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The map label for this gene is metC [H]

Identifier: 118479432

GI number: 118479432

Start: 4061413

End: 4062642

Strand: Direct

Name: metC [H]

Synonym: BALH_3852

Alternate gene names: 118479432

Gene position: 4061413-4062642 (Clockwise)

Preceding gene: 118479425

Following gene: 118479433

Centisome position: 77.26

GC content: 38.54

Gene sequence:

>1230_bases
GTGAAAAATTTGACAGATGAGAAGAAGACTCTATTCAAACCGAAAGCCTTCTTCTTAGAAGGCTTTTTTTATTTTATATT
CAACTACTGGTTCAATTTAAAAAGGAGGAATTTTTACATGTCAACTATCGAAACAAAACTAGCGCAAATCGGAAACCGGA
GTGAAACTACAACAGGAACTGTTAATCCGCCTGTTTACTTTTCAACTGCTTATCGTCACGAAGGAATTGGTAAATCTACT
GGATTTGACTATTCACGAACTGGAAATCCAACTCGCGGCCTATTAGAACAGGCAATCGCAGACTTAGAATACGGCGAACA
AGGTTATGCCTGTAGTTCCGGTATGGCATCTGTGCTCCTTGTCCTTTCCCTATTCCGCTCTGGAGACGAACTTATTGTAT
CCGAAGATTTATACGGGGGCACTTATCGATTATTTTCTGAGCACGAAAAAAAGTGGAATGTTCGATGTAGATACGTAAAT
ACACAATCTATTAAACAAATTGAGCAAGCTATCACAACTGAAACGAAAGCTATTTTCATAGAAACCCCGACAAATCCATT
AATGCAAGTTACTGATATTGCCGCTGTCGCAACTGTAGCAAAAAGACACGGACTACTTCTTATTGTAGACAACACATTCT
ACACGCCTTATATACAGCAGCCATTAACAGAAGGTGCTGACATTGTACTTCATAGCGCAACAAAATATTTAGGAGGACAT
AACGATGTACTAAGCGGACTTGTCGTTGCAAAAGGAAAGGAACTTTGTGAGGAAATCGCCCATTATCATAATGCATCAGG
TGCGGTCTTAAGTCCATTTGACTCATGGCTATTAATCCGTGGTATGAAAACGTTAGCGCTTCGCATGAGACAACATGAAG
AAAATGCAAAAGCAGTTGTTGCTTATTTAAATGATGAGGACGGGGTGACAGATGTATTTTATCCTGGAAGAGGCGGCATG
ATCTCATTTCGTCTTAAAGATGAAACATGGATTAATCCATTCTTACAATCTTTATCCTTAATTACATTCGCCGAAAGTCT
TGGTGGTGTTGAAAGTTTAATGACATATCCAGCAACACAAACACACGCTGATATTCCTGAAGAAATCAGAACAGCAAACG
GTGTATGTAATCGTCTTCTTCGATTTTCTGTTGGCATTGAAAATAGTAACGATTTAATTCAAGACTTACAGCAAGCCATT
AAACTTGTAAAAGAAGGTGTAAGAATATGA

Upstream 100 bases:

>100_bases
TTTCATACGAACATTCTTATCTAGAGAGGTAGAGGGACTGGCCCTATGACGCCTCAGCAACCATTAACATTTGTTAATAA
GGTGCTAATTCCAGCAAATT

Downstream 100 bases:

>100_bases
GTTATTCTATAGATACACTCTTACTACACAACCAATATAAACATGATCCACAAACAGGAGCGGTTAACGTTCCCATCTAT
AACACATCAACATTCCACCA

Product: cystathionine gamma-synthase

Products: NA

Alternate protein names: CGS; O-acetylhomoserine (thiol)-lyase; O-acetylhomoserine sulfhydrylase; OAH sulfhydrylase [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MKNLTDEKKTLFKPKAFFLEGFFYFIFNYWFNLKRRNFYMSTIETKLAQIGNRSETTTGTVNPPVYFSTAYRHEGIGKST
GFDYSRTGNPTRGLLEQAIADLEYGEQGYACSSGMASVLLVLSLFRSGDELIVSEDLYGGTYRLFSEHEKKWNVRCRYVN
TQSIKQIEQAITTETKAIFIETPTNPLMQVTDIAAVATVAKRHGLLLIVDNTFYTPYIQQPLTEGADIVLHSATKYLGGH
NDVLSGLVVAKGKELCEEIAHYHNASGAVLSPFDSWLLIRGMKTLALRMRQHEENAKAVVAYLNDEDGVTDVFYPGRGGM
ISFRLKDETWINPFLQSLSLITFAESLGGVESLMTYPATQTHADIPEEIRTANGVCNRLLRFSVGIENSNDLIQDLQQAI
KLVKEGVRI

Sequences:

>Translated_409_residues
MKNLTDEKKTLFKPKAFFLEGFFYFIFNYWFNLKRRNFYMSTIETKLAQIGNRSETTTGTVNPPVYFSTAYRHEGIGKST
GFDYSRTGNPTRGLLEQAIADLEYGEQGYACSSGMASVLLVLSLFRSGDELIVSEDLYGGTYRLFSEHEKKWNVRCRYVN
TQSIKQIEQAITTETKAIFIETPTNPLMQVTDIAAVATVAKRHGLLLIVDNTFYTPYIQQPLTEGADIVLHSATKYLGGH
NDVLSGLVVAKGKELCEEIAHYHNASGAVLSPFDSWLLIRGMKTLALRMRQHEENAKAVVAYLNDEDGVTDVFYPGRGGM
ISFRLKDETWINPFLQSLSLITFAESLGGVESLMTYPATQTHADIPEEIRTANGVCNRLLRFSVGIENSNDLIQDLQQAI
KLVKEGVRI
>Mature_409_residues
MKNLTDEKKTLFKPKAFFLEGFFYFIFNYWFNLKRRNFYMSTIETKLAQIGNRSETTTGTVNPPVYFSTAYRHEGIGKST
GFDYSRTGNPTRGLLEQAIADLEYGEQGYACSSGMASVLLVLSLFRSGDELIVSEDLYGGTYRLFSEHEKKWNVRCRYVN
TQSIKQIEQAITTETKAIFIETPTNPLMQVTDIAAVATVAKRHGLLLIVDNTFYTPYIQQPLTEGADIVLHSATKYLGGH
NDVLSGLVVAKGKELCEEIAHYHNASGAVLSPFDSWLLIRGMKTLALRMRQHEENAKAVVAYLNDEDGVTDVFYPGRGGM
ISFRLKDETWINPFLQSLSLITFAESLGGVESLMTYPATQTHADIPEEIRTANGVCNRLLRFSVGIENSNDLIQDLQQAI
KLVKEGVRI

Specific function: Catalyzes the transformation of O-succinylhomoserine into cystathionine, as well as O-acetylhomoserine and sulfide into homocysteine [H]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=376, Percent_Identity=40.9574468085106, Blast_Score=274, Evalue=9e-74,
Organism=Homo sapiens, GI299473759, Length=376, Percent_Identity=38.031914893617, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI25453487, Length=375, Percent_Identity=35.2, Blast_Score=206, Evalue=4e-53,
Organism=Escherichia coli, GI1790375, Length=366, Percent_Identity=40.9836065573771, Blast_Score=291, Evalue=5e-80,
Organism=Escherichia coli, GI1789383, Length=391, Percent_Identity=26.3427109974425, Blast_Score=122, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17560056, Length=384, Percent_Identity=40.3645833333333, Blast_Score=277, Evalue=6e-75,
Organism=Caenorhabditis elegans, GI17538055, Length=362, Percent_Identity=41.7127071823204, Blast_Score=276, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI71980708, Length=367, Percent_Identity=36.2397820163488, Blast_Score=210, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6319307, Length=368, Percent_Identity=42.3913043478261, Blast_Score=281, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6321254, Length=400, Percent_Identity=31.25, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6323333, Length=416, Percent_Identity=31.4903846153846, Blast_Score=170, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6321170, Length=277, Percent_Identity=33.5740072202166, Blast_Score=149, Evalue=9e-37,
Organism=Saccharomyces cerevisiae, GI6321904, Length=391, Percent_Identity=27.8772378516624, Blast_Score=131, Evalue=2e-31,
Organism=Drosophila melanogaster, GI19922554, Length=368, Percent_Identity=39.4021739130435, Blast_Score=280, Evalue=1e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =2.5.1.48; =2.5.1.49 [H]

Molecular weight: Translated: 45916; Mature: 45916

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00868 CYS_MET_METAB_PP ; PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLTDEKKTLFKPKAFFLEGFFYFIFNYWFNLKRRNFYMSTIETKLAQIGNRSETTTGT
CCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCC
VNPPVYFSTAYRHEGIGKSTGFDYSRTGNPTRGLLEQAIADLEYGEQGYACSSGMASVLL
CCCCEEEEECHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
VLSLFRSGDELIVSEDLYGGTYRLFSEHEKKWNVRCRYVNTQSIKQIEQAITTETKAIFI
HHHHHHCCCCEEEECCCCCCHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHCCCEEEEE
ETPTNPLMQVTDIAAVATVAKRHGLLLIVDNTFYTPYIQQPLTEGADIVLHSATKYLGGH
ECCCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHCCCCCEEEEHHHHHHCCC
NDVLSGLVVAKGKELCEEIAHYHNASGAVLSPFDSWLLIRGMKTLALRMRQHEENAKAVV
HHHHHHHHHHCCHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHHHCCCCCEEEE
AYLNDEDGVTDVFYPGRGGMISFRLKDETWINPFLQSLSLITFAESLGGVESLMTYPATQ
EEECCCCCCEEEEECCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCC
THADIPEEIRTANGVCNRLLRFSVGIENSNDLIQDLQQAIKLVKEGVRI
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKNLTDEKKTLFKPKAFFLEGFFYFIFNYWFNLKRRNFYMSTIETKLAQIGNRSETTTGT
CCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCC
VNPPVYFSTAYRHEGIGKSTGFDYSRTGNPTRGLLEQAIADLEYGEQGYACSSGMASVLL
CCCCEEEEECHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
VLSLFRSGDELIVSEDLYGGTYRLFSEHEKKWNVRCRYVNTQSIKQIEQAITTETKAIFI
HHHHHHCCCCEEEECCCCCCHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHCCCEEEEE
ETPTNPLMQVTDIAAVATVAKRHGLLLIVDNTFYTPYIQQPLTEGADIVLHSATKYLGGH
ECCCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHCCCCCEEEEHHHHHHCCC
NDVLSGLVVAKGKELCEEIAHYHNASGAVLSPFDSWLLIRGMKTLALRMRQHEENAKAVV
HHHHHHHHHHCCHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHHHCCCCCEEEE
AYLNDEDGVTDVFYPGRGGMISFRLKDETWINPFLQSLSLITFAESLGGVESLMTYPATQ
EEECCCCCCEEEEECCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCC
THADIPEEIRTANGVCNRLLRFSVGIENSNDLIQDLQQAIKLVKEGVRI
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]