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The map label for this gene is yhcA [H]

Identifier: 118478496

GI number: 118478496

Start: 3041754

End: 3043295

Strand: Reverse

Name: yhcA [H]

Synonym: BALH_2869

Alternate gene names: 118478496

Gene position: 3043295-3041754 (Counterclockwise)

Preceding gene: 118478498

Following gene: 118478495

Centisome position: 57.89

GC content: 37.61

Gene sequence:

>1542_bases
GTGCAAATATGCAAACGATTTAAACGAATCAATGTAATTTATAATGAAGGGGCAAATAAATATATGAGTGAAACGTTACA
TAAAAGAAAACCACCATATGTAATGCTTGTAATCCTTTTTATTGGGGCATTTGTTTCATTTCTAAATAACTCGCTTTTAA
ATGTAGCCTTGCCATCAATAATGAAGGATTTAGACATTAAAGATTATTCAACGATCCAGTGGCTTTCTACAGGATATATG
CTTGTAAGTGGTATATTAATTCCCGCATCAGCATTTTTAATAACACGCTTCTCCAATAGGAGCTTATTTATTACATCTAT
GATGATTTTTACTCTTGGTACGGCCTTAGCGGCTGTAGCACCGAACTTCGGTTTATTACTGACTGGCCGAATGGTTCAAG
CAGCAGGTTCTTCAGTCATGGGGCCTTTGTTAATGAATATTATGCTAGTAAGCTTTCCGAGAGAAAAAAGGGGAACAGCA
ATGGGGATTTTTGGACTAGTTATGATTACAGCCCCAGCTATTGGACCGACATTATCAGGTTATATTGTAGAGTATTATGA
CTGGCGTTTGCTTTTTGAAATGATTTTACCGTTAGCAATCATTAGCTTACTGTTAGGGATTTGGAAATCAGAGAATGTCA
TGAGACAAAACAAAAATGCAAAACTTGATTATCTTTCATTACTATTATCTTCTATCGGTTTTGGCGGTTTATTATATGGG
TTCAGTTCTGCAAGCTCTGATGGTTGGACGAATAAAGTTGTCGTAACAACCTTAATCATAGGCGCTATTGCCCTAATTGC
TTTCATTATCCGTCAATTAAAAATGAATGAACCGTTATTGGATTTACGTGTTTATAAGTACCCAATGTTTGCACTTGCGT
CTGTAATTGCAATTGTCAACGCAGTGGCCATGTTTTCAGGTATGATTTTAACACCAGCTTATGTACAAAATGTCCGCGGT
ATTTCACCGCTGAGCTCTGGGCTGATGATGCTTCCAGGTGCGGTAATAATGGGGATTATGTCACCAATTACAGGTAAACT
ATTTGATAAATATGGCCCTCGTATTCTTGGTATAGTAGGACTTTCCATTACAGCCGTTTCAACTTATATGCTAGCAAACC
TACAACTCGACTCTAGTCACACACATATTATTCTTATTTACACACTGCGGATGTTTGGGATGGCGATGGTGATGATGCCG
CTTATGACAAATGGCCTTAATCAATTGCCAACTCGCTTAAATCCGCACGGTACAGCTGTTAATAATACAGCTCAACAAGT
ATCCGGTTCAATTGGTACTGCTATTCTTGTTACCATTATGAATTCTGTAACAAAAACAAAAGCTGAAAGTTTAATGGCTC
ATGTAGATCCAACAAACTTCACAGAAGCTACGAAGATAATGTTAACGCAGAAGGCTTTATTATCCGGAATTCAGCATTCA
TTCTATGTAGCACTTGGCATGAATGTCGTTGCGCTACTATTAGTTTTTTTCGTTAAACGTGTAGATACAAGCCCGGAAGC
TGTTGAGAGGTTAAATCGATAG

Upstream 100 bases:

>100_bases
ATATGCATTCAAAATTTTAAGTTGAGCAAGTAGAATTGCTAAAAAGAGAATATCCATTCGAAGAGTTTGGCAAAATACTG
CAAGGACAACACGTATTCTT

Downstream 100 bases:

>100_bases
AGCAAAATAAAAATCAAGATGATGATTTCTACTAAAAGGGCTGAAAAAAAGTGAAATAATTACACATAATGAAAAGGATC
TGATATTCATATCAGATCCT

Product: multidrug resistance protein B

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MQICKRFKRINVIYNEGANKYMSETLHKRKPPYVMLVILFIGAFVSFLNNSLLNVALPSIMKDLDIKDYSTIQWLSTGYM
LVSGILIPASAFLITRFSNRSLFITSMMIFTLGTALAAVAPNFGLLLTGRMVQAAGSSVMGPLLMNIMLVSFPREKRGTA
MGIFGLVMITAPAIGPTLSGYIVEYYDWRLLFEMILPLAIISLLLGIWKSENVMRQNKNAKLDYLSLLLSSIGFGGLLYG
FSSASSDGWTNKVVVTTLIIGAIALIAFIIRQLKMNEPLLDLRVYKYPMFALASVIAIVNAVAMFSGMILTPAYVQNVRG
ISPLSSGLMMLPGAVIMGIMSPITGKLFDKYGPRILGIVGLSITAVSTYMLANLQLDSSHTHIILIYTLRMFGMAMVMMP
LMTNGLNQLPTRLNPHGTAVNNTAQQVSGSIGTAILVTIMNSVTKTKAESLMAHVDPTNFTEATKIMLTQKALLSGIQHS
FYVALGMNVVALLLVFFVKRVDTSPEAVERLNR

Sequences:

>Translated_513_residues
MQICKRFKRINVIYNEGANKYMSETLHKRKPPYVMLVILFIGAFVSFLNNSLLNVALPSIMKDLDIKDYSTIQWLSTGYM
LVSGILIPASAFLITRFSNRSLFITSMMIFTLGTALAAVAPNFGLLLTGRMVQAAGSSVMGPLLMNIMLVSFPREKRGTA
MGIFGLVMITAPAIGPTLSGYIVEYYDWRLLFEMILPLAIISLLLGIWKSENVMRQNKNAKLDYLSLLLSSIGFGGLLYG
FSSASSDGWTNKVVVTTLIIGAIALIAFIIRQLKMNEPLLDLRVYKYPMFALASVIAIVNAVAMFSGMILTPAYVQNVRG
ISPLSSGLMMLPGAVIMGIMSPITGKLFDKYGPRILGIVGLSITAVSTYMLANLQLDSSHTHIILIYTLRMFGMAMVMMP
LMTNGLNQLPTRLNPHGTAVNNTAQQVSGSIGTAILVTIMNSVTKTKAESLMAHVDPTNFTEATKIMLTQKALLSGIQHS
FYVALGMNVVALLLVFFVKRVDTSPEAVERLNR
>Mature_513_residues
MQICKRFKRINVIYNEGANKYMSETLHKRKPPYVMLVILFIGAFVSFLNNSLLNVALPSIMKDLDIKDYSTIQWLSTGYM
LVSGILIPASAFLITRFSNRSLFITSMMIFTLGTALAAVAPNFGLLLTGRMVQAAGSSVMGPLLMNIMLVSFPREKRGTA
MGIFGLVMITAPAIGPTLSGYIVEYYDWRLLFEMILPLAIISLLLGIWKSENVMRQNKNAKLDYLSLLLSSIGFGGLLYG
FSSASSDGWTNKVVVTTLIIGAIALIAFIIRQLKMNEPLLDLRVYKYPMFALASVIAIVNAVAMFSGMILTPAYVQNVRG
ISPLSSGLMMLPGAVIMGIMSPITGKLFDKYGPRILGIVGLSITAVSTYMLANLQLDSSHTHIILIYTLRMFGMAMVMMP
LMTNGLNQLPTRLNPHGTAVNNTAQQVSGSIGTAILVTIMNSVTKTKAESLMAHVDPTNFTEATKIMLTQKALLSGIQHS
FYVALGMNVVALLLVFFVKRVDTSPEAVERLNR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1788710, Length=451, Percent_Identity=26.6075388026608, Blast_Score=149, Evalue=5e-37,
Organism=Escherichia coli, GI1789042, Length=487, Percent_Identity=24.0246406570842, Blast_Score=145, Evalue=7e-36,
Organism=Escherichia coli, GI87081983, Length=410, Percent_Identity=25.8536585365854, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1790195, Length=406, Percent_Identity=27.0935960591133, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1788392, Length=405, Percent_Identity=25.9259259259259, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6322958, Length=522, Percent_Identity=21.455938697318, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323735, Length=328, Percent_Identity=22.8658536585366, Blast_Score=67, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 56163; Mature: 56163

Theoretical pI: Translated: 10.32; Mature: 10.32

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
6.6 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
6.6 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQICKRFKRINVIYNEGANKYMSETLHKRKPPYVMLVILFIGAFVSFLNNSLLNVALPSI
CHHHHHHHHHHHEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHH
MKDLDIKDYSTIQWLSTGYMLVSGILIPASAFLITRFSNRSLFITSMMIFTLGTALAAVA
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHC
PNFGLLLTGRMVQAAGSSVMGPLLMNIMLVSFPREKRGTAMGIFGLVMITAPAIGPTLSG
CCCCEEEECHHHHHCCCHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHCCCCCCCHHH
YIVEYYDWRLLFEMILPLAIISLLLGIWKSENVMRQNKNAKLDYLSLLLSSIGFGGLLYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHCCCHHHHHH
FSSASSDGWTNKVVVTTLIIGAIALIAFIIRQLKMNEPLLDLRVYKYPMFALASVIAIVN
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
AVAMFSGMILTPAYVQNVRGISPLSSGLMMLPGAVIMGIMSPITGKLFDKYGPRILGIVG
HHHHHHCHHCCHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHH
LSITAVSTYMLANLQLDSSHTHIILIYTLRMFGMAMVMMPLMTNGLNQLPTRLNPHGTAV
HHHHHHHHHHHHEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCC
NNTAQQVSGSIGTAILVTIMNSVTKTKAESLMAHVDPTNFTEATKIMLTQKALLSGIQHS
CCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
FYVALGMNVVALLLVFFVKRVDTSPEAVERLNR
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
>Mature Secondary Structure
MQICKRFKRINVIYNEGANKYMSETLHKRKPPYVMLVILFIGAFVSFLNNSLLNVALPSI
CHHHHHHHHHHHEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHH
MKDLDIKDYSTIQWLSTGYMLVSGILIPASAFLITRFSNRSLFITSMMIFTLGTALAAVA
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHC
PNFGLLLTGRMVQAAGSSVMGPLLMNIMLVSFPREKRGTAMGIFGLVMITAPAIGPTLSG
CCCCEEEECHHHHHCCCHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHCCCCCCCHHH
YIVEYYDWRLLFEMILPLAIISLLLGIWKSENVMRQNKNAKLDYLSLLLSSIGFGGLLYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHCCCHHHHHH
FSSASSDGWTNKVVVTTLIIGAIALIAFIIRQLKMNEPLLDLRVYKYPMFALASVIAIVN
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
AVAMFSGMILTPAYVQNVRGISPLSSGLMMLPGAVIMGIMSPITGKLFDKYGPRILGIVG
HHHHHHCHHCCHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHH
LSITAVSTYMLANLQLDSSHTHIILIYTLRMFGMAMVMMPLMTNGLNQLPTRLNPHGTAV
HHHHHHHHHHHHEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCC
NNTAQQVSGSIGTAILVTIMNSVTKTKAESLMAHVDPTNFTEATKIMLTQKALLSGIQHS
CCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
FYVALGMNVVALLLVFFVKRVDTSPEAVERLNR
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969498 [H]