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The map label for this gene is ldh [H]

Identifier: 118480083

GI number: 118480083

Start: 4766332

End: 4767435

Strand: Reverse

Name: ldh [H]

Synonym: BALH_4532

Alternate gene names: 118480083

Gene position: 4767435-4766332 (Counterclockwise)

Preceding gene: 118480084

Following gene: 118480082

Centisome position: 90.69

GC content: 35.05

Gene sequence:

>1104_bases
ATGACGAAAATGGAATATAACAATTCACAAAAAGGACAAAAACTTTGTTCAATATTTCACAAAGTATCCATGGTTTCTAT
CGTGGGAACCTCTATAATTAGGAGTGTAAGGAACAAAAGAAATAGATTATATGATCAATTAGGAGAGATTGCTATGAAAA
GACATACAAGAAAAATTGCAATTATCGGTACTGGATTAGTTGGATCAAGTTGTGCATATTCCATTGTCAATCAAGGCATT
TGCGAAGAGCTATTATTAATTGATATAAATCATGAACGTGCAGTTGGGGAAGCGATGGATTTATCGCACTGCATTAACTT
TACAAATACAAGAACAAAAGTATATGCAGGAAGCTATGAAGACTGCAAAGATATGGACATCGTTATTATTACAGCAGGAC
CAGCACCAAAACCAGGACAAAGTCGCTTAGATACTTTAGGAGCGAGCGCGAAGATTATGGAAAGTGTTGTTGGCGGCGTA
ATGGAAAGTGGATTTGATGGTATTTTCTTACTTGCATCGAACCCAGTTGATATTATTACGTATCAAGTGTGGAAATTATC
TGGATTACCTAGAAATCGTGTGATTGGTACTGGTACATCACTAGATTCTTCTCGCTTACGAACAATTTTATCTGAAATGT
TACATGTAGACCCTCGTAGTATTCATGGGTATTCATTAGGAGAACATGGTGATTCTCAAATGGTTGCTTGGTCACACGTA
ACTGTTGGTGGAAAACCAATTCTGCAAATATTAGAAGAACAAAAAGAACGATTTGGTGAAATAGATTTAGATGAAATCGT
TGAGAAGACTGCAAAAGCTGGATGGGAAATTTATAAACGAAAAGGTACTACTTATTATGGAATTGGAAATTCTCTAGCAT
ATATTGCGAGCTCAATCTTTAACGATGATCACCGTGTAATTGCTGTATCAGCCATTTTAGATGGTGAGTATGGTGAATAT
GATATTTGTACAGGAGTACCAGCTATTATTACTAGAGATGGTATAAGAGAAATTGTAGAACTAAATTTAACAGAGGATGA
AGAATCTCGATTCGCAAAATCAAACGATATTTTACGTGATTATATGAAAACAATTGGTTACTAA

Upstream 100 bases:

>100_bases
GGAATAATAGGATGAAAAAACGAGCGAAAATGGATTCGCTCGTTTTCTTTTTGTATATGTCAATAAATACATAATAAATA
TTTTTCCAGTTGTAACAAAT

Downstream 100 bases:

>100_bases
CTTATAGGAGAAGGTGAAACAAATGAAGGAATATATAATGTCTCGTGTATTTAAAGCATCAGCTGGAATCGCACAAGGTA
TTTTCGTATCCCTTGGAATT

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: L-LDH 3 [H]

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MTKMEYNNSQKGQKLCSIFHKVSMVSIVGTSIIRSVRNKRNRLYDQLGEIAMKRHTRKIAIIGTGLVGSSCAYSIVNQGI
CEELLLIDINHERAVGEAMDLSHCINFTNTRTKVYAGSYEDCKDMDIVIITAGPAPKPGQSRLDTLGASAKIMESVVGGV
MESGFDGIFLLASNPVDIITYQVWKLSGLPRNRVIGTGTSLDSSRLRTILSEMLHVDPRSIHGYSLGEHGDSQMVAWSHV
TVGGKPILQILEEQKERFGEIDLDEIVEKTAKAGWEIYKRKGTTYYGIGNSLAYIASSIFNDDHRVIAVSAILDGEYGEY
DICTGVPAIITRDGIREIVELNLTEDEESRFAKSNDILRDYMKTIGY

Sequences:

>Translated_367_residues
MTKMEYNNSQKGQKLCSIFHKVSMVSIVGTSIIRSVRNKRNRLYDQLGEIAMKRHTRKIAIIGTGLVGSSCAYSIVNQGI
CEELLLIDINHERAVGEAMDLSHCINFTNTRTKVYAGSYEDCKDMDIVIITAGPAPKPGQSRLDTLGASAKIMESVVGGV
MESGFDGIFLLASNPVDIITYQVWKLSGLPRNRVIGTGTSLDSSRLRTILSEMLHVDPRSIHGYSLGEHGDSQMVAWSHV
TVGGKPILQILEEQKERFGEIDLDEIVEKTAKAGWEIYKRKGTTYYGIGNSLAYIASSIFNDDHRVIAVSAILDGEYGEY
DICTGVPAIITRDGIREIVELNLTEDEESRFAKSNDILRDYMKTIGY
>Mature_366_residues
TKMEYNNSQKGQKLCSIFHKVSMVSIVGTSIIRSVRNKRNRLYDQLGEIAMKRHTRKIAIIGTGLVGSSCAYSIVNQGIC
EELLLIDINHERAVGEAMDLSHCINFTNTRTKVYAGSYEDCKDMDIVIITAGPAPKPGQSRLDTLGASAKIMESVVGGVM
ESGFDGIFLLASNPVDIITYQVWKLSGLPRNRVIGTGTSLDSSRLRTILSEMLHVDPRSIHGYSLGEHGDSQMVAWSHVT
VGGKPILQILEEQKERFGEIDLDEIVEKTAKAGWEIYKRKGTTYYGIGNSLAYIASSIFNDDHRVIAVSAILDGEYGEYD
ICTGVPAIITRDGIREIVELNLTEDEESRFAKSNDILRDYMKTIGY

Specific function: Catalyzes The Reversible Oxidation Of Malate To Oxaloacetate. [C]

COG id: COG0039

COG function: function code C; Malate/lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH/MDH superfamily. LDH family [H]

Homologues:

Organism=Homo sapiens, GI5031857, Length=335, Percent_Identity=36.4179104477612, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI260099723, Length=335, Percent_Identity=36.4179104477612, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI47059044, Length=312, Percent_Identity=36.8589743589744, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI221136809, Length=312, Percent_Identity=36.8589743589744, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI291575128, Length=327, Percent_Identity=33.9449541284404, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI4557032, Length=327, Percent_Identity=33.9449541284404, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI9257228, Length=316, Percent_Identity=36.7088607594937, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI4504973, Length=316, Percent_Identity=36.7088607594937, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI15082234, Length=307, Percent_Identity=34.5276872964169, Blast_Score=202, Evalue=6e-52,
Organism=Homo sapiens, GI260099727, Length=237, Percent_Identity=37.1308016877637, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI260099725, Length=206, Percent_Identity=40.2912621359223, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI207028494, Length=234, Percent_Identity=36.7521367521368, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI103472011, Length=294, Percent_Identity=28.9115646258503, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI103472015, Length=185, Percent_Identity=31.8918918918919, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI21735621, Length=239, Percent_Identity=28.0334728033473, Blast_Score=75, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17535107, Length=298, Percent_Identity=36.241610738255, Blast_Score=194, Evalue=8e-50,
Organism=Saccharomyces cerevisiae, GI6322765, Length=267, Percent_Identity=27.7153558052434, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17136226, Length=335, Percent_Identity=35.8208955223881, Blast_Score=214, Evalue=8e-56,
Organism=Drosophila melanogaster, GI45550422, Length=308, Percent_Identity=30.1948051948052, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24663599, Length=339, Percent_Identity=25.6637168141593, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24647881, Length=316, Percent_Identity=25.3164556962025, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: 2640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 260 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2380 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). 260 Molecules/Cell In: Stationary Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001557
- InterPro:   IPR011304
- InterPro:   IPR018177
- InterPro:   IPR022383
- InterPro:   IPR001236
- InterPro:   IPR015955
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02866 Ldh_1_C; PF00056 Ldh_1_N [H]

EC number: =1.1.1.27 [H]

Molecular weight: Translated: 40627; Mature: 40496

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00064 L_LDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKMEYNNSQKGQKLCSIFHKVSMVSIVGTSIIRSVRNKRNRLYDQLGEIAMKRHTRKIA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
IIGTGLVGSSCAYSIVNQGICEELLLIDINHERAVGEAMDLSHCINFTNTRTKVYAGSYE
EEECCCCCCHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEECCCC
DCKDMDIVIITAGPAPKPGQSRLDTLGASAKIMESVVGGVMESGFDGIFLLASNPVDIIT
CCCCCCEEEEECCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEE
YQVWKLSGLPRNRVIGTGTSLDSSRLRTILSEMLHVDPRSIHGYSLGEHGDSQMVAWSHV
EEEEEECCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEE
TVGGKPILQILEEQKERFGEIDLDEIVEKTAKAGWEIYKRKGTTYYGIGNSLAYIASSIF
ECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHH
NDDHRVIAVSAILDGEYGEYDICTGVPAIITRDGIREIVELNLTEDEESRFAKSNDILRD
CCCCCEEEEEEEECCCCCCEEHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
YMKTIGY
HHHHHCC
>Mature Secondary Structure 
TKMEYNNSQKGQKLCSIFHKVSMVSIVGTSIIRSVRNKRNRLYDQLGEIAMKRHTRKIA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
IIGTGLVGSSCAYSIVNQGICEELLLIDINHERAVGEAMDLSHCINFTNTRTKVYAGSYE
EEECCCCCCHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEECCCC
DCKDMDIVIITAGPAPKPGQSRLDTLGASAKIMESVVGGVMESGFDGIFLLASNPVDIIT
CCCCCCEEEEECCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEE
YQVWKLSGLPRNRVIGTGTSLDSSRLRTILSEMLHVDPRSIHGYSLGEHGDSQMVAWSHV
EEEEEECCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEE
TVGGKPILQILEEQKERFGEIDLDEIVEKTAKAGWEIYKRKGTTYYGIGNSLAYIASSIF
ECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHH
NDDHRVIAVSAILDGEYGEYDICTGVPAIITRDGIREIVELNLTEDEESRFAKSNDILRD
CCCCCEEEEEEEECCCCCCEEHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
YMKTIGY
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]