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The map label for this gene is pcp [H]

Identifier: 118478392

GI number: 118478392

Start: 2920218

End: 2920865

Strand: Reverse

Name: pcp [H]

Synonym: BALH_2757

Alternate gene names: 118478392

Gene position: 2920865-2920218 (Counterclockwise)

Preceding gene: 118478393

Following gene: 118478391

Centisome position: 55.56

GC content: 38.27

Gene sequence:

>648_bases
ATGAAAACAGTATTATTAACAGGATTTGATCCGTTCGGTGGAGAAAGTATCAATCCAGCTTGGGAAGTCGCAAAAAGTTT
GCATGAAAAAACAATCGGAGAATACAAGATTATTAGTAAACAAGTACCGACTGTATTTCATAAATCAATCAGCGTATTAA
AAGAGTATATAGAAGAACTAGCACCGGAATTTATTATATGCATTGGACAAGCTGGGGGTAGAACAGATATTACGATAGAG
CGTGTTGCAATTAATATTGATGATGCAAGAATTGCTGACAATGAAGGGAACCAACCGGTAGATGTACCGGTTGTAGAAGA
AGGACCAGCTGCTTATTGGTCTACACTTCCGATGAAAGCAATTGTAAAAAAACTTCAAGAAGAAGGTATACCGGCTTCCG
TTTCACAAACAGCAGGTACGTTCGTTTGTAATCATTTATTCTATGGTCTCATGCATGAACTAGAGAAACATGATACAAAA
ATGAAAGGCGGATTTATTCATATTCCGTTTTTACCAGAGCAAGCGAGTAATTATCCAGGGCAACCGAGTATGTCACTTTC
TACTATTCGTAAAGGGATAGAGTTGGCAGTTGAAGTAACGACGACAGTTGAGGTAGATATAGTGGAAATTGGAGGCACGA
CGCATTAA

Upstream 100 bases:

>100_bases
GTTATTAAAGCGCAAGTACCAATTGCTCTTTCAATCTTCATCATAAATATGTTTATCATGTACGGCCTAGTATATCGTTT
CTAATTAGGAGGAGAAAACT

Downstream 100 bases:

>100_bases
GTAGAATGAATTGTACGACACCTCCTGTAAACAACTGGTATAATAAGTATAGCAATATACATAGAGGTGATTTTTGTGCA
ACAATTTGAAGAAGTACGTT

Product: pyrrolidone-carboxylate peptidase

Products: NA

Alternate protein names: 5-oxoprolyl-peptidase; Pyroglutamyl-peptidase I; PGP-I; Pyrase [H]

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MKTVLLTGFDPFGGESINPAWEVAKSLHEKTIGEYKIISKQVPTVFHKSISVLKEYIEELAPEFIICIGQAGGRTDITIE
RVAINIDDARIADNEGNQPVDVPVVEEGPAAYWSTLPMKAIVKKLQEEGIPASVSQTAGTFVCNHLFYGLMHELEKHDTK
MKGGFIHIPFLPEQASNYPGQPSMSLSTIRKGIELAVEVTTTVEVDIVEIGGTTH

Sequences:

>Translated_215_residues
MKTVLLTGFDPFGGESINPAWEVAKSLHEKTIGEYKIISKQVPTVFHKSISVLKEYIEELAPEFIICIGQAGGRTDITIE
RVAINIDDARIADNEGNQPVDVPVVEEGPAAYWSTLPMKAIVKKLQEEGIPASVSQTAGTFVCNHLFYGLMHELEKHDTK
MKGGFIHIPFLPEQASNYPGQPSMSLSTIRKGIELAVEVTTTVEVDIVEIGGTTH
>Mature_215_residues
MKTVLLTGFDPFGGESINPAWEVAKSLHEKTIGEYKIISKQVPTVFHKSISVLKEYIEELAPEFIICIGQAGGRTDITIE
RVAINIDDARIADNEGNQPVDVPVVEEGPAAYWSTLPMKAIVKKLQEEGIPASVSQTAGTFVCNHLFYGLMHELEKHDTK
MKGGFIHIPFLPEQASNYPGQPSMSLSTIRKGIELAVEVTTTVEVDIVEIGGTTH

Specific function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline [H]

COG id: COG2039

COG function: function code O; Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C15 family [H]

Homologues:

Organism=Homo sapiens, GI8923198, Length=178, Percent_Identity=25.2808988764045, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000816
- InterPro:   IPR016125 [H]

Pfam domain/function: PF01470 Peptidase_C15 [H]

EC number: =3.4.19.3 [H]

Molecular weight: Translated: 23531; Mature: 23531

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS01333 PYRASE_GLU ; PS01334 PYRASE_CYS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVLLTGFDPFGGESINPAWEVAKSLHEKTIGEYKIISKQVPTVFHKSISVLKEYIEEL
CCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
APEFIICIGQAGGRTDITIERVAINIDDARIADNEGNQPVDVPVVEEGPAAYWSTLPMKA
CCCEEEEEECCCCCCCEEEEEEEEECCCCEECCCCCCCCCCCEEECCCCCHHHHHCCHHH
IVKKLQEEGIPASVSQTAGTFVCNHLFYGLMHELEKHDTKMKGGFIHIPFLPEQASNYPG
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHCCCCC
QPSMSLSTIRKGIELAVEVTTTVEVDIVEIGGTTH
CCCCCHHHHHHCCEEEEEEEEEEEEEEEECCCCCC
>Mature Secondary Structure
MKTVLLTGFDPFGGESINPAWEVAKSLHEKTIGEYKIISKQVPTVFHKSISVLKEYIEEL
CCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
APEFIICIGQAGGRTDITIERVAINIDDARIADNEGNQPVDVPVVEEGPAAYWSTLPMKA
CCCEEEEEECCCCCCCEEEEEEEEECCCCEECCCCCCCCCCCEEECCCCCHHHHHCCHHH
IVKKLQEEGIPASVSQTAGTFVCNHLFYGLMHELEKHDTKMKGGFIHIPFLPEQASNYPG
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHCCCCC
QPSMSLSTIRKGIELAVEVTTTVEVDIVEIGGTTH
CCCCCHHHHHHCCEEEEEEEEEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA