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The map label for this gene is pyrB

Identifier: 118479110

GI number: 118479110

Start: 3738781

End: 3739701

Strand: Reverse

Name: pyrB

Synonym: BALH_3519

Alternate gene names: 118479110

Gene position: 3739701-3738781 (Counterclockwise)

Preceding gene: 118479111

Following gene: 118479109

Centisome position: 71.14

GC content: 38.87

Gene sequence:

>921_bases
ATGACGATGAGCCATTTGTTAACGATGAGTGAATTATCGGAAGTAGAAATTTCAGAAATCCTAAAAGACGCAGAAGATTT
TGCGAATGGGAAAGAGAGCAAAACGACAGAGCAAACTTTTGTTGCGAACTTGTTCTTTGAGAATAGTACGAGAACGAGAT
TTAGCTTTGAAGTTGCTGAGAAGAGGTTAGGACTTGATGTTTTAAACTTTTCAGCTGATGCATCTAGCGTACAAAAAGGA
GAAACTTTATACGATACGATAAGAACACTAGAATCAATCGGAACAAAAGCAGTGGTCATCCGCCATGAGCAAGATCGCTA
CTTCGATGAACTAAAAGATCAGGTGAATATCCCGATCTTAAACGCTGGAGATGGATGTGGAAACCACCCAACGCAGTGCC
TACTTGACCTTCTTACAATTAAACAAGAGTTTGGAAGATTTGAAGGTTTGCAGATTGCGATAGTAGGAGATGTTCGTCAT
AGCCGAGTAGCACGTTCTAATGCAGAAGCATTAACGAAGCTGGGTGCAACAATTTACTTTGCAAGTCCAGAAGAGTGGAA
AGATGAAGACAACACATTTGGAACATACAAACCATTAGATGAACTTGTTCCAGAAGTGGATGTAATGATGTTACTTCGTG
TACAACATGAGCGTCATGATCATTATGAAACAGACATTATGAAAGAGTATCATGAGAAACACGGATTAACAGTGGAAAGA
GAAAAGCGTATGAAAGAAGGAAGCATTATTATGCATCCAGCTCCTGTAAACCGAGATGTTGAAATTGCAAGTGAACTTGT
TGAGTGTGAGCGTTCACGCATATTTAAACAAATGGAAAATGGAGTTTACGTAAGAATGGCTGTACTAAAACGCGCCTTAC
CAAATGTATTAGGAGGAATGAAACATGAATTACTTGTTTAA

Upstream 100 bases:

>100_bases
CTTCTTTCTTGCACCCTAGTCTCACACGACTAGGGTATTTTTATGCAAAGGTTGTTATAAAAATACAAAAGTGGTAACAT
AAAAATCAGAAAGATGAGGG

Downstream 100 bases:

>100_bases
AAATGGTCGTTATATGAATGAAGAAGGAAAAATCGTAGCAACGGATCTTCTCGTACAAGACGGTAAAATCGCTAAGGTAG
CAGAAAATATTACGGCAGAT

Product: aspartate carbamoyltransferase catalytic subunit

Products: NA

Alternate protein names: Aspartate transcarbamylase; ATCase

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MTMSHLLTMSELSEVEISEILKDAEDFANGKESKTTEQTFVANLFFENSTRTRFSFEVAEKRLGLDVLNFSADASSVQKG
ETLYDTIRTLESIGTKAVVIRHEQDRYFDELKDQVNIPILNAGDGCGNHPTQCLLDLLTIKQEFGRFEGLQIAIVGDVRH
SRVARSNAEALTKLGATIYFASPEEWKDEDNTFGTYKPLDELVPEVDVMMLLRVQHERHDHYETDIMKEYHEKHGLTVER
EKRMKEGSIIMHPAPVNRDVEIASELVECERSRIFKQMENGVYVRMAVLKRALPNVLGGMKHELLV

Sequences:

>Translated_306_residues
MTMSHLLTMSELSEVEISEILKDAEDFANGKESKTTEQTFVANLFFENSTRTRFSFEVAEKRLGLDVLNFSADASSVQKG
ETLYDTIRTLESIGTKAVVIRHEQDRYFDELKDQVNIPILNAGDGCGNHPTQCLLDLLTIKQEFGRFEGLQIAIVGDVRH
SRVARSNAEALTKLGATIYFASPEEWKDEDNTFGTYKPLDELVPEVDVMMLLRVQHERHDHYETDIMKEYHEKHGLTVER
EKRMKEGSIIMHPAPVNRDVEIASELVECERSRIFKQMENGVYVRMAVLKRALPNVLGGMKHELLV
>Mature_305_residues
TMSHLLTMSELSEVEISEILKDAEDFANGKESKTTEQTFVANLFFENSTRTRFSFEVAEKRLGLDVLNFSADASSVQKGE
TLYDTIRTLESIGTKAVVIRHEQDRYFDELKDQVNIPILNAGDGCGNHPTQCLLDLLTIKQEFGRFEGLQIAIVGDVRHS
RVARSNAEALTKLGATIYFASPEEWKDEDNTFGTYKPLDELVPEVDVMMLLRVQHERHDHYETDIMKEYHEKHGLTVERE
KRMKEGSIIMHPAPVNRDVEIASELVECERSRIFKQMENGVYVRMAVLKRALPNVLGGMKHELLV

Specific function: Pyrimidine biosynthesis; second step. [C]

COG id: COG0540

COG function: function code F; Aspartate carbamoyltransferase, catalytic chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family

Homologues:

Organism=Homo sapiens, GI18105007, Length=266, Percent_Identity=37.593984962406, Blast_Score=167, Evalue=2e-41,
Organism=Escherichia coli, GI2367364, Length=305, Percent_Identity=34.7540983606557, Blast_Score=164, Evalue=7e-42,
Organism=Escherichia coli, GI1790703, Length=188, Percent_Identity=28.7234042553192, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1786469, Length=194, Percent_Identity=28.3505154639175, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193204318, Length=283, Percent_Identity=36.0424028268551, Blast_Score=139, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6322331, Length=263, Percent_Identity=35.7414448669202, Blast_Score=136, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24642586, Length=273, Percent_Identity=36.2637362637363, Blast_Score=155, Evalue=4e-38,

Paralogues:

None

Copy number: 2080 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 14328 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): PYRB_BACAH (A0RHR1)

Other databases:

- EMBL:   CP000485
- RefSeq:   YP_896261.1
- ProteinModelPortal:   A0RHR1
- SMR:   A0RHR1
- STRING:   A0RHR1
- EnsemblBacteria:   EBBACT00000068370
- GeneID:   4544127
- GenomeReviews:   CP000485_GR
- KEGG:   btl:BALH_3519
- NMPDR:   fig|412694.5.peg.3379
- eggNOG:   COG0540
- GeneTree:   EBGT00050000002562
- HOGENOM:   HBG579429
- OMA:   MNRGLEI
- ProtClustDB:   PRK00856
- BioCyc:   BTHU412694:BALH_3519-MONOMER
- HAMAP:   MF_00001
- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002082
- PRINTS:   PR00100
- PRINTS:   PR00101
- TIGRFAMs:   TIGR00670

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N; SSF53671 Asp/Orn_carbamoyltranf

EC number: =2.1.3.2

Molecular weight: Translated: 34921; Mature: 34790

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMSHLLTMSELSEVEISEILKDAEDFANGKESKTTEQTFVANLFFENSTRTRFSFEVAE
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHEECCCCCCEEHHHHHH
KRLGLDVLNFSADASSVQKGETLYDTIRTLESIGTKAVVIRHEQDRYFDELKDQVNIPIL
HHHCCHHEECCCCHHHHHCCHHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHCCCCEE
NAGDGCGNHPTQCLLDLLTIKQEFGRFEGLQIAIVGDVRHSRVARSNAEALTKLGATIYF
ECCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCEEEE
ASPEEWKDEDNTFGTYKPLDELVPEVDVMMLLRVQHERHDHYETDIMKEYHEKHGLTVER
CCCHHCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHH
EKRMKEGSIIMHPAPVNRDVEIASELVECERSRIFKQMENGVYVRMAVLKRALPNVLGGM
HHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHCCC
KHELLV
HHHHCC
>Mature Secondary Structure 
TMSHLLTMSELSEVEISEILKDAEDFANGKESKTTEQTFVANLFFENSTRTRFSFEVAE
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHEECCCCCCEEHHHHHH
KRLGLDVLNFSADASSVQKGETLYDTIRTLESIGTKAVVIRHEQDRYFDELKDQVNIPIL
HHHCCHHEECCCCHHHHHCCHHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHCCCCEE
NAGDGCGNHPTQCLLDLLTIKQEFGRFEGLQIAIVGDVRHSRVARSNAEALTKLGATIYF
ECCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCEEEE
ASPEEWKDEDNTFGTYKPLDELVPEVDVMMLLRVQHERHDHYETDIMKEYHEKHGLTVER
CCCHHCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHH
EKRMKEGSIIMHPAPVNRDVEIASELVECERSRIFKQMENGVYVRMAVLKRALPNVLGGM
HHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHCCC
KHELLV
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA