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The map label for this gene is hslU [H]

Identifier: 118479051

GI number: 118479051

Start: 3673479

End: 3674909

Strand: Reverse

Name: hslU [H]

Synonym: BALH_3460

Alternate gene names: 118479051

Gene position: 3674909-3673479 (Counterclockwise)

Preceding gene: 118479052

Following gene: 118479050

Centisome position: 69.9

GC content: 37.11

Gene sequence:

>1431_bases
TTGTGGAAGAATTGTAGAATCGTAAGGGAGGCATTTTATATGCATTTACATTTTACTCCGCGTCAAATTGTGGAAAAATT
AGATCAATACATTATCGGTCAAAAAGATGCGAAGAAAGCGGTTGCTGTAGCTTTAAGAAATCGATACCGCCGAAGTAAAT
TAGCTGAAAATCTACGTGATGAAATTGCACCTAAAAATATTTTAATGATTGGACCGACAGGTGTTGGTAAAACAGAGGTA
GCACGACGAATGGCGAAACTCGTTGGAGCACCTTTTATTAAGGTTGAAGCTACGAAATTTACAGAAGTTGGATATGTAGG
TAGAGATGTAGAATCGATGGTACGTGACCTTGTGGAAACGTCCGTTCGTATCGTGAAAGAAGAAATGGTAGTTAAAGTAC
AAGACAAAGCAGAAGAACAAGCGAACCAACGTCTTGTTGAAATTTTAGTGCCGAGTCCGGAGAAGCAATCTGGATTTAAA
AACCCATTAGAAATGCTATTTGGTGGCACTCAAAATTCGAATCAAACAACAGATTCACAGGAAGATGTTGAAATCGAAAA
GAAACGTCAAGATGTGGAAAGAAAGCTTGCTGCGGGGCTTCTTGAAGATGAAATTGTATCGATTGAAGTGACGGAACAGC
AGTCTTCTATGTTCGATATGTTGCAAGGAACTGGCATGGAACAAATGGGGATGAATTTCCAAGATGCGTTAGGAAGTTTT
ATGCCGAAAAAAACAAAAAAACGTAAACTTTCTGTAAAAGAAGCAAGAAAAGTCTTGACAAATGAGGAAGCACAGCGCTT
AATTGATATGGATGAAGTTACACAAGAGGCTGTTTATCGTGCTGAACAGCTCGGGATTATTTTTATCGATGAAATTGACA
AAATTGCTGGTAAGCAGTCGAATAGCGTAGACGTATCACGTGAAGGTGTGCAACGTGACATTTTACCAATTGTAGAAGGG
TCAAATGTTGCGACAAAATACGGATCAGTAAAAACGGATTATATTTTATTCGTTGCAGCTGGAGCGTTTCATATGTCTAA
ACCGTCAGATTTAATTCCGGAATTACAAGGGAGATTTCCGATTCGAGTAGAATTAACAAAATTATCAACTGATGATTTTG
TTAAAATATTAATCGAGCCTGACAATGCGTTGATTAAACAATATATGGCTTTATTAGCGACTGAAGGTATAGAAATTGAA
TTTTCAGACGAAGCTATTCGTAAGATTGCTGAGATTGCTTATCAAGTTAATCAGGATACAGATAATATTGGAGCAAGAAG
ACTTCATACGATTATGGAGAAGCTCCTTGAAGATTTATCGTTTGAAGCATCTGAAATTACGTTAGAGAAAATAACGATAA
CACCTCAATACGTTGAGGAGAAATTAGCAACGATTGCTAAAAATAAAGATGTGAGCCAGTTTATTTTGTAA

Upstream 100 bases:

>100_bases
TTAAAACAATATGCAAGTGAACATTTAACAGCGAAGCAAATTGCGAAAGCGAGTTTAGAAATTGCTGGCGATATTTGTGT
TTATACAAACCACAACATAA

Downstream 100 bases:

>100_bases
TAGTGTCATCAGGTGACTCGCCCTAGTTTCCAAGTGATGAAAAAATATGTGAGTAACATGTAGGAGGAACTTTTGAAATG
GAATTATTAGCAAAAACAAG

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MWKNCRIVREAFYMHLHFTPRQIVEKLDQYIIGQKDAKKAVAVALRNRYRRSKLAENLRDEIAPKNILMIGPTGVGKTEV
ARRMAKLVGAPFIKVEATKFTEVGYVGRDVESMVRDLVETSVRIVKEEMVVKVQDKAEEQANQRLVEILVPSPEKQSGFK
NPLEMLFGGTQNSNQTTDSQEDVEIEKKRQDVERKLAAGLLEDEIVSIEVTEQQSSMFDMLQGTGMEQMGMNFQDALGSF
MPKKTKKRKLSVKEARKVLTNEEAQRLIDMDEVTQEAVYRAEQLGIIFIDEIDKIAGKQSNSVDVSREGVQRDILPIVEG
SNVATKYGSVKTDYILFVAAGAFHMSKPSDLIPELQGRFPIRVELTKLSTDDFVKILIEPDNALIKQYMALLATEGIEIE
FSDEAIRKIAEIAYQVNQDTDNIGARRLHTIMEKLLEDLSFEASEITLEKITITPQYVEEKLATIAKNKDVSQFIL

Sequences:

>Translated_476_residues
MWKNCRIVREAFYMHLHFTPRQIVEKLDQYIIGQKDAKKAVAVALRNRYRRSKLAENLRDEIAPKNILMIGPTGVGKTEV
ARRMAKLVGAPFIKVEATKFTEVGYVGRDVESMVRDLVETSVRIVKEEMVVKVQDKAEEQANQRLVEILVPSPEKQSGFK
NPLEMLFGGTQNSNQTTDSQEDVEIEKKRQDVERKLAAGLLEDEIVSIEVTEQQSSMFDMLQGTGMEQMGMNFQDALGSF
MPKKTKKRKLSVKEARKVLTNEEAQRLIDMDEVTQEAVYRAEQLGIIFIDEIDKIAGKQSNSVDVSREGVQRDILPIVEG
SNVATKYGSVKTDYILFVAAGAFHMSKPSDLIPELQGRFPIRVELTKLSTDDFVKILIEPDNALIKQYMALLATEGIEIE
FSDEAIRKIAEIAYQVNQDTDNIGARRLHTIMEKLLEDLSFEASEITLEKITITPQYVEEKLATIAKNKDVSQFIL
>Mature_476_residues
MWKNCRIVREAFYMHLHFTPRQIVEKLDQYIIGQKDAKKAVAVALRNRYRRSKLAENLRDEIAPKNILMIGPTGVGKTEV
ARRMAKLVGAPFIKVEATKFTEVGYVGRDVESMVRDLVETSVRIVKEEMVVKVQDKAEEQANQRLVEILVPSPEKQSGFK
NPLEMLFGGTQNSNQTTDSQEDVEIEKKRQDVERKLAAGLLEDEIVSIEVTEQQSSMFDMLQGTGMEQMGMNFQDALGSF
MPKKTKKRKLSVKEARKVLTNEEAQRLIDMDEVTQEAVYRAEQLGIIFIDEIDKIAGKQSNSVDVSREGVQRDILPIVEG
SNVATKYGSVKTDYILFVAAGAFHMSKPSDLIPELQGRFPIRVELTKLSTDDFVKILIEPDNALIKQYMALLATEGIEIE
FSDEAIRKIAEIAYQVNQDTDNIGARRLHTIMEKLLEDLSFEASEITLEKITITPQYVEEKLATIAKNKDVSQFIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Homo sapiens, GI7242140, Length=111, Percent_Identity=36.9369369369369, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1790366, Length=460, Percent_Identity=50.8695652173913, Blast_Score=463, Evalue=1e-131,
Organism=Escherichia coli, GI1786642, Length=227, Percent_Identity=33.4801762114537, Blast_Score=98, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6319704, Length=141, Percent_Identity=31.9148936170213, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24648291, Length=259, Percent_Identity=30.5019305019305, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24648289, Length=259, Percent_Identity=30.5019305019305, Blast_Score=96, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 53912; Mature: 53912

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWKNCRIVREAFYMHLHFTPRQIVEKLDQYIIGQKDAKKAVAVALRNRYRRSKLAENLRD
CCCCHHHHHHHHHHHEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EIAPKNILMIGPTGVGKTEVARRMAKLVGAPFIKVEATKFTEVGYVGRDVESMVRDLVET
HCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHCCCCCCCHHHHHHHHHHH
SVRIVKEEMVVKVQDKAEEQANQRLVEILVPSPEKQSGFKNPLEMLFGGTQNSNQTTDSQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCH
EDVEIEKKRQDVERKLAAGLLEDEIVSIEVTEQQSSMFDMLQGTGMEQMGMNFQDALGSF
HHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEHHHHHHHHHHHCCCHHHHCCCHHHHHHHH
MPKKTKKRKLSVKEARKVLTNEEAQRLIDMDEVTQEAVYRAEQLGIIFIDEIDKIAGKQS
CCCHHHHHHCCHHHHHHHHCCHHHHHHHCHHHHHHHHHHHHHHCCEEEEECHHHHHCCCC
NSVDVSREGVQRDILPIVEGSNVATKYGSVKTDYILFVAAGAFHMSKPSDLIPELQGRFP
CCCCCCHHHHHHHCHHHCCCCCCEECCCCCCCCEEEEEEECCCCCCCCHHHHHHHCCCCC
IRVELTKLSTDDFVKILIEPDNALIKQYMALLATEGIEIEFSDEAIRKIAEIAYQVNQDT
EEEEEEECCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHCCCC
DNIGARRLHTIMEKLLEDLSFEASEITLEKITITPQYVEEKLATIAKNKDVSQFIL
CHHHHHHHHHHHHHHHHHHCCCHHHEEEEEEECCHHHHHHHHHHHHCCCCHHHHCC
>Mature Secondary Structure
MWKNCRIVREAFYMHLHFTPRQIVEKLDQYIIGQKDAKKAVAVALRNRYRRSKLAENLRD
CCCCHHHHHHHHHHHEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EIAPKNILMIGPTGVGKTEVARRMAKLVGAPFIKVEATKFTEVGYVGRDVESMVRDLVET
HCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHCCCCCCCHHHHHHHHHHH
SVRIVKEEMVVKVQDKAEEQANQRLVEILVPSPEKQSGFKNPLEMLFGGTQNSNQTTDSQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCH
EDVEIEKKRQDVERKLAAGLLEDEIVSIEVTEQQSSMFDMLQGTGMEQMGMNFQDALGSF
HHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEHHHHHHHHHHHCCCHHHHCCCHHHHHHHH
MPKKTKKRKLSVKEARKVLTNEEAQRLIDMDEVTQEAVYRAEQLGIIFIDEIDKIAGKQS
CCCHHHHHHCCHHHHHHHHCCHHHHHHHCHHHHHHHHHHHHHHCCEEEEECHHHHHCCCC
NSVDVSREGVQRDILPIVEGSNVATKYGSVKTDYILFVAAGAFHMSKPSDLIPELQGRFP
CCCCCCHHHHHHHCHHHCCCCCCEECCCCCCCCEEEEEEECCCCCCCCHHHHHHHCCCCC
IRVELTKLSTDDFVKILIEPDNALIKQYMALLATEGIEIEFSDEAIRKIAEIAYQVNQDT
EEEEEEECCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHCCCC
DNIGARRLHTIMEKLLEDLSFEASEITLEKITITPQYVEEKLATIAKNKDVSQFIL
CHHHHHHHHHHHHHHHHHHCCCHHHEEEEEEECCHHHHHHHHHHHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA