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The map label for this gene is pdhA [H]

Identifier: 118479184

GI number: 118479184

Start: 3817562

End: 3818686

Strand: Reverse

Name: pdhA [H]

Synonym: BALH_3595

Alternate gene names: 118479184

Gene position: 3818686-3817562 (Counterclockwise)

Preceding gene: 118479186

Following gene: 118479183

Centisome position: 72.64

GC content: 40.09

Gene sequence:

>1125_bases
GTGAACGGAATGGGTACTAAAACAAAAAAGACCCTATTTAATGTTGATGAGCAAATGAAAGCTATCGCAGCTCAATTTGA
AACATTACAAATTTTAAATGAAAAAGGCGAAGTTGTGAATGAAGCAGCTATGCCTGAATTATCTGATGATCAATTAAAAG
AATTAATGCGCCGTATGGTGTATACTCGCGTACTAGATCAACGTTCTATTTCTTTAAACCGTCAAGGACGTTTAGGTTTC
TACGCACCAACAGCTGGACAAGAGGCTTCTCAATTAGCAAGTCATTTCGCACTTGAAGCAGAAGATTTCATCTTACCAGG
ATATCGTGATGTGCCACAATTAGTATGGCACGGTTTACCATTATACCAAGCATTCTTATTCTCTCGTGGACATTTCATGG
GTAACCAAATGCCTGAGAACGTAAATGCACTTGCTCCACAAATCATCATCGGTGCGCAAATCATCCAAACTGCTGGTGTT
GCGTTAGGTATGAAATTACGTGGCAAAAAATCTGTTGCAATTACTTACACTGGTGACGGTGGTGCTTCACAAGGTGACTT
CTACGAAGGTATGAACTTTGCGGGTGCATTCAAAGCTCCAGCAATCTTCGTTGTACAAAACAACCGTTATGCGATCTCTA
CTCCAGTAGAAAAGCAATCTGCAGCTAAAACTGTAGCACAAAAAGCAGTAGCAGCAGGTATTTACGGAATTCAAGTAGAC
GGTATGGATCCATTAGCTGTATACGCAGCAACTGCTTTCGCTCGTGAGCGTGCAGTAAATGGTGAAGGTCCTACTTTAAT
CGAGACTTTAACATTCCGTTACGGTCCACATACAATGGCTGGTGATGACCCAACTCGTTACCGTACAAAAGATATCGAGA
ACGAATGGGAACAAAAAGATCCAATCGTACGCTTCCGTGCATTCTTAGAAAACAAAGGCCTATGGTCTCAAGAAGTTGAA
GAGAAAGTAATCGAAGAAGCAAAAGAAGATATCAAACAAGCAATTGCTAAGGCTGACCAAGCTCCAAAACAAAAAGTTAC
TGATTTAATGGAAATCATGTACGAAAAAATGCCTTACAACTTAGCTGAACAATATGAAATTTACAAAGAAAAGGAGTCGA
AGTAA

Upstream 100 bases:

>100_bases
TCTCAACCGACAAATAAATTTGTTGGTTTACATTGTTGCGTTTTCCACCTAGCTAATAGATAGTGAAAGCGTTTCAGAAT
ATGGTTCAAGAGAGGAAGAG

Downstream 100 bases:

>100_bases
GCCATGGCTCAAATGACAATGATTCAAGCAATCACTGATGCTTTACGCGTTGAAATGAAAAATGACCCTAACGTACTTGT
GTTTGGTGAAGACGTTGGTG

Product: pyruvate dehydrogenase complex E1 component, subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MNGMGTKTKKTLFNVDEQMKAIAAQFETLQILNEKGEVVNEAAMPELSDDQLKELMRRMVYTRVLDQRSISLNRQGRLGF
YAPTAGQEASQLASHFALEAEDFILPGYRDVPQLVWHGLPLYQAFLFSRGHFMGNQMPENVNALAPQIIIGAQIIQTAGV
ALGMKLRGKKSVAITYTGDGGASQGDFYEGMNFAGAFKAPAIFVVQNNRYAISTPVEKQSAAKTVAQKAVAAGIYGIQVD
GMDPLAVYAATAFARERAVNGEGPTLIETLTFRYGPHTMAGDDPTRYRTKDIENEWEQKDPIVRFRAFLENKGLWSQEVE
EKVIEEAKEDIKQAIAKADQAPKQKVTDLMEIMYEKMPYNLAEQYEIYKEKESK

Sequences:

>Translated_374_residues
MNGMGTKTKKTLFNVDEQMKAIAAQFETLQILNEKGEVVNEAAMPELSDDQLKELMRRMVYTRVLDQRSISLNRQGRLGF
YAPTAGQEASQLASHFALEAEDFILPGYRDVPQLVWHGLPLYQAFLFSRGHFMGNQMPENVNALAPQIIIGAQIIQTAGV
ALGMKLRGKKSVAITYTGDGGASQGDFYEGMNFAGAFKAPAIFVVQNNRYAISTPVEKQSAAKTVAQKAVAAGIYGIQVD
GMDPLAVYAATAFARERAVNGEGPTLIETLTFRYGPHTMAGDDPTRYRTKDIENEWEQKDPIVRFRAFLENKGLWSQEVE
EKVIEEAKEDIKQAIAKADQAPKQKVTDLMEIMYEKMPYNLAEQYEIYKEKESK
>Mature_374_residues
MNGMGTKTKKTLFNVDEQMKAIAAQFETLQILNEKGEVVNEAAMPELSDDQLKELMRRMVYTRVLDQRSISLNRQGRLGF
YAPTAGQEASQLASHFALEAEDFILPGYRDVPQLVWHGLPLYQAFLFSRGHFMGNQMPENVNALAPQIIIGAQIIQTAGV
ALGMKLRGKKSVAITYTGDGGASQGDFYEGMNFAGAFKAPAIFVVQNNRYAISTPVEKQSAAKTVAQKAVAAGIYGIQVD
GMDPLAVYAATAFARERAVNGEGPTLIETLTFRYGPHTMAGDDPTRYRTKDIENEWEQKDPIVRFRAFLENKGLWSQEVE
EKVIEEAKEDIKQAIAKADQAPKQKVTDLMEIMYEKMPYNLAEQYEIYKEKESK

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=347, Percent_Identity=32.8530259365994, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI258645172, Length=347, Percent_Identity=32.8530259365994, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI291084742, Length=331, Percent_Identity=30.8157099697885, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI4505685, Length=331, Percent_Identity=30.8157099697885, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI291084744, Length=211, Percent_Identity=36.4928909952607, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI4885543, Length=307, Percent_Identity=29.3159609120521, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI291084757, Length=313, Percent_Identity=29.073482428115, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI86563357, Length=346, Percent_Identity=33.5260115606936, Blast_Score=195, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI86563355, Length=346, Percent_Identity=33.5260115606936, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI32564172, Length=304, Percent_Identity=31.9078947368421, Blast_Score=130, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI17536047, Length=304, Percent_Identity=31.9078947368421, Blast_Score=130, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6321026, Length=334, Percent_Identity=28.7425149700599, Blast_Score=131, Evalue=1e-31,
Organism=Drosophila melanogaster, GI21355903, Length=347, Percent_Identity=31.4121037463977, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24639744, Length=323, Percent_Identity=30.9597523219814, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI28571106, Length=323, Percent_Identity=30.9597523219814, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24639740, Length=323, Percent_Identity=30.9597523219814, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24639746, Length=289, Percent_Identity=32.1799307958478, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24639748, Length=287, Percent_Identity=30.3135888501742, Blast_Score=115, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 41744; Mature: 41744

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGMGTKTKKTLFNVDEQMKAIAAQFETLQILNEKGEVVNEAAMPELSDDQLKELMRRMV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHH
YTRVLDQRSISLNRQGRLGFYAPTAGQEASQLASHFALEAEDFILPGYRDVPQLVWHGLP
HHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCH
LYQAFLFSRGHFMGNQMPENVNALAPQIIIGAQIIQTAGVALGMKLRGKKSVAITYTGDG
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCEEECCCCEEEEEEECCC
GASQGDFYEGMNFAGAFKAPAIFVVQNNRYAISTPVEKQSAAKTVAQKAVAAGIYGIQVD
CCCCCCHHHCCCCCCCCCCCEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHCEEEEEEC
GMDPLAVYAATAFARERAVNGEGPTLIETLTFRYGPHTMAGDDPTRYRTKDIENEWEQKD
CCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCC
PIVRFRAFLENKGLWSQEVEEKVIEEAKEDIKQAIAKADQAPKQKVTDLMEIMYEKMPYN
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
LAEQYEIYKEKESK
HHHHHHHHHHHCCC
>Mature Secondary Structure
MNGMGTKTKKTLFNVDEQMKAIAAQFETLQILNEKGEVVNEAAMPELSDDQLKELMRRMV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHH
YTRVLDQRSISLNRQGRLGFYAPTAGQEASQLASHFALEAEDFILPGYRDVPQLVWHGLP
HHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCH
LYQAFLFSRGHFMGNQMPENVNALAPQIIIGAQIIQTAGVALGMKLRGKKSVAITYTGDG
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCEEECCCCEEEEEEECCC
GASQGDFYEGMNFAGAFKAPAIFVVQNNRYAISTPVEKQSAAKTVAQKAVAAGIYGIQVD
CCCCCCHHHCCCCCCCCCCCEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHCEEEEEEC
GMDPLAVYAATAFARERAVNGEGPTLIETLTFRYGPHTMAGDDPTRYRTKDIENEWEQKD
CCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCC
PIVRFRAFLENKGLWSQEVEEKVIEEAKEDIKQAIAKADQAPKQKVTDLMEIMYEKMPYN
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
LAEQYEIYKEKESK
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA