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The map label for this gene is gabP [H]

Identifier: 118478945

GI number: 118478945

Start: 3553250

End: 3554644

Strand: Reverse

Name: gabP [H]

Synonym: BALH_3350

Alternate gene names: 118478945

Gene position: 3554644-3553250 (Counterclockwise)

Preceding gene: 118478947

Following gene: 118478944

Centisome position: 67.62

GC content: 37.2

Gene sequence:

>1395_bases
TTGGATAAAAATCTTAAGAAAGACCTCAAAATACGCCACATTACAATGATCTCAATTGGCGGCGTAATAGGAGCTGGTTT
GTTTGTTGGAAGTGGGGCAGTTGTGCATTCAGCAGGACCAGGTTCTATCGTTTCATATGCATTAGCAGGACTTTTAGTCG
TTTTCGTTATGAGAATGCTTGGGGAAATGGCAGCTATTAACCCGACAAGTGGATCATTTGCAACATATGCAAGAGAAGCA
ATTGGTCCGTGGGCCGGTTATACAATTGGGTGGCTATATTGGTTTTTCTGGGTAATTGTTATTGCGATAGAAGCCACAGC
GGGTGCTGGTATTATTCAGTACTGGATTCCAGAAATCCCGCTTTGGTTATTAAGCTTAATATTAACGATTTTATTAACAT
TGACGAATGTTTTTTCAGTGAAATCATTTGGAGAGTTTGAATATTGGTTTTCTTTTATTAAAGTAATAAGTATTGTTTTG
TTCCTTTGTCTTGGACTAGCTGTTATTTTAGGATTTGTACCAGGAACGGAAGCACCTGGCACTTCGAACTTAGTGGGGCA
AGGAGGATTTATGCCAAACGGTATAAGTTCGGTGCTACTTGGAATTACTGTCGTTATATTTTCATTTATGGGATCAGAGA
TTGTAGCGGTAGCAGCTGGTGAGTCTGCAGAACCTGTAAAAGCAGTAAAAACAGCAACAAATAGTGTAATTTGGCGTATT
CTCGTATTTTTCATTGGATCTATCGCTGTAGTTGTTACACTTCTTCCGTGGAATTCAGCAAACATACTAAAAAGTCCGTT
TGTAGCGGTGCTAGAACATATAGGGATACCAGCGGCAGCGCAAATTATGAATTTTATCGTTTTAACAGCTGTACTTTCTT
GTTTAAATTCTGGTTTATATACGAACTCAAGAATGCTTTTTTCGATGGCGGAAAGAGGAGATGCTTCAAAGGCGTTCTTG
AAATTGAACAGTAGTGGTGTTCCAGTTCGGGCCGTTTTATTCGGAACGTTCTTCGCTTATATTGGAGTTGTTTTTAGTTA
CATATCTCCAGATAAAGTCTTTTTATTTTTAGTGAATGCCTCTGGTGGGATTGCGTTACTCGTTTATCTCGTTATAGCTA
TTTCGCATTTAAAGATTCGTAAAAAAATGGGAAGGGTAGAACAACAAAATTTGAAAGTGAAAATGTGGTTTTTCCCGTAT
GTGACGTATGTTACAATTGCAGCTATTATAGCAGTTTTAATTGCGATGCTTGCCATTGAATCTTTACGTTCACAAGCACT
TTTGACGATGCTTGTCACTGTTCTTATAATCATTTCTTATTTTATTTTTAATAGAAATAAAAATAGTACATTGTTGAATA
CTAAAAGTAAGAATGAGGAATCTGTCCGATTTTAA

Upstream 100 bases:

>100_bases
CCTAACTTCTTTGTTTCGGCTGAATTTTGAGGTGGGGGTCTTACTGCCCGTTAATGCGGGATAAATTTCAAAATTACATT
TGGAAGGGGATGTATAAGAG

Downstream 100 bases:

>100_bases
TTTCTTGTTTTCTAAGAAATGCTACATCCAACCATTGGTAGAAAAGAGTAATTACTATTGTCATAGTGAATATAAACTTT
TTTCTTGACTTTTTATACGA

Product: gamma-aminobutyrate permease

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: 4-amino butyrate transport carrier; Gamma-aminobutyrate permease [H]

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MDKNLKKDLKIRHITMISIGGVIGAGLFVGSGAVVHSAGPGSIVSYALAGLLVVFVMRMLGEMAAINPTSGSFATYAREA
IGPWAGYTIGWLYWFFWVIVIAIEATAGAGIIQYWIPEIPLWLLSLILTILLTLTNVFSVKSFGEFEYWFSFIKVISIVL
FLCLGLAVILGFVPGTEAPGTSNLVGQGGFMPNGISSVLLGITVVIFSFMGSEIVAVAAGESAEPVKAVKTATNSVIWRI
LVFFIGSIAVVVTLLPWNSANILKSPFVAVLEHIGIPAAAQIMNFIVLTAVLSCLNSGLYTNSRMLFSMAERGDASKAFL
KLNSSGVPVRAVLFGTFFAYIGVVFSYISPDKVFLFLVNASGGIALLVYLVIAISHLKIRKKMGRVEQQNLKVKMWFFPY
VTYVTIAAIIAVLIAMLAIESLRSQALLTMLVTVLIIISYFIFNRNKNSTLLNTKSKNEESVRF

Sequences:

>Translated_464_residues
MDKNLKKDLKIRHITMISIGGVIGAGLFVGSGAVVHSAGPGSIVSYALAGLLVVFVMRMLGEMAAINPTSGSFATYAREA
IGPWAGYTIGWLYWFFWVIVIAIEATAGAGIIQYWIPEIPLWLLSLILTILLTLTNVFSVKSFGEFEYWFSFIKVISIVL
FLCLGLAVILGFVPGTEAPGTSNLVGQGGFMPNGISSVLLGITVVIFSFMGSEIVAVAAGESAEPVKAVKTATNSVIWRI
LVFFIGSIAVVVTLLPWNSANILKSPFVAVLEHIGIPAAAQIMNFIVLTAVLSCLNSGLYTNSRMLFSMAERGDASKAFL
KLNSSGVPVRAVLFGTFFAYIGVVFSYISPDKVFLFLVNASGGIALLVYLVIAISHLKIRKKMGRVEQQNLKVKMWFFPY
VTYVTIAAIIAVLIAMLAIESLRSQALLTMLVTVLIIISYFIFNRNKNSTLLNTKSKNEESVRF
>Mature_464_residues
MDKNLKKDLKIRHITMISIGGVIGAGLFVGSGAVVHSAGPGSIVSYALAGLLVVFVMRMLGEMAAINPTSGSFATYAREA
IGPWAGYTIGWLYWFFWVIVIAIEATAGAGIIQYWIPEIPLWLLSLILTILLTLTNVFSVKSFGEFEYWFSFIKVISIVL
FLCLGLAVILGFVPGTEAPGTSNLVGQGGFMPNGISSVLLGITVVIFSFMGSEIVAVAAGESAEPVKAVKTATNSVIWRI
LVFFIGSIAVVVTLLPWNSANILKSPFVAVLEHIGIPAAAQIMNFIVLTAVLSCLNSGLYTNSRMLFSMAERGDASKAFL
KLNSSGVPVRAVLFGTFFAYIGVVFSYISPDKVFLFLVNASGGIALLVYLVIAISHLKIRKKMGRVEQQNLKVKMWFFPY
VTYVTIAAIIAVLIAMLAIESLRSQALLTMLVTVLIIISYFIFNRNKNSTLLNTKSKNEESVRF

Specific function: Transporter for GABA [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI258614005, Length=370, Percent_Identity=25.4054054054054, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI258614003, Length=370, Percent_Identity=25.4054054054054, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI258645169, Length=369, Percent_Identity=25.2032520325203, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI4507047, Length=429, Percent_Identity=24.2424242424242, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI110347453, Length=352, Percent_Identity=23.8636363636364, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789017, Length=450, Percent_Identity=49.7777777777778, Blast_Score=426, Evalue=1e-120,
Organism=Escherichia coli, GI1786302, Length=418, Percent_Identity=38.2775119617225, Blast_Score=306, Evalue=1e-84,
Organism=Escherichia coli, GI48994972, Length=450, Percent_Identity=38, Blast_Score=305, Evalue=3e-84,
Organism=Escherichia coli, GI1788480, Length=411, Percent_Identity=39.9026763990268, Blast_Score=301, Evalue=7e-83,
Organism=Escherichia coli, GI87081708, Length=455, Percent_Identity=35.3846153846154, Blast_Score=299, Evalue=2e-82,
Organism=Escherichia coli, GI1786789, Length=445, Percent_Identity=34.3820224719101, Blast_Score=294, Evalue=1e-80,
Organism=Escherichia coli, GI1790653, Length=431, Percent_Identity=36.4269141531323, Blast_Score=290, Evalue=1e-79,
Organism=Escherichia coli, GI1786602, Length=457, Percent_Identity=35.2297592997812, Blast_Score=270, Evalue=2e-73,
Organism=Escherichia coli, GI87081915, Length=411, Percent_Identity=36.9829683698297, Blast_Score=261, Evalue=8e-71,
Organism=Escherichia coli, GI87081869, Length=316, Percent_Identity=24.3670886075949, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI2367353, Length=460, Percent_Identity=23.695652173913, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=374, Percent_Identity=23.7967914438503, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17533459, Length=340, Percent_Identity=25, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=426, Percent_Identity=34.037558685446, Blast_Score=229, Evalue=5e-61,
Organism=Saccharomyces cerevisiae, GI6324061, Length=425, Percent_Identity=33.6470588235294, Blast_Score=228, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6320717, Length=469, Percent_Identity=29.637526652452, Blast_Score=200, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6324553, Length=388, Percent_Identity=33.7628865979381, Blast_Score=191, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6324059, Length=427, Percent_Identity=32.7868852459016, Blast_Score=190, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6319824, Length=472, Percent_Identity=27.9661016949153, Blast_Score=184, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6324990, Length=408, Percent_Identity=32.3529411764706, Blast_Score=182, Evalue=9e-47,
Organism=Saccharomyces cerevisiae, GI6322892, Length=394, Percent_Identity=33.502538071066, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6324924, Length=440, Percent_Identity=29.0909090909091, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6321629, Length=405, Percent_Identity=30.1234567901235, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6321053, Length=420, Percent_Identity=30.2380952380952, Blast_Score=179, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6319542, Length=405, Percent_Identity=28.641975308642, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6319543, Length=394, Percent_Identity=26.3959390862944, Blast_Score=159, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6320251, Length=409, Percent_Identity=27.8728606356968, Blast_Score=156, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6322967, Length=404, Percent_Identity=28.4653465346535, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6319608, Length=436, Percent_Identity=25, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6324981, Length=399, Percent_Identity=28.0701754385965, Blast_Score=126, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6320364, Length=488, Percent_Identity=22.7459016393443, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI221512776, Length=334, Percent_Identity=23.3532934131737, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24666159, Length=334, Percent_Identity=23.3532934131737, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24667468, Length=419, Percent_Identity=23.3890214797136, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24668806, Length=405, Percent_Identity=23.2098765432099, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI21356285, Length=405, Percent_Identity=23.2098765432099, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24668802, Length=405, Percent_Identity=23.2098765432099, Blast_Score=75, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- InterPro:   IPR011265 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50290; Mature: 50290

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKNLKKDLKIRHITMISIGGVIGAGLFVGSGAVVHSAGPGSIVSYALAGLLVVFVMRML
CCCCCHHCCCEEEEEEEEHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHH
GEMAAINPTSGSFATYAREAIGPWAGYTIGWLYWFFWVIVIAIEATAGAGIIQYWIPEIP
HHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LWLLSLILTILLTLTNVFSVKSFGEFEYWFSFIKVISIVLFLCLGLAVILGFVPGTEAPG
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
TSNLVGQGGFMPNGISSVLLGITVVIFSFMGSEIVAVAAGESAEPVKAVKTATNSVIWRI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
LVFFIGSIAVVVTLLPWNSANILKSPFVAVLEHIGIPAAAQIMNFIVLTAVLSCLNSGLY
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCC
TNSRMLFSMAERGDASKAFLKLNSSGVPVRAVLFGTFFAYIGVVFSYISPDKVFLFLVNA
CCCHHHHHHHHCCCCCHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEC
SGGIALLVYLVIAISHLKIRKKMGRVEQQNLKVKMWFFPYVTYVTIAAIIAVLIAMLAIE
CCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
SLRSQALLTMLVTVLIIISYFIFNRNKNSTLLNTKSKNEESVRF
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCC
>Mature Secondary Structure
MDKNLKKDLKIRHITMISIGGVIGAGLFVGSGAVVHSAGPGSIVSYALAGLLVVFVMRML
CCCCCHHCCCEEEEEEEEHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHH
GEMAAINPTSGSFATYAREAIGPWAGYTIGWLYWFFWVIVIAIEATAGAGIIQYWIPEIP
HHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LWLLSLILTILLTLTNVFSVKSFGEFEYWFSFIKVISIVLFLCLGLAVILGFVPGTEAPG
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
TSNLVGQGGFMPNGISSVLLGITVVIFSFMGSEIVAVAAGESAEPVKAVKTATNSVIWRI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
LVFFIGSIAVVVTLLPWNSANILKSPFVAVLEHIGIPAAAQIMNFIVLTAVLSCLNSGLY
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCC
TNSRMLFSMAERGDASKAFLKLNSSGVPVRAVLFGTFFAYIGVVFSYISPDKVFLFLVNA
CCCHHHHHHHHCCCCCHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEC
SGGIALLVYLVIAISHLKIRKKMGRVEQQNLKVKMWFFPYVTYVTIAAIIAVLIAMLAIE
CCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
SLRSQALLTMLVTVLIIISYFIFNRNKNSTLLNTKSKNEESVRF
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8951816; 8969499; 9384377 [H]