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The map label for this gene is xecD [H]

Identifier: 118478730

GI number: 118478730

Start: 3302231

End: 3302638

Strand: Direct

Name: xecD [H]

Synonym: BALH_3120

Alternate gene names: 118478730

Gene position: 3302231-3302638 (Clockwise)

Preceding gene: 118478729

Following gene: 118478733

Centisome position: 62.81

GC content: 38.73

Gene sequence:

>408_bases
TTGTCTGGGGTATTCCTTTCTAATAAATATTCGATTGAACAATTTCTTAAACAAGGTACAGGTGGTGTCATCGTTAACGC
TGGTTCAATTCATAGTTTTGTTTCATTACCTACCACAACAGCATACTCCTCTGCAAAAGGCGGTGTGAAACTATTAACTC
AAAATTTATGTACTGCCTACGCTAAATATGGAATACGTATTAATGCGGTGTGCCCTGGTTATATTCACACCCCTTTACTC
GGTAGTGTTAATCCTCAACAGAAAGAATATTTAGCTTCACTTCATCCGCAAGGCAGACTTGGAACACCAGAAGAAGTCGC
TAAAGCTGTCTTATTTTTAGCAAGTGATGATGCTAGTTTTGTTAACGGTACAACACTTCTTGTTGATGGAGGCTATACTG
CACGTTAA

Upstream 100 bases:

>100_bases
CGGTAAATTAGATATTATGTATGCCAATGCCGGCGTTGCTGATGATGCACCGGCAAACGAATTATCCTATGAAAAGTGAA
AAAGAACTATTGATATTAAT

Downstream 100 bases:

>100_bases
TTTAAAAATTTTGAAGTACCCTAAGAAATATATAGTCTTCAACAAGAAAAAGCACCGTCACAAATGACGGTGCTTTTTCT
ATGTAAGAGCTACTAGAAGA

Product: short chain dehydrogenase

Products: NA

Alternate protein names: R-HPCDH; Aliphatic epoxide carboxylation component III [H]

Number of amino acids: Translated: 135; Mature: 134

Protein sequence:

>135_residues
MSGVFLSNKYSIEQFLKQGTGGVIVNAGSIHSFVSLPTTTAYSSAKGGVKLLTQNLCTAYAKYGIRINAVCPGYIHTPLL
GSVNPQQKEYLASLHPQGRLGTPEEVAKAVLFLASDDASFVNGTTLLVDGGYTAR

Sequences:

>Translated_135_residues
MSGVFLSNKYSIEQFLKQGTGGVIVNAGSIHSFVSLPTTTAYSSAKGGVKLLTQNLCTAYAKYGIRINAVCPGYIHTPLL
GSVNPQQKEYLASLHPQGRLGTPEEVAKAVLFLASDDASFVNGTTLLVDGGYTAR
>Mature_134_residues
SGVFLSNKYSIEQFLKQGTGGVIVNAGSIHSFVSLPTTTAYSSAKGGVKLLTQNLCTAYAKYGIRINAVCPGYIHTPLLG
SVNPQQKEYLASLHPQGRLGTPEEVAKAVLFLASDDASFVNGTTLLVDGGYTAR

Specific function: Catalyzes the oxidation of 2-(R)-hydroxyalkyl thioesters of CoM to 2-oxoalkyl thioesters of CoM. The enzyme highly specific for the R enantiomers [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=131, Percent_Identity=36.6412213740458, Blast_Score=90, Evalue=6e-19,
Organism=Homo sapiens, GI66933014, Length=140, Percent_Identity=31.4285714285714, Blast_Score=75, Evalue=1e-14,
Organism=Homo sapiens, GI40254992, Length=129, Percent_Identity=35.6589147286822, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI4503301, Length=123, Percent_Identity=34.1463414634146, Blast_Score=71, Evalue=2e-13,
Organism=Homo sapiens, GI59889578, Length=123, Percent_Identity=35.7723577235772, Blast_Score=69, Evalue=8e-13,
Organism=Homo sapiens, GI32483357, Length=132, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=9e-13,
Organism=Homo sapiens, GI7705925, Length=122, Percent_Identity=31.1475409836066, Blast_Score=65, Evalue=2e-11,
Organism=Homo sapiens, GI19923817, Length=137, Percent_Identity=35.036496350365, Blast_Score=65, Evalue=2e-11,
Organism=Homo sapiens, GI4758504, Length=113, Percent_Identity=37.1681415929204, Blast_Score=63, Evalue=8e-11,
Organism=Escherichia coli, GI87082100, Length=141, Percent_Identity=34.7517730496454, Blast_Score=94, Evalue=3e-21,
Organism=Escherichia coli, GI1788459, Length=132, Percent_Identity=35.6060606060606, Blast_Score=92, Evalue=1e-20,
Organism=Escherichia coli, GI1789208, Length=135, Percent_Identity=35.5555555555556, Blast_Score=90, Evalue=6e-20,
Organism=Escherichia coli, GI1790717, Length=132, Percent_Identity=34.0909090909091, Blast_Score=87, Evalue=5e-19,
Organism=Escherichia coli, GI1787335, Length=132, Percent_Identity=34.0909090909091, Blast_Score=81, Evalue=3e-17,
Organism=Escherichia coli, GI2367175, Length=135, Percent_Identity=37.037037037037, Blast_Score=77, Evalue=4e-16,
Organism=Escherichia coli, GI87082160, Length=128, Percent_Identity=31.25, Blast_Score=71, Evalue=3e-14,
Organism=Escherichia coli, GI2367365, Length=128, Percent_Identity=33.59375, Blast_Score=61, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17555706, Length=131, Percent_Identity=40.4580152671756, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17536025, Length=128, Percent_Identity=35.9375, Blast_Score=82, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17536651, Length=124, Percent_Identity=36.2903225806452, Blast_Score=82, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI25147288, Length=110, Percent_Identity=39.0909090909091, Blast_Score=79, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71994600, Length=118, Percent_Identity=39.8305084745763, Blast_Score=76, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI71994604, Length=118, Percent_Identity=39.8305084745763, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI115534694, Length=124, Percent_Identity=33.8709677419355, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17560676, Length=134, Percent_Identity=32.089552238806, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17561402, Length=124, Percent_Identity=35.4838709677419, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17538182, Length=113, Percent_Identity=36.283185840708, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17561272, Length=122, Percent_Identity=31.9672131147541, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17562910, Length=143, Percent_Identity=30.0699300699301, Blast_Score=62, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24639444, Length=135, Percent_Identity=39.2592592592593, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24644337, Length=116, Percent_Identity=41.3793103448276, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21357041, Length=121, Percent_Identity=40.495867768595, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24644339, Length=121, Percent_Identity=40.495867768595, Blast_Score=73, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21355319, Length=123, Percent_Identity=36.5853658536585, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28571526, Length=121, Percent_Identity=38.8429752066116, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI23397609, Length=137, Percent_Identity=33.5766423357664, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.268 [H]

Molecular weight: Translated: 14241; Mature: 14110

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGVFLSNKYSIEQFLKQGTGGVIVNAGSIHSFVSLPTTTAYSSAKGGVKLLTQNLCTAY
CCCEEECCCCCHHHHHHCCCCCEEEECCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHH
AKYGIRINAVCPGYIHTPLLGSVNPQQKEYLASLHPQGRLGTPEEVAKAVLFLASDDASF
HHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHEEEECCCCCE
VNGTTLLVDGGYTAR
ECCEEEEEECCCCCC
>Mature Secondary Structure 
SGVFLSNKYSIEQFLKQGTGGVIVNAGSIHSFVSLPTTTAYSSAKGGVKLLTQNLCTAY
CCEEECCCCCHHHHHHCCCCCEEEECCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHH
AKYGIRINAVCPGYIHTPLLGSVNPQQKEYLASLHPQGRLGTPEEVAKAVLFLASDDASF
HHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHEEEECCCCCE
VNGTTLLVDGGYTAR
ECCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7704278; 9405410; 12524213 [H]