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The map label for this gene is ribD [H]

Identifier: 118479310

GI number: 118479310

Start: 3940680

End: 3941819

Strand: Direct

Name: ribD [H]

Synonym: BALH_3725

Alternate gene names: 118479310

Gene position: 3940680-3941819 (Clockwise)

Preceding gene: 118479309

Following gene: 118479311

Centisome position: 74.96

GC content: 38.77

Gene sequence:

>1140_bases
TTGATTTTTTTAGGAGAGGTGAAGAAAATGACAGATCAAGAATATATGAGGATTGCCCTGCAATTAGCAGAAGGAACATC
TGGGCAAACAAGTCCAAATCCTATGGTTGGTGCTGTTGTTGTAAAAGACGGAAACATCGTCGGTATGGGGGCTCATTTAC
GTGCTGGTGAAGAACACGCAGAAGTTCATGCTCTTCATATGGCTGGTGACAAAGCAAAAGGAGCCACCGTGTATGTAACC
CTTGAACCATGTAGCCATTTTGGAAAAACACCACCTTGCTGTGATTTGCTCATAAAAAAAGGAATCACACGGGTTGTAAT
TGCTACTCTTGATTGCAATCCGCTCGTTTCTGGTAATGGAAAAAGAAAATTAGAGGAAGCTGGCATCGAAGTAACTACCG
GTGTTCTGGAAGCAGAAGCAGTTTTATTAAATCGCTACTTTTTTCACTACATGAAAACGAAACGTCCATTTGTAACAATA
AAAACAGCGATGAGCTTAGACGGAAAAACAGCAACTGTTACTGGTGAAAGTAAGTGGATTACAGGTGAAAAAGCACGAGC
TGATGTTCACCAATACCGCCATACACATGATGCGATTCTCGTTGGAGTGAATACAGTTATAGCTGATAATCCGCATTTAA
CAACAAGAATTCCTAACGGGGGGCAAAATCCTATACGAGTTATTTTAGATACCCATTTACGAACGCCACCATCTTCTCAT
GTCATAACAGATTCTTTAGCACCGACATGGATTATAGTTGGTACGGATGTAAATAAAGAGAAAATAGCTTCTTATGAATC
TGAAAATATAACGATATTCCAAATGAAAACGAAACAGATTGAAATACAGGATGTTTTACACTTACTCGGCGAAAAACAAA
TTCTTTCTCTTTTCGTCGAAGGGGGGCAAACAGTTCATGCAAGCTTCTTACAAACAAAGTATTTCAATGAAATTATAACT
TATATAAGTCCAAAATTAATTGGTGGAAGTAAGGCCCCTACTTTATTTGGCGGAAATGGTTTTTCAACATTACAAGATGC
GCTTTCCTTGGAAATTCAAGAGATGAAACAAATTGGTGATGATATAAAAATCGTTGCGCATGCCCGAAACGAGGTGACGA
AATGTTTACAGGAATTGTAG

Upstream 100 bases:

>100_bases
CAATCATCGTTAGGTTTCTTTCCTATACTTTCGTATTCGAACTATATTTCTAGAAATCACGTCTCCCAAACCCCAAGGAT
ATTAAAATCCTTGGGGTTTT

Downstream 100 bases:

>100_bases
AAGAATTAGGAACGATAACAAATATGCAACAAAGCGGAGAAGCAATGAAGTTAACGATACATGCCAATAAAATTTTATCA
GATGTTCACTTAGGTGATAG

Product: 5-amino-6-(5-phosphoribosylamino)uracil reductase / diaminohydroxyphosphoribosylaminopyrimidine deaminase

Products: NA

Alternate protein names: Diaminohydroxyphosphoribosylaminopyrimidine deaminase; DRAP deaminase; Riboflavin-specific deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase; HTP reductase [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MIFLGEVKKMTDQEYMRIALQLAEGTSGQTSPNPMVGAVVVKDGNIVGMGAHLRAGEEHAEVHALHMAGDKAKGATVYVT
LEPCSHFGKTPPCCDLLIKKGITRVVIATLDCNPLVSGNGKRKLEEAGIEVTTGVLEAEAVLLNRYFFHYMKTKRPFVTI
KTAMSLDGKTATVTGESKWITGEKARADVHQYRHTHDAILVGVNTVIADNPHLTTRIPNGGQNPIRVILDTHLRTPPSSH
VITDSLAPTWIIVGTDVNKEKIASYESENITIFQMKTKQIEIQDVLHLLGEKQILSLFVEGGQTVHASFLQTKYFNEIIT
YISPKLIGGSKAPTLFGGNGFSTLQDALSLEIQEMKQIGDDIKIVAHARNEVTKCLQEL

Sequences:

>Translated_379_residues
MIFLGEVKKMTDQEYMRIALQLAEGTSGQTSPNPMVGAVVVKDGNIVGMGAHLRAGEEHAEVHALHMAGDKAKGATVYVT
LEPCSHFGKTPPCCDLLIKKGITRVVIATLDCNPLVSGNGKRKLEEAGIEVTTGVLEAEAVLLNRYFFHYMKTKRPFVTI
KTAMSLDGKTATVTGESKWITGEKARADVHQYRHTHDAILVGVNTVIADNPHLTTRIPNGGQNPIRVILDTHLRTPPSSH
VITDSLAPTWIIVGTDVNKEKIASYESENITIFQMKTKQIEIQDVLHLLGEKQILSLFVEGGQTVHASFLQTKYFNEIIT
YISPKLIGGSKAPTLFGGNGFSTLQDALSLEIQEMKQIGDDIKIVAHARNEVTKCLQEL
>Mature_379_residues
MIFLGEVKKMTDQEYMRIALQLAEGTSGQTSPNPMVGAVVVKDGNIVGMGAHLRAGEEHAEVHALHMAGDKAKGATVYVT
LEPCSHFGKTPPCCDLLIKKGITRVVIATLDCNPLVSGNGKRKLEEAGIEVTTGVLEAEAVLLNRYFFHYMKTKRPFVTI
KTAMSLDGKTATVTGESKWITGEKARADVHQYRHTHDAILVGVNTVIADNPHLTTRIPNGGQNPIRVILDTHLRTPPSSH
VITDSLAPTWIIVGTDVNKEKIASYESENITIFQMKTKQIEIQDVLHLLGEKQILSLFVEGGQTVHASFLQTKYFNEIIT
YISPKLIGGSKAPTLFGGNGFSTLQDALSLEIQEMKQIGDDIKIVAHARNEVTKCLQEL

Specific function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate [H]

COG id: COG1985

COG function: function code H; Pyrimidine reductase, riboflavin biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HTP reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786616, Length=365, Percent_Identity=43.013698630137, Blast_Score=285, Evalue=2e-78,
Organism=Saccharomyces cerevisiae, GI6319629, Length=185, Percent_Identity=29.1891891891892, Blast_Score=63, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193
- InterPro:   IPR004794
- InterPro:   IPR011549
- InterPro:   IPR002734 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1; PF01872 RibD_C [H]

EC number: =3.5.4.26; =1.1.1.193 [H]

Molecular weight: Translated: 41459; Mature: 41459

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFLGEVKKMTDQEYMRIALQLAEGTSGQTSPNPMVGAVVVKDGNIVGMGAHLRAGEEHA
CEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCEEEECCCCCCCCCHH
EVHALHMAGDKAKGATVYVTLEPCSHFGKTPPCCDLLIKKGITRVVIATLDCNPLVSGNG
EEEEEEECCCCCCCCEEEEEECCHHHCCCCCCHHHHHHHCCCCEEEEEEECCCCCCCCCC
KRKLEEAGIEVTTGVLEAEAVLLNRYFFHYMKTKRPFVTIKTAMSLDGKTATVTGESKWI
CHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEECCCEEE
TGEKARADVHQYRHTHDAILVGVNTVIADNPHLTTRIPNGGQNPIRVILDTHLRTPPSSH
CCCHHHHHHHHHHCCCCEEEEEEEEEEECCCEEEEECCCCCCCCEEEEEECCCCCCCCCC
VITDSLAPTWIIVGTDVNKEKIASYESENITIFQMKTKQIEIQDVLHLLGEKQILSLFVE
EEECCCCCEEEEEECCCCHHHHHCCCCCCEEEEEEECCEEEHHHHHHHHCCHHHHHHHHC
GGQTVHASFLQTKYFNEIITYISPKLIGGSKAPTLFGGNGFSTLQDALSLEIQEMKQIGD
CCCEEEHHHHHHHHHHHHHHHHCCHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCC
DIKIVAHARNEVTKCLQEL
CEEEEEEHHHHHHHHHHHC
>Mature Secondary Structure
MIFLGEVKKMTDQEYMRIALQLAEGTSGQTSPNPMVGAVVVKDGNIVGMGAHLRAGEEHA
CEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCEEEECCCCCCCCCHH
EVHALHMAGDKAKGATVYVTLEPCSHFGKTPPCCDLLIKKGITRVVIATLDCNPLVSGNG
EEEEEEECCCCCCCCEEEEEECCHHHCCCCCCHHHHHHHCCCCEEEEEEECCCCCCCCCC
KRKLEEAGIEVTTGVLEAEAVLLNRYFFHYMKTKRPFVTIKTAMSLDGKTATVTGESKWI
CHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEECCCEEE
TGEKARADVHQYRHTHDAILVGVNTVIADNPHLTTRIPNGGQNPIRVILDTHLRTPPSSH
CCCHHHHHHHHHHCCCCEEEEEEEEEEECCCEEEEECCCCCCCCEEEEEECCCCCCCCCC
VITDSLAPTWIIVGTDVNKEKIASYESENITIFQMKTKQIEIQDVLHLLGEKQILSLFVE
EEECCCCCEEEEEECCCCHHHHHCCCCCCEEEEEEECCEEEHHHHHHHHCCHHHHHHHHC
GGQTVHASFLQTKYFNEIITYISPKLIGGSKAPTLFGGNGFSTLQDALSLEIQEMKQIGD
CCCEEEHHHHHHHHHHHHHHHHCCHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCC
DIKIVAHARNEVTKCLQEL
CEEEEEEHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7934829; 9384377; 2112225; 9068650 [H]