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The map label for this gene is pbpA [H]

Identifier: 118479446

GI number: 118479446

Start: 4077175

End: 4079313

Strand: Reverse

Name: pbpA [H]

Synonym: BALH_3866

Alternate gene names: 118479446

Gene position: 4079313-4077175 (Counterclockwise)

Preceding gene: 118479447

Following gene: 118479445

Centisome position: 77.6

GC content: 36.98

Gene sequence:

>2139_bases
TTGGTAGAGGGGGTTTGTATGAGCAAGAAGCAGAAACAACAAAAGAAAAAGACTCACGTTCCTTTTCGGTTAAACGTGCT
GTTTTTCTGCGTGTTTTTAATGTTCTCCGCGGTTATTGTAAGGCTTGGATATGTACAAATTGTTCGCGGTGAGGAATATA
AAAATGAAGTGGAGAGGAAAGAGAACTCGACGATTAGTAATCCTGTACCACGTGGGAAAATATTTGACCGTTATGGGCGA
GCTGTAGTAGATAATGCAGCTGTACGTACGATTACATTTACAAAAATGAAAGGATCAACTGCAGAGGCTCGCTTAGAAAC
AGCGAAAAAGCTAGCAGATTTGATTGAAGTACCGACAGATAAATTAACAGATCGCGATAAGAAAGATTATTGGCTTGCTA
TTCATAAAGAGGAAGCTAAAGAAAAAATTACGAATAAAGATCGTCAAGAGTTTAAAGATAAAAAAATTGACGATAAAGAA
TTAGATGAGCGTCAACGAAATCGCGTGACAGAAGAAGAAGTGAATCAATTATCCGCAAAAGATTTAGAAGTACTAGCGAT
TAAAAGCAAAATGGACGGCGGATATGCGATGACGCCACAAGTTATTAAAAAGGATGCTACAGAACAAGAATACGCTATTA
TTAGTGAAAATCTAGCAACATTACCGGGTGTAGATACGAATGTTGATTGGGATCGAAAGTATATTTATGATGATTTATTC
CGAAGTGTACTTGGCGGGGTGTCAACGTCTGATGAAGGTTTACCTAGAGAAAGACTAGATTACTATCTTGTTCGTGATTA
TAATCGAAATGACCGCGTAGGGAAAAGTTATCTTGAGCAGCAATATGAAGATAGTTTGCACGGTAATAAAGCGGAAGTGA
GAAATGTTACAGATAAAAACGGTAATATTTTAGAAACGATTAATGTATCAAAAGGGCAAAGTGGTAATAATCTAAATTTA
ACAATTGATATGGAATTACAAAAGCGTGTAGAAGAAATTATCACGAAAAATTTATTGAGATATAAAGGTGGACAACCCTA
TTTAGATCGTGCATTCGTTGTAATGATGAATCCAAAAAATGGTGAAGTTTTATCTATGGCAGGGAAACAGTTAGTGGAAG
AAAATGGCGAAACGAAAGTACAAGATTTCGCATTAGGAACGATGACAAGCTCTTATCCGATGGGATCAACTGTAAAAGGT
GCGACAGTACTTACAGGATATCAAACAGGTGCAATTCAACCAGGTTCAGTTCAACTTGATGAACCAATCAGATTAAAGGG
AACGCCACCAAAATCTTCGTGGAAGACGATGGGATATATTAATGATTTAACAGCATTAAAAATGTCTTCTAACGTATATA
TGTTTAAAACAGCGATGAATATCGCAGGCGTTCAATATGTAAGAGGTGGTACGTTAGATATACCACAAAAAGCATTTGAT
ACGATGCGTTATTATTTCGGACAGTTTGGACTTGGCGTAAAAACAGGTATTGATTTACCAAATGAATCTGCGGGCCAAAC
AGGTAGAGGAAATCAGCCAGGTTTCCTACTAGATTTATCAATTGGACAGTATGATACGTATACGCCACTTCAATTAGCAC
AATATGTTTCAACAATTGCAAATGGTGGATATCGTATGCAGCCGCAAGTTGTAAAGGAAATTCGTCAACCGTCAGCGAAA
CAAGACGAAGTTGGAAAAGTTGTTCATTCAATGGAGCCGAAAGTACTAAATCGTATTGATATGCCTGAATCACAAATTAA
ACGTGTTCAGGAAGGATTTAGACAAGTATTTAACGATTCTGGTGGTACAGCTGCGAAATACTTTGCAGGTGCACCATATA
AAGCTGCTGGTAAAACAGGTACAGCTCAAACTGTGTATGGCGGAGATAAAGAGATTGGTAAAAAGGCAAACGGTGAGCGT
AAAGAAACATATAATTTAACATTAGTAGGTTATGCGCCACTTGAAGACCCTGAAGTAGCATTTTCTGTTGTTGTACCTTG
GGTAGATGATAAATCAGGTATTAACGGATATATTAGCCGTGACATTATGGACGCGTACTTTGATTTGAAAAAAGTAGAAA
ATGGCGAAGCTACTAAAGATGAAATAGATAAGAAAAATAAAGAACAAGATGATGAATAA

Upstream 100 bases:

>100_bases
GAAGGTTAACTTCTCTTTTGTTTTATGCTAGAATAGAAAAAGATGTAAGACAGCAGTGAGGACACCTGTATGAAGGTGTC
CCTTTCACATTACATAGCTG

Downstream 100 bases:

>100_bases
AAAGTTGTAAAAAAAGCACACTATCTGAAAAGATAGTGTGCTTTTTTTTATGGTTCATGCATACGTTTTAATAAGGTGGA
CAAGCATATTATATCGAAAA

Product: penicillin-binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 712; Mature: 712

Protein sequence:

>712_residues
MVEGVCMSKKQKQQKKKTHVPFRLNVLFFCVFLMFSAVIVRLGYVQIVRGEEYKNEVERKENSTISNPVPRGKIFDRYGR
AVVDNAAVRTITFTKMKGSTAEARLETAKKLADLIEVPTDKLTDRDKKDYWLAIHKEEAKEKITNKDRQEFKDKKIDDKE
LDERQRNRVTEEEVNQLSAKDLEVLAIKSKMDGGYAMTPQVIKKDATEQEYAIISENLATLPGVDTNVDWDRKYIYDDLF
RSVLGGVSTSDEGLPRERLDYYLVRDYNRNDRVGKSYLEQQYEDSLHGNKAEVRNVTDKNGNILETINVSKGQSGNNLNL
TIDMELQKRVEEIITKNLLRYKGGQPYLDRAFVVMMNPKNGEVLSMAGKQLVEENGETKVQDFALGTMTSSYPMGSTVKG
ATVLTGYQTGAIQPGSVQLDEPIRLKGTPPKSSWKTMGYINDLTALKMSSNVYMFKTAMNIAGVQYVRGGTLDIPQKAFD
TMRYYFGQFGLGVKTGIDLPNESAGQTGRGNQPGFLLDLSIGQYDTYTPLQLAQYVSTIANGGYRMQPQVVKEIRQPSAK
QDEVGKVVHSMEPKVLNRIDMPESQIKRVQEGFRQVFNDSGGTAAKYFAGAPYKAAGKTGTAQTVYGGDKEIGKKANGER
KETYNLTLVGYAPLEDPEVAFSVVVPWVDDKSGINGYISRDIMDAYFDLKKVENGEATKDEIDKKNKEQDDE

Sequences:

>Translated_712_residues
MVEGVCMSKKQKQQKKKTHVPFRLNVLFFCVFLMFSAVIVRLGYVQIVRGEEYKNEVERKENSTISNPVPRGKIFDRYGR
AVVDNAAVRTITFTKMKGSTAEARLETAKKLADLIEVPTDKLTDRDKKDYWLAIHKEEAKEKITNKDRQEFKDKKIDDKE
LDERQRNRVTEEEVNQLSAKDLEVLAIKSKMDGGYAMTPQVIKKDATEQEYAIISENLATLPGVDTNVDWDRKYIYDDLF
RSVLGGVSTSDEGLPRERLDYYLVRDYNRNDRVGKSYLEQQYEDSLHGNKAEVRNVTDKNGNILETINVSKGQSGNNLNL
TIDMELQKRVEEIITKNLLRYKGGQPYLDRAFVVMMNPKNGEVLSMAGKQLVEENGETKVQDFALGTMTSSYPMGSTVKG
ATVLTGYQTGAIQPGSVQLDEPIRLKGTPPKSSWKTMGYINDLTALKMSSNVYMFKTAMNIAGVQYVRGGTLDIPQKAFD
TMRYYFGQFGLGVKTGIDLPNESAGQTGRGNQPGFLLDLSIGQYDTYTPLQLAQYVSTIANGGYRMQPQVVKEIRQPSAK
QDEVGKVVHSMEPKVLNRIDMPESQIKRVQEGFRQVFNDSGGTAAKYFAGAPYKAAGKTGTAQTVYGGDKEIGKKANGER
KETYNLTLVGYAPLEDPEVAFSVVVPWVDDKSGINGYISRDIMDAYFDLKKVENGEATKDEIDKKNKEQDDE
>Mature_712_residues
MVEGVCMSKKQKQQKKKTHVPFRLNVLFFCVFLMFSAVIVRLGYVQIVRGEEYKNEVERKENSTISNPVPRGKIFDRYGR
AVVDNAAVRTITFTKMKGSTAEARLETAKKLADLIEVPTDKLTDRDKKDYWLAIHKEEAKEKITNKDRQEFKDKKIDDKE
LDERQRNRVTEEEVNQLSAKDLEVLAIKSKMDGGYAMTPQVIKKDATEQEYAIISENLATLPGVDTNVDWDRKYIYDDLF
RSVLGGVSTSDEGLPRERLDYYLVRDYNRNDRVGKSYLEQQYEDSLHGNKAEVRNVTDKNGNILETINVSKGQSGNNLNL
TIDMELQKRVEEIITKNLLRYKGGQPYLDRAFVVMMNPKNGEVLSMAGKQLVEENGETKVQDFALGTMTSSYPMGSTVKG
ATVLTGYQTGAIQPGSVQLDEPIRLKGTPPKSSWKTMGYINDLTALKMSSNVYMFKTAMNIAGVQYVRGGTLDIPQKAFD
TMRYYFGQFGLGVKTGIDLPNESAGQTGRGNQPGFLLDLSIGQYDTYTPLQLAQYVSTIANGGYRMQPQVVKEIRQPSAK
QDEVGKVVHSMEPKVLNRIDMPESQIKRVQEGFRQVFNDSGGTAAKYFAGAPYKAAGKTGTAQTVYGGDKEIGKKANGER
KETYNLTLVGYAPLEDPEVAFSVVVPWVDDKSGINGYISRDIMDAYFDLKKVENGEATKDEIDKKNKEQDDE

Specific function: Cell Wall Formation; Pbp-2 Is Responsible For The Determination Of The Rod Shape Of The Cell. Its Synthesize Cross- Linked Peptidoglycan From The Lipid Intermediates. [C]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=526, Percent_Identity=25.8555133079848, Blast_Score=129, Evalue=9e-31,
Organism=Escherichia coli, GI1786272, Length=403, Percent_Identity=27.0471464019851, Blast_Score=80, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 80018; Mature: 80018

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEGVCMSKKQKQQKKKTHVPFRLNVLFFCVFLMFSAVIVRLGYVQIVRGEEYKNEVERK
CCCCCCCCHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHH
ENSTISNPVPRGKIFDRYGRAVVDNAAVRTITFTKMKGSTAEARLETAKKLADLIEVPTD
HCCCCCCCCCCCHHHHHHCHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCH
KLTDRDKKDYWLAIHKEEAKEKITNKDRQEFKDKKIDDKELDERQRNRVTEEEVNQLSAK
HHCCCCCCCEEEEEEHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHC
DLEVLAIKSKMDGGYAMTPQVIKKDATEQEYAIISENLATLPGVDTNVDWDRKYIYDDLF
CEEEEEEEECCCCCEECCHHHHHCCCCHHHHHHHHCCHHHCCCCCCCCCCCHHHHHHHHH
RSVLGGVSTSDEGLPRERLDYYLVRDYNRNDRVGKSYLEQQYEDSLHGNKAEVRNVTDKN
HHHHCCCCCCCCCCCHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCCCCC
GNILETINVSKGQSGNNLNLTIDMELQKRVEEIITKNLLRYKGGQPYLDRAFVVMMNPKN
CCEEEEEECCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCC
GEVLSMAGKQLVEENGETKVQDFALGTMTSSYPMGSTVKGATVLTGYQTGAIQPGSVQLD
CCCHHHHHHHHHHCCCCCCHHHHEEHHCCCCCCCCCCCCCCEEEECCCCCCCCCCCEECC
EPIRLKGTPPKSSWKTMGYINDLTALKMSSNVYMFKTAMNIAGVQYVRGGTLDIPQKAFD
CCEEECCCCCCCCCCCCCHHHHHHHEEECCCEEEEEEHHHHCCCCEECCCCCCCCHHHHH
TMRYYFGQFGLGVKTGIDLPNESAGQTGRGNQPGFLLDLSIGQYDTYTPLQLAQYVSTIA
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHH
NGGYRMQPQVVKEIRQPSAKQDEVGKVVHSMEPKVLNRIDMPESQIKRVQEGFRQVFNDS
CCCEEECHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHCCC
GGTAAKYFAGAPYKAAGKTGTAQTVYGGDKEIGKKANGERKETYNLTLVGYAPLEDPEVA
CCCHHHHHCCCCCCCCCCCCCCEEECCCCHHHCCCCCCCCCEEEEEEEEEECCCCCCCEE
FSVVVPWVDDKSGINGYISRDIMDAYFDLKKVENGEATKDEIDKKNKEQDDE
EEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCC
>Mature Secondary Structure
MVEGVCMSKKQKQQKKKTHVPFRLNVLFFCVFLMFSAVIVRLGYVQIVRGEEYKNEVERK
CCCCCCCCHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHH
ENSTISNPVPRGKIFDRYGRAVVDNAAVRTITFTKMKGSTAEARLETAKKLADLIEVPTD
HCCCCCCCCCCCHHHHHHCHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCH
KLTDRDKKDYWLAIHKEEAKEKITNKDRQEFKDKKIDDKELDERQRNRVTEEEVNQLSAK
HHCCCCCCCEEEEEEHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHC
DLEVLAIKSKMDGGYAMTPQVIKKDATEQEYAIISENLATLPGVDTNVDWDRKYIYDDLF
CEEEEEEEECCCCCEECCHHHHHCCCCHHHHHHHHCCHHHCCCCCCCCCCCHHHHHHHHH
RSVLGGVSTSDEGLPRERLDYYLVRDYNRNDRVGKSYLEQQYEDSLHGNKAEVRNVTDKN
HHHHCCCCCCCCCCCHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCCCCC
GNILETINVSKGQSGNNLNLTIDMELQKRVEEIITKNLLRYKGGQPYLDRAFVVMMNPKN
CCEEEEEECCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCC
GEVLSMAGKQLVEENGETKVQDFALGTMTSSYPMGSTVKGATVLTGYQTGAIQPGSVQLD
CCCHHHHHHHHHHCCCCCCHHHHEEHHCCCCCCCCCCCCCCEEEECCCCCCCCCCCEECC
EPIRLKGTPPKSSWKTMGYINDLTALKMSSNVYMFKTAMNIAGVQYVRGGTLDIPQKAFD
CCEEECCCCCCCCCCCCCHHHHHHHEEECCCEEEEEEHHHHCCCCEECCCCCCCCHHHHH
TMRYYFGQFGLGVKTGIDLPNESAGQTGRGNQPGFLLDLSIGQYDTYTPLQLAQYVSTIA
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHH
NGGYRMQPQVVKEIRQPSAKQDEVGKVVHSMEPKVLNRIDMPESQIKRVQEGFRQVFNDS
CCCEEECHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHCCC
GGTAAKYFAGAPYKAAGKTGTAQTVYGGDKEIGKKANGERKETYNLTLVGYAPLEDPEVA
CCCHHHHHCCCCCCCCCCCCCCEEECCCCHHHCCCCCCCCCEEEEEEEEEECCCCCCCEE
FSVVVPWVDDKSGINGYISRDIMDAYFDLKKVENGEATKDEIDKKNKEQDDE
EEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]