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The map label for this gene is glmU [H]

Identifier: 118479440

GI number: 118479440

Start: 4069694

End: 4072048

Strand: Reverse

Name: glmU [H]

Synonym: BALH_3860

Alternate gene names: 118479440

Gene position: 4072048-4069694 (Counterclockwise)

Preceding gene: 118479441

Following gene: 118479439

Centisome position: 77.46

GC content: 36.01

Gene sequence:

>2355_bases
ATGAAGGGGGTTATTTTAGCTGGAGGAAAAGGACGACGCCTTAGACCATTAACATGTAATACTCCAAAGCCGATGTTGCC
ATTATTAGAAAAGCCAGTTTTGGAATACAATATTGAATTATTGCGTCAGCATGGTATACGTGAGATTGCAATTACTGTTC
AGTATATGAGTACGGCCATTAAGCAATATTTTGGTGACGGTAGCAAATGGGGCGTTAACTTGTACTACTTTGAAGACTCT
CCACCGCTTGGAACTGCAGGGAGTATTAAACAAGCGGAAAAATTTTTGGATGAAACGTTTGTTGTCATAAGTGGGGATGC
GTTAACTGATTTTCAATTATCAAAAGGAATTACGTTTCATGAACAACAGAAAAGAATGGTAACTATGTTTGTAAAGGAAG
TAGAAAATCCACTCTCATTCGGTCTAGTTGTAATGAACAAAGAACAAGAGGTTACACGATATATAGAAAAACCGAGTTGG
AATGAAGTAGTCTCTAATATTGTGAATACAGGTATATATATTATGGAGCCAGAAATTTTTTCTTACATACCGCGCCGAGA
ATTTTTTGATTTCAGTCAAGATGTGTTTCCATTATTGGCAAATAAAAACGCATTATTTGCATATTTATCAGAAGGTTATT
GGTTAGATATCGGCACATTTGATCAATATCGACAAGCCCAATTTGATTTGTTAACAAAAAAATTGCAAGTACCTATTCCT
TATACTGAAGTATTGCCGATGGTATGGATGGGGGAAGGTGTGACGATTGGAAAAGGCACAAAAATTCACGGCCCTTCTTT
TATTGGAGAGGGAGCAAAAATTGGTGCCGGGGCTGTAATTGAGCCGTACTCTATTATCGGGAAAAATAGTATTGTTTCGA
GTTATTCTCATCTTCAAAAAAGTATTGTTTTTGCAAATGCGCACATTGGACAATATTGCGAGTTATTAGAAACGACAATA
GGAGAGCATACAATGGTGGAAGATGACGTTACATTGTTTCAAAAAAGCATTGTAGCAGATCATTGTCATATAGGGAAAAG
TACGGTAATTAAGCAAAAGGGAAAACTATGGCCATATAAGGCGATTGATAGCTATTCGGTAGTAGGATCGGCTGGTGTTC
AAGAAAGTGAAAAGAGCGCCGGATGGCTGCAAAAAAGTCGCATTGTAGGAAGAGGGAACGTTGAAATCACCCCTCAATTT
ATAGTAAAGGTAGCGATGGCGTACGGATCCCTTTTTACCAAAGGGGAAAGTATATTAATCGGGAGCCAAGAACATATAGA
AACGACTTCTTATAAAAATCTTTTTCTTCATGCGATTCATGGTATTGGGATTCATACGATGGAATGCAAAGAAATGAACG
AATCGCTTTTTCAGTATAGCATTCAAGATTTACAATGTGCAGGTGGAGTTTTCATTCAAGTGGAAAATGAAAAAGAAGTT
ATTATAAAGTTGTATGGTCAGGATGGGGCACAATTAACGTATAAGCAGCAAAAAGCGATAGAACAAGTATATATGTCTGA
GTCTTTTTATTACGTATGTGAGAAAGAAATGGGGCGAAATAAGCTGGTCCATGTTTCTTTACATGATTATATAGAGGCTG
TATTAGAGCGCATTGATATTGAGAAAATACAAAAACAGAAGTTCCACCTTCTTATTAATAAGAGAAATGATATGTTACAA
CATTTACTTATGCTTTTTTTGCAAAGGCTTGGATGCACAGTTACGTGGATTTATGCAGGTGAACAGAAGGATCATGTGAA
GGCCTTGATGAAATCAAGTAAAGCGAATATGGCACTCATGTTTTCAGAGCAAGGAAATTATTTTGAGTTATATGATAATC
ATAGTAACATTTACCAGGGGACAGATTTTGAAGAGGTAGATATTCCAGATTTATTACTTGAATCGGCAGGAAATATTTAC
CCAATGTCTTTGAAATTAGGAGAATGTTACCTTCTATTTTATACGCAGGATGAAAAAAAGTCGTTTCAAACAAGGTGGAA
GCGAGATATCCTATATAGAATTGGAAAATTATTTGAGCTAATAGCATTGCAGGGAAAAACATTTCTCAGCATAGTAGAGC
AATCACCTCCGCTCTATTTACTTTGTGATGAAGTTGTATGTTCATGGAATGAAAAAGGGAAAGTGATGAGGAAATTATTG
GCTGATATGGAAAGAAAGGAAGAAGGTATATTTGAAGGAGTACAGTTCAAATATACCGAAAAAGAGTGGTCTTATATCGT
TTCTGACACAAAACAACCGAAATTTTTAGTGTATTCACATGCTAGAAACCCAGTCATAGCAAGGGAAAACATGAAAAATC
TTATAGAAAAAATTAGACAATATCAAAAGGTGTAG

Upstream 100 bases:

>100_bases
TAATGAAATTTTTATTTTATACTGCTAGTTACTGCTGGGTAGATAATATACATATCGTATATGAAGTTACTGAACATTAT
ATAAGTGGAGGCTGAAGTAT

Downstream 100 bases:

>100_bases
AATTTTTATTTTAAAAGTGGTATTATAGTATAGTCTGATTTAAGTTATTAGTACTGGAGGGAAATAAGAATGCGTGTGAA
TATTACTCTAGCATGTACAG

Product: nucleoside-diphosphate-sugar pyrophosphorylase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 784; Mature: 784

Protein sequence:

>784_residues
MKGVILAGGKGRRLRPLTCNTPKPMLPLLEKPVLEYNIELLRQHGIREIAITVQYMSTAIKQYFGDGSKWGVNLYYFEDS
PPLGTAGSIKQAEKFLDETFVVISGDALTDFQLSKGITFHEQQKRMVTMFVKEVENPLSFGLVVMNKEQEVTRYIEKPSW
NEVVSNIVNTGIYIMEPEIFSYIPRREFFDFSQDVFPLLANKNALFAYLSEGYWLDIGTFDQYRQAQFDLLTKKLQVPIP
YTEVLPMVWMGEGVTIGKGTKIHGPSFIGEGAKIGAGAVIEPYSIIGKNSIVSSYSHLQKSIVFANAHIGQYCELLETTI
GEHTMVEDDVTLFQKSIVADHCHIGKSTVIKQKGKLWPYKAIDSYSVVGSAGVQESEKSAGWLQKSRIVGRGNVEITPQF
IVKVAMAYGSLFTKGESILIGSQEHIETTSYKNLFLHAIHGIGIHTMECKEMNESLFQYSIQDLQCAGGVFIQVENEKEV
IIKLYGQDGAQLTYKQQKAIEQVYMSESFYYVCEKEMGRNKLVHVSLHDYIEAVLERIDIEKIQKQKFHLLINKRNDMLQ
HLLMLFLQRLGCTVTWIYAGEQKDHVKALMKSSKANMALMFSEQGNYFELYDNHSNIYQGTDFEEVDIPDLLLESAGNIY
PMSLKLGECYLLFYTQDEKKSFQTRWKRDILYRIGKLFELIALQGKTFLSIVEQSPPLYLLCDEVVCSWNEKGKVMRKLL
ADMERKEEGIFEGVQFKYTEKEWSYIVSDTKQPKFLVYSHARNPVIARENMKNLIEKIRQYQKV

Sequences:

>Translated_784_residues
MKGVILAGGKGRRLRPLTCNTPKPMLPLLEKPVLEYNIELLRQHGIREIAITVQYMSTAIKQYFGDGSKWGVNLYYFEDS
PPLGTAGSIKQAEKFLDETFVVISGDALTDFQLSKGITFHEQQKRMVTMFVKEVENPLSFGLVVMNKEQEVTRYIEKPSW
NEVVSNIVNTGIYIMEPEIFSYIPRREFFDFSQDVFPLLANKNALFAYLSEGYWLDIGTFDQYRQAQFDLLTKKLQVPIP
YTEVLPMVWMGEGVTIGKGTKIHGPSFIGEGAKIGAGAVIEPYSIIGKNSIVSSYSHLQKSIVFANAHIGQYCELLETTI
GEHTMVEDDVTLFQKSIVADHCHIGKSTVIKQKGKLWPYKAIDSYSVVGSAGVQESEKSAGWLQKSRIVGRGNVEITPQF
IVKVAMAYGSLFTKGESILIGSQEHIETTSYKNLFLHAIHGIGIHTMECKEMNESLFQYSIQDLQCAGGVFIQVENEKEV
IIKLYGQDGAQLTYKQQKAIEQVYMSESFYYVCEKEMGRNKLVHVSLHDYIEAVLERIDIEKIQKQKFHLLINKRNDMLQ
HLLMLFLQRLGCTVTWIYAGEQKDHVKALMKSSKANMALMFSEQGNYFELYDNHSNIYQGTDFEEVDIPDLLLESAGNIY
PMSLKLGECYLLFYTQDEKKSFQTRWKRDILYRIGKLFELIALQGKTFLSIVEQSPPLYLLCDEVVCSWNEKGKVMRKLL
ADMERKEEGIFEGVQFKYTEKEWSYIVSDTKQPKFLVYSHARNPVIARENMKNLIEKIRQYQKV
>Mature_784_residues
MKGVILAGGKGRRLRPLTCNTPKPMLPLLEKPVLEYNIELLRQHGIREIAITVQYMSTAIKQYFGDGSKWGVNLYYFEDS
PPLGTAGSIKQAEKFLDETFVVISGDALTDFQLSKGITFHEQQKRMVTMFVKEVENPLSFGLVVMNKEQEVTRYIEKPSW
NEVVSNIVNTGIYIMEPEIFSYIPRREFFDFSQDVFPLLANKNALFAYLSEGYWLDIGTFDQYRQAQFDLLTKKLQVPIP
YTEVLPMVWMGEGVTIGKGTKIHGPSFIGEGAKIGAGAVIEPYSIIGKNSIVSSYSHLQKSIVFANAHIGQYCELLETTI
GEHTMVEDDVTLFQKSIVADHCHIGKSTVIKQKGKLWPYKAIDSYSVVGSAGVQESEKSAGWLQKSRIVGRGNVEITPQF
IVKVAMAYGSLFTKGESILIGSQEHIETTSYKNLFLHAIHGIGIHTMECKEMNESLFQYSIQDLQCAGGVFIQVENEKEV
IIKLYGQDGAQLTYKQQKAIEQVYMSESFYYVCEKEMGRNKLVHVSLHDYIEAVLERIDIEKIQKQKFHLLINKRNDMLQ
HLLMLFLQRLGCTVTWIYAGEQKDHVKALMKSSKANMALMFSEQGNYFELYDNHSNIYQGTDFEEVDIPDLLLESAGNIY
PMSLKLGECYLLFYTQDEKKSFQTRWKRDILYRIGKLFELIALQGKTFLSIVEQSPPLYLLCDEVVCSWNEKGKVMRKLL
ADMERKEEGIFEGVQFKYTEKEWSYIVSDTKQPKFLVYSHARNPVIARENMKNLIEKIRQYQKV

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=365, Percent_Identity=29.5890410958904, Blast_Score=164, Evalue=3e-40,
Organism=Homo sapiens, GI11761619, Length=385, Percent_Identity=27.7922077922078, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI31881779, Length=355, Percent_Identity=29.0140845070423, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI45447090, Length=355, Percent_Identity=29.0140845070423, Blast_Score=117, Evalue=3e-26,
Organism=Escherichia coli, GI1788351, Length=227, Percent_Identity=30.8370044052863, Blast_Score=93, Evalue=8e-20,
Organism=Escherichia coli, GI1790224, Length=235, Percent_Identity=31.4893617021277, Blast_Score=92, Evalue=2e-19,
Organism=Escherichia coli, GI1789837, Length=383, Percent_Identity=21.6710182767624, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1788355, Length=271, Percent_Identity=25.4612546125461, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI133931050, Length=353, Percent_Identity=29.7450424929178, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17509979, Length=341, Percent_Identity=26.9794721407625, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17509981, Length=331, Percent_Identity=25.9818731117825, Blast_Score=91, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320148, Length=374, Percent_Identity=27.807486631016, Blast_Score=158, Evalue=3e-39,
Organism=Drosophila melanogaster, GI21355443, Length=361, Percent_Identity=31.5789473684211, Blast_Score=161, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24644084, Length=361, Percent_Identity=31.5789473684211, Blast_Score=161, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24653912, Length=372, Percent_Identity=27.1505376344086, Blast_Score=116, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 89778; Mature: 89778

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGVILAGGKGRRLRPLTCNTPKPMLPLLEKPVLEYNIELLRQHGIREIAITVQYMSTAI
CCCEEEECCCCCEECCEECCCCCCCHHHHHCCHHHHHHHHHHHCCCEEEEEHHHHHHHHH
KQYFGDGSKWGVNLYYFEDSPPLGTAGSIKQAEKFLDETFVVISGDALTDFQLSKGITFH
HHHHCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHCCEEEEEECCCEECCHHHCCCCHH
EQQKRMVTMFVKEVENPLSFGLVVMNKEQEVTRYIEKPSWNEVVSNIVNTGIYIMEPEIF
HHHHHHHHHHHHHHCCCHHEEEEEECCHHHHHHHHCCCCHHHHHHHHHHCCEEEECCHHH
SYIPRREFFDFSQDVFPLLANKNALFAYLSEGYWLDIGTFDQYRQAQFDLLTKKLQVPIP
HHCCCHHHCCCCCCHHHHHCCCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHCCCCC
YTEVLPMVWMGEGVTIGKGTKIHGPSFIGEGAKIGAGAVIEPYSIIGKNSIVSSYSHLQK
HHHHCCHHEECCCEEECCCCEECCCCCCCCCCCCCCCCEECCHHHHCCHHHHHHHHHHHH
SIVFANAHIGQYCELLETTIGEHTMVEDDVTLFQKSIVADHCHIGKSTVIKQKGKLWPYK
HHEEECCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCC
AIDSYSVVGSAGVQESEKSAGWLQKSRIVGRGNVEITPQFIVKVAMAYGSLFTKGESILI
CCCCEEECCCCCCCCCHHHHCHHHHHCEEECCCCEECHHHHHHHHHHHHHHHCCCCEEEE
GSQEHIETTSYKNLFLHAIHGIGIHTMECKEMNESLFQYSIQDLQCAGGVFIQVENEKEV
CCHHHCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEE
IIKLYGQDGAQLTYKQQKAIEQVYMSESFYYVCEKEMGRNKLVHVSLHDYIEAVLERIDI
EEEEECCCCCEEEHHHHHHHHHHHHCCCEEEEEEHHCCCCCEEEEEHHHHHHHHHHHHCH
EKIQKQKFHLLINKRNDMLQHLLMLFLQRLGCTVTWIYAGEQKDHVKALMKSSKANMALM
HHHHHHHEEEEEECHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCCEEEE
FSEQGNYFELYDNHSNIYQGTDFEEVDIPDLLLESAGNIYPMSLKLGECYLLFYTQDEKK
EECCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHCCCCEEEEEEEECCEEEEEEECCHHH
SFQTRWKRDILYRIGKLFELIALQGKTFLSIVEQSPPLYLLCDEVVCSWNEKGKVMRKLL
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEECHHHHCCCCCHHHHHHHH
ADMERKEEGIFEGVQFKYTEKEWSYIVSDTKQPKFLVYSHARNPVIARENMKNLIEKIRQ
HHHHHHHHHHHCCCEEEEECCHHHHEECCCCCCEEEEEECCCCCEEEHHHHHHHHHHHHH
YQKV
HHCC
>Mature Secondary Structure
MKGVILAGGKGRRLRPLTCNTPKPMLPLLEKPVLEYNIELLRQHGIREIAITVQYMSTAI
CCCEEEECCCCCEECCEECCCCCCCHHHHHCCHHHHHHHHHHHCCCEEEEEHHHHHHHHH
KQYFGDGSKWGVNLYYFEDSPPLGTAGSIKQAEKFLDETFVVISGDALTDFQLSKGITFH
HHHHCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHCCEEEEEECCCEECCHHHCCCCHH
EQQKRMVTMFVKEVENPLSFGLVVMNKEQEVTRYIEKPSWNEVVSNIVNTGIYIMEPEIF
HHHHHHHHHHHHHHCCCHHEEEEEECCHHHHHHHHCCCCHHHHHHHHHHCCEEEECCHHH
SYIPRREFFDFSQDVFPLLANKNALFAYLSEGYWLDIGTFDQYRQAQFDLLTKKLQVPIP
HHCCCHHHCCCCCCHHHHHCCCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHCCCCC
YTEVLPMVWMGEGVTIGKGTKIHGPSFIGEGAKIGAGAVIEPYSIIGKNSIVSSYSHLQK
HHHHCCHHEECCCEEECCCCEECCCCCCCCCCCCCCCCEECCHHHHCCHHHHHHHHHHHH
SIVFANAHIGQYCELLETTIGEHTMVEDDVTLFQKSIVADHCHIGKSTVIKQKGKLWPYK
HHEEECCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCC
AIDSYSVVGSAGVQESEKSAGWLQKSRIVGRGNVEITPQFIVKVAMAYGSLFTKGESILI
CCCCEEECCCCCCCCCHHHHCHHHHHCEEECCCCEECHHHHHHHHHHHHHHHCCCCEEEE
GSQEHIETTSYKNLFLHAIHGIGIHTMECKEMNESLFQYSIQDLQCAGGVFIQVENEKEV
CCHHHCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEE
IIKLYGQDGAQLTYKQQKAIEQVYMSESFYYVCEKEMGRNKLVHVSLHDYIEAVLERIDI
EEEEECCCCCEEEHHHHHHHHHHHHCCCEEEEEEHHCCCCCEEEEEHHHHHHHHHHHHCH
EKIQKQKFHLLINKRNDMLQHLLMLFLQRLGCTVTWIYAGEQKDHVKALMKSSKANMALM
HHHHHHHEEEEEECHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCCEEEE
FSEQGNYFELYDNHSNIYQGTDFEEVDIPDLLLESAGNIYPMSLKLGECYLLFYTQDEKK
EECCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHCCCCEEEEEEEECCEEEEEEECCHHH
SFQTRWKRDILYRIGKLFELIALQGKTFLSIVEQSPPLYLLCDEVVCSWNEKGKVMRKLL
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEECHHHHCCCCCHHHHHHHH
ADMERKEEGIFEGVQFKYTEKEWSYIVSDTKQPKFLVYSHARNPVIARENMKNLIEKIRQ
HHHHHHHHHHHCCCEEEEECCHHHHEECCCCCCEEEEEECCCCCEEEHHHHHHHHHHHHH
YQKV
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]