSTLSEEEVKDGKAVAASIAEYAIECSLNKVFGSEVLDYTVDEGVQIHGGYGFM
AEYEIERMYRDSRINRIFEGTNEINRLIVPGTFLRKAMKGELPLLQKAQKLQEELMMMMPEEVGDEPLALQKYLVTNAKK
IGLMVAGLAAQKYGKALDKEQEILVNIADIVSNLYAMESAVLRTEKAIKTTGLEKNKQKVLYTEVFCQEAFNEIEAHAKE
TLIAVENGDMLRMMLSSLRKLTRHTPLNVIPKKREIAAKILEDERYTV

Sequences:

>Translated_608_residues
MREAAYENMKEEIFMEKTVGNAVKGGSFLVDEITIDQVFTPEDFSSEHKMIAKTTEDFIVNEVLPELEYLEQHEFDRSVR
LLKEAGELGLLGADVPEEYGGIGLDKVSSALIAEKFSRAGGFAITHGAHVGIGSLPIVLFGNEEQKKKYLPLLATGEKLA
AYALTEPGSGSDALGAKTTARLNAEGTHYVLNGEKQWITNSAFADVFIVYAKIDGEHFSAFIVEKDYAGVSTSPEEKKMG
IKCSSTRTLILEDALVPKENLLGEIGKGHIIAFNILNIGRYKLGVGTVGSAKRAVEISAQYANQRQQFKQPIARFPLIQE
KLANMAAKTYAAESSVYRTVGLFESRMSTLSEEEVKDGKAVAASIAEYAIECSLNKVFGSEVLDYTVDEGVQIHGGYGFM
AEYEIERMYRDSRINRIFEGTNEINRLIVPGTFLRKAMKGELPLLQKAQKLQEELMMMMPEEVGDEPLALQKYLVTNAKK
IGLMVAGLAAQKYGKALDKEQEILVNIADIVSNLYAMESAVLRTEKAIKTTGLEKNKQKVLYTEVFCQEAFNEIEAHAKE
TLIAVENGDMLRMMLSSLRKLTRHTPLNVIPKKREIAAKILEDERYTV
>Mature_608_residues
MREAAYENMKEEIFMEKTVGNAVKGGSFLVDEITIDQVFTPEDFSSEHKMIAKTTEDFIVNEVLPELEYLEQHEFDRSVR
LLKEAGELGLLGADVPEEYGGIGLDKVSSALIAEKFSRAGGFAITHGAHVGIGSLPIVLFGNEEQKKKYLPLLATGEKLA
AYALTEPGSGSDALGAKTTARLNAEGTHYVLNGEKQWITNSAFADVFIVYAKIDGEHFSAFIVEKDYAGVSTSPEEKKMG
IKCSSTRTLILEDALVPKENLLGEIGKGHIIAFNILNIGRYKLGVGTVGSAKRAVEISAQYANQRQQFKQPIARFPLIQE
KLANMAAKTYAAESSVYRTVGLFESRMSTLSEEEVKDGKAVAASIAEYAIECSLNKVFGSEVLDYTVDEGVQIHGGYGFM
AEYEIERMYRDSRINRIFEGTNEINRLIVPGTFLRKAMKGELPLLQKAQKLQEELMMMMPEEVGDEPLALQKYLVTNAKK
IGLMVAGLAAQKYGKALDKEQEILVNIADIVSNLYAMESAVLRTEKAIKTTGLEKNKQKVLYTEVFCQEAFNEIEAHAKE
TLIAVENGDMLRMMLSSLRKLTRHTPLNVIPKKREIAAKILEDERYTV

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=553, Percent_Identity=35.8047016274864, Blast_Score=313, Evalue=4e-85,
Organism=Homo sapiens, GI76496475, Length=596, Percent_Identity=32.5503355704698, Blast_Score=265, Evalue=7e-71,
Organism=Homo sapiens, GI4557235, Length=567, Percent_Identity=33.8624338624339, Blast_Score=265, Evalue=1e-70,
Organism=Homo sapiens, GI4557233, Length=410, Percent_Identity=35.1219512195122, Blast_Score=246, Evalue=4e-65,
Organism=Homo sapiens, GI7656849, Length=396, Percent_Identity=32.8282828282828, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI226958412, Length=398, Percent_Identity=33.9195979899498, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI187960098, Length=395, Percent_Identity=34.6835443037975, Blast_Score=217, Evalue=3e-56,
Organism=Homo sapiens, GI4557231, Length=395, Percent_Identity=34.6835443037975, Blast_Score=217, Evalue=3e-56,
Organism=Homo sapiens, GI226958414, Length=360, Percent_Identity=35.5555555555556, Blast_Score=208, Evalue=1e-53,
Organism=Homo sapiens, GI4501859, Length=393, Percent_Identity=30.5343511450382, Blast_Score=184, Evalue=3e-46,
Organism=Homo sapiens, GI4501857, Length=411, Percent_Identity=32.1167883211679, Blast_Score=182, Evalue=1e-45,
Organism=Homo sapiens, GI4503943, Length=397, Percent_Identity=31.4861460957179, Blast_Score=180, Evalue=4e-45,
Organism=Homo sapiens, GI7669494, Length=293, Percent_Identity=35.1535836177474, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI48976061, Length=423, Percent_Identity=23.8770685579196, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI211971008, Length=423, Percent_Identity=23.8770685579196, Blast_Score=79, Evalue=2e-14,
Organism=Escherichia coli, GI1786223, Length=364, Percent_Identity=28.5714285714286, Blast_Score=132, Evalue=8e-32,
Organism=Escherichia coli, GI87081958, Length=355, Percent_Identity=31.5492957746479, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI87082384, Length=286, Percent_Identity=24.8251748251748, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71985184, Length=520, Percent_Identity=37.1153846153846, Blast_Score=278, Evalue=7e-75,
Organism=Caenorhabditis elegans, GI17534899, Length=382, Percent_Identity=35.3403141361257, Blast_Score=224, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI71985192, Length=356, Percent_Identity=40.1685393258427, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17569725, Length=400, Percent_Identity=34, Blast_Score=219, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17538396, Length=400, Percent_Identity=34, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17570075, Length=387, Percent_Identity=33.3333333333333, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17506239, Length=397, Percent_Identity=33.5012594458438, Blast_Score=194, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17508101, Length=390, Percent_Identity=31.5384615384615, Blast_Score=191, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI17533517, Length=395, Percent_Identity=29.620253164557, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17534353, Length=393, Percent_Identity=30.5343511450382, Blast_Score=162, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI71990804, Length=259, Percent_Identity=37.8378378378378, Blast_Score=157, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI32563615, Length=238, Percent_Identity=38.2352941176471, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI71982178, Length=289, Percent_Identity=32.1799307958478, Blast_Score=133, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17505929, Length=404, Percent_Identity=25.990099009901, Blast_Score=119, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17551932, Length=367, Percent_Identity=27.7929155313352, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17531909, Length=244, Percent_Identity=27.4590163934426, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI86563383, Length=342, Percent_Identity=26.0233918128655, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI86563381, Length=342, Percent_Identity=26.0233918128655, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17540912, Length=319, Percent_Identity=23.8244514106583, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI281363737, Length=471, Percent_Identity=37.1549893842887, Blast_Score=265, Evalue=9e-71,
Organism=Drosophila melanogaster, GI21356377, Length=413, Percent_Identity=36.5617433414044, Blast_Score=252, Evalue=5e-67,
Organism=Drosophila melanogaster, GI24646207, Length=402, Percent_Identity=34.0796019900498, Blast_Score=217, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24660351, Length=381, Percent_Identity=35.4330708661417, Blast_Score=215, Evalue=6e-56,
Organism=Drosophila melanogaster, GI21355753, Length=381, Percent_Identity=33.8582677165354, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24666513, Length=390, Percent_Identity=32.8205128205128, Blast_Score=192, Evalue=7e-49,
Organism=Drosophila melanogaster, GI19920834, Length=269, Percent_Identity=35.3159851301115, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI221473076, Length=357, Percent_Identity=23.8095238095238, Blast_Score=67, Evalue=5e-11,
Organism=Drosophila melanogaster, GI45550141, Length=357, Percent_Identity=23.8095238095238, Blast_Score=67, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 67366; Mature: 67366

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREAAYENMKEEIFMEKTVGNAVKGGSFLVDEITIDQVFTPEDFSSEHKMIAKTTEDFIV
CCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCEECCCCCCCCHHHHHHHHHHHHH
NEVLPELEYLEQHEFDRSVRLLKEAGELGLLGADVPEEYGGIGLDKVSSALIAEKFSRAG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCHHHCCCCHHHHHHHHHHHHHHHCC
GFAITHGAHVGIGSLPIVLFGNEEQKKKYLPLLATGEKLAAYALTEPGSGSDALGAKTTA
CEEEECCCEECCCCCCEEEECCCHHHHHCCCEEECCCCCEEEEECCCCCCCCCCCCCCEE
RLNAEGTHYVLNGEKQWITNSAFADVFIVYAKIDGEHFSAFIVEKDYAGVSTSPEEKKMG
EECCCCCEEEECCCHHHHCCCHHEEEEEEEEEECCCCEEEEEEEECCCCCCCCCHHHHCC
IKCSSTRTLILEDALVPKENLLGEIGKGHIIAFNILNIGRYKLGVGTVGSAKRAVEISAQ
EEECCCCEEEEECCCCCHHHHHHHCCCCCEEEEEEEECCEEEECCCCCCCCCCEEEHHHH
YANQRQQFKQPIARFPLIQEKLANMAAKTYAAESSVYRTVGLFESRMSTLSEEEVKDGKA
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
VAASIAEYAIECSLNKVFGSEVLDYTVDEGVQIHGGYGFMAEYEIERMYRDSRINRIFEG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCC
TNEINRLIVPGTFLRKAMKGELPLLQKAQKLQEELMMMMPEEVGDEPLALQKYLVTNAKK
HHHHCEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHCHHH
IGLMVAGLAAQKYGKALDKEQEILVNIADIVSNLYAMESAVLRTEKAIKTTGLEKNKQKV
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
LYTEVFCQEAFNEIEAHAKETLIAVENGDMLRMMLSSLRKLTRHTPLNVIPKKREIAAKI
HHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
LEDERYTV
HCCCCCCC
>Mature Secondary Structure
MREAAYENMKEEIFMEKTVGNAVKGGSFLVDEITIDQVFTPEDFSSEHKMIAKTTEDFIV
CCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCEECCCCCCCCHHHHHHHHHHHHH
NEVLPELEYLEQHEFDRSVRLLKEAGELGLLGADVPEEYGGIGLDKVSSALIAEKFSRAG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCHHHCCCCHHHHHHHHHHHHHHHCC
GFAITHGAHVGIGSLPIVLFGNEEQKKKYLPLLATGEKLAAYALTEPGSGSDALGAKTTA
CEEEECCCEECCCCCCEEEECCCHHHHHCCCEEECCCCCEEEEECCCCCCCCCCCCCCEE
RLNAEGTHYVLNGEKQWITNSAFADVFIVYAKIDGEHFSAFIVEKDYAGVSTSPEEKKMG
EECCCCCEEEECCCHHHHCCCHHEEEEEEEEEECCCCEEEEEEEECCCCCCCCCHHHHCC
IKCSSTRTLILEDALVPKENLLGEIGKGHIIAFNILNIGRYKLGVGTVGSAKRAVEISAQ
EEECCCCEEEEECCCCCHHHHHHHCCCCCEEEEEEEECCEEEECCCCCCCCCCEEEHHHH
YANQRQQFKQPIARFPLIQEKLANMAAKTYAAESSVYRTVGLFESRMSTLSEEEVKDGKA
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
VAASIAEYAIECSLNKVFGSEVLDYTVDEGVQIHGGYGFMAEYEIERMYRDSRINRIFEG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCC
TNEINRLIVPGTFLRKAMKGELPLLQKAQKLQEELMMMMPEEVGDEPLALQKYLVTNAKK
HHHHCEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHCHHH
IGLMVAGLAAQKYGKALDKEQEILVNIADIVSNLYAMESAVLRTEKAIKTTGLEKNKQKV
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
LYTEVFCQEAFNEIEAHAKETLIAVENGDMLRMMLSSLRKLTRHTPLNVIPKKREIAAKI
HHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
LEDERYTV
HCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]